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Reproducible Learning of Gaussian Graphical Models via Graphical Lasso Multiple Data Splitting

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Acta Mathematica Sinica,English Series 2024年

作者： Kang HU Danning LI Binghui liu KLAS and School of Mathematics & Statistics Northeast Normal University

Gaussian graphical models (GGMs) are widely used as intuitive and efficient tools for data analysis in several application domains. To address the reproducibility issue of structure learning of a GGM,it is essential to control the false discovery rate (FDR) of the estimated edge set of the graph in terms of the graphical model. Hence, in recent years, the problem of GGM estimation with FDR control is receiving more and more attention. In this paper, we propose a new GGM estimation method by implementing multiple data splitting alternatively. Instead of using the node-by-node regressions to estimate each row of the precision matrix, we suggest directly estimating the entire precision matrix using the graphical Lasso in the multiple data splitting, and our calculation speed is p times faster than the previous speed. We show that the proposed method can asymptotically control FDR, and the simulation study suggests that with suitable FDR and power results, the proposed method has significant advantages in computational efficiency. Finally, we demonstrate the usefulness of the proposed method through a real data analysis.

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Miyaoka-type inequalities for terminal threefolds with nef anti-canonical divisors

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Science China Mathematics 2024年

作者： Masataka Iwai Chen Jiang Haidong liu Department of Mathematics Graduate School of Science Osaka University Shanghai Center for Mathematical Sciences & School of Mathematical Sciences Fudan University Department of mathematics Sun Yat-sen University

In this paper,we study Miyaoka-type inequalities on Chern classes of terminal projective 3-folds with nef anti-canonical *** X be a terminal projective 3-fold such that-KXis *** show that if c1（X）·c2（X）≠0,then c1（X）·c2（X）≥1/252;if further X is not rationally connected,then c1（X）·c2（X）≥4/5 and this inequality is *** order to prove this,we give a partial classification of such varieties along with many *** also study the nonvanishing of c1（X）dimX-2·c2（X） for terminal weak Fano varieties and prove a Miyaoka-Kawamata-type inequality.

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Extraction and bioactivities of the chemical composition from Pleurotus ostreatus:a review

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Journal of Future Foods 2024年第2期4卷 111-118页

作者： Qingchun Zhao Xiaopeng liu Lili Cui changyang Ma National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Functional Food Engineering Technology Research Center Kaifeng 475004China Joint International Research Laboratory of Food&Medicine Resource Function Kaifeng 475004China

Pleurotus ostreatus as an edible mushroom with pharmacological potential,belonging to class basidiomycetes of kingdom Mycota is known to have immense therapeutic *** contains polysaccharides,proteins,sterols,volatile oils and *** has a variety of biological activities,including anti-oxidant,anti-hyperlipidemic,anti-tumor,immunoregulatory and *** paper summarizes the extraction methods,chemical components and biological activities of ***,and find it is good resources to develop medicine and health food.

关键词： Pleurotus ostreatus Extraction methods Chemical components Biological activities

普通叶酸与活性叶酸补充对于MTHFR 677TT型不明原因反复流产患者红细胞叶酸水平的影响

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上海交通大学学报（医学版） 2024年第6期44卷 741-745页

作者：卢永杰侯树辰常亮刘平北京大学第三医院妇产科生殖医学中心女性生育力促进全国重点实验室国家妇产疾病临床医学研究中心(北京大学第三医院)辅助生殖教育部重点实验室(北京大学)北京市生殖内分泌与辅助生殖技术重点实验室(北京大学第三医院)北京100191 北京中医药大学研究生院北京100029

目的·研究普通叶酸与活性叶酸补充对亚甲基四氢叶酸还原酶(methylenetetrahydrofolate reductase,MTHFR)677TT型不明原因反复流产(unexplained recurrent pregnancy loss,URPL)患者红细胞叶酸水平的影响。方法·选取2021年1—12月于北京大学第三医院生殖医学中心就诊的MTHFR 677TT型URPL患者45例。按照叶酸补充方式将其分为3组,包括A组16例(研究开始前尚未接受任何形式的叶酸补充,研究开始后进行活性叶酸补充),B组15例(研究开始前进行过普通叶酸的补充,研究开始后进行活性叶酸补充),以及C组14例(研究开始前进行过普通叶酸的补充,研究开始后进行普通叶酸与活性叶酸联合补充)。分别于入组时(第一次)、入组补充后(第二次)对3组患者的红细胞5-甲基四氢叶酸(5-methyltetrahydrofolate,5-MTHF)浓度进行检测,并开展比较。结果·在3组患者中,任意2组的第一次红细胞5-MTHF浓度间差异均无统计学意义。与第一次红细胞5-MTHF浓度相比,3组患者的第二次红细胞5-MTHF浓度均有提高(均P=0.000),且B组患者的红细胞5-MTHF浓度的增幅高于A组(t=2.373,P=0.049),但与C组间差异无统计学意义。结论·与补充普通叶酸相比,补充活性叶酸可以更好地在短时间内提高MTHFR 677TT型URPL患者的红细胞叶酸水平。

关键词：亚甲基四氢叶酸还原酶基因不明原因反复流产 5-甲基四氢叶酸

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Asymptotic false discovery control of the Benjamini-Hochberg procedure for pairwise comparisons

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Science China Mathematics 2024年

作者： Weidong liu Dennis Leung Qiman Shao School of Mathematical Sciences Shanghai Jiao Tong University School of Mathematics and Statistics University of Melbourne Department of Statistics and Data Science SICM Southern University of Science and Technology

In a one-way analysis-of-variance(ANOVA) model, the number of pairwise comparisons can become large even with a moderate number of groups. Motivated by this, we consider a regime with a growing number of groups and prove that, when testing pairwise comparisons, the Benjamini-Hochberg(BH) procedure can asymptotically control false discoveries, despite the fact that the involved t-statistics do not exhibit the wellknown positive dependence structure required for exact false discovery rate(FDR) control. Following Tukey's perspective that the difference between the means of any two groups cannot be exactly zero, our main result provides control over the directional false discovery rate and directional false discovery proportion. A key technical contribution of our work is demonstrating that the dependence among the t-statistics is sufficiently weak to establish the convergence result typically required for asymptotic FDR control. Our analysis does not rely on conventional assumptions such as normality, variance homogeneity, or a balanced design, thereby offering a theoretical foundation for applications in more general settings.

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Movement Function Assessment Based on Human Pose Estimation from Multi-View

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Computer Systems Science & Engineering 2024年第2期48卷 321-339页

作者： Lingling Chen Tong liu Zhuo Gong Ding Wang School of Artificial Intelligence Hebei University of TechnologyTianjin300400China Intelligent Rehabilitation Device and Detection Technology Engineering Research Centre of the Ministry of Education Tianjin300400China

Human pose estimation is a basic and critical task in the field of computer vision that involves determining the position(or spatial coordinates)of the joints of the human body in a given image or *** is widely used in motion analysis,medical evaluation,and behavior *** this paper,the authors propose a method for multi-view human pose *** image sensors were placed orthogonally with respect to each other to capture the pose of the subject as they moved,and this yielded accurate and comprehensive results of three-dimensional(3D)motion reconstruction that helped capture their multi-directional *** this,we propose a method based on 3D pose estimation to assess the similarity of the features of motion of patients with motor dysfunction by comparing differences between their range of motion and that of normal *** converted these differences into Fugl–Meyer assessment(FMA)scores in order to quantify ***,we implemented the proposed method in the Unity framework,and built a Virtual Reality platform that provides users with human–computer interaction to make the task more enjoyable for them and ensure their active participation in the assessment *** goal is to provide a suitable means of assessing movement disorders without requiring the immediate supervision of a physician.

关键词： Human pose estimation 3D pose reconstruction assessment of movement function plane of features of human motion

A multi-omics technology to the study of lactic acid bacteria responses to environmental stress: the past， current and future trends

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Food Science and Human Wellness 2024年

作者： Yaqi liu Wen Ma Gang Jin Wine Research Institute， Ningxia University Engineering Research Center of Grape and Wine， Ministry of Education

Lactic acid bacteria and the fermentation environment interact to form an intertwined system. Lactic acid bacteria are constantly evolving to adapt to different fermentation environments， causing changes in their physiological processes. To achieve a targeted improvement of their adaptability to various environments， a detail analysis of their evolutionary physiological processes is required. While several studies have been carried out in the past by using single-omics techniques to investigate their response to environmental stress， most researchers are now using a multi-omics approach to explore more detail in the biological regulatory networks and molecular mechanisms of lactic acid bacteria in response to environmental stress， thereby overcoming the limitations of single- omics analysis. Scope and approach: In this review， we describe the various single-omics approaches that have been used to study environmental stress in lactic acid bacteria， present the advantages of various multi-omics combined analysis approaches， and discuss the potential and practicality of applying emerging single-cell transcriptomics and single-cell metabolomics techniques to the molecular mechanism study of microbes response to environmental stress. Key ?ndings and conclusions: Multi-omics approaches enable the accurate identification of complex microbial physiological processes in different environments， allow people to comprehensively reveal the molecular mechanisms of microbes response to stress from different perspectives. Single-cell omics techniques， analyze the targeted regulation of microbial functions in a multi-dimensional space， provides a new perspective on understanding microbes responses environment stress.

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FPR1 Antagonist (BOC-MLF) Inhibits Amniotic Epithelial-mesenchymal Transition

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Current Medical Science 2024年第1期44卷 187-194页

作者： Xiao-mei HUANG E LIAO Jun-qun LIAO Ya-ling liu Yong SHAO Department of Obstetrics and Gynecology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Obstetrics Maternal and Child Health Hospital of Hubei ProvinceWuhan 430070China Medical Laboratory Science The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Obstetrics Yubei Maternity and Child Healthcare HospitalChongqing 400042China

Objective:Premature rupture of membranes(PROM)is a common pregnancy disorder that is closely associated with structural weakening of fetal *** have found that formyl peptide receptor 1(FPR1)activates inflammatory pathways and amniotic epithelial-mesenchymal transition(EMT),stimulates collagen degradation,and leads to membrane weakening and membrane *** purpose of this study was to investigate the anti-inflammatory and EMT inhibitory effects of FPR1 antagonist(BOC-MLF)to provide a basis for clinical prevention of ***:The relationship between PROM,FPR1,and EMT was analyzed in human fetal membrane tissue and plasma samples using Western blotting,PCR,Masson staining,and ELISA ***(LPS)was used to establish a fetal membrane inflammation model in pregnant rats,and BOC-MLF was used to treat the LPS rat *** detected interleukin(IL)-6 in blood from the rat hearts to determine whether the inflammatory model was successful and whether the anti-inflammatory treatment was *** used electron microscopy to analyze the structure and collagen expression of rat fetal ***:Western blotting,PCR and Masson staining indicated that the expression of FPR1 was significantly increased,the expression of collagen was decreased,and EMT appeared in *** rat model indicated that LPS caused the collapse of fetal membrane epithelial cells,increased intercellular gaps,and decreased ***-MLF promoted an increase in fetal membrane collagen,inhibited EMT,and reduced the weakening of fetal ***:The expression of FPR1 in the fetal membrane of PROM was significantly increased,and EMT of the amniotic membrane was ***-MLF can treat inflammation and inhibit amniotic EMT.

关键词： formyl peptide receptor 1 BOC-MLF epithelial-mesenchymal transition premature rupture of membranes

激光增材制造网状结构金属基复合材料的研究进展

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中国有色金属学报 2024年第4期34卷 1052-1070页

作者：伍子纯刘阳李海尊谭振国唐楠宋宇峰刘筱陈宇强湖南科技大学机电工程学院湘潭411201 湖南科技大学高功效轻合金构件成形技术及耐损伤性能评价湖南省工程研究中心湘潭411201 湖南西交智造科技有限公司湘潭411100

相较于传统增强相呈均匀分布的金属基复合材料,网状结构金属基复合材料因其独特的“机械互锁”“位错钉扎”等组织结构特征,具有更优异的室温强度、高温强度、弹性模量和断裂韧性,在航天、航空等领域上具有广泛的应用前景。激光增材制... 详细信息

相较于传统增强相呈均匀分布的金属基复合材料,网状结构金属基复合材料因其独特的“机械互锁”“位错钉扎”等组织结构特征,具有更优异的室温强度、高温强度、弹性模量和断裂韧性,在航天、航空等领域上具有广泛的应用前景。激光增材制造技术可实现对网状结构的精细化调控,为网状结构金属基复合材料的进一步发展提供了新的途径。本文综述了高能量激光束诱导马兰戈尼对流作用下网状结构金属基复合材料的形成机理、影响网状结构形成的因素、不同类型网状结构的显微组织结构特征,分析了网状结构金属基复合材料的多段弯曲断裂、微孔聚集断裂等断裂机制,阐述了在霍尔−佩奇、奥罗万、泰勒、载荷传递等强化机制共同作用下的强化机理,以及独特的增强相贫、富区协同作用下的韧化机理,并对其未来的研究方向进行了展望。

关键词：网状结构激光增材制造金属基复合材料断裂机制强韧化机理

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