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Sequential neoadjuvant chemotherapy using pegylated liposomal doxorubicin and cyclophosphamide followed by taxanes with complete trastuzumab and pertuzumab treatment for HER2-positive breast cancer: A phase Ⅱ single-arm study

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Chinese Journal of Cancer Research 2024年第1期36卷 55-65页

作者： Yaping yang Liang Jin Yudong Li Nanyan Rao chang Gong Shunrong Li Jiannan Wu Jinghua Zhao Linxiaoxiao ding fengxia Gan Jun Zhang Ruifa feng Zhenzhen Liu Qiang Liu Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene RegulationGuangzhou 510120China Department of Thyroid and Breast Surgery Shenzhen Qianhai Shekou Free Trade Zone HospitalShenzhen 518000China Breast and Thyroid Surgery Guilin Medical College Second Affiliated HospitalGuilin 541199China Department of Breast Disease Henan Breast Cancer Centerthe Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhou 450008China

Objective: Despite cardiotoxicity overlap, the trastuzumab/pertuzumab and anthracycline combination remains crucial due to significant benefits. Pegylated liposomal doxorubicin(PLD), a less cardiotoxic anthracycline, was evaluated for efficacy and cardiac safety when combined with cyclophosphamide and followed by taxanes with trastuzumab/pertuzumab in human epidermal growth factor receptor-2(HER2)-positive early breast cancer(BC).Methods: In this multicenter, phase II study, patients with confirmed HER2-positive early BC received four cycles of PLD(30-35 mg/m^(2)) and cyclophosphamide(600 mg/m^(2)), followed by four cycles of taxanes(docetaxel,90-100 mg/m^(2) or nab-paclitaxel, 260 mg/m^(2)), concomitant with eight cycles of trastuzumab(8 mg/kg loading dose,then 6 mg/kg) and pertuzumab(840 mg loading dose, then 420 mg) every 3 weeks. The primary endpoint was total pathological complete response(tp CR, yp T0/is yp N0). Secondary endpoints included breast p CR(bp CR),objective response rate(ORR), disease control rate, rate of breast-conserving surgery(BCS), and safety(with a focus on cardiotoxicity).Results: Between May 27, 2020 and May 11, 2022, 78 patients were treated with surgery, 42(53.8%) of whom had BCS. After neoadjuvant therapy, 47 [60.3%, 95% confidence interval(95% CI), 48.5%-71.2%] patients achieved tp CR, and 49(62.8%) achieved bp CR. ORRs were 76.9%(95% CI, 66.0%-85.7%) and 93.6%(95% CI,85.7%-97.9%) after 4-cycle and 8-cycle neoadjuvant therapy, respectively. Nine(11.5%) patients experienced asymptomatic left ventricular ejection fraction(LVEF) reductions of ≥10% from baseline, all with a minimum value of >55%. No treatment-related abnormal cardiac function changes were observed in mean N-terminal pro-BNP(NT-pro BNP), troponin I, or high-sensitivity ***: This dual HER2-blockade with sequential polychemotherapy showed promising activity with rapid tumor regression in HER2-positive BC. Importantly, this regimen showed an acceptable safety

关键词： Breast cancer HER2-positive breast cancer dual HER2 blockade neoadjuvant therapy sequential therapy

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融合实体和上下文信息的篇章关系抽取研究

自动化学报 2024年第10期50卷 1953-1962页

作者：黄河燕袁长森冯冲北京理工大学计算机学院北京100081 北京理工大学自然语言处理实验室北京100081

篇章关系抽取旨在识别篇章中实体对之间的关系.相较于传统的句子级别关系抽取,篇章级别关系抽取任务更加贴近实际应用,但是它对实体对的跨句子推理和上下文信息感知等问题提出了新的挑战.本文提出融合实体和上下文信息(Fuse entity and ... 详细信息

篇章关系抽取旨在识别篇章中实体对之间的关系.相较于传统的句子级别关系抽取,篇章级别关系抽取任务更加贴近实际应用,但是它对实体对的跨句子推理和上下文信息感知等问题提出了新的挑战.本文提出融合实体和上下文信息(Fuse entity and context information,FECI)的篇章关系抽取方法,它包含两个模块,分别是实体信息抽取模块和上下文信息抽取模块.实体信息抽取模块从两个实体中自动地抽取出能够表示实体对关系的特征.上下文信息抽取模块根据实体对的提及位置信息,从篇章中抽取不同的上下文关系特征.本文在三个篇章级别的关系抽取数据集上进行实验,效果得到显著提升.

关键词：篇章关系抽取实体信息上下文信息提及位置信息跨句子推理

Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1

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Protein & Cell 2024年第6期15卷 419-440页

作者： Wei Ma Lu Zhang Weilong Chen Zhaoxia chang Juchuanli Tu Yuanyuan Qin Yuwen Yao Mengxue Dong Jiajun ding Siqin Li fengkai Li Qiaodan Deng Yifei yang Tingting feng Fanrong Zhang Xiying Shao Xueyan He Lixing Zhang Guohong Hu Quentin Liu Yi-Zhou Jiang Shu Zhu Zhi Xiao Dan Su Tong Liu Suling Liu Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences State Key Laboratory of Genetic EngineeringCancer InstitutesDepartment of OncologyKey Laboratory of Breast Cancer in ShanghaiThe Shanghai Key Laboratory of Medical EpigeneticsShanghai Key Laboratory of Radiation OncologyThe International Co-laboratory of Medical Epigenetics and MetabolismMinistry of Science and TechnologyShanghai Medical CollegeFudan UniversityShanghai 200032China Intelligent Pathology Institute and Department of Pathology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230071China Department of Thyroid Breast and Vascular SurgeryXijing HospitalFourth Military Medical UniversityXi’an 710032China Institute of Immunology CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230027China Department of Pathology The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer (IBMC)Chinese Academy of SciencesHangzhou 310022China Department of Breast Surgery The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer (IBMC)Chinese Academy of SciencesHangzhou 310022China Department of Breast Medical Oncology The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer (IBMC)Chinese Academy of SciencesHangzhou 310022China Shanghai Institute of Nutrition and Health University of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhou 510060China Department of Breast Surgery Xiangya HospitalChangsha 410008China Department of Breast Surgery Tumor Hospital of Harbin Medic

Tumor-resident microbiota in breast cancer promotes cancer initiation and malignant ***,targeting microbiota to improve the effects of breast cancer therapy has not been investigated in ***,we evaluated the microbiota composition of breast tumors and found that enterotoxigenic Bacteroides fragilis(ETBF)was highly enriched in the tumors of patients who did not respond to taxane-based neoadjuvant ***,albeit at low biomass,secreted the toxic protein BFT-1 to promote breast cancer cell stemness and *** studies showed that BFT-1 directly bound to NOD1 and stabilized NOD1 ***1 was highly expressed on ALDH+breast cancer stem cells(BCSCs)and cooperated with GAK to phosphorylate NUMB and promote its lysosomal degradation,thereby activating the NOTCH1-HEY1 signaling pathway to increase ***1 inhibition and ETBF clearance increase the chemosensitivity of breast cancer by impairing BCSCs.

关键词： NOD1 breast chemotherapy

Knowledge-embedded spatio-temporal analysis for euploidy embryos identification in couples with chromosomal rearrangements

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Chinese Medical Journal 2024年第6期137卷 694-703页

作者： Fangying Chen Xiang Xie Du Cai Pengxiang yan Chenhui ding yangxing Wen yanwen Xu feng Gao Canquan Zhou Guanbin Li Qingyun Mai Reproductive Medicine Center The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510080China Guangdong Provincial Key Laboratory of Reproductive Medicine GuangzhouGuangdong 510080China School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong 510006China Department of General Surgery(Colorectal Surgery) The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510655China Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510655China Biomedical Innovation Center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510655China Shanghai Artificial Intelligence Laboratory Shanghai 200232China

Background:The goal of the assisted reproductive treatment is to transfer one euploid blastocyst and to help infertile women giving birth one healthy *** algorithms have been used to assess the ploidy status of embryos derived from couples with normal chromosome,who subjected to preimplantation genetic testing for aneuploidy(PGT-A)***,it is currently unknown whether artificial intelligence model can be used to assess the euploidy status of blastocyst derived from populations with chromosomal ***:From February 2020 to May 2021,we collected the whole raw time-lapse videos at multiple focal planes from in vitro cultured embryos,the clinical information of couples,and the comprehensive chromosome screening results of those blastocysts that had received PGT ***,we developed a novel deep learning model called the Attentive Multi-Focus Selection Network(AMSNet)to analyze time-lapse videos in real time and predict blastocyst *** upon AMSNet,we integrated additional clinically predictive variables and created a second deep learning model,the Attentive Multi-Focus Video and Clinical Information Fusion Network(AMCFNet),to assess the euploidy status of *** efficacy of the AMCFNet was further tested in embryos with parental chromosomal *** receiver operating characteristic curve(ROC)was used to evaluate the superiority of the ***:A total of 4112 embryos with complete time-lapse videos were enrolled for the blastocyst formation prediction task,and 1422 qualified blastocysts received PGT-A(n=589)or PGT for chromosomal structural rearrangement(PGT-SR,n=833)were enrolled for the euploidy assessment task in this *** AMSNet model using seven focal raw time-lapse videos has the best real-time *** real-time accuracy for AMSNet to predict blastocyst formation reached above 70%on the day 2 of embryo culture,and then increased to 80%on the day 4 of embryo ***

关键词： Euploidy status Embryo Time-lapse imaging Deep learning Spatio-temporal analysis Preimplantation genetic testing for chromosomal structural rearrangement

富硅或富磷育秧降低水稻砷含量的效果及其分子机制

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生态与农村环境学报 2024年第4期40卷 581-588页

作者：贾梦凡李燕丽王兴祥周志高丁昌峰湿地生态与农业利用教育部工程研究中心/长江大学农学院湖北荆州434025 土壤与农业可持续发展国家重点实验室(中国科学院南京土壤研究所) 江苏南京210008 中国科学院大学北京100049

砷(As)主要通过硅和磷通道进入水稻根系,合理的硅和磷施用方式可有效调控水稻对As的吸收转运。研究通过在水稻育秧阶段进行硅或磷富集,探讨富硅或富磷秧苗移栽至As污染土壤后对糙米As含量的影响及分子机制。试验结果表明,富硅或富磷育... 详细信息

砷(As)主要通过硅和磷通道进入水稻根系,合理的硅和磷施用方式可有效调控水稻对As的吸收转运。研究通过在水稻育秧阶段进行硅或磷富集,探讨富硅或富磷秧苗移栽至As污染土壤后对糙米As含量的影响及分子机制。试验结果表明,富硅或富磷育秧在不影响生长的前提下,可使秧苗的硅或磷整株吸收量分别增至对照的19.6和2.3倍。与常规育秧相比,富硅育秧处理糙米中总砷、三价砷、五价砷以及二甲基砷含量分别降低31.1%、32.1%、58.3%、33.5%。富磷育秧对糙米总砷含量没有显著影响,但使糙米五价砷含量降低59.2%。富硅或富磷育秧可显著增加As在水稻根系中的滞留且不同程度影响As在水稻各部位之间的转移系数。根系As转运基因相对表达量的分析结果表明,与对照相比,富硅育秧对OsLsi1的相对表达量没有显著影响,使OsLsi2的相对表达量下调26%,OsABCC1的相对表达量上调203%;富磷育秧对OsPT1的相对表达量没有显著影响,使OsPT4以及OsPT8的相对表达量分别下降51%和71%,OsABCC1的相对表达量上调22%。综上,富硅或富磷育秧可通过调控水稻根系As相关转运基因的表达来影响水稻对As的吸收及转运,从而降低糙米As含量。研究结果可为稻田As污染风险管控提供重要参考。

关键词：育秧硅磷转运基因砷形态

The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2023

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Cancer Communications 2024年第1期44卷 127-172页

作者： feng-Hua Wang Xiao-Tian Zhang Lei Tang Qi Wu Mu-yan Cai Yuan-Fang Li Xiu-Juan Qu Hong Qiu Yu-Jing Zhang Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin chang Wang Hao Liu Miao-Zhen Qiu Wen-Long Guan Sheng-Xiang Rao Jia-Fu Ji yan Xin Wei-Qi Sheng Hui-Mian Xu Zhi-Wei Zhou Ai-Ping Zhou Jing Jin Xiang-Lin Yuan feng Bi Tian-Shu Liu Han Liang yan-Qiao Zhang Guo-Xin Li Jun Liang Bao-Rui Liu Lin Shen Jin Li Rui-Hua Xu Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer HospitalBeijingP.R.China Department of Radiology Peking University Cancer HospitalBeijingP.R.China Department of Endoscopy Center Peking University Cancer HospitalBeijingP.R.China Department of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoningP.R.China Department of Medical Oncology Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Radiotherapy Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Department of Medical Oncology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China Department of Surgical Oncology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Medical Oncology Fujian Cancer HospitalFuzhouFujianP.R.China Tumor Center The First Hospital of Jilin UniversityChangchunJilinP.R.China Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Department of Radiology Zhongshan HospitalFudan UniversityShanghaiP.R.China Department of

The 2023 update of the Chinese Society of Clinical Oncology(CSCO)Clini-cal Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in China,reflecting the latest advancements in evidence-based medicine,healthcare resource availability,and precision *** updates address the differences in epidemiological characteristics,clinicopatho-logical features,tumor biology,treatment patterns,and drug selections between Eastern and Western gastric cancer *** revisions include a structured template for imaging diagnosis reports,updated standards for molecular marker testing in pathological diagnosis,and an elevated recommendation for neoadju-vant chemotherapy in stage III gastric *** advanced metastatic gastric cancer,the guidelines introduce new recommendations for immunotherapy,anti-angiogenic therapy and targeted drugs,along with updated management strategies for human epidermal growth factor receptor 2(HER2)-positive and deficient DNA mismatch repair(dMMR)/microsatellite instability-high(MSI-H)***,the guidelines offer detailed screening recommendations for hereditary gastric cancer and an appendix listing drug treatment regimens for various stages of gastric *** 2023 CSCO Clinical Guidelines for Gastric Cancer updates are based on both Chinese and international clinical research and expert consensus to enhance their applicability and relevance in clinical practice,particularly in the heterogeneous healthcare landscape of China,while maintaining a commitment to scientific rigor,impartiality,and timely revisions.

关键词： Chinese Society of Clinical Oncology(CSCO) gastric cancer diagnosis surgery neoadjuvant adjuvant radiotherapy chemotherapy targeted therapy immunotherapy

四倍体青绿苔草对低温的生理响应及耐寒性评价

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草地学报 2024年第7期32卷 2089-2098页

作者：董双慧贾明张辉滕珂滕文军温海峰范希峰岳跃森武菊英丁国昌福建农林大学风景园林与艺术学院福建福州350002 北京市农林科学院草业花卉与景观生态研究所农业农村部华北都市农业重点实验室北京100097

为探究四倍体青绿苔草(Carex breviculmis)不同株系的耐寒性,筛选耐寒四倍体青绿苔草株系,本研究以二倍体和同源四倍体青绿苔草株系4、株系8、株系14为例,采用田间自然低温处理,对2023年10月—11月各处理时间段的苔草叶片生理指标进行测... 详细信息

为探究四倍体青绿苔草(Carex breviculmis)不同株系的耐寒性,筛选耐寒四倍体青绿苔草株系,本研究以二倍体和同源四倍体青绿苔草株系4、株系8、株系14为例,采用田间自然低温处理,对2023年10月—11月各处理时间段的苔草叶片生理指标进行测定,同时通过主成分分析和隶属函数法,对四倍体青绿苔草各株系耐寒性进行了评价。结果表明:在低温胁迫过程中,两种倍性青绿苔草的叶片相对含水量和叶绿素含量均呈不同程度的下降,而可溶性糖含量呈不同程度的上升,丙二醛含量、超氧化物歧化酶活性、过氧化氢酶活性和可溶性蛋白含量随低温时长的增加呈不同变化趋势,四倍体青绿苔草株系4、株系8、株系14耐寒性均强于二倍体青绿苔草,其中,四倍体青绿苔草株系14耐寒力最强。上述研究结果为了解青绿苔草耐寒机制及四倍体青绿苔草耐寒株系筛选提供理论依据。

关键词：青绿苔草四倍体耐寒性综合评价

Diverse electronic and magnetic properties of CrS_(2) enabling strain-controlled 2D lateral heterostructure spintronic devices

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npj Computational Materials 2021年第1期7卷 704-712页

作者： Kaiyun Chen Junkai Deng Yuan yan Qian Shi Tieyan chang Xiangdong ding Jun Sun sen yang Jefferson Zhe Liu MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter State Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi’an 710049China Department of Mechanical Engineering The University of MelbourneParkvilleVIC 3010Australia

Lateral heterostructures of two-dimensional(2D)materials,integrating different phases or materials into a single piece of nanosheet,have attracted intensive research interests for electronic *** the 2D lateral heterostructures to spintronics demands more diverse electromagnetic properties of 2D *** this paper,using density functional theory calculations,we survey all IV,V,and VI group transition metal dichalcogenides(TMDs)and discover that CrS_(2)has the most diverse electronic and magnetic properties:antiferromagnetic(AFM)metallic 1T phase,non-magnetic(NM)semiconductor 2H phase,and ferromagnetic(FM)semiconductor 1T′phase with a Curie temperature of~1000 ***,we find that a tensile or compressive strain can turn the 1T′phase into a spin-up or spin-down *** strain tunability can be attributed to the lattice deformation under tensile/compressive strain that selectively promotes the spin-up/spin-down VBM(valence band bottom)orbital *** diverse electromagnetic properties and the strain tunability enable strain-controlled spintronic devices using a single piece of CrS_(2)nanosheet with improved energy *** a demo,a prototypical design of the spin-valve logic device is *** offers a promising solution to address the challenge of high energy consumption in miniaturized spintronic devices.

关键词： strain electronic magnetic

基于真实退化估计与高频引导的内窥镜图像超分辨率重建

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自动化学报 2024年第2期50卷 334-347页

作者：李嫣任文琦张长青张金刚聂云峰中国科学院信息工程研究所北京100093 中国科学院大学网络空间安全学院北京100190 中国科学院大学未来技术学院北京100039 中山大学网络空间安全学院深圳518107 天津大学智能与计算学部天津300350 布鲁塞尔自由大学应用物理与光子学系比利时布鲁塞尔1050

内窥镜是诊断人体器官疾病的重要医疗设备,然而受人体内腔环境影响,内窥镜图像分辨率一般较低,需对其进行超分辨处理.目前多数基于深度学习的超分辨算法直接使用双三次插值下采样从高质量图像中获取低分辨率(Low-resolution, LR)图像以... 详细信息

内窥镜是诊断人体器官疾病的重要医疗设备,然而受人体内腔环境影响,内窥镜图像分辨率一般较低,需对其进行超分辨处理.目前多数基于深度学习的超分辨算法直接使用双三次插值下采样从高质量图像中获取低分辨率(Low-resolution, LR)图像以进行配对训练,此种方式会导致纹理细节丢失,不适用于医学图像.为解决该问题,针对医学内窥镜图像开发了一种新颖的退化框架,首先从真实低质量内窥镜图像中提取丰富多样的真实模糊核与噪声模式,之后提出一种退化注入算法,利用提取的真实模糊核与噪声将高分辨率(High-resolution, HR)内窥镜图像退化为符合真实域的低分辨率图像.同时,提出一种高频引导的残差密集超分辨网络,采用基于双频率信息交互的频率分离策略,并设计多层级融合机制,将提取的多级高频信息逐层嵌入残差密集模块的多层特征,以充分恢复内窥镜图像的高频细节和低频内容.在合成与真实数据集上的大量实验表明,我们的方法优于对比方法,具有更好的主客观质量评价.

关键词：内窥镜图像超分辨率退化估计高频引导卷积神经网络

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