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Regulating metalloimmunology with nanomedicine for cancer therapy

Nano Research 2023年第12期16卷 13164-13181页

作者： Saibo Ma Lin Chen Muhammad Hamza jing chang Motao Zhu College of Marine Life Science Ocean University of ChinaQingdao 266003China CAS Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266235China University of Chinese Academy of Sciences Beijing 100049China

Metals are essential components of both micronutrients and macronutrients in living organisms and are involved in a variety of immune processes in the forms of free ions or protein-coupled complexes(metalloproteins).Multiple aspects of the immune system,from the structural and functional control of immune-related proteins to the cellular responses to immunotherapy,could be affected by ***,the employment of metal for the regulation of immunity,termed as metalloimmunology,is gaining interest as a prevalent and efficacious approach to combating ***,the manipulation of metalloimmunology using traditional drugs presents several challenges,including limited bioavailability,adverse effects,and a lack of targeting *** review provides an overview of the latest findings in metal and metal-regulatory therapeutic agents for the treatment of *** trace metal elements,such as iron,zinc,copper,manganese,magnesium,and calcium,as well as heavy metal drugs and their mechanisms of action,will be discussed with a particular focus on their roles in regulating the tumor-immune *** latest nanotechnology employed in the administration of metal-regulatory drugs and the design concepts for tailored therapeutic interventions will be *** concepts and information offer promising clinical possibilities of modulating cancer immunology by targeting metal metabolism.

关键词： metalloimmunology metal metabolism cancer immunotherapy nano-enabled delivery system cGAS-STING pathway ferroptosis and cuprotosis

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Synthetic biology: From the first synthetic cell to see its current situation and future development

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Chinese Science Bulletin 2011年第3期56卷 229-237页

作者： ZHANG LiuYan chang SuHua WANG jing Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Beijing 100101 China

Synthetic biology is an emerging field,which,since its birth,has shown great value and potential in many fields including medicine,energy,environment and *** is also important for the study of the origin and evolution of *** the publication of the first synthetic cell in May,2010,synthetic biology again attracts high attention and leads to extensive discussions all over the *** have been a number of researches and achievements on synthetic biology in the United States and European *** in China,so far there is no systematic research on synthetic *** order to promote the development of this new discipline in China,we organized this review to systematically introduce the concept and research content of synthetic biology,summarize the achievements,and investigate the current situation in both China and *** also analyzed the opportunities and challenges in synthetic biology,and looked forward to the future development of synthetic biology,especially its future development in China.

关键词：合成生物学细胞生命起源欧洲国家中国系统价值

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A first-principles study of the structural,electronic and elastic properties of solid nitromethane under pressure

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Science China(Physics,Mechanics & Astronomy) 2013年第10期56卷 1874-1881页

作者： chang jing ZHOU XiaoLin ZHAO GuoPing WANG Li College of Physics and Electronic Engineering Sichuan Normal University

The structural,electronic and elastic properties of solid nitromethane are investigated under pressure by performing first-principles density functional theory(DFT)calculations within the generalized gradient approximation(GGA)and the local density approximation(LDA).The obtained ground state structure properties are found to be consistent with existing experimental and theoretical *** pressure-induced variations of structure parameters(a,b,c and V)indicate that the solid nitromethane has an anisotropic compressibility,and the compression along the c direction is more difficult than along a and b *** the vibration curves of intermolecular bond length and bond angle,we find that the C—N bond is the most sensitive among these bonds under pressure,suggesting that the C—N bonds may be broken first under external *** influence of pressure on the electronic properties of solid NM has been studied,indicating that solid NM is an insulating compound with a large indirect band gap and tends to be a semiconductor with increasing ***,we predict the elastic constants and their pressure dependence for the solid NM with the bulk modulus,Young’s modulus,shear modulus and the Poisson’s ratio derived.

关键词： density functional theory crystal structure electronic structure elastic constants nitromethane

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Core-Corona Structure Formed by Hyaluronic Acid and Poly(L-lysine)via Kinetic Path

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Chinese Journal of Polymer Science 2019年第1期37卷 36-42,1-2页

作者： Wei Pan Dong-Xiao Yin Hai-Rong jing Hao-jing chang Hao Wen De-Hai Liang Beijing National Laboratory for Molecular Sciences and Key Laboratory of Polymer Chemistry and Physics of Ministry of Education College of Chemistry and Molecular Engineering Peking University

The structure and kinetics of the complex formed by hyaluronic acid(HA) and poly(L-lysine)(PLL) were studied by timeresolved laser light scattering, TEM, and AFM. Because HA has a hydrophilic backbone, the complexes formed by HA and PLL are different from those formed by oppositely charged polyelectrolytes both having hydrophobic backbones. Instead of forming strong aggregates and even precipitates, the complex in the presence of excess HA is stable in the studied time period. More importantly, the complex spontaneously forms core-corona structure by the rearrangement of HA chains. The core is composed of complex rich of PLL and the corona is mainly HA. Further analysis shows that the hydrogen bond formed by HA creates a barrier hindering the further relaxation of HA chains. The automatic formation of core-corona structure by PLL/HA is helpful not only to understand the relaxation of polyelectrolyte in complex, but also to develop drug carriers with desirable properties.

关键词： Polyelectrolyte complex Core-corona structure Hyaluronic acid Poly(L-lysine) Laser light scattering

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One-pot tandem Barbier-Prins synthesis of tetrahydropyrans in aqueous media

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Science China Chemistry 2005年第1期48卷 38-41页

作者： WEN Meijiao TANG Long chang Weixing LI jing State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 China State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 China State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 China State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 China

By investigating the effect of the amount of water, the ratio of aldehyde and allyl- bromide, and the reaction temperature on the transformation, 2,4,6-trisubstituted tetrahydro- pyrans are synthesized by a novel tandem Barbier-Prins-cyclization reaction in the presence of micro-amount of water under mild conditions. The experiment is easy to perform without the need to exclude moisture or air. The reaction is atomic economical and environmentally benign.

关键词： Barbier-type, Prins-cyclization, tetrahydropyran, water, environment benign.

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Nonlinear Skew Lie Triple Derivations between Factors

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Acta Mathematica Sinica,English Series 2016年第7期32卷 821-830页

作者： chang jing LI Fang Fang ZHAO Quan Yuan CHEN School of Mathematical Sciences Shandong Normal University School of Information Renmin University of China College of Information Jingdezhen Ceramic Institute

Let A be a factor. For A, B ∈4, define by [A, B]. = AB- BA＊ the skew Lie product of A and B. In this article, it is proved that a map φ： A- A satisfies φ（[[A, B]., C].） = [[φ（A）, B]., C]. ＋ [[A, φ（B）]. C... 详细信息

关键词： Skew Lie triple derivation derivation factor

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Determination of Critical Parameters of Carbon Dioxide+Butyraldehyde System with Different Compositions

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Chemical Research in Chinese Universities 2005年第6期21卷 687-691页

作者： ZHANG jing-chang GAO Xi-xin CAO Wei-liang Key Laboratory of Science and Technology of Controllable Chemical Reactions of Ministry of Education Institute of Modern Catalysis Beijing University of Chemical Technology Beijing 100029 P. R. China

Supercritical carbon dioxide（SC-CO2 ） is considered in green chemistry as a substitute for conventional solvents in chemical reactions due to its environmentally benign character. Recently we have reported the homogeneous hydroformylation of propylene in supercritical carbon dioxide（ SC-CO2 ） , which is an example of this kind of application of carbon dioxide. The determination for the critical parameters of carbon dioxide ＋ butyraldehyde mixtures is necessary for this reaction design which is the focus of the present paper. The critical parameters of the binary systems were determined via the static visual method at a constant volume with the molar fraction of butyraldehyde ranging from 1.0% to 2. 2% and the pressure ranging from 5 to 10 MPa. The experimental results show that the critical pressure and temperature increased with increasing the molar fraction of butyraldehyde. The bubble（dew） temperatures and the bubble （dew） pressures for the binary systems were also determined experimentally. The p-T Figures at different compositions of the binary systems were described. In addition, the critical compressibility factors Zc of the binary systems at different concentrations of n-butyraldehyde were calculated. It was found that the critical compressibility factor values of the binary systems decreased with increasing the molar fraction of n-butyraldehyde in the experimental range.

关键词： Carbon dioxide + butyraldehyde binary system Critical temperature Critical pressure p-T Figure Critical compressibility factor

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Improved BP Neural Network for Transformer Fault Diagnosis

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Journal of China University of Mining and Technology 2007年第1期17卷 138-142页

作者： SUN Yan-jing ZHANG Shen MIAO chang-xin LI jing-meng School of Information and Electrical Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

The back propagation (BP)-based artificial neural nets (ANN) can identify complicated relationships among dissolved gas contents in transformer oil and corresponding fault types, using the highly nonlinear mapping nature of the neural nets. An efficient BP-ALM (BP with Adaptive Learning Rate and Momentum coefficient) algorithm is proposed to reduce the training time and avoid being trapped into local minima, where the learning rate and the momentum coefficient are altered at iterations. We developed a system of transformer fault diagnosis based on Dissolved Gases Analysis (DGA) with a BP-ALM algorithm. Training patterns were selected from the results of a Refined Three-Ratio method (RTR). Test results show that the system has a better ability of quick learning and global convergence than other methods and a superior performance in fault diagnosis compared to convectional BP-based neural networks and RTR.

关键词： transformer fault diagnosis back-propagation artificial neural network momentum coefficient

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Differential effects of insecticides on mitochondrial membrane fluidity and ATPase activity between the wolf spider and the rice stem borer

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Journal of Integrative Agriculture 2015年第12期14卷 2574-2580页

作者： LI Hai-ping chang jing FENG Tao GAO Xi-wu Department of Entomology China Agricultural University College of Agronomy Inner Mongolia Agricultural University College of Life Science Jianghan University

Differential effects of methamidophos and three pyrethroids on ATPase activity and membrane fluidity of mitochondria were investigated between the wolf spider（Pirata subpiraticus（*** Str.））and the rice stem borer（Chilo suppressalis（Walker））.Based on a comparison of LD_（50） values,the toxicities of the tested insecticides were higher to the wolf spider than to the rice stem *** at 1×10^（–4） mmol L^（–1） caused inhibition of the mitochondrial Na~＋-K~＋-ATPase and Ca^（2＋）-Mg^（2＋）-ATPase activities,and it’s inhibitions on Na＋-K＋-ATPase and Ca^（2＋）-Mg^（2＋）-ATPase activities were significantly higher in the wolf spider（44 and 28%）than in the rice stem borer（19 and 11%）.Methamidophos at 1×10^（–4） mmol L^（–1） decreased Ca^（2＋）-Mg^（2＋）-ATPase activity by 16 and 27%in the wolf spider and the rice stem borer,respectively,but no significant effect on the specific activity of Na＋-K＋-ATPase was *** DPH（1,6-diphenyl-1,3,5-hexatriene）fluorescence polarization values of mitochondrial membranes were not significantly affected by methamidophos in either ***,cyhalothrin and alpha-cypermethrin induced the values of DPH polarization of mitochondrial membrane increasing with the concentration of cyhalothrin and alpha-cypermethrin from 20 to 100μmol L^（–1） in the rice stem borer and the wolf *** of ethofenprox on fluidity of the wolf spider and the rice stem borer was *** results suggest that both inhibition of membrane ATPase and changes of membrane fluidity could be appended to the action mechanisms of pyrethroid insecticides.

关键词： pyrethroids membrane fluidity ATPase wolf spider rice stem borer

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Study on Phase Equilibrium Properties for CO_(2)^+ Cosolvent Binary Systems

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Chinese Chemical Letters 2001年第9期12卷 829-832页

作者： Zhang jing chang Wu Xiang YANG Cao Wei LIANG Faculty of Science Beijing University of Chemical TechnologyBeijing 100029

In this study, the constant volume, visual method is used to measure the critical point of CO2+toluene, CO2+cyclohexane, CO2+n-butyraldehyde, CO2+i-butyraldehyde, CO2+methanol and CO2+alcohol binary systems. The relationship between critical point and the concentration of the entrainer for different substances has been discussed, and the comparison of the phase behavior of single component system and that of binary systems have been carried out.

关键词： Critical point supercritical binary system phase equilibrium

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