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Prognostic significance of grade of malignancy based on histopathological differentiation and Ki-67 in pancreatic ductal adenocarcinoma

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Cancer Biology & Medicine 2024年第5期21卷 416-432页

作者： Yuexiang Liang Guannan Sheng Yu guo Yiping Zou Hanhan guo Zhifei Li Shaofei chang Quan Man Song Gao Jihui Hao Department of Pancreatic Cancer Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerTianjin 300060China Department of Gastrointestinal Oncology The First Affiliated Hospital of Hainan Medical UniversityHaikou 570102China Department of Gastrointestinal Pancreatic Surgery Shanxi Provincial People’s HospitalTaiyuan 030012China

Objective:Tumor cell malignancy is indicated by histopathological differentiation and cell ***-67,an indicator of cellular proliferation,has been used for tumor grading and classification in breast cancer and neuroendocrine ***,its prognostic significance in pancreatic ductal adenocarcinoma(PDAC)remains ***:Patients who underwent radical pancreatectomy for PDAC were retrospectively enrolled,and relevant prognostic factors were *** of malignancy(GOM),a novel index based on histopathological differentiation and Ki-67,is proposed,and its clinical significance was ***:The optimal threshold for Ki-67 was determined to be 30%.Patients with a Ki-67 expression level>30%rather than≤30%had significantly shorter 5-year overall survival(OS)and recurrence-free survival(RFS).In multivariate analysis,both histopathological differentiation and Ki-67 were identified as independent prognostic factors for OS and *** GOM was used to independently stratify OS and RFS into 3 tiers,regardless of TNM stage and other established prognostic *** tumor-nodemetastasis-GOM stage was used to stratify survival into 5 distinct tiers,and surpassed the predictive performance of TNM stage for OS and ***:Ki-67 is a valuable prognostic indicator for *** of the GOM in the TNM staging system may potentially enhance prognostic accuracy for PDAC.

关键词： Pancreatic ductal adenocarcinoma prognosis Ki-67 differentiation TNM stage

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Investigation of the quality of life,mental status in patients with gynecological cancer and its influencing factors

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World Journal of Psychiatry 2024年第7期14卷 1053-1061页

作者： Hai-Xia Shang Wen-Ting Ning Jin-Fen Sun Nan guo xin guo Jan-Nan Zhang Hong-xin Yu Su-Hui Wu Department of Gynaecology and Obstetrics The Third Hospital of Shanxi Medical UniversityShanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTaiyuan 030032Shanxi ProvinceChina

BACKGROUND Having a gynecological tumor or undergoing treatment can be a traumatic experience for women,as it affects their self-image and sexual relationships and can lead to psychological *** adjustment following cancer occurrence remains a key issue among the *** To examine the current status of quality of life(QoL),anxiety,and depression in patients with gynecological cancer and to analyze the factors associated with *** Data for 160 patients with gynecological malignancies treated at Shanxi Bethune Hospital from June 2020 to June 2023 were collected and analyzed ***’QoL was assessed using the European Organization for Research on Treatment of Cancer Quality of Life Questionnaire Core 30 and the Functional Assessment of Cancer Therapy-General *** emotional status was evaluated using the Self-Rating Anxiety/Depression *** associated factors of anxiety and depression were *** The overall QoL score of the patients 6 months after surgery was 76.39±3.63 *** included low levels of social and emotional function and severe fatigue and *** scores for physiological,functional,emotional,social,and family well-being exhibited an upward trend following surgery compared with those before *** month after surgery,some patients experienced anxiety and depression,with an incidence of 18.75%and 18.13%,*** analysis revealed that good sleep was a protective factor against anxiety and depression in patients with gynecological tumors,whereas physical pain was a risk *** Patients with gynecological malignancies often experience anxiety and *** analyzing the factors that affect patients’QoL,effective nursing measures can be administered.

关键词： Gynecological Tumors Quality of life Anxiety Depression

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Abnormal mechanochemical effect in ultraprecision machining of an additively manufactured precipitation-strengthened high-entropy alloy

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Journal of Materials Science & Technology 2024年第3期170卷 221-237页

作者： Long Xu Yuchao Bai Yunfa guo chang Ren Xiaohua Tan Yandong Jia Gang Wang Hao Wang Institute of Materials Shanghai UniversityShanghai 200444China Zhejiang Institute of Advanced Materials Shanghai UniversityJiashan 314100China Department of Mechanical Engineering National University of SingaporeSingapore 117575Singapore

Recently,researchers have explored the use of precipitation strengthening and finer microstructures with high-density dislocations in additive manufacturing to produce high-entropy alloys(HEAs)with adjustable ***,the inherent surface roughness and lack of machinability research in AMed HEAs limit their engineering *** this study,we systematically investigated the microstructural characteristics,mechanical properties,and machinability of Fe_(29.3)Co_(28.7)Ni_(28.6)Al_(6.8)Ti_(6.6)(at.%)HEAs with three different structures:single FCC phase cellular(SPC),dual precipitation-strengthened(DPS),and single precipitation-strengthened(SPS).These structures were fabricated by selective laser melting and isothermally annealing at 780 and 940℃.Compared to SPC HEA,DPS HEA exhibits a significant increase in yield strength and ultimate tensile strength but with a dramatic sacrifice in *** HEA exhibits similar mechanical properties to SPC HEA due to the pronounced coarsening of L21 *** ultraprecision machining micro-cutting test showed that SPC HEA had a significant mechanochem-ical effect,as evidenced by a sharp drop in cutting force for inked workpieces,but not DPS *** abnormal finding was that the negligible reflection of cutting force for SPS HEAs suggested a negative mechanochemical effect,even though SPS HEA had equally excellent plasticity like SPC *** was found that nanocrystallization-induced strength enhancement and ductility reduction of SPS HEA lead to chips’deformation dominated by shear avalanche rather than chip folding of SPC HEA,which involves the reduction of surface energy and friction of chips’***,these results and our research findings may guide the machining of AMed precipitation-strengthened HEAs and accelerate their engineering ap-plication.

关键词： High-entropy alloy Selective laser melting Precipitation strengthening Machinability Mechanochemical effect

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Evaluation of development potential of pumped hydroelectric storage and geothermal utilization system in abandoned coal mine

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Journal of Central South University 2024年第8期31卷 2872-2890页

作者： Wang, Meng guo, Ping-ye Jin, xin Dang, Guan-jie guo, Yi-chen Li, Yi State Key Laboratory for Tunnel Engineering China University of Mining and Technology-Beijing Beijing China School of Mechanics and Civil Engineering China University of Mining and Technology-Beijing Bgijing China

Every year in China, a significant number of mines are closed or abandoned. The pumped hydroelectric storage (PHS) and geothermal utilization are vital means to efficiently repurpose resources in abandoned mine. In this work, the development potentials of the PHS and geothermal utilization systems were evaluated. Considering the geological conditions and meteorological data available of Jiahe abandoned mine, a simple evaluation model for PHS and geothermal utilization was established. The average efficiency of the PHS system exceeds 70% and the regulatable energy of a unit volume is over 1.53 kW·h/m3. The PHS system achieves optimal performance when the wind/solar power ratio reaches 0.6 and 0.3 in daily and year scale, respectively. In the geothermal utilization system, the outlet temperature and heat production are significantly affected by the injection flow rate. The heat production performance is more stable at lower rate flow, and the proportion of heat production is higher in the initial stage at greater flow rate. As the operating time increases, the proportion of heat production gradually decreases. The cyclic heat storage status has obvious advantages in heat generation and cooling. Furthermore, the energy-saving and emission reduction benefits of PHS and geothermal utilization systems were calculated.

关键词： abandoned mine underground reservoir wind/solar energy pumped hydroelectric storage geothermal

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Cryptic diversity and rampant hybridization in annual gentians on the Qinghai-Tibet Plateau revealed by population genomic analysis

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Plant Diversity 2024年第2期46卷 194-205页

作者： Peng-Cheng Fu Qiao-Qiao guo Di chang Qing-Bo Gao Shan-Shan Sun School of Life Science Luoyang Normal UniversityLuoyang 471934PR China Key Laboratory of Adaptation and Evolution of Plateau Biota Northwest Institute of Plateau BiologyChinese Academy of SciencesXining 810001PR China

Understanding the evolutionary and ecological processes involved in population differentiation and speciation provides critical insights into biodiversity formation. In this study, we employed 29,865 single nucleotide polymorphisms(SNPs) and complete plastomes to examine genomic divergence and hybridization in Gentiana aristata, which is endemic to the Qinghai-Tibet Plateau(QTP) region. Genetic clustering revealed that G. aristata is characterized by geographic genetic structures with five clusters(West, East, Central, South and North). The West cluster has a specific morphological character(i.e., blue corolla) and higher values of FSTcompared to the remaining clusters, likely the result of the geological barrier formed by the Yangtze River. The West cluster diverged from the other clusters in the Early Pliocene;these remaining clusters diverged from one another in the Early Quaternary. Phylogenetic reconstructions based on SNPs and plastid data revealed substantial cyto-nuclear conflicts. Genetic clustering and D-statistics demonstrated rampant hybridization between the Central and North clusters,along the Bayankala Mountains, which form the geological barrier between the Central and North clusters. Species distribution modeling demonstrated the range of G. aristata expanded since the Last Interglacial period. Our findings provide genetic and morphological evidence of cryptic diversity in G. aristata, and identified rampant hybridization between genetic clusters along a geological *** findings suggest that geological barriers and climatic fluctuations have an important role in triggering diversification as well as hybridization, indicating that cryptic diversity and hybridization are essential factors in biodiversity formation within the QTP region.

关键词： Gentiana aristata Hybrid zone Qinghai-Tibet Plateau Plastome Nuclear SNPs

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Wide‑field swept‑source OCT angiography of the periarterial capillary‑free zone before and after anti‑VEGF therapy for branch retinal vein occlusion

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Eye and Vision 2024年第2期10卷 31-40页

作者： Wenyi Tang Wei Liu Jingli guo Lili Zhang Gezhi Xu Keyan Wang Qing chang Department of Ophthalmology Eye and ENT Hospital of Fudan University83 Fenyang RoadShanghai 200031China Shanghai Key Laboratory of Visual Impairment and Restoration Fudan UniversityShanghaiChina NHC Key Laboratory of Myopia(Fudan University) Laboratory of MyopiaChinese Academy of Medical SciencesShanghaiChina

Background:The aim of the study was to investigate the changes in the periarterial capillary-free zone(paCFZ)after anti-vascular endothelial growth factor(VEGF)therapy in patients with branch retinal vein occlusion(BRVO)by widefield swept-source optical coherence tomography angiography(SS-OCTA)and assess their associations with clinical ***:In this retrospective observational study of 54 treatment-naive BRVO patients with macular edema,we reviewed the findings of 12×12 mm^(2)SS-OCTA at baseline,3,6,and 12 months after intravitreal ranibizumab *** paCFZ and major retinal artery areas were measured on SS-OCTA *** paCFZ area to artery area(P/A)ratio was ***:The paCFZ areas and P/A ratios of first-and second-order arteries were significantly greater in BRVO eyes than in contralateral eyes(all P<0.01),but there were no differences in the first-and second-order artery areas(P=0.20 and 0.25,respectively).The paCFZ areas and P/A ratios decreased significantly at 3,6,and 12 months after anti-VEGF therapy(all P<0.01).The baseline P/A ratio was significantly correlated with the baseline best-corrected visual acuity(BCVA),central retinal thickness,and their improvements at 3,6,and 12 months(all P<0.05).Baseline BCVA and P/A ratios of first-and second-order arteries were independently associated with the final BCVA in multivariate linear ***:Wide-field SS-OCTA shows that anti-VEGF therapy can lead to a significant improvement in the paCFZ parameters in *** baseline P/A ratios on SS-OCTA tend to predict better visual outcomes at 12 months after anti-VEGF therapy.

关键词： Swept-source optical coherence tomography angiography Branch retinal vein occlusion Periarterial capillary free zone Anti-VEGF treatment Prognosis

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透射式GaAs光电阴极性能提高以及结构优化

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物理学报 2024年第3期73卷 266-272页

作者：吕行富容国常本康郭欣王芝南京理工大学电子工程与光电技术学院南京210094 昆明物理研究所昆明650221 西安应用光学研究所西安710065

为了提高透射式GaAs光电阴极性能,将国内与美国ITT公司的透射式GaAs光电阴极量子效率曲线进行对比,可知我国透射式光电阴极积分灵敏度已经达到2130μA/lm,美国ITT达到了2330μA/lm.利用修正后的量子效率、光学性能以及积分灵敏度的理论... 详细信息

为了提高透射式GaAs光电阴极性能,将国内与美国ITT公司的透射式GaAs光电阴极量子效率曲线进行对比,可知我国透射式光电阴极积分灵敏度已经达到2130μA/lm,美国ITT达到了2330μA/lm.利用修正后的量子效率、光学性能以及积分灵敏度的理论模型,分别对两者进行光学结构拟合.结果表明,国内光电阴极在窗口层和发射层的厚度、电子扩散长度以及后界面复合速率等方面均与ITT有一定差距.为了缩短两者的差距,优化阴极结构参数,具体研究了电子扩散长度和发射层厚度对量子效率的影响,结果表明如果均匀掺杂透射式GaAs光电阴极发射层厚度为1.3μm、电子扩散长度为7μm,则积分灵敏度可以达到2800μA/lm以上.

关键词： Ga As光电阴极透射式结构优化光学性能光电发射性能

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Molecular mechanism of hypoxia and alpha-ketoglutaric acid on collagen expression in scleral fibroblasts

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1780-1790页

作者： Yun Sun Zhuo-Zheng Li Jing Yang Ya-Ru Sha xin-Yu Hou Hong Fu Jia-Yin Li Shu-chang Bai Yong-Fang Xie guo-Hui Wang School of Life Science and Technology Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina

AIM:To investigate the molecular mechanisms underlying the influence of hypoxia and alpha-ketoglutaric acid(α-KG)on scleral collagen ***:Meta-analysis and clinical statistics were used to prove the changes in choroidal thickness(ChT)during *** establishment of a hypoxic myopia model(HYP)for rabbit scleral fibroblasts through hypoxic culture and the effects of hypoxia andα-KG on collagen expression were demonstrated by Sirius red *** analysis was used to verify the genes and pathways that hypoxia andα-KG affect collagen ***,real-time quantitative reverse transcription polymerase chain reaction(RT-qPCR)was used for reverse ***:Meta-analysis results aligned with clinical statistics,revealing a thinning of ChT,leading to scleral *** red staining indicated lower collagen expression in the HYP group and higher collagen expression in the HYP+α-KG group,showed that hypoxia reduced collagen expression in scleral fibroblasts,whileα-KG can elevated collagen expression under HYP *** analysis unveiled the related genes and signaling pathways of hypoxia andα-KG affect scleral collagen expression and the results were verified by ***:The potential molecular mechanisms through which hypoxia andα-KG influencing myopia is unraveled and three novel genes TLCD4,TBC1D4,and EPHX3 are *** findings provide a new perspective on the prevention and treatment of myopia via regulating collagen expression.

关键词： sclera scleral collagen expression hypoxia alpha-ketoglutaric acid myopia

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Effect of cerium alloying on microstructure,texture and mechanical properties of magnesium during cold-rolling process

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Journal of Rare Earths 2024年第5期42卷 1001-1008,I0007页

作者： Zhen Zhang Huanhuan Chen Shiju Cao Jinhua Peng Peng guo chang Long Shan Wang chang Chen Yong Wu Ji'an Huang Xiaodong Du Haigen Wei School of Materials Science and Engineering Hefei University of TechnologyHefei230009China NationalLocal Joint Research Center of Non-ferrous Metal Materials and Processing Technology Hefei230009China Laboratory of Nonferrous Metal Material and Processing Engineering of Anhui Province Hefei230009China School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang212003China Institute of Industry and Equipment Technology Hefei University of TechnologyHefei230009China Faculty of Materials Metallurgy and Chemistry Jiangxi University of Science and TechnologyGanzhou341000China

Hot-extrusion and cold-rolling were conducted on Mg-Ce binary alloys to explore the effect of cerium(Ce)on microstructure,texture and mechanical properties of Mg *** addition of Ce results in significant grain refinement both in as-cast and hot-extruded *** basal texture is also weakened after extrusion and an inclined basal texture is formed with Ce *** strength and elongation of the Mg-Ce alloys are improved simultaneously due to such grain refinement and texture weakening *** cold-rolling,plenty of twins are found in the pure Mg and AZ31 plates while grains in the Mg-0.3Ce plate deform more uniformly without lamellar twin ***,Mg-0.3Ce alloys own strong and continuous strain hardening because Ce atoms and Mg-Ce precipitated phases serve as obstacles for dislocation slip.

关键词： Mg-Ce alloys Hot extrusion Cold-rolling Rare earths

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High cerium content(Nd-Pr-Ce)_(2)Fe_(14)B melt-spun ribbons with high coercivity

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Journal of Rare Earths 2024年第4期42卷 690-695页

作者： Yujiang Zhong Junming Wang Zikai Yuan Ruijin Liu Minggang Zhu Zhe Liu xin Chen Wei Li Zhaohui guo Division of Functional Materials Central Iron and Steel Research InstituteBeijing100081China Ningbo Jinji Strong Magnetic Material Co. Ltd.Ningbo315172China Jiangxi Jiangwu Rare Metal New Material Co. Ltd.Nanchang330013China

The effects of wheel speeds on the magnetic properties and microstructures of[(Nd,Pr)_(1-x)Ce_(x)]-Fe-B meltspun ribbons were *** to melt-spun ribbons with low cerium(Ce)content(x=0.2),amorphous formation can be suppressed at high wheel speed in the ribbons with a relatively high Ce content(x=0.8),and with the increase of the wheel speed,the magnetic properties of the ribbons with high Ce content raise *** high wheel speed,the coercivity mechanism of melt-spun ribbons is mainly pinning field,and the high wheel speed introduces a large number of defects into the matrix as pinning ***,ribbons with high Ce content form a fine and uniform grain structure,so the grain boundary area enlarges,which further hinders the movement of domain *** combined effects of the above factors enable ribbons with high Ce content to have excellent magnetic properties(Hcj=0.977 T,Mr=64 m^(2) A/kg)at the wheel speed of 35 m/s.

关键词： Wheel speed Cecontent Microstructure Magnetic properties Rare earths

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