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Protein Arginine Methyltransferase 1 Ablation in Motor Neurons Causes Mitochondrial Dysfunction Leading to Age-related Motor Neuron Degeneration with Muscle Loss

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Research 2024年第1期2023卷 637-649页

作者： hyun-Kyung So Hyebeen Kim Jinwoo Lee chang-lim You Chae-Eun Yun Hyeon-Ju Jeong Eun-Ju Jin Yunju Jo Dongryeol Ryu Gyu-Un Bae Jong-Sun Kang Department of Molecular Cell Biology Sungkyunkwan University School of MedicineSuwonKorea Single Cell Network Research Center Sungkyunkwan University School of MedicineSuwonKorea Research Institute of Aging-Related Diseases AniMusCureInc.SuwonKorea Drug Information Research Institute Muscle Physiome Research CenterCollege of PharmacySookmyung Women’s UniversitySeoulKorea

Neuromuscular dysfunction is tightly associated with muscle wasting that occurs with age or due to degenerative ***,the molecular mechanisms underlying neuromuscular dysfunction are currently *** studies have proposed important roles of Protein arginine methyltransferase 1(Prmt1)in muscle stem cell function and muscle *** the current study,we set out to determine the role of Prmt1 in neuromuscular function by generating mice with motor neuron-specific ablation of Prmt1(mnKO)using *** exhibited age-related motor neuron degeneration and neuromuscular dysfunction leading to premature muscle loss and ***1 deficiency also impaired motor function recovery and muscle reinnervation after sciatic nerve *** transcriptome analysis of aged mnKO lumbar spinal cords revealed alterations in genes related to inflammation,cell death,oxidative stress,and ***,mnKO lumbar spinal cords of sciatic nerve injury model or aged mice exhibited elevated cellular stress response in motor ***,Prmt1 inhibition in motor neurons elicited mitochondrial *** findings demonstrate that Prmt1 ablation in motor neurons causes agerelated motor neuron degeneration attributing to muscle ***,Prmt1 is a potential target for the prevention or intervention of sarcopenia and neuromuscular dysfunction related to aging.

关键词： degeneration impaired prevention

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氮掺杂对环境空气中TiO_(2)纳米催化剂抗甲醛光催化矿化的影响

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Chinese Journal of Catalysis 2024年第4期59卷 303-323页

作者： Dae-Hwan lim Aadil Bathla Hassan Anwer Sherif AYounis Danil WBoukhvalov Ki-hyun Kim 汉阳大学土木与环境工程系韩国首尔国立科技大学环境工程系巴基斯坦伊斯兰堡埃及石油研究所分析与评估部埃及开罗南京林业大学材料物理与化学研究所理学院江苏南京乌拉尔联邦大学物理与技术研究所俄罗斯叶卡捷琳堡

通过氮掺杂TiO_(2)(N-TiO_(2))浸渍蜂窝过滤器构建了一系列原型光催化空气净化器(AP(N_(x)-C_(y)))系统,并用于在UV-LED光(1 W)照射条件下光催化分解0.5-5 ppm甲醛(CH_(2)O)蒸汽.在上述催化过滤器系统中,Nx和Cy分别代表N/Ti摩尔比(0-20)... 详细信息

通过氮掺杂TiO_(2)(N-TiO_(2))浸渍蜂窝过滤器构建了一系列原型光催化空气净化器(AP(N_(x)-C_(y)))系统,并用于在UV-LED光(1 W)照射条件下光催化分解0.5-5 ppm甲醛(CH_(2)O)蒸汽.在上述催化过滤器系统中,Nx和Cy分别代表N/Ti摩尔比(0-20)和N-TiO_(2)浓度(2-20 mg mL^(-1)).光催化分解实验结果表明,AP(N_(10)-C_(10))的性能最好,其催化CH2O转化为CO_(2)的转化率最高,循环反应10次后CO_(2)产率仍达到89.2%,在干燥空气中的清洁空气输送速率为9.45 L min^(-1).N10-C10的电荷载流子寿命(τa:1.70 ns)优于其他样品(如纯TiO_(2)的电荷载流子寿命为1.37 ns),这表明N缺陷(No)有助于降低带隙(3.10 eV)和产生氧空位OVs-Ti^(3+),这与密度泛函理论(DFT)模拟结果一致.采用原位漫反射红外傅里叶变换、电子顺磁共振和DFT分析等多种方法研究了CH_(2)O的光催化氧化途径.结果表明,氧化过程涉及多个能量有利的中间步骤(例如CH2O以CH_(2)O_(2)的形式在TiO_(2)-OV{110}表面的桥连O/OH基团上发生放热共价吸附,随后通过催化脱氢/氧化反应直接生成CO_(2):CH_(2)O_(2)/HCOO^(-)+•OH→H_(2)O+CO_(2)).这些步骤与具有N杂质的{101}表面上化学活性Ti原子的态密度计算结果一致.预计No缺陷和OVs的存在将通过降低活化能垒来影响反应能量和中间产物,从而在加湿条件下实现有效的矿化.综上,本文为设计和构建先进的光催化系统,并用于环境空气中醛类挥发性有机物(VOCs)的有效矿化提供了新思路.

关键词：光催化蜂窝过滤器甲醛氮掺杂TiO_(2) 密度泛函理论计算催化反应途径空气净化

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Intramedullary spinal cord metastasis from pancreatic neuroendocrine tumor

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World Journal of Gastroenterology 2014年第38期20卷 14063-14067页

作者： Jung Ho Kim chang lim hyun Sang Hoon Han Department of Internal Medicine Gachon University Gil Medical Center Department of Pathology Jeju National University School of Medicine Department of Internal Medicine Jeju National University School of Medicine

Intramedullary spinal cord metastasis(ISCM) is very rare and its optimal treatment remains controversial. Pancreatic neuroendocrine tumor(pNET) is a rare tumor that usually presents with hepatic metastasis. Hepatic failure due to tumor progression is the major cause of death in cases of pNET. To date,no report has described a case of ISCM from pNET. Although spinal cord metastasis of a solid tumor is uncommon,it is a critical condition that can cause a potentially irreversible loss of neurologic function. Here,we report the case of a 45-year-old man who presented with leg weakness and voiding difficulty,and was found to have ISCM from pNET. Surgical treatment prevented further neurological deterioration. This is the first case report of ISCM from pNET.

关键词： Intramedullary Spinal cord neoplasm Metastasis Neu

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Matched pair analysis of the effect of longer hypothermic machine perfusion time on kidney transplant outcomes

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World Journal of Transplantation 2024年第3期14卷 95-101页

作者： Carlos Verdiales Luke Baxter hyun Ja lim Gavin Beck Michael A Moser Department of Surgery University of SaskatchewanSaskatoonSaskatchewan S7N 0W8Canada College of Medicine University of SaskatchewanSaskatoonSaskatchewan S7N 0W8Canada Canada and Northern Ontario School of Medicine Thunder BayOntario P7B 5E1Canada Department of Community Health and Epidemiology University of SaskatchewanSaskatoonSaskatchewan S7N 0W8Canada

BACKGROUND Hypothermic machine perfusion(HMP)has demonstrated benefits in terms of early kidney transplant function compared to static cold *** longer preservation times have shown detrimental effects,a previous paired study indicated that longer pump times(the second kidney in a pair)might lead to improved *** To revisit the prior paired study's somewhat unexpected results by reviewing our program's *** A total of 61 pairs of transplant recipients who received kidneys from the same donor(2012-2021)were *** were divided into two groups depending on whether they were transplanted first(K1)or second(K2).Therefore,the patients in each pair had identical donor characteristics,except for time on the *** analyses included Kaplan-Meyer analysis and paired tests,including McNemar's test,student's paired t-test,or Wilcoxon's test,as *** The two groups of recipients had similar demographics(age,body mass index,diabetes,time on dialysis,sensit-ization and retransplants).Cold ischemic times for K1 and K2 were 8.9(95%CI:7.9,9.8)and 14.7 hours(13.7,15.8)(P<0.0001),***,K2 had a higher rate of freedom from biopsy-proven acute rejection at 1 year(P=0.015).Delayed graft function was less common in K2,12/61(20%)than in K1,20/61(33%)(P=0.046).Finally,K2 showed a higher graft survival than K1(P=0.023).CONCLUSION Our results agree with a previous study that suggested possible advantages to longer pump *** studies should encourage further research into HMP's potential anti-inflammatory effect.

关键词： Hypothermic machine perfusion Paired kidney study Early acute rejection

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Primary intestinal lymphangiectasia with generalized warts

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World Journal of Gastroenterology 2015年第27期21卷 8467-8472页

作者： Soon Jae Lee hyun Joo Song Sun-Jin Boo Soo-Young Na Heung Up Kim chang lim hyun Department of Internal Medicine Jeju National University School of Medicine Department of Pathology Jeju National University School of Medicine

Primary intestinal lymphangiectasia(PIL) is a rare protein-losing enteropathy with lymphatic leakage into the small intestine. Dilated lymphatics in the small intestinal wall and mesentery are observed in this disease. Laboratory tests of PIL patients revealed hypoalbuminemia, lymphocytopenia, hypogammaglobulinemia and increased stool α-1 antitrypsin clearance. Cell-mediated immunodeficiency is also present in PIL patients because of loss of lymphocytes. As a result, the patients are vulnerable to chronic viral infection and lymphoma. However, cases of PIL with chronic viral infection, such as human papilloma virus-induced warts, are rarely reported. We report a rare case of PIL with generalized warts in a 36-year-old male patient. PIL was diagnosed by capsule endoscopy and colonoscopic biopsy with histological tissue confirmation. Generalized warts were observed on the head, chest, abdomen, back, anus, and upper and lower extremities, including the hands and feet of the patient.

关键词： Protein-losing enteropathy Lymphocytopenia Cell-mediated immunodeficiency Primary intestinallymphangiectasia Warts

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Incomplete High Radial Nerve Palsy Due to Schwannoma of Radial Nerve in the Upper Arm—A Case Report

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Open Journal of Orthopedics 2017年第2期7卷 72-78页

作者： hyun Seong Kang Chen Tai Teong Jee Eun Park Sang Rim Kim Kyu Bum Seo chang lim hyun Kwang Hun Song Department of Orthopedic Surgery Jeju National University School of Medicine Jeju Korea Department of Pathology Jeju National University School of Medicine Jeju Korea Department of Orthopedic Surgery SOO Hospital Jeonju Korea

A schwannoma is a benign soft tissue tumor composed of Schwann cells. Clinically, the tumor is slow-growing and usually asymptomatic, rarely developing neurological symptoms. We present a case of a 44-year-old female who was diagnosed with an incomplete high radial nerve palsy, showing a wrist drop and extension of fingers due to schwannoma on the radial nerve of the upper arm. The patient showed excellent result after excision of the schwannoma and neurorrhaphy of the radial nerve.

关键词： Radial Nerve Schwannoma Wrist Drop Incomplete High Radial Nerve Palsy

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Small cell carcinoma of the liver and biliary tract without jaundice

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World Journal of Gastroenterology 2013年第44期19卷 8146-8150页

作者： Jae-Min Jo Yoo-Kyung Cho chang-lim hyun Kyoung-Hee Han Ji-Young Rhee Jung-Mi Kwon Woo-Kun Kim Sang-Hoon Han Department of Internal Medicine Jeju National University Hospital Jeju-si 890-716 Jeju Self-Governing Province South Korea Department of Pathology Jeju National University Hospital Jeju-si 890-716 Jeju Self-Governing ProvinceSouth Korea Jeju National University School of Medicine Jeju-si 890-716 Jeju Self-Governing Province South Korea

An 80-year-old woman presenting with chest pain was found to have a large,lobulated soft tissue mass in the liver and nearby tissues on abdominal computed tomography(CT).The tumor had invaded the common hepatic artery and main portal *** developed 4 wk later,at which point,a pancreas and biliary CT scan revealed a large mass in the right lobe of the liver and a hilar duct obstruction,which was found to be a small cell *** its rarity,liver and bile duct small cell carcinoma should be considered in the differential diagnosis of atypical chest pain without jaundice.

关键词： Extrapulmonary small cell carcinoma Jaundice Liver mass Bile duct mass Neuroendocrine tumor

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Sub-2 nm mixed metal oxide for electrochemical reduction of carbon dioxide to carbon monoxide

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能源化学:英文版 2023年第9期84卷 303-310页

作者： Devina Thasia Wijaya Andi Haryanto hyun Woo lim Kyoungsuk Jin Chan Woo Lee Department of Chemistry Kookmin UniversitySeoul 02707Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Chemistry Korea UniversitySeoul 02841Republic of Korea

Mixed metal oxide(MMO) represents a critical class of materials that can allow for obtaining a dynamic interface between its components:reduced metal and its metal oxide counterpart during an electrocatalytic ***,a synthetic method utilizing a MOF-derived micro/mesoporous carbon as a template to prepare sub-2 nm MMO catalysts for CO_(2) electro reduction is *** from the zeolite imidazolate framework(ZIF-8),the pyrolyzed derivatives were used to synthesize sub-2 nm Pd-Ni MMO with different *** Ni-rich(Pd_(20)-Ni_(80)/ZC) catalyst exhibits unexpectedly superior performance for CO production with an improved Faradaic efficiency(FE) of 95.3% at the current density of 200 mA cm^(-2) at-0.56 V *** hydrogen electrode(RHE) compared to other Pd-Ni compositions.X-ray photoelectron spectroscopy(XPS) analysis confirms the presence of Ni^(2+) and Pd^(2+) in all compositions,demonstrating the presence of *** functional theory(DFT) calculation reveals that the lower CO binding energy on the surface of the Pd_(20)-Ni_(80) cluster eases CO desorption,thus increasing its *** work provides a general synthetic strategy for MMO electrocatalysts and can pave a new way for screening multimetallic catalysts with a dynamic electrochemical interface.

关键词： Carbon dioxide reduction Mixed metal oxide Nanoalloy Carbon monoxide Metal-organic framework

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Rapid detection of influenza A(H1N1)virus by conductive polymer-based nanoparticle via optical response to virus-specific binding

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Nano Research 2022年第3期15卷 2254-2262页

作者： Geunseon Park hyun-Ouk Kim Jong-Woo lim Chaewon Park Minjoo Yeom Daesub Song Seungjoo Haam Department of Chemical&Biomolecular Engineering Yonsei UniversitySeoul 03722Republic of Korea Division of Chemical Engineering and Bioengineering College of Art Culture and EngineeringKangwon National UniversityChuncheon-siGangwon-do 24341Republic of Korea Biohealth-machinery Convergence Engineering Kangwon National UniversityChuncheonGangwon-do 24341Republic of Korea College of Pharmacy Korea UniversitySejong 30019Republic of Korea

A recurrent pandemic with unpredictable viral nature has implied the need for a rapid diagnostic technology to facilitate timely and appropriate countermeasures against viral *** this study,conductive polymer-based nanoparticles have been developed as a tool for rapid diagnosis of influenza A(H1N1)*** distinctive property of a conductive polymer that transduces stimulus to respond,enabled immediate optical signal processing for the specific recognition of H1N1 *** poly(aniline-co-pyrrole)-encapsulated polymeric vesicles,functionalized with peptides,were fabricated for the specific recognition of H1N1 *** low solubility of conductive polymers was successfully improved by employing vesicles consisting of amphiphilic copolymers,facilitating the viral titer-dependent production of the optical *** optical response of the detection system to the binding event with H1N1,a mechanical stimulation,was extensively analyzed and provided concordant information on viral titers of H1N1 virus in 15 *** specificity toward the H1N1 virus was experimentally demonstrated via a negative optical response against the control group,***,the designed system that transduces the optical response to the target-specific binding can be a rapid tool for the diagnosis of H1N1.

关键词： influenza A(H1N1)virus conductive polymer optical property rapid detection

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Bilateral snapping triceps syndrome:A case report

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World Journal of Clinical Cases 2023年第34期11卷 8228-8234页

作者： Chul-hyun Cho Kyung-Hwan lim Du-Han Kim Department of Orthopedic Surgery Keimyung University Dongsan HospitalKeimyung University School of MedicineDaegu 42601South Korea Orthopedic Surgery Allright HospitalDaegu 42038South Korea

BACKGROUND Snapping triceps syndrome(STS)is a rare disease,while occurrence of bilateral STS is extremely *** is usually accompanied by dislocation of the ulnar nerve and double snapping is a clinically important ***,to the best of our knowledge,there has been no report of bilateral STS in young active *** SUMMARY A 23-year-old male presented with a complaint of discomfort and snapping on the medial side of both elbows while performing *** physical examination,two distinct snaps that were both palpable and audible were detected on additional clinical *** ultrasonography showed that the ulnar nerve and the medial head of the triceps were dislocated anteriorly over the medial epicondyle of the elbow during flexion ***,he was diagnosed as dislocation of the ulnar nerve and *** anterior subcutaneous transposition of the ulnar nerve combined with partial resection of the snapping portion of the triceps was *** patient’s pain and snapping symptoms were resolved immediately after *** months later,the patient was completely asymptomatic and returned to normal *** STS should be included in the differential diagnosis for active young patients who present with painful snapping on the medial side of the elbow joint,particularly when dislocation of the ulnar nerve is *** sonography is used to assist in accurate diagnosis and differentiation between isolated dislocation of the ulnar nerve and STS.

关键词： Triceps Triceps snapping syndrome Ulnar nerve Elbow Dynamic sonography Case report

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