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Bone Research 2024年第1期12卷 122-136页

作者： Nan-Yu Zou Ran liu Mei Huang Yu-Rui Jiao Jie Wei Yangzi Jiang Wen-Zhen He Min Huang Yi-li Xu ling liu Yu-Chen Sun Mi Yang Qi Guo Yan Huang Tian Su Ye Xiao Wei-Shan Wang Chao Zeng Guang-Hua Lei Xiang-Hang Luo chang-jun li Department of Endocrinology Endocrinology Research CenterXiangya Hospital of Central South UniversityChangshaHunan 410008China Department of Orthopaedics Xiangya Hospital of Central South UniversityChangshaHunan 410008China Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangshaChina Hunan Key Laboratory of Joint Degeneration and Injury ChangshaHunan 410008China Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment Ministry of EducationXiangya HospitalCentral South UniversityChangshaChina School of Biomedical Sciences Institute for Tissue Engineering and Regenerative MedicineFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Department of Orthopaedics The First Affiliated Hospital of Shihezi UniversityShiheziXinjiangChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China

Skeletal stem/progenitor cell(SSPC)senescence is a major cause of decreased bone regenerative potential with aging,but the causes of SSPC senescence remain *** this study,we revealed that macrophages in calluses secrete prosenescent factors,including grancalcin(GCA),during aging,which triggers SSPC senescence and impairs fracture *** injection of human rGCA in young mice induced SSPC senescence and delayed fracture *** deletion of Gca in monocytes/macrophages was sufficient to rejuvenate fracture repair in aged mice and alleviate SSPC ***,GCA binds to the plexin-B2 receptor and activates Arg2-mediated mitochondrial dysfunction,resulting in cellular *** of Plxnb2 in SSPCs impaired fracture *** of GCA-neutralizing antibody enhanced fracture healing in aged ***,our study revealed that senescent macrophages within calluses secrete GCA to trigger SSPC secondary senescence,and GCA neutralization represents a promising therapy for nonunion or delayed union in elderly individuals.

关键词： healing union senescence

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Performance Evaluation and Improvement of Chipset Assembly & Test Production line Based on Variability

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International Journal of Automation and computing 2019年第2期16卷 186-198页

作者： chang-jun li Zong-Shi Xie Xin-Ran Peng Bo li School of Aeronautics and Astronautics University of Electronic Science and Technology of China

"Factory physics principles" provided a method to evaluate the performance of a simple production line, whose fundamental parameters are known or given. However, it is difficult to obtain the exact and reasonable parameters in actual manufacturing environment, especially for the complex chipset assembly & test production line(CATPL). Besides, research in this field tends to focus on evaluation and improvement of CATPL without considering performance interval and status with variability level. A developed internal benchmark method is proposed, which established three-parameter method based on the little′s law. It integrates the variability factors, such as processing time, random failure time, and random repair time, to meet performance evaluation and improvement. A case study in a chipset assembly and test factory for the performance of CATPL is implemented. The results demonstrate the potential of the proposed method to meet performance evaluation and emphasise its relevance for practical applications.

关键词： Performance evaluation and improvement chipset assembly & test production line (CATPL) parameters little's law variability

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Analysis on the influencing factors of radioactive tritium leakage and diffusion from an indoor high‑pressure storage vessel

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Nuclear Science and Techniques 2022年第12期33卷 1-11页

作者： chang‑jun li Xing‑Fu Cai Ming‑Qing Xiao Yong‑Gang Huo Peng Xu Su‑Fen li Xiao‑Yan Cao Xi’an Research Institute of High-Tech Xi’an 710025China Air Force Engineering University Xi’an 710051China

Radioactive tritium leakage from high-pressure storage vessels is a common nuclear leakage *** leakage conditions have different effects on tritium diffusion,resulting in different degrees of radioactive *** study focuses on tritium leakage from high-pressure storage vessels and analyzes the influence of different leakage orifice shapes,leakage positions,and the presence of obstacles in the scene space on tritium leakage *** results show that there is little difference in the radial diffusion velocity of tritium gas along the jet axis between circular and square leakage *** radial diffusion velocity of tritium gas in the long-axis direction of the rectangular leakage orifice is larger than that in the short-axis direction,and the larger the aspect ratio of the rectangle is,the greater the difference is in the diffusion *** addition,leakage from the storage vessel below the air inlet is beneficial to the dilution of tritium,whereas leakage from the air vents leads to a slow decrease in the tritium *** obstacles present in the tritium scene space hinder the migration of tritium gas and prolong the time for the tritium concentration to reach *** study provides a theoretical basis for the disposal of tritium in tritium leakage accidents by analyzing the influence of different leakage conditions in storage vessels on tritium gas diffusion.

关键词： Tritium leakage Leakage orifice shape Leakage position Obstacles

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Blockade of HCN2 Channels Provides Neuroprotection Against Ischemic Injury via Accelerating Autophagic Degradation in Hippocampal Neurons

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Neuroscience Bulletin 2020年第8期36卷 875-894页

作者： Cheng Chen li liu Ya-Qiao Shu Ping Jing Yun Lu Xiao-Xue Zhang Xian-Gang Zong lian-jun Guo chang-jun li Department of Pharmacology School of Basic Medical SciencesTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Neurology The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Office of Academic Research The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pharmacy Zhongnan Hospital of Wuhan UniversityWuhan 430030China Department of Clinical Laboratory Wuhan PuAi HospitalWuhan 430033China Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation Wuhan 430030China Center for Integrated Protein Science and Zentrum fur Pharmaforschung Department PharmazieLudwig-Maximilians-Universitat Miinchen80539 MunichGermany

In the central nervous system,hyperpolarizationactivated cyclic nucleotide-gated(HCN)channels are essential to maintain normal neuronal *** studies have shown that HCN channels may be involved in the pathological process of ischemic brain injury,but the mechanisms remain *** is activated in cerebral ischemia,but its role in cell death/survival remains *** this study,our results showed that the HCN channel blocker ZD7288 remarkably decreased the percentage of apoptotic neurons and corrected the excessive autophagy induced by oxygen-glucose deprivation followed by reperfusion(OGD/R)in hippocampal HT22 ***,in the OGD/R group,p-mTOR,p-ULK1(Ser757),and p62 were significantly decreased,while p-ULK1(Ser317),atg5,and beclin1 were remarkably ***7288 did not change the expression of p-ULK1(Ser757),ULK1(Ser317),p62,Beclin1,and atg5,which are involved in regulating autophagosome ***,we found that OGD/R induced a significant increase in Cathepsin D expression,but not *** with ZD7288 at 10μmol/L in the OGD/R group did not change the expression of cathepsin D and ***,chloroquine(CQ),which decreases autophagosome-lysosome fusion,eliminated the correction of excessive autophagy and neuroprotection by ***,shRNA knockdown of HCN2 channels significantly reduced the accumulation of LC3-Ⅱand increased neuron survival in the OGD/R and transient global cerebral ischemia(TGCI)models,and CQ also eliminated the effects of ***,we found that the percentage of LC3-positive puncta that co-localized with LAMP-1-positive lysosomes decreased in Con-shRNAtransfected HT22 neurons exposed to OGD/R or *** HCN2-shRNA-transfected HT22 neurons,the percentage of LC3-positive puncta that co-localized with LAMP-1-positive lysosomes increased under OGD/R;however,the percentage was significantly decreased by the addition of CQ to HCN2-shRNA-transfected HT22 *** present re

关键词： HCN2 channel Autophagy Neuroprotection Oxygen-glucose deprivation/reperfusion Transient global cerebral ischemia

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An Improved Synthetic Method of Saquinavir

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Chemical Research in Chinese Universities 2006年第1期22卷 51-55页

作者： YANG Qin-gang HE Xu-chang LEI li-jun ZHOU Qi-ting BAI Dong-lu Shanghai Institute of Materia Medica Shanghai Institutes of Biological Sciences Chinese Academy of Sciences Shanghai 201203 P. R. China

An improved synthetic method of saquinavir, an HIV protease inhibitor, is described. In comparison with the methods in the reported works, the improved procedures had several advantages, such as less expensive agents, shorter reaction time, and a smaller amount of the solvent needed. To measure the optical purities of the products, the intermediates were determined by means of chiral HPLC. Some of the intermediates can also be used for the preparation of new protease inhibitors.

关键词： HIV Protease inhibitor Saquinavir Synthesis

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Chinese Herbal Medicine for Osteosarcoma in the Mouse: A Systematic Review and Meta-Analysis

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Chinese Journal of Integrative Medicine 2019年第5期25卷 370-377页

作者： chang jun-li WANG Wen-yi li Yi-mian HU Shao-pu YAO Min CUI Xue-jun ZHI Wen-lan SHI Qi WANG Yong-jun YANG Yan-ping Orthopedic Surgery Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai(200032)China Institute of Spine Shanghai University of Traditional Chinese MedicineShanghai(200032)China

Objective: To summarize and critically assess the inhibitory effects of Chinese herbal medicine(CHM) on tumor volume and tumor weight for the treatment of osteosarcoma(OS) in mouse models. Methods:PubMed, Embase, Web of Science, China Knowledge Resource Integrated Database(CNKI), Wanfang Database, VIP Database, and Chinese BioMedical(CBM) were searched since their inception dates to March10, 2016. Two reviewers independently selected the controlled studies estimating effects of CHM on mouse OS by administration in vivo. A pair-wise meta-analysis was performed. Twenty-five studies with adequate randomization were included in the systematic review. Results: CHM may signi?cantly inhibit OS growth in mice, as assessed using the tumor weight [20 studies, n=443; 290 for CHM and 153 for the control; pooled mean difference(MD)=–2.90; 95% confidence interval(CI): –3.50 to –2.31; Plinical and clinical trials in future.

关键词： Chinese herbal medicine osteosarcoma systematic review meta-analysis mouse xenograft model

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Wax deposition modeling in oil-water stratified pipe flow

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Petroleum Science 2023年第1期20卷 526-539页

作者： Hui-Shu liu Ji-Miao Duan Jiang li Jian Wang Hao Yan Ke-Yu lin Ke-Cheng Gu chang-jun li Petroleum Engineering School Southwest Petroleum UniversityChengdu610500China Petroleum Oil and Lubricants DepartmentArmy Logistics AcademyChongqing401311China

Wax deposition in oil-water stratified flow is commonly encountered onshore and offshore oil production pipe systems,and typically reduces transportation capacity of *** accurate predicted model of wax deposition has becomes an indispensable approach to design effective remediation ***,a reliable mechanistic model for wax deposition prediction in oil-water two-phase stratified pipe flow is lacking to validate the deposition *** this work,a three-dimensional(axial,radial,and angular)robust wax deposit model for oil-water stratified circular pipe flow was *** model of formation of a gel deposit based on the first principles of rheology was developed,associated with the results obtained from hydrodynamics and heat/mass transfer *** predictions for wax deposition are found to compare satisfactorily with experimental data with two different oils for single phase and four different water cuts for oil-water stratified pipe *** can be seen from the wax gelation mechanism that an increase in water cut can help to reduce the wall/oil-deposit interface shear stress,thereby leading to an increase in the degree of gelation as well as the deposit ***,a local deposit analysis in the circumferential direction was conducted,for water cut 75%and total flow rate 5 m3/h,which provided insights to understand that the thickness on pipe wall was roughly uniformly distributed locates near the top of the pipe and the nearer the position gets close to two points,where the oil-water interface contacts the inner wall,the deposition thickness quickly dropped to *** was attributed to the fact that a roughly uniformly thickness far away from the oil-water interface contact the inner wall resulted in the slowly changes temperature along the circumferential pipe wall wetted by oil.

关键词： Wax deposition Oil-water flow Stratified flow Heat and mass transfer

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Unraveling the complex roles of macrophages in obese adipose tissue:an overview

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Frontiers of Medicine 2024年第2期18卷 205-236页

作者： chang Peng jun Chen Rui Wu Haowen Jiang Jia li Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou310000China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of Sciences Beijing100049China Department of Prosthodontics Shanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyNational Clinical Research Center for Oral DiseasesShanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai200011China

Macrophages,a heterogeneous population of innate immune cells,exhibit remarkable plasticity and play pivotal roles in coordinating immune responses and maintaining tissue homeostasis within the context of metabolic *** activation of inflammatory macrophages in obese adipose tissue leads to detrimental effects,inducing insulin resistance through increased inflammation,impaired thermogenesis,and adipose tissue ***,adipose tissue macrophages also play a beneficial role in maintaining adipose tissue homeostasis by regulating angiogenesis,facilitating the clearance of dead adipocytes,and promoting mitochondrial *** the heterogeneity of macrophages in obese adipose tissue is crucial for unraveling the pathogenesis of obesity and holds significant potential for targeted therapeutic ***,the dual effects and some potential regulatory mechanisms of macrophages in adipose tissue have been elucidated using single-cell *** this review,we present a comprehensive overview of the intricate activation mechanisms and diverse functions of macrophages in adipose tissue during obesity,as well as explore the potential of drug delivery systems targeting macrophages,aiming to enhance the understanding of current regulatory mechanisms that may be potentially targeted for treating obesity or metabolic diseases.

关键词： obesity inflammation adipose tissue macrophages adipose tissue homeostasis

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CO_(2) hydrogenation to methanol over the copper promoted In_(2)O_(3) catalyst

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Journal of Energy Chemistry 2024年第6期93卷 135-145,I0004页

作者： Rui Zou Chenyang Shen Kaihang Sun Xinbin Ma Zhuoshi li Maoshuai li chang-jun liu School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China Collaborative Innovation Center of Chemical Science&Engineering Tianjin UniversityTianjin 300072China

The metal promoted In_(2)O_(3) catalysts for CO_(2) hydrogenation to methanol have attracted wide attention because of their high activity with high methanol ***,there was still no experimental confirmation if copper could be a good promoter for In_(2)O_(3).Herein,the Cu promoted In_(2)O_(3) catalyst was prepared using a deposition-precipitation *** prepared Cu/In_(2)O_(3) catalyst shows significantly higher CO_(2) conversion and space time yield(STY)of methanol,compared to the un-promoted In_(2)O_(3) *** loading of Cu facilitates the activation of both H_(2) and CO_(2) with the interface between the Cu cluster and defective In_(2)O_(3) as the active *** Cu/In_(2)O_(3) catalyst takes the CO hydrogenation pathway for methanol synthesis from CO_(2) *** exhibits a unique size effect on the CO *** temperatures below 250℃,CO adsorption on Cu/In_(2)O_(3) is stronger than that on In_(2)O_(3),causing higher methanol *** increasing temperatu res,the Cu catalyst aggregates,which leads to the formation of weak CO adsorption site and causes a decrease in the methanol *** with other metal promoted In_(2)O_(3) catalysts,it can be concluded that the catalyst with stronger CO adsorption possesses higher methanol selectivity.

关键词： CO_(2)hydrogenation Methanol Cu In_(2)O_(3) CO Selectivity DFT

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miR-205 is frequently downregulated in prostate cancer and acts as a tumor suppressor by inhibiting tumor growth

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Asian Journal of Andrology 2013年第6期15卷 735-741,I0005页

作者： Ning Wang Qi li Ning-Han Feng Gong Cheng Zhao-Long Guan Yang Wang Chao Qin chang-jun Yin li-Xin Hua Department of Urology First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China

The purpose of this study was to elucidate the molecular mechanisms of microRNA-205 （miR-205） as a tumor suppressor in prostate cancer （PCa）o In the present study, microRNA microarray analysis suggested that the expression of miR-205 was significantly decreased in advanced PCa compared with early PCa. Real-time PCR analysis also indicated that miR-205 expression was significantly decreased in PCa tissues compared with non-cancerous tissues. Moreover, the expression of miR-205 has been demonstrated to be associated with the clinicopathological stage and total/free prostate-specific antigen （PSA） level of PCa. Functional analyses showed that both the overexpression of miR-205 and the knockdown of c-SRC in PCa cell lines could inhibit cell growth, colony formation, migration, invasion and the cell cycle as well as induce cell apoptosis in vitro. Furthermore, over-expressing miR-205 reduced tumorigenicity in vivo. Through a luciferase activity assay and Western blotting, c-SRCwas identified as a target of miR-205 in cells. The overexpression of miR-205 suppressed c-SRC and its downstream signaling molecules, including FAK, p-FAK, ERK1/2 and D-ERK1/2, and attenuated cell proliferation, invasion and tumor growth.

关键词： c-SRC miR-205 prostate cancer (PCa) tumor growth

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