检索结果-南通市图书馆

Mutational separation and clinical outcomes of TP53 and CDH1 in gastric cancer

World Journal of Gastrointestinal Surgery 2023年第12期15卷 2855-2865页

作者： He-Li Liu Huan Peng chang-hao huang Hai-Yan Zhou Jie Ge Department of Gastrointestinal Surgery Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Clinical Nursing Teaching and Research Section Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Teaching and Research Section of Clinical Nursing Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

BACKGROUND Gastric cancer(GC)is a deadly tumor with the fifth highest occurrence and highest global mortality *** to its heterogeneity,the underlying mechanism of GC remains unclear,and chemotherapy offers little benefit to *** To investigate the clinical outcomes of TP53 and CDH1 mutations in *** In this study,202 gastric adenocarcinoma tumor tissues and their corresponding normal tissues were collected.A total of 490 genes were identified using target *** t-test and Wilcoxon rank-sum test,somatic mutations,microsatellite instability,and clinical statistics,including overall survival,were detected,compared,and *** The mutation rates of 32 genes,including TP53,SPEN,FAT1,and CDH1 exceeded 10%.TP53 mutations had a slightly lower overall occurrence rate(33%).The TP53 mutation rate was significantly higher in advanced stages(stage Ⅲ/Ⅳ)than that in early stages(stage Ⅰ/Ⅱ)(P<0.05).In contrast,CDH1 mutations were significantly associated with diffuse ***53 is related to poor prognosis of advanced-stage tumors;nevertheless,CDH1 corresponds to a diffuse type of ***53 is exclusively mutated in CDH1 and is primarily affected by two distinct GC *** Different somatic mutation patterns in TP53 and CDH1 indicate two major mechanisms of GC.

关键词： Gastric cancer TP53 mutation CDH1 mutation Clinical outcome Somatic mutation Diffuse gastric cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The role of axon guidance molecules in the pathogenesis of epilepsy

引用

Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： Zheng Liu Chunhua Pan hao huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

引用

Science China Life Sciences 2025年第1期 204-218页

作者： Chen Xiong Hong Ling Yingdan huang Hanzhi Dong Bangxiang Xie Qian hao Xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Deciphering the role of ultra-low-loaded rhodium in NiFe-MIL-53 for superior oxygen evolution reaction

引用

Journal of Energy Chemistry 2025年第1期100卷 77-86页

作者： Jinzhi Jia Jinhua Zhang Kailu Guo Lanyue Zhang Gening Du hao You Junfeng huang Mudong Tu Hua Li Yong Peng Wei Dou Cailing Xu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering School of Materials and Energy Lanzhou University College of Chemistry and Chemical Engineering Luoyang Normal University

Designing highly active and stable electrocatalysts of oxygen evolution reaction （OER） is one of the crucial *** this study,a novel OER electrocatalyst,NiFe-MIL-53 modified with ultra-low rhodium（Rh@NiFe-MIL-53）,is successfully prepared via the hydrothermal ***-situ Raman spectroscopy and electrochemical impedance spectroscopy reveal that the doped Rh accelerates the phase transformation of NiFe-MIL-53 and the in-situ formed Rh@NiFeOOH is the actual active *** importantly,the enhanced reversibility of electrochemical reconstruction between NiFeOOH and NiFe（OH）2after doping Rh is beneficial for improving the electrochemical stability of the catalyst.X-ray photoelectron spectroscopy spectra show the strong electronic interaction between single-atom Rh and Ni/Fe in Rh@***,theoretical calculations confirm that the integration of single-atom Rh into the NiFeOOH successfully reduces the band gap,regulates the d-band center （εd）,accelerates the charge transfer,and optimizes the adsorption behavior of oxygen-containing intermediates,thereby lowering the energy barrier of rate-determining ***,the optimized Rh@NiFe-MIL-53 exhibits excellent OER activity （240 mV） with a small Tafel slope of 48.2 mV dec-1and long-term durability (over1270 h at 10 m A cm-2and 110 h at 200 mA cm-2).This work presents a new perspective on designing highly efficient OER electrocatalysts.

关键词： NiFe-MIL-53 Rh Electrochemical reconstruction Catalytic mechanism Oxygen evolution reaction

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

术前营养风险筛查对胃癌和结肠癌患者围手术期营养支持的临床意义

引用

中国现代医学杂志 2016年第5期26卷 119-123页

作者：郭添羽黄昌浩袁伟杰中南大学湘雅医学院检验系湖南长沙410013 中南大学湘雅医院胃肠外科湖南长沙410008

目的讨论术前营养风险筛查对胃癌和结直肠癌患者术后并发症的预测作用,以及对围手术期营养支持的指导作用,为临床合理开展营养支持治疗提供依据。方法回顾性研究2015年1月-2015年12月在中南大学湘雅医院普通外科行根治性切除的436例胃... 详细信息

目的讨论术前营养风险筛查对胃癌和结直肠癌患者术后并发症的预测作用,以及对围手术期营养支持的指导作用,为临床合理开展营养支持治疗提供依据。方法回顾性研究2015年1月-2015年12月在中南大学湘雅医院普通外科行根治性切除的436例胃癌患者和713例结直肠癌患者,根据营养风险筛查2002(NRS 2002)结果,将两类肿瘤患者分别分为存在营养风险和不存在营养风险患者,再分别比较两种同类肿瘤患者中,行营养支持和未行营养支持患者手术前、后血红蛋白(Hb)、白蛋白(Alb)、前白蛋白(PA)水平以及术后并发症发生率和术后住院时间。结果 436例胃癌患者中205例术前存在营养风险,不存在营养风险231例。未行术前营养支持治疗的患者术后Hb、Alb、PA水平均低于行术前营养支持的患者(P0.05)。结论术前营养支持治疗能够降低有营养风险的胃癌和结直肠癌患者的术后并发症发生率,缩短住院时间,有效改善预后。

关键词：胃癌结直肠癌营养风险筛查术后并发症营养支持

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

蛋白质及碳水化合物摄入量与结直肠癌关系的meta分析

引用

中国现代医学杂志 2016年第12期26卷 82-88页

作者：郭添羽王欣侯菲黄昌浩袁伟杰中南大学湘雅医学院湖南长沙410013 中南大学湘雅医院胃肠外科湖南长沙410008 大连医科大学附属第一医院营养科辽宁大连116000

目的探讨蛋白质及碳水化合物的摄入量对结直肠癌发病率的影响,并对性别和结肠直肠进行亚组分析。方法在Pubmed、Embase和Cochrane Library数据库里通过检索式检索,选取1991年1月1日-2015年12月31日的蛋白质及碳水化合物摄入量与结直肠... 详细信息

目的探讨蛋白质及碳水化合物的摄入量对结直肠癌发病率的影响,并对性别和结肠直肠进行亚组分析。方法在Pubmed、Embase和Cochrane Library数据库里通过检索式检索,选取1991年1月1日-2015年12月31日的蛋白质及碳水化合物摄入量与结直肠癌关系的英文文献,筛选文献并对纳入文献进行质量评分和数据提取,使用Stata 12.0统计软件进行meta分析。结果最终共纳入22个研究,16 012例患者。蛋白质摄入与结直肠癌发生率无关(RR∧:1.03,95%CI:0.85,1.25);碳水化合物摄入与结直肠癌发生率无关(RR∧:1.15,95%CI:0.99,1.33)。仅分析其中的病例对照研究,碳水化合物摄入可以增加结直肠癌的发生率(RR∧:1.35,95%CI:1.07,1.69)。亚组分析显示男性的碳水化合物摄入可以增加结直肠癌的发生率(RR∧:1.21,95%CI:1.01,1.45)。然而,碳水化合物相关研究则发现了明显的发表偏倚Begg(P=0.000)或Egger’s(P=0.001)。结论笔者的结论并没有足够的证据说明在目前的研究中蛋白质/碳水化合物摄入与结直肠癌存在关联性,对于该争议还需要进一步随机对照实验及机制研究来考量。

关键词：蛋白质碳水化合物结直肠癌 meta分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

锯齿形氮化铝纳米带负阻器件电子输运性质研究

引用

原子与分子物理学报 2025年第2期42卷 85-90页

作者：黄绛雪黄启俊何进王豪常胜武汉大学物理科学与技术学院武汉430072

低维纳米带材料因为其结构的特异性而呈现出新奇的物理性质.修饰纳米带的边缘能够调制其电子性质.本文运用基于密度泛函理论(DFT)的第一性原理计算方法,探究了锯齿形氮化铝纳米带(ZAlNNR)单边氟化、单边氯化以及单边氢化的电子结构和输... 详细信息

低维纳米带材料因为其结构的特异性而呈现出新奇的物理性质.修饰纳米带的边缘能够调制其电子性质.本文运用基于密度泛函理论(DFT)的第一性原理计算方法,探究了锯齿形氮化铝纳米带(ZAlNNR)单边氟化、单边氯化以及单边氢化的电子结构和输运特性.研究表明:锯齿型氮化铝纳米带可以通过以上手段实现能带结构的半导体-金属转换.计算电子输运特性,我们发现三种边缘修饰的器件均呈现出负微分电阻效应,其中AlN-F器件有最大峰谷电流比(PVCR),达到了1.78×10^(7),是硅烯纳米器件以及黑磷纳米器件的10^(6)倍.值得一提的是,相比于H-AlN-Cove纳米器件,AlN-F器件能够在更小的偏压范围内实现高PVCR.该结果为锯齿形氮化铝纳米带在低功耗纳米器件中的应用提供了广泛的前景.

关键词：锯齿形氮化铝纳米带电子输运负微分电阻效应第一性原理

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

甲骨文词典编纂的创造性转化与创新性发展

引用

河北学刊 2025年第1期45卷 74-81页

作者：洪飏吴昌昊辽宁师范大学文学院

甲骨文词典传统编纂体例存在受众群体有限、蕴含殷商社会文化成分较少、不利于展开专题研究等问题,再结合主题分类词典从古至今的发展应用情况,不难发现甲骨文领域中仅赵诚的《甲骨文简明词典——卜辞分类读本》是按主题分类编排的,但... 详细信息

甲骨文词典传统编纂体例存在受众群体有限、蕴含殷商社会文化成分较少、不利于展开专题研究等问题,再结合主题分类词典从古至今的发展应用情况,不难发现甲骨文领域中仅赵诚的《甲骨文简明词典——卜辞分类读本》是按主题分类编排的,但其分类标准并不纯粹。因此,急需编纂一部词汇学意义上的、按主题分类编排的甲骨文词典。新时代的甲骨文词典的编纂,需在习近平文化思想指引下,从编纂体例、编纂方法、成果产出、数据库建设等四个方面坚持守正创新,推动中华优秀传统文化创造性转化与创新性发展,采用人机协同的方法深度解析甲骨刻辞;应注重多成果产出,在编纂词典的同时,系联出主题分类词表、类纂和同义词词典;建立智能图文检索数据库,解决现有数据库不支持图片检索的难题,实现语言学、计算机技术和甲骨文研究的跨学科高度融合。

关键词：甲骨文词典主题分类数据库创新

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

引用

Science China Chemistry 2025年第1期 369-376页

作者： Song-Meng Wang hao Nian Yan-Fang Wang Li-Shuo Zheng Yu-Tao Zheng Yi-Wei Dong Liping huang Xiaoping Wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于量子进化支持向量机的模拟电路故障诊断

引用

系统仿真学报 2009年第9期21卷 2599-2602,2637页

作者：罗志勇向敏朴昌浩黄智宇蔡林沁重庆邮电大学网络化控制与智能仪器仪表教育部重点实验室重庆400065

基于量子进化算法的最小二乘小波支持向量机(LS-WSVM),设计了一种模拟电路故障诊断方法。将量子进化算法应用于多类LS-WSVM分类器来选取正规化参数和核参数,针对从测试点得到的各种故障状态下输出电压信号,采用小波提升变换对其进行分... 详细信息

基于量子进化算法的最小二乘小波支持向量机(LS-WSVM),设计了一种模拟电路故障诊断方法。将量子进化算法应用于多类LS-WSVM分类器来选取正规化参数和核参数,针对从测试点得到的各种故障状态下输出电压信号,采用小波提升变换对其进行分解获取多尺度的小波系数,对经处理的小波系数提取出故障特征量,以此作为样本训练多类LS-WSVM分类器来确定模拟电路故障诊断的模型。采用雷达扫描电路进行了仿真,结果表明,设计的模拟电路故障诊断方法效果良好。

关键词：支持向量机量子进化算法小波提升变换模拟电路故障诊断

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：