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Systemic immune-inflammation index,neutrophilto-lymphocyte ratio,and platelet-to-lymphocyte ratio in patients with type 2 diabetes at different stages of diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 877-882页

作者： Ying Gao Rong-Xin Lu Yun Tang Xin-Yi Yang Hu Meng chang-lin zhao Yi-Lu Chen Feng Yan Qian Cao Department of Ophthalmology Sir Run Run HospitalNanjing Medical UniversityNanjing 211112Jiangsu ProvinceChina Department of Ophthalmology Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina Department of Thoracic Surgery the First Affiliated Hospital with Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Medical School Nanjing UniversityNanjing 210093Jiangsu ProvinceChina Department of Ophthalmology Taikang Xianlin Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210046Jiangsu ProvinceChina

AIM:To investigate systemic immune-inflammation index(SII),neutrophil-to-lymphocyte ratio(NLR),and plateletto-lymphocyte ratio(PLR)levels in patients with type 2 diabetes at different stages of diabetic retinopathy(DR).METHODS:This retrospective study included 141 patients with type 2 diabetes mellitus(DM):45 without diabetic retinopathy(NDR),47 with non-proliferative diabetic retinopathy(NPDR),and 49 with proliferative diabetic retinopathy(PDR).Complete blood counts were obtained,and NLR,PLR,and SII were *** study analysed the ability of inflammatory markers to predict DR using receiver operating characteristic(ROC)*** relationships between DR stages and SII,PLR,and NLP were assessed using multivariate logistic ***:The average NLR,PLR,and SII were higher in the PDR group than in the NPDR group(P=0.011,0.043,0.009,respectively);higher in the NPDR group than in the NDR group(P<0.001 for all);and higher in the PDR group than in the NDR group(P<0.001 for all).In the ROC curve analysis,the NLR,PLR,and SII were significant predictors of DR(P<0.001 for all).The highest area under the curve(AUC)was for the PLR(0.929 for PLR,0.925 for SII,and 0.821 for NLR).Multivariate regression analysis indicated that NLR,PLR,and SII were statistically significantly positive and independent predictors for the DR stages in patients with DM[odds ratio(OR)=1.122,95%confidence interval(CI):0.200–2.043,P<0.05;OR=0.038,95%CI:0.018–0.058,P<0.05;OR=0.007,95%CI:0.001–0.01,P<0.05,respectively).CONCLUSION:The NLR,PLR,and SII may be used as predictors of DR.

关键词： diabetic retinopathy neutrophil-tolymphocyte ratio platelet-to-lymphocyte ratio systemic immune-inflammation index

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New species and phylogeny of Perenniporia based on morphological and molecular characters

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Fungal Diversity 2013年第1期58卷 47-60页

作者： chang-lin zhao Bao-Kai Cui Yu-Cheng Dai Institute of Microbiology Beijing Forestry UniversityP.O.Box 61Beijing 100083China State Key Laboratory of Forest and Soil Ecology Institute of Applied EcologyChinese Academy of SciencesShenyang 110164China

Three new resupinate,poroid,wood-inhabiting fungi,Perenniporia aridula,*** and ***,are introduced on the basis of morphological and molecular *** study based on sequence data from the ribosomal ITS and LSU regions supported the three new species’positions in Perenniporia s.s.,and all of them formed monophyletic lineages with strong support(100%BP,1.00 BPP).Phylogenetic analysis revealed seven clades for the 31 species of Perenniporia *** in this *** them,Perenniporiella clustered with Perenniporia ochroleuca group,and then subsequently grouped with *** addition,the *** group,the *** group,the *** group and *** formed well supported monophyletic entities,which could be recognized as distinct genera,and they are not related to ***-panis which belongs to Perenniporia *** identification key to 38 species of Perenniporia occurring in China is provided.

关键词： Phylogeny ITS and nLSU Polypore Taxonomy China

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Effects of moxibustion on Treg cells in sarcoma microenvironment

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Journal of Integrative Medicine 2021年第3期19卷 251-257页

作者： Li-jun Li Yu-chong Shi Min-xiang Luo chang-lin zhao Department of Acupuncture Guangdong Clifford HospitalGuangzhou 511495Guangdong ProvinceChina School of Traditional Chinese Medicine Jinan UniversityGuangzhou 510632Guangdong ProvinceChina Health Science College Guangdong Pharmaceutical UniversityGuangzhou 510006Guangdong ProvinceChina

Objective:To investigate the therapeutic effect of moxibustion on sarcomas from mesenchymal tissues,which have a low response rate to chemotherapy and ***:S180 sarcoma cell line was inoculated in C57 BL/6 mice to form transplanted *** therapy was directly applied at the transplanted tumor sites,at a distance of 3.0 cm,10 min per session,till skin temperature reached 45°C,once a day,for 14 consecutive days of *** the mice were killed,serum was collected and used to detect concentrations of interleukin-10(IL-10),transforming growth factor-b1(TGF-b1),IL-4 and interferon-c(IFN-c)by Luminex liquid suspension *** numbers of Treg^(^(+) )T cells and CD4^(+) CD25^(+) Forkhead Box P3(Foxp3)^(+) T cells were detected by flow *** in situ hybridization was used to analyze the changes of CD4,CD8,Foxp3 and TGF-b1 in the tumor microenvironment(TME).Results:Weight of S180 transplanted tumor in the control group was(2.03±0.54)g,and that in the moxibustion group was(1.27±0.29)g,which was statistically different(P=0.023).The mean value of Foxp3^(+) T cells in the normal group was 2.01%,which increased to 3.63%after the formation of transplanted tumor,and decreased to 1.48%after moxibustion *** moxibustion group also had reduced numbers of CD4^(+) CD25^(+) Foxp3^(+) T cells in the spleen of mice with transplanted *** concentrations of IL-10,TGF-b1 and IL-4 decreased in the serum of mice with transplanted tumor,while the concentration of IFN-c *** was associated with downregulation in expression of Foxp3,IL-10 and TGF-b1 genes in the transplanted tumor,and increases in the gene expression of CD4^(+) T cells and CD8^(+) T cells in the ***:Moxibustion may have therapeutic effects on sarcomas by reducing the number of Treg cells in the blood and controlling the infiltration of Treg cells in the TME.

关键词： Sarcoma Moxibustion Treg cells Tumor microenvironment

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Fragiliporiaceae,a new family of Polyporales(Basidiomycota)

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Fungal Diversity 2015年第1期70卷 115-126页

作者： chang-lin zhao Bao-Kai Cui Jie Song Yu-Cheng Dai Institute of Microbiology and Beijing Key Laboratory for Forest Pest Control Beijing Forestry UniversityP.O.Box 61Beijing 100083China

Fragiliporiaceae ***.,a new poroid wood-inhabiting family,is introduced based on the combination of molecular and morphological data,and is typified by Fragiliporia *** phylogenetic analysis shows that Fragiliporia fragilis *** a monophyletic group within Polyporales and warrants the introduction of a new fragiliporia clade based on molecular data of ITS+nLSU rRNA gene *** ITS,nLSU,mtSSU,TEF1 and RPB2 sequence data also demonstrated that the new family Fragiliporiaceae also formed a monophyletic lineage(70%BS,57%BP,0.99 BPP),and grouped with the phlebioid clade,residual polyporoid clade and core polyporoid *** has unique macromorphological characters in having resupinate basidiocarps with very soft tubes when fresh,which become brittle when dry(becoming almost powdery when bruised);a monomitic hyphal system with thick-walled generative hyphae,clamp connections,and frequently H-,W-or Y-shaped hyphae branching from the clamp connections.

关键词： Fragiliporia clade Multi-marker analysis Polypores Taxonomy

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Current assessment and management of measurable residual disease in patients with acute lymphoblastic leukemia in the setting of CAR-T-cell therapy

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Chinese Medical Journal 2024年第2期137卷 140-151页

作者： Minghao lin Xiaosu zhao Yingjun chang Xiangyu zhao Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China

Chimeric antigen receptor(CAR)-modified T-cell therapy has achieved remarkable success in the treatment of acute lymphoblastic leukemia(ALL).Measurable/minimal residual disease(MRD)monitoring plays a significant role in the prognostication and management of patients undergoing CAR-T-cell *** MRD detection methods include flow cytometry(FCM),polymerase chain reaction(PCR),and next-generation sequencing(NGS),and each method has advantages and *** has been well documented that MRD positivity predicts a poor prognosis and even disease ***,how to perform prognostic evaluations,stratify risk based on MRD status,and apply MRD monitoring to guide individual therapeutic decisions have important implications in clinical *** review assesses the common and novel MRD assessment *** addition,we emphasize the critical role of MRD as a prognostic biomarker and summarize the latest studies regarding MRD-directed combination therapy with CAR-T-cell therapy and allogeneic hematopoietic stem cell transplantation(allo-HSCT),as well as other therapeutic strategies to improve treatment ***,this review discusses current challenges and strategies for MRD detection in the setting of disease relapse after targeted therapy.

关键词： Measurable/minimal residual disease Acute lymphoblastic leukemia Chimeric antigen receptor-modified T-cell therapy Allogeneic hematopoietic stem cell transplantation Relapse

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Broadband absorption performance of 3D-printed polyetheretherketone-based electromagnetic wave-absorbing composites

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Chinese Journal of Aeronautics 2024年第8期37卷 547-558页

作者： lin BAI Nan chang Meiying zhao Chi HOU Yi CAO Dichen LI School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Chengdu Aircraft Design and Research Institute Chengdu 610091China Xi’an Key Laboratory of Advanced Structure Design and Application of Aircraft Northwestern Polytechnical UniversityXi’an 710072China State Key Laboratory for Manufacturing System Engineering Xi’an Jiaotong UniversityXi’an 710054China

The rapid development of additive manufacturing technology has offered a new avenue for designing and fabricating high wave-absorbing meta *** this study,the mechanical properties and broadband absorption performance of Poly-Ether-Ether-Ketone(PEEK)–based electromagnetic wave–absorbing composite materials was *** high-performance polymer PEEK was used as the matrix,and the materials with electromagnetic wave loss,such as reduced graphene oxide,Carbonyl Iron(CI),and Flake CI(FCI),were used as *** on the theory of impedance matching,a wave-absorbing structure with a gradual impedance gradient was designed and *** test results showed that at the 2.0–18.0 GHz frequency band,the coverage rate of the effective absorption bandwidth was up to 72.0%,the average optimal reflectivity was–18.09 dB,and the wide-angle absorption range was 0°–30°.The advantages of additive manufacturing technology in designing and fabricating wave-absorbing structures are presented,demonstrating that the technology is an effective method for creating broadband absorbing structures.

关键词： Absorption performance Additive manufacturing Electromagnetic absorption PEEK composite materials Gradual structure Broadband absorption

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Tuning interface mechanism of FeCo alloy embedded N,S-codoped carbon substrate for rechargeable Zn-air battery

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Journal of Energy Chemistry 2024年第6期93卷 400-410,I0010页

作者： Hui chang Lulu zhao Shan zhao Zong-lin Liu Peng-Fei Wang Ying Xie Ting-Feng Yi School of Materials Science and Engineering Northeastern UniversityShenyang 110819LiaoningChina Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080HeilongjiangChina Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province School of Resources and MaterialsNortheastern University at QinhuangdaoQinhuangdao 066004HebeiChina

The interface mechanism between catalyst and carbon substrate has been the focus of *** this paper,the FeCo alloy embedded N,S co-doped carbon substrate bifunctional catalyst(FeCo/S-NC)is obtained by a simple one-step pyrolysis *** experimental results and density functional theory(DFT)calculation show that the formation of FeCo alloy is conducive to promoting electron transfer,and the introduction of S atom can enhance the interaction between FeCo alloy and carbon substrate,thus inhibiting the migration and agglomeration of particles on the surface of carbon *** FeCo/SNC catalysts show outstanding performance for oxygen reduction reaction(ORR)and oxygen evolution reaction(OER).FeCo/S-NC shows a high half-wave potential(E_(1/2)=0.8823 V)for ORR and a low overpotential at 10 mA cm^(-2)(E_(j=10)=299 mV)for *** addition,compared with Pt/C+RuO_(2) assembled Zn-air battery(ZAB),the FeCo/S-NC assembled ZAB exhibits a larger power density(198.8 mW cm^(-2)),a higher specific capacity(786.1 mA h g_(zn)~(-1)),and ultra-stable cycle *** results confirm that the optimized composition and the interfacial interaction between catalyst and carbon substrate synergistically enhance the electrochemical performance.

关键词： FeCo alloy N S co-doped carbon DFT calculation Zn-air batteries Interfacial interaction

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Species diversity, updated classification and divergence times of the phylum Mucoromycota

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Fungal Diversity 2023年第6期123卷 49-157页

作者： Heng zhao Yong Nie Tong-Kai Zong Ke Wang Mei-lin Lv Yu-Jin Cui Ablat Tohtirjap Jia-Jia Chen chang-lin zhao Fang Wu Bao-Kai Cui Yuan Yuan Yu-Cheng Dai Xiao-Yong Liu Institute of Microbiology School of Ecology and Nature ConservationBeijing Forestry UniversityBeijing 100083China College of Life Sciences Shandong Normal UniversityJinan 250358China School of Civil Engineering and Architecture Anhui University of TechnologyMa’anshan 243002China Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China Ministry of EducationSouthwest Forestry UniversityKunming 650224China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Research Center for Analytical Sciences College of SciencesNortheastern UniversityShenyang 110819China Permanent Research Base of National Forestry and Grassland Administration Jiangsu Vocational College of Agriculture and ForestryZhenjiang 212499China

Zygomycetes are phylogenetically early diverging,ecologically diverse,industrially valuable,agriculturally beneficial,and clinically pathogenic *** new phyla and subphyla have been constantly established to accommodate spe-cific members and a subkingdom Mucoromyceta,comprising Calcarisporiellomycota,Glomeromycota,Mortierellomycota and Mucoromycota,was erected to unite core zygomycetous fungi,phylogenetic relationships within phyla have not been well *** account of the information of monophyly and divergence time estimated from ITS and LSU rDNA sequences,the present study updates the classification framework of the phylum Mucoromycota from the class down to the generic rank:three classes,three orders,20 families(including five new families Circinellaceae,Protomycocladaceae,Rhizomucoraceae,Syzygitaceae and Thermomucoraceae)and 64 *** taxonomic hierarchy was calibrated with estimated divergence times:phylum earlier than 617 Mya,classes and orders earlier than 547 Mya,families earlier than 199 Mya,and genera earlier than 12 *** with this outline,all genera of Mucoromycota are annotated and 58 new species are *** addition,three new combinations are *** this study,we update the taxonomic backbone of the phylum Mucoromycota and reinforce its *** also contribute numerous new taxa and enrich the diversity of Mucoromycota.

关键词： Early-diverging fungi Zygomycetes Phylogenomics New taxa

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Visual test paper based on Au/δ-MnO_(2) hollow nanosphere oxidase-like activity regulation using hexavalent chromium as a smart switch

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Rare Metals 2024年第2期43卷 711-722页

作者： Wen-chang Zhuang Hai-Yue Zhang Zhen-Yang Chen Wen-Jing Cheng Wei-Dan Na zhao Li lin Tian School of Materials and Chemical Engineering Xuzhou University of TechnologyXuzhou221018China School of Chemistry and Environmental Science Yili Normal UniversityYining835000China

Paper-based sensing platform is a point of need analytical toolkit for safety ***,the sensitivity,specificity,and simplicity are still ***,we report a novel strategy(Au/δ-MnO_(2) hollow nanosphere and 3,3′,5,5′-tetramethylbenzidine(TMB)induced test strips for signal-on detection)that can be utilized for hexavalent chromium(Cr^(6+))***,Cr^(6+)(CrO_(4)^(2−)) as a smart switch can remarkably enhance the oxidase-like activity of Au/δ-MnO_(2) hollow *** presence of Cr^(6+) can regulate the surface electronic redistribution of Au/δ-MnO_(2) and adjust the geometric configuration,which leads to the improvement in oxidase-like activity of Au/δ-MnO_(2).As a proof-of-concept application,a visual paper-based sensing platform of Cr^(6+) along with quantitative analysis by the test strips was successfully *** paper-based sensing platform exhibits a linear range with excellent selectivity for other interfering substances and lower limit of detection of 0.09μmol·L^(−1),providing a promising toolkit at-home Cr^(6+) measurement and environmental monitoring.

关键词： Point of need Colorimetric biosensing platform Au/δ-MnO_(2) hollow nanosphere Test strip Cr^(6+)

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Contrasting strategies of optimizing carrier concentration in bulk InSe for enhanced thermoelectric performance

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Rare Metals 2024年第9期43卷 4425-4432页

作者： Hao-Nan Shi Shu-lin Bai Yu-Ping Wang Li-Zhong Su Qian Cao Cheng chang Li-Dong zhao School of Materials Science and Engineering Beihang University School of Materials Science and Engineering Taiyuan University of Science and Technology Huabei Cooling Device Co.Ltd.

Indium selenide (InSe),as a wide-bandgap semiconductor,has received extensive attention in the flexible electronics field in recent years due to its exceptional plasticity and promising thermoelectric ***,the low carrier concentration severely limits its thermoelectric performance *** this work,we conducted contrasting strategies that can be employed to increase the carrier concentration of InSe,including bandgap narrowing and heterovalent ***,the carrier concentration initially increases as a result of the reduced bandgap upon Te alloying and then slightly decreases due to the weak electronegativity of *** Br doping realizes high carrier concentration by pushing the Fermi level into the conduction bands and activating the multiple *** the other hand,both Te and Br obviously suppress the thermal conductivity due to the point defect *** contrast,Br doping realizes a higher thermoelectric performance with a maximum ZT of～0.13 at 773 K benefiting from the better optimization of carrier *** work elucidates the strategies for enhancing carrier concentration at anion sites and demonstrates the high efficiency of halogen doping in ***,the carrier concentration of InSe is promising to be further optimized,and future work should focus on employing approaches such as cation doping or secondphase compositing.

关键词： Bandgap Carrier concentration Heterovalent doping InSe Thermoelectric

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