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Contrast-enhanced ultrasonography for the evaluation of liver fibrosis after biliary obstruction

World Journal of Gastroenterology 2015年第9期21卷 2614-2621页

作者： hyun Joo Shin Eun Young chang Hye Sun Lee Jung Hwa Hong Gyuri Park hyun Gi kim Myung-Joon kim Mi-Jung Lee Department of Radiology and Research Institute of Radiological Science Severance Children’s HospitalYonsei University College of MedicineSeoul 120-752South Korea Department of Pediatric Surgery Severance Children’s HospitalYonsei University College of MedicineSeoul 120-752South Korea Biostatistics Collaboration Unit Yonsei University College of MedicineSeoul 120-752South Korea Department of Laboratory Animal Resources Avison Bio Medical Research CenterYonsei University College of MedicineSeoul 120-752South Korea

AIM:To investigate perfusion change in contrastenhanced ultrasonography(CEUS) to evaluate liver fibrosis based on biliary obstruction using an animal ***:New Zealand white rabbits(3-4 kg) underwent bile duct ligation to form a biliary obstruction *** performed liver CEUS and laboratory tests on the day before the operation(day 0) and every 7 postoperative days until the rabbits were *** CEUS,signal intensity of liver parenchyma with a time-intensity curve was *** parameters were automatically calculated from regionof-interests,including peak signal intensity,mean transit time,area under the curve and time to *** grades of liver fibrosis were assessed according to the Metavir score system immediately after *** estimating equations were used to analyze the association between liver fibrosis grades and perfusion parameters for statistical *** perfusion parameters were measured on the last day and the difference between day 0 and the last day were ***:From the nine rabbits,histological grades of liver fibrosis were grade 1 in one rabbit,grade 2 and 3 in three rabbits each,and grade 4 in two *** the four CEUS parameters,only the peak signal intensity measured on the last day demonstrated a significant association with liver fibrosis grades(OR =1.392,95%CI:1.114-1.741,P =0.004).The difference in peak signal intensity between day 0 and the last dayalso demonstrated an association with liver fibrosis(OR =1.191,95%CI:0.999-1.419,P =0.051).The other parameters tested,including mean transit time,area under the curve,and time to peak,showed no significant correlation with liver fibrosis ***:This animal study demonstrates that CEUS can be used to evaluate liver fibrosis from biliary obstruction using peak signal intensity as a parameter.

关键词： Ultrasonography Contrast enhanced ultrasound Liver

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Formal Approach to Workow Application Fragmentations Over Cloud Deployment Models

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Computers, Materials & Continua 2021年第6期67卷 3071-3088页

作者： hyun Ahn Kwanghoon Pio kim Division of Computer Science and Engineering Gyeonggi16227Korea

Workow management technologies have been dramatically improving their deployment architectures and systems along with the evolution and proliferation of cloud distributed computing ***,such cloud computing environments ought to be providing a suitable distributed computing paradigm to deploy very large-scale workow processes and applications with scalable on-demand *** this paper,we focus on the distribution paradigm and its deployment formalism for such very large-scale workow applications being deployed and enacted across the multiple and heterogeneous cloud computing *** propose a formal approach to vertically as well as horizontally fragment very large-scale workow processes and their applications and to deploy the workow process and application fragments over three types of cloud deployment models and *** concretize the formal approach,we rstly devise a series of operational situations fragmenting into cloud workow process and application components and deploying onto three different types of cloud deployment models and *** concrete approaches are called the deployment-driven fragmentation mechanism to be applied to such very large-scale workow process and applications as an implementing component for cloud workow management ***,we strongly believe that our approach with the fragmentation formalisms becomes a theoretical basis of designing and implementing very large-scale and maximally distributed workow processes and applications to be deployed on cloud deployment models and architectural computing environments as well.

关键词： Cloud workows cloud deployment model workow application fragmentations information control net

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In situ synthesis of chemically bonded NaTi2（PO4）3/rGO 2D nanocomposite for high-rate sodium-ion batteries

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Nano Research 2016年第6期9卷 1844-1855页

作者： Ha-Kyung Roh hyun-Kyung kim Myeong-Seong kim Dong-hyun kim Kyung Yoon Chung Kwang Chul Roh Kwang-Bum kim Department of Material Science & Engineering Yonsei University 50 Yonsei-ro Seodaemun-gu Seou103722 Republic of Korea Department of Materials Science and Metallurgy University of Cambridge 27 Charles Babbage Road Cambridge CB30FS UK Center for Energy Convergence Korea Institute of Science and Technology 5 Hwarang-ro 14-gil Seongbuk-gu Seou102792 Republic of Korea Energy & Environmental Division Korea Institute of Ceramic Engineering & Technology 101 Soho-ro Jinju-si Gyeongsangnam-do 52851 Republic of Korea

A phase-pure NaTi2（PO4）3/reduced graphene oxide （rGO） nanocomposite was prepared using a microwave-assisted one-pot method and subsequent heat treatment. The well-crystallized NaTi2（PO4）3 nanoparticles （30-40 nm） were uniformly precipitated on rGO templates through Ti-O-C bonds. The chemical interactions between the NaTi2（PO4）3 nanoparticles and rGO could immobilize the NaTi2（PO4）3 nanoparticles on the rGO sheets, which might be responsible for the excellent electrochemical performance of the nanocomposite. The NaTi2（PO4）B/rGO nanocomposite exhibited a specific capacity of 128.6 mA-h.g-1 approaching the theoretical value at a 0.1 C-rate with an excellent rate capability （72.9% capacity retention at 50 C-rate） and cycling performance （only 4.5% capacity loss after 1,000 cycles at a high rate of 10 C）. These properties were maintained even when the electrodes were prepared without the use of an additional conducting agent. The excellent sodium storage properties of the NaTi2（PO4）B/rGO nanocomposite could be attributed to the nano-sized NaTi2（PO4）3 particles, which significantly reduced the transport lengths for Na＋ ions, and an intimate contact between the NaTi2（PO4）3 particles and rGO due to chemical bonding.

关键词： NaTi2(PO4)dreducedgraphene oxide (rGO)nanocomposite chemical bonding energy-efficiency in situ synthesis high-rate sodium-ion batteries

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Comparison of scoring systems in predicting the severity of acute pancreatitis

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World Journal of Gastroenterology 2015年第8期21卷 2387-2394页

作者： Joon hyun Cho Tae Nyeun kim hyun Hee Chung Kook hyun kim Division of Gastroenterology and Hepatology Department of Internal Medicine Yeungnam University College of Medicine

AIM:To investigate the prognostic usefulness of several existing scoring systems in predicting the severity of acute pancreatitis(AP).METHODS:We retrospectively analyzed the prospectively collected clinical database from consecutive patients with AP in our institution between January 2011 and December ***,Acute Physiology and Chronic Health Evaluation(APACHE)-Ⅱ,and bedside index for severity in acute pancreatitis(BISAP)scores,and computed tomography severity index(CTSI)of all patients were *** C-reactive protein(CRP)levels were measured at admission(CRPi)and after 24h(CRP24).Severe AP was defined as persistent organ failure for more than 48 *** predictive accuracy of each scoring system was measured by the area under the receiver-operating curve(AUC).RESULTS:Of 161 patients,21(13%)were classified as severe AP,and 3(1.9%)*** significant cutoff values for prediction of severe AP were Ranson≥3,BISAP≥2,APACHE-Ⅱ≥8,CTSI≥3,and CRP24≥*** for Ranson,BISAP,APACHE-Ⅱ,CTSI,and CRP24 in predicting severe AP were 0.69(95%CI:0.62-0.76),0.74(95%CI:0.66-0.80),0.78(95%CI:0.70-0.84),0.69(95%CI:0.61-0.76),and0.68(95%CI:0.57-0.78),***-Ⅱdemonstrated the highest accuracy for prediction of severe AP,however,no statistically significant pairwise differences were observed between APACHE-Ⅱand the other scoring systems,including ***:Various scoring systems showed similar predictive accuracy for severity of *** models are needed in order to achieve further improvement of prognostic accuracy.

关键词： Severity Scoring systems Predictors Acute pancreat

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Distribution of Ge Self-Assembled Quantum Dots on Six Ge1 - x Buffer Layers

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Journal of Rare Earths 2004年第Z2期22卷 133-135页

作者： Joonyeon chang hyungjun kim Nano Device Research Center Korea Institute of Science and TechnologySeoul 136-791Korea Department of Electrical EngireeringUniversity of California LosAngelesCA 90095-1595USA

The effect of buried misfit dislocation on the distribution of Ge self-assembled quantum dots (SAQDs) grown on a relaxed SiGe buffer layer was investigated. The strain field of arrays of buried dislocations in a relaxed SiGe buffer layer provided preferential nucleation sites for quantum dots. Burgers vector analysis using plan-view transmission electron microscopy (TEM) verified that the preferential nucleation sites of Ge SAQDs depended on the Burgers vector direction of corresponding dislocations. The measurement of the lateral distance between SAQDs and dislocations together with crosssection TEM observation clarified that the location of SAQDs was at the intersection of the dislocation slip plane and the top surface. The misfit strain should be an additional factor governing the uniformity in size, shape and distribution of Ge SAQDs.

关键词： misfit dislocation Ge self assembled quantum dots molecular beam epitaxy transmission electron microscopy

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Materialization of strained CVD-graphene using thermal mismatch

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Nano Research 2015年第6期8卷 2082-2091页

作者： Seung-Mo Lee Sang-Min kim Min Young Na Hye Jung chang Kwang-Seop kim hyunung Yu Hak-Joo Lee Jae-hyun kim Nano-Convergence Mechanical Systems Research Division Korea Institute of Machinery & Materials (KIMM) 156 Gajungbuk-ro Yuseong-gu Daejeon 305-343 Republic of Korea Nano Mechatronics University of Science and Technology (UST) 217 Gajeong-ro Yuseong-gu Daejeon 305-333 Republic of Korea Graduate School of Energy Environment Water and Sustainability Korea Advanced Institute of Science & Technology (KAIST) Daejeon 305-701 Republic of Korea Department of Materials Science and Engineering Yonsei University SO Yonsei-ro Seodaemun-gu Seou1120-749 Republic of Korea Advanced Analysis Center Korea Institute of Science and Technology (KIST) Hwarang-ro 14-gil 5 Seongbuk-gu Seoul 130-791 Republic of Korea Korea Research Institute of Standards and Science (KRISS) 267 Gajeong-ro Yuseong-gu Daejeon 305-343 Republic of Korea

Theoretical physics foretells that ＂strain engineering＂ of graphene could hold the key to finding treasures still hidden in two-dimensional （2D） condensed matter physics and commercializing graphene-based devices. However, to produce strained graphene in large quantities is not an easy task by any means. Here, we demonstrate that thermal annealing of graphene placed on various substrates could be a surprisingly simple method for preparing strained graphene with a large area. We found that enhanced graphene-substrate interfacial adhesion plays a critical role in developing strained graphene. Creative device architectures that consider the thermal mismatch between graphene and the target substrate could enable the resulting strain to be intentionally tailored. We believe that our proposed method could suggest a shortcut to realization of graphene straintronics.

关键词： graphene strain engineering thermal mismatch strained graphene

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Malignant mesothelioma of the greater omentum mimicking omental infarction:A case report

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World Journal of Gastroenterology 2009年第38期15卷 4856-4859页

作者： Min-Kee Shin Ok-Jae Lee chang-Yoon Ha hyun-Joo Min Tae-Hyo kim Department of Internal Medicine & Institute of Health Science Gyeongsang National University School of Medicine

Mesothelioma develops most commonly in the pleura, and less frequently in the peritoneum. Usually, it manifests as diffuse peritoneal thickening and multiple nodules, and rarely as a solitary mass. We report a rare case of primary malignant mesothelioma of the greater omentum, which mimicked omental infarct. A 54-year-old Korean man was admitted because of severe abdominal pain of sudden onset. A tender mass with indistinct margins was palpated in the upper abdomen. Abdominal ultrasound and computed tomography showed an ill- def ined mass in the greater omentum and little ascites in the peri-hepatic space, and neutrophil-dominant exudates were documented on paracentesis. Intravenous antibiotics and analgesics were given for omental infarction with superimposed infection, which resulted in symptomatic improvement. The imaging studies after a week revealed a growing mass and ascites. Laparoscopic surgery was performed and an 8 cm×3.3 cm greater omental mass was found, with multiple small nodules on the peritoneum, diaphragm, and pelvic cavity wall. Histological examination showed proliferating malignant epithelioid cells that stained strongly for calretinin, which was compatible with malignant mesothelioma. We recommend that primary omental mesothelioma should be included in the differential diagnosis of patients with omental infarction, despite its rarity.

关键词： Infarction Mesothelioma, Omentum

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Measurements of Formaldehyde and TVOC Emission from Paints and Coating Materials using Small Chamber Method for Building Composites

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Journal of Wuhan University of Technology(Materials Science) 2012年第1期27卷 120-125页

作者： Jin-A kim Sumin kim hyun-Joong kim Janghoo SEO National Instrumentation Center for Environmental Management Seoul National University Seoul 151-921 Republic of Korea Laboratory of Adhesion & Bio-Composites Program in Environmental Materials Science Seoul National University Seoul 151-921 Republic of Korea Building Environment & Materials Lab School of Architecture Soongsil University Seoul 156-743 Republic of Korea School of Architecture Chosun University Gwangju 507-759 Korea

An optimal test method for paint is proposed; additionally, the Field and Laboratory Emission Cell （FLEC） method used in Europe is applied as a substitute for the 20 L small chamber method. The emission factors of total volatile organic compounds （TVOC） and formaldehyde from oil-based paint, emulsion paint, and water-dispersion paint with a coating weight of 300 g/m2, cured for 24/48 hours, were measured using the 20 L small chamber method. The emission rate of TVOC and formaldehyde from all paints began to stabilize after approximately 7 days after 24/48 hours of curing even though Korean standards stipulate that paint should be measured and analyzed after the third day of application. The emission factor of TVOC and formaldehyde from oil-based, emulsion, and water-dispersion paints were also measured using the FLEC method. There was good correlation between the 20 L small chamber method and the FLEC method for oil-based, emulsion, and water-dispersion paint emissions. With the FLEC method, using paints prepared under identical conditions, the emission rate was stable 24 hours after installation of samples because the air flow rate of FLEC is much higher than that of a 20 L small chamber, and the relative cell volume of FLEC is much smaller than that of a 20 L small chamber.

关键词： formaldehyde TVOC paints coating materials FLEC

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A NUMERICAL ANALYSIS OF THE BLOOD FLOW AROUND THE BILEAFLET MECHANICAL HEART VALVES WITH DIFFERENT ROTATIONAL IMPLANTATION ANGLES

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Journal of Hydrodynamics 2011年第5期23卷 607-614页

作者： HONG Taehyup kim chang Nyung Department of Mechanical Engineering Graduate School Kyung Hee UniversityYongin Korea Department of Mechanical Engineering College of Engineering Kyung Hee University Yongin Korea

The effects of implantation angles of Bileaflet Mechanical Heart Valves （BMHVs） on the blood flow and the leaflet motion are investigated in this paper. The physiological blood flow interacting with the moving leaflets of a BMHV is simulated with a strongly coupled implicit Fluid-Structure Interaction （FSI） method based on the Arbitrary-Lagrangian-Eulerian （ALE） approach and the dynamic mesh method （remeshing） in Fluent. BMHVs are widely used to be implanted to replace the diseased heart valves, but the patients would suffer from some complications such as hemolysis, platelet activation, tissue overgrowth and device failure. These complications are closely related to both the flow characteristics near the valves and the leaflet dynamics. The current numerical model is validated against a previous experimental study. The numerical results show that as the rotation angle of BMHV is increased the degree of asymmetry of the blood flow and the leaflet motion is increased, which may lead to an unbalanced force acting on the BMHVs. This study shows the applicability of the FSI model for the interaction between the blood flow and the leaflet motion in BMHVs.

关键词： mechanical heart valve rotational implantation blood flow leaflet motion fluid-structure interaction

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Trends in colorectal cancer incidence according to an increase in the number of colonoscopy cases in Korea

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 51-60页

作者： Ga Hee kim Yeong Chan Lee Tae Jun kim Sung Noh Hong Dong Kyung chang Young-Ho kim Dong-Hoon Yang chang Mo Moon Kyunga kim hyun Gun kim Eun-Ran kim Division of Gastroenterology Department of Internal MedicineAsan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Digital Health Samsung Advanced Institute for Health Science and TechnologySungkyunkwan University School of MedicineSeoul 06351South Korea Division of Gastroenterology Department of Internal MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Division of Gastroenterology Department of Internal MedicineEwha Womans UniversitySeoul 07985South Korea Biomedical Statistics Center Samsung Medical CenterSeoul 06351South Korea Division of Gastroenterology Department of Internal MedicineSoonchunhyang University College of MedicineSeoul 04401South Korea

BACKGROUND The incidence of colorectal cancer(CRC)and preinvasive CRC(e.g.,early colon cancer and advanced adenoma)is gradually increasing in several *** To evaluate the trend in incidence of CRC and preinvasive CRC according to the increase in the number of colonoscopies performed in *** This retrospective cohort study enrolled Korean patients from 2002 to 2020 to evaluate the incidence of CRC and preinvasive CRC,and assess the numbers of diagnostic colonoscopies and colonoscopic ***-related complications by age group were also *** The incidence of CRC showed a rapid increase,then decreased after 2012 in the 50-75 year-age *** the study period,the rate of incidence of preinvasive CRC increased at a similar level in patients under 50 and 50-75 years of *** 2009,the increase has been rapid,showing a pattern similar to the increase in *** rate of colonoscopic polypectomy in patients aged under 50 was similar to the rate in patients over 75 years of age after *** rate of complications after colonoscopy and related deaths within 3 mo was high for those over 75 years of *** The diagnosis of preinvasive CRC increased with the increase in the number of colonoscopies *** the risk of colonoscopy-related hospitalization and death is high in the elderly,if early lesions at risk of developing CRC are diagnosed and treated under or at the age of 75,colonoscopy-related complications can be reduced for those aged 76 years or over.

关键词： Colorectal cancer Preinvasive colorectal cancer Colorectal polypectomy Colonoscopy

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