检索结果-南通市图书馆

A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-κB pathway

引用

Acta Pharmaceutica Sinica B 2023年第3期13卷 1093-1109页

作者： Sae-Bom Yoon Hyowon Hong Hee-Jong Lim Ji Hye Choi Yoon Pyo Choi seong Wook Seo Hyuk Woo Lee Chong Hak Chae Woo-Kyu Park Hyun Young Kim Daeyoung Jeong Tran Quang De chang-seon myung Heeyeong Cho Therapeutics&Biotechnology Division Korea Research Institute of Chemical TechnologyYuseong-guDaejeon 34114Republic of Korea Department of Pharmacology Chungnam National University College of PharmacyYuseong-guDaejeon 34134Republic of Korea Future Medicine Co. Ltd.Rm616 LH-Business Growth CenterSeongnamGyeonggido 13449Republic of Korea Department of Chemistry College of Natural SciencesCan Tho UniversityCan Tho city 9000Viet Nam

Interleukin-1 receptor-associated kinase 4(IRAK4)is a pivotal enzyme in the Toll-like receptor(TLR)/MYD88 dependent signaling pathway,which is highly activated in rheumatoid arthritis tissues and activated B cell-like diffuse large B-cell lymphoma(ABC-DLBCL).Inflammatory responses followed by IRAK4 activation promote B-cell proliferation and aggressiveness of ***,proviral integration site for Moloney murine leukemia virus 1(PIM1)functions as an anti-apoptotic kinase in propagation of ABC-DLBCL with ibrutinib *** developed a dual IRAK4/PIM1 inhibitor KIC-0101 that potently suppresses the NF-κB pathway and proinflammatory cytokine induction in vitro and in *** rheumatoid arthritis mouse models,treatment with KIC-0101 significantly ameliorated cartilage damage and ***-0101 inhibited the nuclear translocation of NF-κB and activation of JAK/STAT pathway in *** addition,KIC-0101 exhibited an anti-tumor effect on ibrutinib-resistant cells by synergistic dual suppression of TLR/MYD88-mediated NF-κB pathway and PIM1 *** results suggest that KIC-0101 is a promising drug candidate for autoimmune diseases and ibrutinib-resistant B-cell lymphomas.

关键词： Drug discovery IRAK4 PIM1 NF-κB pathway Rheumatoid arthritis ABC-DLBCL Ibrutinib resistance Dual inhibitor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Capsosiphon fulvescens suppresses LPS-stimulated inflammatory responses by suppressing TLR4/NF-κB activation in RAW264.7 murine macrophages

引用

Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 115-126页

作者： seon Yeong Ji EunJin Bang Hyun Hwangbo Min Yeong Kim Da Hye Kim Su Hyun Hong Shin-Hyung Park chang-Young Kwon Gi-Young Kim You-Jin Jeon Suengmok Cho Yung Hyun Choi Department of Biochemistry Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Basic Research Laboratory for the Regulation of Microplastic-Mediated Diseases and Anti-Aging Research Center Dong-eui UniversityBusan 47227Republic of Korea Department of Pathology Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Department of Oriental Neuropsychiatry Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Department of Marine Life Science Jeju National UniversityJeju 63243Republic of Korea Department of Food Science and Technology/Institute of Food Science Pukyong National UniversityBusan 48513Republic of Korea

Objective:To evaluate the effects of Capsosiphon fulvescens(***)ethanolic extract on inflammation in lipopolysaccharide(LPS)-induced RAW296.7 ***:The protective effects of *** ethanolic extract on LPS-induced inflammation in RAW264.7 macrophages were assessed using biochemical analysis,including enzyme-linked immunosorbent assay,quantitative reverse transcription-polymerase chain reaction,and Western blot *** examine reactive oxygen species(ROS)production,flow cytometry analysis,and immunofluorescence staining were ***,the modulatory effect of *** ethanolic extract on NF-κB activation was ***:*** ethanolic extract significantly attenuated LPS-induced levels of pro-inflammatory cytokines and notably reduced the secretion and mRNA levels of LPS-mediated matrix *** addition,*** ethanolic extract decreased ROS production and suppressed the TLR4/NF-κB signaling ***:*** ethanolic extract alleviates inflammation as well as oxidative stress by modulating the TLR4/NF-κB signaling in LPS-induced RAW264.7 *** can be used as a potential therapeutic agent to suppress inflammation and oxidative stress-associated diseases.

关键词： Capsosiphon fulvescens Inflammation Oxidative stress NF-κB Nrf2 TLR4

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses

引用

Cell Research 2007年第5期17卷 435-440页

作者： seon Hee chang Unit 906 Houston USA TX 77030 7455 Fannin Department of Immunology MD Anderson Cancer Center

CD4+ helper T (TH) cells play crucial roles in immune responses. Recently a novel subset of TH cells, termed TH,TH17 or inflammatory TH (THi), has been identified as critical mediators of tissue inflammation. These cells produceIL-17 (also called IL-17 A) and IL-17F, two most homologous cytokines sharing similar regulations. Here we reportthat when overexpressed in 293T cells, IL-17 and IL-17F form not only homodimers but also heterodimers, which wename as IL-17A/F. Fully differentiated mouse THi cells also naturally secrete IL-17A/F as well as IL-17 and IL-17Fhomodimeric cytokines. Recombinant IL-17A/F protein exhibits intermediate levels of potency in inducing IL-6 andKC (CXCL1) as compared to homodimeric cytokines. IL-17A/F regulation of IL-6 and KC expression is dependent onIL-17RA and TRAF6. Thus, IL-17A/F cytokine represents another mechanism whereby T cells regulate inflammatoryresponses and may serve as a novel target for treating various immune-mediated diseases.

关键词： inflammation IL-17 T cells

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Expression and regulation of IL-22 in the *** CD4+T lymphocytes

引用

Cell Research 2006年第11期16卷 902-907页

作者： Yeonseok Chung seon Hee chang Department of lmmunology MD Anderson Cancer CenterHoustonTX 77030USA

IL-22 is a novel cytokine in the IL-10 family that functions to promote innate immunity of tissues against *** CD4+helper T lymphocytes(TH)were found as a source of IL-22,the regulation of this cytokine has beenpoorly ***,we show that IL-22 is expressed at both mRNA and protein levels by a novel subset of THcells that also makes ***-22 and IL-17 were found to be coordinately regulated by TGFβ and IL-6 during TH dif-ferentiation by real-time PCR as well as ELISA ***,IL-22 does not regulate TH differentiation; exogenousIL-22 or an IL-22 antagonist had no effect on TH *** data demonstrate a novel cytokine expressed byIL-17-producing T cells,and suggest interaction and synergy of IL-22 and IL-17 signaling pathways in tissue inflam-mation and autoimmune diseases.

关键词： cytokines helper T cells T cell activation gene regulation

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Cumulative incidence and risk factors for pouch adenomas associated with familial adenomatous polyposis following restorative proctocolectomy

引用

World Journal of Gastroenterology 2022年第30期28卷 4152-4162页

作者： Hyo seon Ryu chang Sik Yu Young Il Kim Jong Lyul Lee Chan Wook Kim Yong Sik Yoon In Ja Park Seok-Byung Lim Jin Cheon Kim Division of Colon and Rectal Surgery Department of SurgeryUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND The emergence of restorative total proctocolectomy has significantly reduced the lifetime colorectal cancer risk associated with familial adenomatous polyposis(FAP).However,adenomas may develop in the ileal pouch over time and may even progress to *** evaluated the cumulative incidence,time to development,and risk factors associated with ileal pouch *** To evaluate the cumulative incidence,time to development,and risk factors associated with pouch *** In this retrospective,observational study conducted at a tertiary center,95 patients with FAP who underwent restorative proctocolectomy at our center between 1989 and 2018 were consecutively *** mean follow-up period was 88 *** Pouch adenomas were found in 24(25.3%)patients,with a median time of 52 mo to their first *** adenomas were detected in most patients(95.9%).There were no high-grade dysplasia or *** the 24 patients with pouch adenomas,13 had all detected adenomas *** the 13 patients who underwent complete adenoma removal,four(38.5%)developed *** 11(45.8%)patients with numerous polyps within the pouch,seven(63.6%)exhibited progression of pouch *** cumulative risks of pouch adenoma development at 5,10,and 15 years after pouch surgery were 15.2%,29.6%,and 44.1%,*** colorectal polyposis(with more than 1000 polyps)was a significant risk factor for pouch adenoma development(hazard ratio,2.49;95% confidence interval:1.04-5.96;P=0.041).CONCLUSION Pouch adenomas occur at a fairly high rate in association with FAP after restorative proctocolectomy,and a high colorectal polyp count is associated with pouch adenoma development.

关键词： Adenomatous polyposis coli Familial adenomatous polyposis Adenoma Intestinal polyps Proctocolectomy,restorative Ileal pouch anal anastomosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Performance Study of a Hybrid Heat Pump Dryer based on Numerical Analysis and Experimental Set-up

引用

Journal of Thermal Science 2021年第1期30卷 111-122页

作者： SHAMSUDDEEN Mohamed Murshid CHA Dong-An KIM seon-chang KANEMOTO Toshiaki KIM Jin-Hyuk Industrial Technology Korea University of Science&TechnologyDaejeon 34113Republic of Korea Thermal&Fluid System R&D Group Korea Institute of Industrial TechnologyCheonan 31056Republic of Korea Institute of Ocean Energy Saga UniversityHonjo 1Saga 840-8502Japan

Seafood,especially sea cucumbers and oysters are an expensive delicacy in several Asian *** sun-drying of these products takes 3 to 4 days and fetches a lower market *** industrial drying machines used for seafood drying are unable to dry sea cucumbers and oysters without texture and color degradation as they are delicate,temperature-sensitive and have longer drying *** economical drying system that does not cause texture or color degradation is the heat pump drying system and is commonly applied for agriculture and fabric *** this study,the heat pump technology is applied to develop two hybrid dryer models(bottom discharge and front discharge)to dry shellfish and sea cucumbers in large scale for storage and *** model is tested in a laboratory-scale with wet sponges as input material for its dehumidification capacity and the power consumed to attain the target *** front discharge model is found to have rapid drying capability and *** fluid dynamic tools are used to study the hot air flow behavior and flow uniformity inside the drying *** front discharge model showed smooth uniform flow over the trays with fewer losses in the flow *** front discharge model with higher drying rate,lower power consumption and uniform airflow distribution over the trays is chosen for the industrial-scale design.

关键词： heat pump hybrid dryer CFD drying rate sea cucumber oyster

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Electrophoretic Deposition of Oxide Nanoparticles for Electron Emission Enhancement

引用

Journal of Materials Science & Technology 2010年第11期26卷 1032-1036页

作者： Jong Rok Ahn Gil seon Kang Hwack Joo Lee chang Joon Park Korea Research Institute of standards and Science

Four oxide nanoparticles,such as yttrium oxide,lanthanum oxide,cerium oxide and zirconium oxide were coated on rhenium filaments by an electrophoretic deposition *** oxide coatings were examined by scanning electron microscopy,and electron emission characteristics of the oxide-coated rhenium were studied to find alternative oxide materials for replacing the hazardous thorium *** four oxides tested in this work,yttrium oxide and lanthanum oxide coated rhenium showed enhanced electron emission compared with an uncoated ***,lanthanum oxide coating evaporated too quickly in a vacuum chamber,and hence yttrium oxide was found to be the only alternative material for use in a routine mass *** optimum coating thickness of the yttrium oxide and lanthanum oxide was around 20 μm.

关键词： Electrophoretic deposition Oxide nanoparticles Scanning electron microscopy (SEM) Electron emission

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Increased type III interferons and NK cell functions in SARS-CoV-2-infected children

引用

Signal Transduction and Targeted Therapy 2023年第3期8卷 888-890页

作者： seong Dong Jeong Hoyoung Lee Ju Young chang seong Yong Lee Ji Eun Choi Eunmi Yang Hye Won Jeong Jae-Phil Choi Mi seon Han Eui-Cheol Shin The Center for Viral Immunology Korea Virus Research InstituteInstitute for Basic Science(IBS)Daejeon 34126Republic of Korea Department of Pediatrics Seoul Metropolitan Government-Seoul National University Boramae Medical Center and Seoul National University of College of MedicineSeoul 07061Republic of Korea Division of infectious diseases Seoul Medical CenterSeoul 02053Republic of Korea Department of Internal Medicine Chungbuk National University College of MedicineCheongju 28644Republic of Korea Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea

Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection is more likely to progress to severe disease in the elderly,and the rates of hospitalization for coronavirus disease 2019(COVID-19)increase with age.1,2 Herein,we comprehensively compared adaptive and innate immune responses between children and adults infected with SARS-CoV-2.

关键词： infected acute respiratory

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Utilization of nano/micro-size iron recovered from the fine fraction of automobile shredder residue for phenol degradation in water

引用

Frontiers of Environmental Science & Engineering 2016年第4期10卷 53-59页

作者： Jiwan SINGH Yoon-Young chang Jae-Kyu YANG seon-Hong KANG Janardhan Reddy KODURU Department of Environmental Engineering Kwangwoon University Seoul 139-701 Republic of Korea Division of General Education Kwangwoon University Seoul 139-701 Republic of Korea Graduate School of Environmental S~dies Kwangwoon university Seoul 139-701 Republic of Korea

The study investigates the magnetic separation of Fe from automobile shredder residue （ASR）（〈 0.25 mm） and its application for phenol degradation in water. The magnetically separated Fe was subjected to an ultrasonically assisted acid treatment, and the degradation of phenol in an aqueous solution using nano/micro-size Fe （n/m Fe） was investigated in an effort to evaluate the possibility of utilizing n/m Fe to remove phenol from wastewater. The prepared n/m Fe was analyzed by scanning electron microscopy （SEM） and Fourier transform infrared spectroscopy （FTIR）. The eflects of the dosages ot n/mFe, pH, concentration of phenol and amount of H2O2 on phenol removal were evaluated. The results confirm that the phenol degradation rate was improved with an increase in the dosages of n/mFe and H2O2; however, the rate is reduced when the phenol concentration is higher. The degradation of phenol by n/mFe followed the pseudo-first-order kinetics. The value of the reaction rate constant （k）was increased as the amounts of n/m Fe and H2O2 increased. Conversely, the value of k was reduced when the concentration of phenol was increased. The probable mechanism behind the degradation of phenol by n/m Fe is the oxidation of phenol through hydroxyl radicals which are produced during the reaction between H2O2 and n/m Fe.

关键词： Automobile shredder residue (ASR)Fe Phenol Scanning electron microscopy (SEM) andFourier transform infrared spectroscopy(FTIR)Mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Self-expandable metal stents for choledocholithiasis in Billroth II gastrectomy patients

引用

Hepatobiliary & Pancreatic Diseases International 2018年第6期17卷 546-552页

作者： Min-Gui Han Eunae Cho chang-Hwan Park Chung-Hwan Jun seon-Young Park Division of Gastroenterology Department of Internal MedicineChonnam National University Hospital42Jaebong-roDong-KuGwangju 61482Korea

Background: Efficient ampullary intervention is essential for endoscopic retrograde cholangiopancreatography(ERCP) in patients with a prior Billroth II gastrectomy. We retrospectively evaluated the safety and effectiveness of ampullary intervention using fully covered self-expandable metal stents(FCSEMSs) for the management of common bile duct(CBD) stones in a subset of patients with a history of Billroth II gastrectomy. Methods: This retrospective analysis involved patients with a prior Billroth II gastrectomy who underwent ampullary intervention with FCSEMSs for the management of CBD stones. The factors associated with FCSEMSs placement, treatment success, and procedural complications were analyzed. Results: A group of 15 patients(10 males; median age, 78 years) underwent biliary metal stent placement for high degree of CBD angulation(6), small or flat papilla with unclear margin(5), current use of double antiplatelet agents or an anticoagulant(2), unwanted instrumentation of the cystic duct(1), and insecure position of the scope(1). Ampullary intervention with FCSEMSs was successful in all patients. After dilating the ampulla of Vater and building a durable conduit with FCSEMSs immediately, CBD stones were removed successfully from all patients in a single session. A mild post-ERCP pancreatitis occurred in one patient, who recovered without complications. Conclusion: Ampullary intervention with FCSEMSs is safe and effective for the management of CBD stones in a subset of patients with a history of Billroth II gastrectomy.

关键词： Common bile duct stone Endoscopic retrograde cholangiopancreatography Stent placement Stone extraction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：