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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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Precise gradient separation of nanoparticles using reduced graphene oxide-polyoxomolybdate membranes

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Science China Chemistry 2025年第01期 209-216页

作者： Yixin Yang Wanlei Zhao Ruoxuan zheng Hongqiang Li Wei Chen Yu-Fei Song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Quzhou Institute for Innovation in Resource Chemical Engineering

The purification and size sieving of nanoparticles （NPs） represents a significant scientific ***,the r GO-polyoxometalates (POMs=PMo12,Mo132and Mo368) membranes were fabricated successfully via a simple and scalable POMsassisted in-situ photoreduction *** the mass ratio of r GO to PMo12was 1:30,the resultant r GO-PMo12membranes with highly ordered and uniform nanochannels of 1.0 nm can be obtained,which showed an accurate carbon quantum dots（CQDs） separation with a cut-off size approximately 1.0 *** increase of the size of the interlayered POMs from PMo12（1.0 nm）,{Mo132}（2.9 nm） to{Mo368}（3.8 nm）,the resultant r GO-PMo12,r GO-Mo132and r GO-Mo368exhibited precise gradient separation of CQDs and Au nanoparticles by size exclusion *** results pave a promising way to construct new twodimensional （2D） membranes for highly efficient size-selective separation.

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Fast approximate maximum likelihood period estimation from incomplete timing data

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Chinese Journal of Aeronautics 2013年第2期26卷 435-441页

作者： ye Haohuan Liu zheng Jiang Wenli College of Electronic Science & Engineering National University of Defense Technology

To estimate the period of a periodic point process from noisy and incomplete observations, the classical periodogram algorithm is modified. The original periodogram algorithm yields an estimate by performing grid search of the peak of a spectrum, which is equivalent to the periodogram of the periodic point process, thus its performance is found to be sensitive to the chosen grid spacing. This paper derives a novel grid spacing formula, after finding a lower bound of the width of the spectral mainlobe. By employing this formula, the proposed new estimator can determine an appropriate grid spacing adaptively, and is able to yield approximate maximum likelihood estimate （MLE） with a computational complexity of O（n2）. Experimental results prove that the proposed estimator can achieve better trade-off between statistical accuracy and complexity, as compared to existing methods. Simulations also show that the derived grid spacing formula is also applicable to other estimators that operate similarly by grid search.

关键词： Grid search Maximum likelihood period estimation Periodic point process Periodogram Pulse repetition frequency

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'Structure units' as material genes in cathode materials for lithium-ion batteries

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National Science Review 2020年第2期7卷 242-245页

作者： Jiaxin zheng Yaokun ye Feng Pan School of Advanced Materials Peking University Shenzhen Graduate School

The basic structure unit of crystals is the lattice atom and its coordination environment. They are arranged periodically in certain combinations (*** group) to form crystals. Generally speaking, the bonding interaction and electronic structure in the structure unit determine the intrinsic physical and chemical properties of crystals [1],similar to the key role of genes in life.

关键词： as material genes in cathode materials for lithium-ion batteries Structure units

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Intermolecular reductive coupling of aliphatic ketones with alkynes and alkenes by BCN photocatalysts

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Science China Chemistry 2025年第1期 181-185页

作者： Yanping Xia Luyang Sun Jiajia Cheng Sibo Wang Meifang zheng Xinchen Wang State Key Laboratory of Photocatalysis on Energy and Environment College of Chemistry Fuzhou University

A photocatalytic process was developed for intermolecular reductive coupling of aliphatic ketones with alkynes/alkenes to furnish tertiary alcohols. Mechanistic studies support that boron carbonitrides(BCN) promote the single electron reduction of unactivated aliphatic ketones to generate ketyl radicals with visible light irradiation, which then react with alkynes and alkenes to afford the allylic and aliphatic alcohols, respectively. The heterogeneous photocatalytic system is compatible with diverse substrates including pharmaceutical-related molecules(43 examples) with reusability and scale-up experiments, verifying the complementary synthetic utility of this method to the homogeneous catalysts.

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Study of the XYZ states at the BESIII

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Frontiers of physics 2015年第6期10卷 59-69页

作者： chang-zheng Yuan Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China

With its unique data samples at energies of 3.8-4.6 GeV, the BESIII experiment made a significant contribution to the study of charmonium and charinonium-like states, i.e., the XYZ states. We review the results for observations of the Zc（3900） and Zc（4020） states, the X（3872） in e^＋e^- annihilation, and charmonium ψ（13D2） state, as well as measurements of the cross-sections of ωχcJ and ηJ/ψ, and the search for e^＋e^-→γχcJ and γY（4140）. We also present data from BESIII that may further strengthen the study of the XYZ and conventional charmonium states, and discuss perspectives on future experiments.

关键词： charmonium exotic states e^+e^- annihilation hadronic transitions radiative transtitions

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Dynamic phase transition theory

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Science China(Physics,Mechanics & Astronomy) 2023年第2期66卷 102-108页

作者： Qi-Jun ye Xin-zheng Li State Key Laboratory for Artificial Microstructure and Mesoscopic Physics Frontier Science Center for Nano-optoelectronics and School of PhysicsPeking UniversityBeijing 100871China Interdisciplinary Institute of Light-Element Quantum Materials Research Center for Light-Element Advanced Materialsand Collaborative Innovation Center of Quantum MatterPeking UniversityBeijing 100871China Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China

Thermodynamic conventions suffer from describing dynamical distinctions,especially when the structural and energetic changes induced by rare events are *** using the ensemble theory in the trajectory space,we present a statistical approach to address this *** than spatial particle-particle interaction which dominates thermodynamics,the temporal correlation of events dominates the *** zeros of dynamic partition function mark phase transitions in the space-time,i.e.,dynamic phase transition(DPT),as Yang and Lee formulate traditional phase transitions,and hence determine dynamic phases on both sides of the *** to the role of temperature(pressure) as thermal(mechanical) potential,we interpret the controlling variable of DPT,i.e., dynamic field,as the dynamical *** findings offer possibility towards a unified picture of phase and phase transition.

关键词： transition phase transition

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Nickel-Catalyzed Reductive Coupling of Aldehydes with Alkynes Mediated by Alcohol

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Chinese Journal of Chemistry 2020年第5期38卷 489-493页

作者： Yan-Long zheng Mengchun ye State Key Laboratory and Institute of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China

A nickel-catalyzed reductive coupling of aldehydes with aikynes using 1-phenylethanol as reducing agent has been *** key achievement of this work is that we demonstrate environmentally benign 1-phenylethanol can serve as a viable alternative reducing agent to Et3B,ZnEt2 and R3SiH for the nickel-catalyzed reductive coupling reaction of aldehyde and alkynes.

关键词： nickel catalyzed coupling

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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-zheng Lan zheng Wu Wen-Jia Chen Xin-Ning Yu Hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

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High-temperature self-powered X-ray detection in a bilayered hybrid ferroelectric halide perovskite

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Science China Chemistry 2025年

作者： Yingying zheng Panpan Yu Yunpeng Yao Shihai You Zeng-Kui Zhu Junhua Luo School of Chemistry and Chemical Engineering Jiangxi Normal University Key Laboratory of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education Jiangxi Normal University School of Environmental and Material Engineering Yantai University Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China

X-ray detectors which convert X-ray irradiation into electrical signals play an important role in diverse applications including medical diagnosis, security examination, nondestructive inspection, personal X-ray dosimeters and fundamental research[1–5]. Recently, metal halide perovskites（MHP） have been developed as a promising family for X-ray detection contributing to their intrinsic advantages, e.g.,simple synthesis, efficient X-ray absorption and excellent semiconducting properties[5–10].

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