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Sterol Composition and Biosynthesis in Hairy Root Cultures of Cassia obtusifolia

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中草药 1998年第11期29卷 723-727页

作者： chang zhenzhan Guo Dean Norton R A and Zheng Junhua(School of Pharmaceutical Sciences, Beijing Medical University 100083) 北京医科大学北京 100083 北京医科大学北京

应用发根农杆菌（Agrobacteriiumrhizogens）感染决明无菌苗建立了决明毛状根培养体系。分析了决明毛状根中的甾醇类化学成分并初步探讨了它们的生物合成途径。用薄层色谱（TLC）、气相色谱（GLC）、高效液相色谱（HPLC）和质谱（MS）... 详细信息

应用发根农杆菌（Agrobacteriiumrhizogens）感染决明无菌苗建立了决明毛状根培养体系。分析了决明毛状根中的甾醇类化学成分并初步探讨了它们的生物合成途径。用薄层色谱（TLC）、气相色谱（GLC）、高效液相色谱（HPLC）和质谱（MS）等方法从毛状根中分离鉴定了12个甾醇类成分。根据研究结果提出了其中主要甾醇类成分的生物合成途径。

关键词：决明毛状根培养甾醇生物合成

Genomic,transcriptomic,and epigenomic analysis of a medicinal snake,Bungarus multicinctus,to provides insights into the origin of Elapidae neurotoxins

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2234-2249页

作者： Jiang Xu Shuai Guo Xianmei Yin Mingqian Li He Su Xuejiao Liao Qiushi Li Liang Le Shiyu Chen Baosheng Liao Haoyu Hu Juan Lei Yingjie Zhu Xiaohui Qiu Lu Luo Jun Chen Ruiyang Cheng zhenzhan chang Han Zhang Nicholas Chieh Wu Yiming Guo Dianyun Hou Jin Pei Jihai Gao Yan Hua Zhihai Huang Shilin Chen Institute of Herbgenomics State Key Laboratory of Southwest Chinese Medicine ResourcesPharmacy CollegeChengdu University of Traditional Chinese MedicineChengdu 611137China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Cancer Prevention and Therapy Combining Traditional Chinese and Western Medicine of Zhejiang Province Zhejiang Academy of Traditional Chinese MedicineTongde Hospital of Zhejiang ProvinceHangzhou 310012China Guangdong Provincial Hospital of Chinese Medicine(the Second Clinical Medical College of Guangzhou University of Chinese Medicine Guangdong Provincial Hospital of Traditional Chinese Medicine)Guangzhou 510006China Pharmacy College Shandong University of Traditional Chinese MedicineJinan 250355China Department of Pathology Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Beijing Engineering Research Center of Pediatric Surgery Engineering and Transformation CenterBeijing Children's HospitalNational Center for Children's HealthCapital Medical UniversityBeijing 100045China School of Basic Medical Sciences Peking UniversityBeijing 100191China School of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 300193China School of Life and Environmental Sciences the University of SydneyNSW2006Australia University of Pittsburgh Kenneth P.Dietrich School of Arts and SciencesPittsburghPA 15260USA Agricultural College Henan University of Science and TechnologyLuoyang 471000China Guangdong Provincial Key Laboratory of Silviculture Protection and UtilizationGuangdong Academy of ForestryGuangzhou 510520China

The many-banded krait,Bungarus multicinctus,has been recorded as the animal resource of JinQianBaiHuaShe in the Chinese *** of its venoms classified chief phyla of modern animal ***,the evolutionary origin and diversification of its neurotoxins as well as biosynthesis of its active compounds remain largely unknown due to the lack of its high-quality ***,we present the 1.58 Gbp genome of *** assembled into 18 chromosomes with contig/scaffold N50 of 7.53 Mbp/149.8 *** bungarotoxin-coding genes were clustered within genome by family and found to be associated with ancient local *** truncation of glycosylphosphatidylinositol anchor in the 3'-terminal of a LY6E paralog released modern three-finger toxins(3FTxs)from membrane tethering before the Colubroidea *** expansion and mutations diversified and recruited these *** the cobra/krait divergence,the modern unit-B ofβ-bungarotoxin emerged with an extra cysteine residue.A subsequent point substitution in unit-A enabled theβ-bungarotoxin covalent *** *** gene expression,chromatin topological organization,and histone modification characteristics were featured by transcriptome,proteome,chromatin conformation capture sequencing,and *** results highlighted that venom production was under a sophisticated *** findings provide new insights into snake neurotoxin research,meanwhile will facilitate antivenom development,toxin-driven drug discovery and the quality control of JinQianBaiHuaShe.

关键词： Medicinal snake Neurotoxin origin Antivenoms Gene regulation Chromatin

Effect of heat treatment on microstructure and mechanical properties of selective laser-melted PH13-8Mo stainless steel

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Journal of Iron and Steel Research International 2024年第4期31卷 945-955页

作者： Yuan Zhang Xiang Liu chang-jun Wang chang Liu School of Material Science and Engineering Kunming University of Science and TechnologyKunming 650093YunnanChina Central Iron&Steel Research Institute Co. Ltd.Beijing 100081China

PH13-8Mo stainless steel powder with high sphericity and well fluidity was prepared by the plasma rotating electrode *** formed parts with ultra-high purity were manufactured by selective laser *** tensile and impact mechanical properties of the printed parts under three heat treatment regimes were compared to those without heat *** microstructure,grain orientation and phase composition were characterized by electron-backscatter diffraction,X-ray diffraction and transmission electron *** characterization results reveal that the addition of heat treatment makes the grains enlarge,and after different heat treatments,the average grain size from 1.51μm in the printed state increases to 2.78,3.09 and 2.06μm,*** formed parts are mainly composed of martensite and retained ***,the NiAl and M23C precipitates form,which are the major strengthening phases of PH13-8Mo stainless *** optimal heat treatment process is 925℃×1 h water cooling(WC)+0℃×2 h air cooling(AC)+540℃×4 h *** this heat treatment process,PH13-8Mo formed parts have the optimal comprehensive mechanical properties:the tensile strength,yield strength and impact energy KU2 are 1492 MPa,1432 MPa and 63 J,*** strengthening and toughening via heat treatment are mainly attributed to dislocation strengthening,the formation of NiAl and M23Co precipitates and the change of volume fraction of the retained austenite.

关键词： High-strength stainless steel-Selective laser melting-Heat treatment Microstructure Mechanical property

Inverse-time Backup Protection Based on Unified Characteristic Equation for Distribution Networks with High Proportion of Distributed Generations

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 202-212页

作者： Nana chang Guobing Song Zhongxue chang Yuping Zheng Xingang Yang the School of Electrical Engineering Xi’an Jiaotong UniversityXi’anChina State Key Laboratory of Smart Grid Protection and Control NARI Group CorporationNanjingChina Electric Power Research Institute of State Grid Shanghai Electric Power Company ShanghaiChina

The setting work of backup protection using steady-state current is tedious,and mismatches occasionally occur due to the increased proportion of distributed generations(DGs)connected to the power ***,there is a practical need to study a backup protection technology that does not require step-by-step setting and can be adaptively *** paper proposes an action sequence adaptive to fault positions that uses only positive sequence fault component(PSFC)*** the influence of DGs,the unified time dial setting can be obtained by selecting specific *** protection performance is improved by using the adjacent upstream and downstream protections to meet the coordination time interval in the case of metallic faults at the near-and far-ends of the ***,the expression and implementation scheme for inverse-time backup protection(ITBP)based on the unified characteristic equation is *** results show that this scheme can adapt to DG penetration scenarios and can realize the adaptive coordination of multi-level relays.

关键词： Inverse-time backup protection(ITBP) distributed generation(DG) positive sequence fault component(PSFC)voltage unified characteristic equation adaptive coordination

Polymeric piezoelectric accelerometers with high sensitivity,broad bandwidth,and low noise density for organic electronics and wearable microsystems

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Microsystems & Nanoengineering 2024年第3期10卷 63-74页

作者： chang Ge Edmond Cretu The Department of Electrical and Computer Engineering The University of British ColumbiaVancouverBCCanada

Piezoelectric accelerometers excel in vibration *** the emerging trend of fully organic electronic microsystems,polymeric piezoelectric accelerometers can be used as vital front-end components to capture dynamic signals,such as vocal vibrations in wearable speaking assistants for those with speaking ***,high-performance polymeric piezoelectric accelerometers suitable for such applications are *** organic compounds such as PVDF have inferior properties to their inorganic counterparts such as ***,most existing polymeric piezoelectric accelerometers have very unbalanced performance *** often sacrifice resonance frequency and bandwidth for a flat-band sensitivity comparable to those of PZT-based accelerometers,leading to increased noise density and limited application *** this study,a new polymeric piezoelectric accelerometer design to overcome the material limitations of PVDF is *** new design aims to simultaneously achieve high sensitivity,broad bandwidth,and low *** samples were manufactured and characterized,demonstrating an average sensitivity of 29.45 pC/g within a±10 g input range,a 5%flat band of 160 Hz,and an in-band noise density of 1.4μg/√*** results surpass those of many PZT-based piezoelectric accelerometers,showing the feasibility of achieving comprehensively high performance in polymeric piezoelectric accelerometers to increase their potential in novel applications such as organic microsystems.

关键词： piezoelectric polymeric overcome

Recent Progresses of the DAMPE Mission

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空间科学学报 2024年第4期44卷 633-642页

作者： chang Jin Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210033 School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026

The DArk Matter Particle Explorer(DAMPE)is a space high-energy particle andγ-ray detector whose major scientific goals are the indirect detection of dark matter particles,the origin of cosmic rays and highenergyγ-ray *** its successful launch in December 2015,the DAMPE has been operated smoothly in orbit for more than 8 *** direct measurements of the boron-to-carbon and boron-to-oxygen flux ratios,and the proton+Helium spectrum up to 316 TeV have been obtained,revealing new spectral features with very high *** search results ofγ-ray spectral line and fractionally charged particles indicate a good potential of DAMPE for indirect dark matter detection and new physical discovery in *** DAMPE measurements are expected to significantly advance our understanding of the fundamental problems in astroparticle physics.

关键词： DAMPE Dark matter Indirect detection Cosmic rays

Preface to the Special Issue:Additive Manufacturing—Expanding Production Horizon

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 1-2页

作者： Lai-chang Zhang Centre for Advanced Materials and Manufacturing School of EngineeringEdith Cowan University270 Joondalup DriveJoondalupPerthWA6027Australia

Additive manufacturing(AM),commonly known as 3D printing,has become a transformative technology that has a profound impact on various industrial *** encompasses a set of techniques for building objects layer by layer from digital *** conventional subtractive manufacturing methods that involve removing material from large blocks,AM adds material incrementally,providing unprecedented design flexibility and efficiency.

关键词： removing printing Expanding

Breakthrough in Li-mediated continuous electrosynthesis of ammonia

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Science China Chemistry 2024年第10期67卷 3191-3192页

作者： Fei Zhan chang Yu State Key Laboratory of Chemical Resource Engineering College of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of Fine Chemicals Liaoning Key Lab for Energy Materials and Chemical EngineeringSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China

Ammonia(NH3)ranks among the manufactured chemicals,with an annual production surpassing 182 million tons[1],which is an indispensable raw material for fertilizer industry and has been recognized as a promising carbon-... 详细信息

关键词： ammonia Ammonia suppl

An interview with *** Zhang

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High Power Laser Science and Engineering 2024年第3期12卷 122-125页

作者： Guoqing chang Institute of Physics Chinese Academy of SciencesBeijingChina

*** Zhang,a distinguished physicist,has made significant contributions in the fields of high-energy-density physics and inertial confinement *** of these,he was elected academician of the Chinese Academy of Sciences in 2003,academician of the German National Academy of Sciences in 2007,Fellow of the Academy of Sciences for the Developing World(TWAS)in 2008,foreign member of the Royal Academy of Engineering in the United Kingdom in 2011 and foreign associate of the National Academy of Sciences in the United States in *** 2015,he was awarded the prestigious Edward Teller Medal,the most important international award in inertial confinement fusion and high-energy-density *** 2021,he was awarded the Future Science Prize in Physical Sciences.

关键词： interview award Jie