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Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying Chen Fa Shen chang Cheng Yu-Han Wang Wen-Chao Cheng De-Zhi Yuan Wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

ACNU-CDDP Continuous Infusion Chemotherapy for Malignant Glioma

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ACNU-CDDP Continuous Infusion Chemotherapy for Malignant Gli...

第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： chang Hun rhee M.D.Department of Neurosurgery Korea Institute of Radiological and Medical Science

＜正＞Purpose:To evaluate the activity and the toxicity of ACNU （1 - （4 - amino - 2methyl - 5pyrimidinyl） - methyl - 3 - （2 -cholroethyl） - 3 - nitrosourea hydrochloride） administered with cisplatin by intravenous infusion for 72 hours in select patients with recurrent *** and Methods:From April 1996 to 2002,thirty-seven patients with histologically proven glioblastoma,who showedre-currence on image study after operation and radiation, met the eligibility criteria of our cohort. The mean time to recurrence was 9.7± 7.0（1 - 26 months） .Treatment response was evaluated every 6 weeks using magnetic resonance imaging （MRI）. Complete blood counts were collected every week to monitor and treat possible bone marrow suppression from the *** rates were analyzed using the Kaplan - Meier and log rank test. Results: Post - chemotherapy MRI was available in 36 of 37 patients. Response to treatment was observed in 19 patients （53%） including 2 cases of complete *** patients （17%） showed progression （PD） and 11 patients （31%） had stable disease （SD）. Two or more cycles of chemotherapy was the only factor that predicted response to treatment. The overall median survival for all patients was 17.0±3.3 *** （＜ 40 years） and time to recurrence （＜ 1 year） were the clinical factors that predicted improved overall *** gain after chemotherapy was 9 ***’s median survival in those who responded and thoee with SD after treatment （11 months） had a longer median survival compared to PD （5 months）（p = 0.01） .Myelosuppression was severe （grade III/IV leukopenia in 15 patients （40%） and grade III/IV thrombocytopenia in 19 patients （52%）） but most recovered more than WHO grade II at the end of the chemotherapy cycles. There was only one fatality due to sepsis from pneumonia during the initial leukopenic state. Conclusion: ACNU and cisplatin chemotherapy can be an effective salvage therapy for recurrent glioblastoma patients.

关键词： Glioblastoma Recurrent ACNU Cisplatin Chemotherapy

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巨噬细胞极化在组织修复过程中的可视化分析

中国组织工程研究 2025年第7期29卷 1486-1496页

作者：常金霞刘羽飞牛少辉王唱曹建春北京中医药大学北京市100029 中国中医科学院西苑医院北京市100091 北京中医药大学东方医院北京市100078

背景:巨噬细胞在组织修复和再生过程的各个阶段展现出促炎、抗炎、促纤维化、促伤口愈合等多重活性,巨噬细胞的异质性及其平衡极化对器官修复具有决定性作用。目的:通过可视化分析方法探究巨噬细胞极化在组织修复领域的研究热点和发展趋... 详细信息

背景:巨噬细胞在组织修复和再生过程的各个阶段展现出促炎、抗炎、促纤维化、促伤口愈合等多重活性,巨噬细胞的异质性及其平衡极化对器官修复具有决定性作用。目的:通过可视化分析方法探究巨噬细胞极化在组织修复领域的研究热点和发展趋势,以及该领域全球科研与临床工作者的研究水平。方法:利用文献计量分析方法,采用Citespace文献可视化分析软件和VOSviewer工具,在Web of Science Core Collection的科学引文索引扩展(SCI-Expanded)和社会科学引文索引扩展(SSCI-Expanded)数据库中检索2013-2023年间的相关文献,通过动态图谱形式呈现分析结果,揭示研究的主要趋势和焦点。结果与结论:在2013-2023年,有关巨噬细胞极化在组织修复领域的发文量迅速增加,尤其从2017年增加显著;中国研究者的发文量居于第一位(642篇),美国研究者较早关注到该领域;Elisseeff Hennifer H教授对该领域研究有非常高的贡献;上海交通大学是发文量最多的机构;近年来“透明质酸”“调控”等关键词出现频率较高。巨噬细胞极化在组织修复领域的研究主要集中在其多功能性的调节机制、与其他细胞类型的相互作用以及在特定病理条件下的表现,研究热点涵盖了巨噬细胞在创面、心血管疾病、慢性炎症、肿瘤微环境及再生医学中的作用。通过深入理解巨噬细胞的多功能性和极化机制可以开发新的治疗策略,促进组织修复和再生,提高患者治疗效果。

关键词：文献计量学巨噬细胞极化组织修复 VOSviewer Citespace

Preparation and Properties of Water-based Conducting Polyaniline

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Chemical Research in Chinese Universities 1998年第3期14卷 87-92页

作者： WANG Xian-hong GENG Yan-hou YU Lei SUN Zai-cheng Li Ji JING Xia-bin WANG Fo-song LEE chang-jin rhee Suh-bong Polymer Chemistry Lab Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022 Korea Research Institute of Chemical Technology Taejeon 305-600Korea

A convenient way to prepare water soluble or water dispersible conducting polyaniline was developed by employing protonic acid dopants containing hydrophilic ethyleneoxide oligomer as counter-ion. The conducting polyaniline possesses electrical conductivity in the range of 10^(-3) to 10^(-2)S/cm depending on the chosen dopant, and it displays an excellent electrochemical redox reversibility in non aqueous systems.

关键词： Conducting polyaniline Water solubility Water dispersibility

Combination of cell signaling molecules can facilitate MYOD1-mediated myogenic transdifferentiation of pig fibroblasts

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Journal of Animal Science and Biotechnology 2021年第4期12卷 1662-1674页

作者： Jinsol Jeong Kwang-Hwan Choi Seung-Hun Kim Dong-kyung Lee Jong-Nam Oh Mingyun Lee Gyung Cheol Choe chang-kyu Lee Department of Agricultural Biotechnology Animal Biotechnology Majorand Research Institute of Agriculture and Life ScienceSeoul National UniversitySeoul 08826South Korea Present address:Research and Development Center Space F corporationHwasung-siGyeonggi-do 18471South Korea Institute of Green Bio Science and Technology Seoul National UniversityPyeong ChangKangwon-do 25354South Korea

Background:Myogenic transdifferentiation can be accomplished through ectopic MYOD1 expression,which is facilitated by various signaling pathways associated with *** this study,we attempted to transdifferentiate pig embryonic fibroblasts(PEFs)myogenically into skeletal muscle through overexpression of the pig MYOD1 gene and modulation of the FGF,TGF-β,WNT,and cAMP signaling ***:The MYOD1 overexpression vector was constructed based on comparative sequence analysis,demonstrating that pig MYOD1 has evolutionarily conserved domains across various *** forced MYOD1 expression through these vectors triggered the expression of endogenous muscle markers,transdifferentiated muscle cells from fibroblasts were not ***,various signaling molecules,including FGF2,SB431542,CHIR99021,and forskolin,along with MYOD1 overexpression were applied to enhance the myogenic *** modified conditions led to the derivation of myotubes and activation of muscle markers in PEFs,as determined by qPCR and ***,a sarcomere-like structure was observed,indicating that terminally differentiated skeletal muscle could be obtained from transdifferentiated ***:In summary,we established a protocol for reprogramming MYOD1-overexpressing PEFs into the mature skeletal muscle using signaling *** myogenic reprogramming can be used as a cell source for muscle disease models in regenerative medicine and the production of cultured meat in cellular agriculture.

关键词： MYOD1 Pig Sequence analysis Skeletal muscle Transdifferentiation

数字经济赋能养老服务业跨越“低水平均衡陷阱”

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河北学刊 2025年第1期45卷 152-161页

作者：夏杰长罗敬蔚中国社会科学院财经战略研究院中央财经大学法学院

中国养老服务业正面临低水平需求与高成本供给之间的矛盾,这直接导致养老服务业陷入“低水平均衡陷阱”。数字经济在优化养老资源配置、降低养老服务成本和完善养老生态系统等方面发挥了重要作用,是跨越养老服务业“低水平均衡陷阱”的... 详细信息

中国养老服务业正面临低水平需求与高成本供给之间的矛盾,这直接导致养老服务业陷入“低水平均衡陷阱”。数字经济在优化养老资源配置、降低养老服务成本和完善养老生态系统等方面发挥了重要作用,是跨越养老服务业“低水平均衡陷阱”的重要力量。借力数字经济推动养老服务实现高水平均衡,进而实现养老服务业高质量发展,需要综合施策:适当延长老年群体工作年限;对老年人口进行数字技术培训,助力他们跨越数字鸿沟;利用数字技术优化养老服务的资源配置;多渠道降低养老服务业成本;提升从业人员数字素养。

关键词： “低水平均衡陷阱” 老龄化数字经济养老服务业

Customizable design ofmultiple-biomolecule delivery platform for enhanced osteogenic responses via‘tailored assembly system’

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Bio-Design and Manufacturing 2022年第3期5卷 451-464页

作者： Hyun Lee Min-kyu Lee Ginam Han Hyoun-Ee Kim Juha Song Yuhyeon Na chang-Bun Yoon SeKwon Oh Tae-Sik Jang Hyun-Do Jung Department of Biomedical-Chemical Engineering Catholic University of KoreaBucheon 14662Republic of Korea Department of Biotechnology The Catholic University of KoreaBucheon 14662Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Querrey Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIL 60208USA Biomedical Implant Convergence Research Center Advanced Institutes of Convergence TechnologySuwon 443-270Republic of Korea School of Chemical and Biomedical Engineering Nanyang Technological University70 Nanyang DriveSingapore 637457Singapore Department of Advanced Materials Engineering Korea Polytechnic UniversitySiheung-siGyeonggi-do 15073Republic of Korea Surface R&D Group Korea Institute of Industrial TechnologyIncheon 21999Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangju 61452Republic of Korea

Porous titanium(Ti)scaffolds have been extensively utilized as bone substitute scaffolds due to their superior biocompatibility and excellent mechanical ***,naturally formed TiO2 on the surface limits fast *** biomolecules have been widely utilized to overcome this issue;however,homogeneous porous Ti scaffolds could not simultaneously deliver multiple biomolecules that have different release *** this study,functionally graded porous Ti scaffolds(FGPTs)with dense inner and porous outer parts were fabricated using a two-body combination and densification *** with growth factor(BMP-2)and antibiotics(TCH)exhibited suitable mechanical properties as bone substituting material and presented good structural *** release of BMP-2 was considerably prolonged,whereas the release of TCH was comparable to that of homogenous porous titanium scaffolds(control group).The osteogenic differentiation obtained using FGPTs was maintained due to the prolonged release of *** antimicrobial properties of these scaffolds were verified using *** in terms of prior release *** addition,various candidates for graded porous Ti scaffolds with altered pore characteristics were presented.

关键词： Functionally graded porous titanium scaffold Tailored assembly system Mechanical tunability Multiplebiomolecule delivery Bone tissue engineering

Thorium distribution on the Moon:new insights from chang’E-2 gamma-ray spectrometer

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Research in Astronomy and Astrophysics 2019年第6期19卷 1-14页

作者： Meng-Hua Zhu Jin chang Tao Ma State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and Technology Taipa Macao China Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210034 China CAS Center for Excellence in Comparative Planetology Hefei 230026 China

We present the thorium distribution on the lunar surface derived from observations by the chang’E-2 gamma-ray spectrometer(CE-2 GRS). This new map shows a similar thorium distribution to previous observations. In combination with this new thorium map and impact cratering model, we investigate the origination of thorium on the Moon’s highlands, which was previously thought to be contributed from Imbrium ejecta. We found that the Imbrium ejecta has a small contribution(~20%–30%) to the thorium on the lunar highlands but most thorium is likely to be indigenous before the deposition of the Imbrium ejecta. This new thorium map also confirms that the eastern highlands have a relatively higher thorium concentration than the western highlands. We propose that the thin crust and large basins on the eastern highlands are responsible for this difference in thorium.

关键词： Moon-chang'E-2 Gamma-ray Spectrometer-Thorium distribution

老子哲学与“道元”:人工智能token的语义与应用探索

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中国科技术语 2025年第1期27卷 57-63页

作者：张中鸿张庆瑞台湾大学哲学系中国台北市320314 中原大学物理系中国台湾中坜106319

自然语言处理建构在“道元(token)”之上,道元是AI算法处理和学习各种文字、图像与声音数据类型的基本元素。道元生成的过程与老子“道生一,一生二,二生三,三生万物”相似。大语言模型利用“间距”产生道元后,转换成位,透过大量数据的... 详细信息

自然语言处理建构在“道元(token)”之上,道元是AI算法处理和学习各种文字、图像与声音数据类型的基本元素。道元生成的过程与老子“道生一,一生二,二生三,三生万物”相似。大语言模型利用“间距”产生道元后,转换成位,透过大量数据的学习与计算,进行新的道元生成与意义重组。由于结合概率重组,人工智能出现类似于人类行为的不可预测性和独特性。未来借鉴老子哲学和汉字的多样性,人工智能可以发展出更全面和创新的框架。

关键词：道元位道元化间距人工智能老子之道