ACNU-CDDP Continuous Infusion Chemotherapy for Malignant Glioma
作者单位：M.D.Department of Neurosurgery Korea Institute of Radiological and Medical Science
会议名称：《第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议》
会议日期：2006年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：Glioblastoma Recurrent ACNU Cisplatin Chemotherapy
摘 要：正Purpose:To evaluate the activity and the toxicity of ACNU （1 - （4 - amino - 2methyl - 5pyrimidinyl） - methyl - 3 - （2 -cholroethyl） - 3 - nitrosourea hydrochloride） administered with cisplatin by intravenous infusion for 72 hours in select patients with recurrent *** and Methods:From April 1996 to 2002,thirty-seven patients with histologically proven glioblastoma,who showedre-currence on image study after operation and radiation, met the eligibility criteria of our cohort. The mean time to recurrence was 9.7± 7.0（1 - 26 months） .Treatment response was evaluated every 6 weeks using magnetic resonance imaging （MRI）. Complete blood counts were collected every week to monitor and treat possible bone marrow suppression from the *** rates were analyzed using the Kaplan - Meier and log rank test. Results: Post - chemotherapy MRI was available in 36 of 37 patients. Response to treatment was observed in 19 patients （53%） including 2 cases of complete *** patients （17%） showed progression （PD） and 11 patients （31%） had stable disease （SD）. Two or more cycles of chemotherapy was the only factor that predicted response to treatment. The overall median survival for all patients was 17.0±3.3 *** （ 40 years） and time to recurrence （ 1 year） were the clinical factors that predicted improved overall *** gain after chemotherapy was 9 ***’s median survival in those who responded and thoee with SD after treatment （11 months） had a longer median survival compared to PD （5 months） （p = 0.01） .Myelosuppression was severe （grade III/IV leukopenia in 15 patients （40%） and grade III/IV thrombocytopenia in 19 patients （52%）） but most recovered more than WHO grade II at the end of the chemotherapy cycles. There was only one fatality due to sepsis from pneumonia during the initial leukopenic state. Conclusion: ACNU and cisplatin chemotherapy can be an effective salvage therapy for recurrent glioblastoma patients.