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Computed tomography radiomic features and clinical factors predicting the response to first transarterial chemoembolization in intermediate-stage hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 361-369页

作者： Zhong-Xing Shi chang-fu li li-Feng Zhao Zhong-Qi Sun li-Ming Cui Yan-Jie Xin Dong-Qing Wang Tan-Rong Kang Hui-Jie Jiang Department of Interventional Radiology the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Department of Digestive Medicine Daqing Longnan HospitalDaqing 163453China Department of Radiology Daqing Longnan HospitalDaqing 163453China Department of Radiology the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China

Background:According to clinical practice guidelines,transarterial chemoembolization(TACE)is the standard treatment modality for patients with intermediate-stage hepatocellular carcinoma(HCC).Early prediction of treatment response can help patients choose a reasonable treatment *** study aimed to investigate the value of the radiomic-clinical model in predicting the efficacy of the first TACE treatment for HCC to prolong patient ***:A total of 164 patients with HCC who underwent the first TACE from January 2017 to September 2021 were *** tumor response was assessed by modified response evaluation criteria in solid tumors(mRECIST),and the response of the first TACE to each session and its correlation with overall survival were *** radiomic signatures associated with the treatment response were identified by the least absolute shrinkage and selection operator(LASSO),and four machine learning models were built with different types of regions of interest(ROIs)(tumor and corresponding tissues)and the model with the best performance was *** predictive performance was assessed with receiver operating characteristic(ROC)curves and calibration ***:Of all the models,the random forest(RF)model with peritumor(+10 mm)radiomic signatures had the best performance[area under ROC curve(AUC)=0.964 in the training cohort,AUC=0.949 in the validation cohort].The RF model was used to calculate the radiomic score(Rad-score),and the optimal cutoff value(0.34)was calculated according to the Youden’s *** were then divided into a high-risk group(Rad-score>0.34)and a low-risk group(Rad-score≤0.34),and a nomogram model was successfully established to predict treatment *** predicted treatment response also allowed for significant discrimination of Kaplan-Meier *** Cox regression identified six independent prognostic factors for overall survival,including male[hazard ratio(HR)=0.500,95%confidence interva

关键词： Hepatocellular carcinoma Transarterial chemoembolization Radiomics Treatment response Prediction

Protection　of　L－arginine　against　lysophosphatidy　lcholine－inducedmy　ocardi　alinjury　inisolated　ratheart

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中国药理学与毒理学杂志 1996年第2期 6-9页

作者： TANG Yu-Hai, PENG chang-fu, li Yuan-Jian 2, XIONG Yan (Department of Pharmacology, Hunan Medical University, changsha 410078)

在离体大鼠心脏观察了Ｌ－精氨酸对溶血性磷脂酰胆碱（ＬＰＣ）损伤心肌作用的影响．ＬＰＣ（５μｍｏｌ·Ｌ－１）引起心率减慢，冠脉流量减少，心脏功能降低（ＬＶＰ和ＬＶｄｐ／ｄｔｍａｘ下降）及肌酸激酶（ＣＰＫ）释放增加．３０... 详细信息

在离体大鼠心脏观察了Ｌ－精氨酸对溶血性磷脂酰胆碱（ＬＰＣ）损伤心肌作用的影响．ＬＰＣ（５μｍｏｌ·Ｌ－１）引起心率减慢，冠脉流量减少，心脏功能降低（ＬＶＰ和ＬＶｄｐ／ｄｔｍａｘ下降）及肌酸激酶（ＣＰＫ）释放增加．３０μｍｏｌ·Ｌ－１Ｌ－精氨酸能促进心率恢复，增加冠脉流量和改善心脏功能，但仅ＬＶｄＰ／ｄｔｍａｘ恢复显示统计学差异；３００μｍｏｌ·Ｌ－１Ｌ－精氨酸能显著改善心脏功能，促进心率和冠脉流量的恢复，减少ＣＰＫ释放．结果提示：Ｌ－精氨酸对ＬＰＣ所致心肌损伤具有一定的保护作用．

关键词：精氨酸溶血性磷脂酰胆碱心脏大鼠

The effection of shMRE11 on the drug resistance of multidrug-resistant hepatocellular carcinoma cell line BEL7402/5-fu

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The effection of shMRE11 on the drug resistance of multidrug...

Quantum public-key crypto via EPR pairs

生命的分子机器及其调控网络——2012年全国生物化学与...

作者： Fang FAN Lei GENG chang-fu li Department of Biochemistry Zunyi Medical College

Objective:To investigate the effect of silencing MRE11 gene by shMRE11 on the chemotherapeutic drug sensitivity and the resistance-associated protein(MRP1) expression on the resistant hepatic cancer cells BEL7402/***:shMRE11 was transiently transfected into BEL7402/5-fu cells via cathodolyte liposome transfection *** the drug sensitivity

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来源： cnki会议评论

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun fu Hong-Wei li Jian-Hong Shi Tan li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou Zhang Shuo li fu Tang Jingkai Zhang Yuetong Kang Hean Zhang lidong li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial

PS-CoT-Adapter: adapting plan-and-solve chain-of-thought for ScienceQA

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Science China(Information Sciences) 2025年第1期68卷 392-393页

作者： Qun li Haixin SUN fu XIAO Yiming WANG Xinping GAO Bir BHANU School of Computer Science Nanjing University of Posts and Telecommunications Purple Mountain Laboratories Department of Electrical and Computer Engineering University of California at Riverside

Large language models (LLMs) have recently shown remarkable performance in a variety of natural language processing (NLP) *** further explore LLMs'reasoning abilities in solving complex problems,recent research [1-3]has investigated chain-of-thought (CoT) reasoning in complex multimodal scenarios,such as science question answering (ScienceQA) tasks [4],by fine-tuning multimodal models through human-annotated CoT ***,collected CoT rationales often miss the necessary rea-soning steps and specific expertise.

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期望绩效反馈、行业竞争压力与企业并购——基于沪深A股上市公司的实证研究

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商业研究 2017年第10期 31-38页

作者：黄昌富李桑迪三峡大学经济与管理学院湖北宜昌443002

并购是企业利用外部资源实现竞争优势的战略选择,本文以2011-2015年间沪深两市发生并购行为主并方的A股上市公司为研究样本,实证考察企业期望绩效反馈、行业竞争压力与企业并购行为的关系,以及行业竞争压力对期望绩效反馈与企业并购之... 详细信息

并购是企业利用外部资源实现竞争优势的战略选择,本文以2011-2015年间沪深两市发生并购行为主并方的A股上市公司为研究样本,实证考察企业期望绩效反馈、行业竞争压力与企业并购行为的关系,以及行业竞争压力对期望绩效反馈与企业并购之间关系的调节作用。研究发现,当企业期望绩效反馈为负向时,随着期望绩效差距的扩大,企业并购意愿及并购规模先升后降,呈倒U型关系;行业竞争压力正向促进企业并购行为,当企业未实现组织期望绩效时,行业竞争压力对期望绩效差距与企业并购行为的倒U型关系存在显著的正向调节效应。上述结论深化了对期望绩效反馈问题的认识,间接考察了企业高管与股东或董事会之间在期望绩效差距存在的情况下在企业并购决策上的分工机制,为企业并购行为的影响因素提供了新的视角,对经理层和股东如何通过理性的并购决策弥合期望绩效差距、防范并购风险具有一定的理论解释意义和实践参考价值。

关键词：期望绩效反馈行业竞争压力企业并购

High‑Entropy Electrode Materials:Synthesis,Properties and Outlook

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Nano-Micro Letters 2025年第1期17卷 472-506页

作者： Dongxiao li chang liu Shusheng Tao Jieming Cai Biao Zhong Jie li Wentao Deng Hongshuai Hou Guoqiang Zou Xiaobo Ji College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083People’s Republic of China School of Chemistry and Chemical Engineering Hunan Institute of EngineeringXiangtan 411104People’s Republic of China

High-entropy materials represent a new category of high-performance materials,first proposed in 2004 and extensively investigated by researchers over the past two *** definition of high-entropy materials has continuously *** the last ten years,the discovery of an increasing number of high-entropy materials has led to significant advancements in their utilization in energy storage,electrocatalysis,and related domains,accompanied by a rise in techniques for fabricating high-entropy electrode ***,the research emphasis has shifted from solely improving the performance of high-entropy materials toward exploring their reaction mechanisms and adopting cleaner preparation ***,the current definition of high-entropy materials remains relatively vague,and the preparation method of high-entropy materials is based on the preparation method of single metal/low-or medium-entropy *** should be noted that not all methods applicable to single metal/low-or medium-entropy materials can be directly applied to high-entropy *** this review,the definition and development of high-entropy materials are briefly ***,the classification of high-entropy electrode materials is presented,followed by a discussion of their applications in energy storage and catalysis from the perspective of synthesis ***,an evaluation of the advantages and disadvantages of various synthesis methods in the production process of different high-entropy materials is provided,along with a proposal for potential future development directions for high-entropy materials.

关键词： High-entropy Energy storage Electrode materials

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沙袋围堰技术在瓜达尔港口项目中的应用

中国港湾建设 2005年第Z1期25卷 134-136页

作者：常福立杨昆郁亮中国港湾建设(集团)总公司北京100027 中港上海航道局上海200002 中港上海航道局上海200002

文章介绍了沙袋围堰技术在瓜达尔项目中的应用,着重介绍了沙袋围堰施工过程中获得的一些成功经验以及在该项目环境中获得的效果,供类似工程参考.

关键词：沙袋围堰难点解决办法效果