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Recent Advances on Surface-modified Biomaterials Promoting Selective Adhesion and Directional Migration of Cells

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Chinese Journal of Polymer Science 2021年第7期39卷 815-823页

作者： Chen-Xi Tu chang-You gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

The surfaces and interfaces of biomaterials interact with the biological systems in multi-scale levels,and thereby influence the biological functions and comprehensive performance in vitro and in *** particular,a surface promoting the selective adhesion and directional migration of desired types of cells in complex environment is extremely important in the repair and regeneration of tissues such as peripheral nerve and blood vessel,and long-term application of intracorporal devices such as intravascular ***,surface modification of biomaterials is a facile and effective method to achieve the desired cell-biomaterials *** this short review,recent advances on the surface modification of biomaterials to regulate selective cell adhesion and migration are briefly *** particular,the surface properties of biomaterials are manipulated via the convenient introduction of amino groups to the ester-based polymers,the formation of polyelectrolyte multilayers,and the fabrication of topology and gradient cues,etc.,followed by the association of chemical and biological signals such as collagen,heparin,hyaluronic acid,peptides and cell growth *** selective adhesion and directional migration of various types of cells such as endothelial cells(ECs),smooth muscle cells(SMCs),hepatocytes and Schwann cells(SCs)are achieved over the competitive counterpart cells by the use of cell-resisting substances and cell-selective motifs on gradient substrates in most *** advances on cell behaviors in three-dimensional(3D)ceH-extracellular matrix(ECM)-mimicking substrates are also reviewed.

关键词： Biomaterials Surface modification Gradient Cell migration Cell selectivity

A New H^2 Regularity Condition of the Solution to Dirichlet Problem of the Poisson Equation and Its Applications

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Acta Mathematica Sinica,English Series 2020年第1期36卷 21-39页

作者： Fu chang gao Ming Jun LAI Department of Mathematics University of IdahoMoscowID 83844 Department of Mathematics University of GeorgiaAthensGA 30602

We study the regularity of the solution of Dirichlet problem of Poisson equations over a bounded domain.A new sufficient condition,uniformly positive reach is *** the assumption that the closure of the underlying domain of interest has a uniformly positive reach,the H^2 regularity of the solution of the Poisson equation is *** particular,this includes all star-shaped domains whose closures are of positive reach,regardless if they are Lipschitz domains or non-Lipschitz *** to the strong solution to the second order elliptic PDE in non-divergence form and the regularity of Helmholtz equations will be presented to demonstrate the usefulness of the new regularity condition.

关键词： Regularity Poisson equations uniformly positive reach non-divergence form

Fine Doppler shift acquisition algorithm for BeiDou software receiver by a look-up table

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Journal of Systems Engineering and Electronics 2020年第3期31卷 612-625页

作者： QIU Wenqi ZENG Qingxi gao chang LYU Chade State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun 130012China Non-destructive Detection and Monitoring Technology for High-speed Transportation Facilities Key Laboratory of Ministry of Industry and Information Technology Nanjing 211106China College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China

The BeiDou software receiver uses the fast Fourier transform(FFT)to perform the *** Doppler shift estimation accuracy should be less than 500 Hz to ensure satellite signals to enter a locked state in the tracking *** the frequency step is usually 500 Hz or larger,the Doppler shift estimation accuracy cannot guarantee that satellite signals are brought into a stable tracking *** straightforward solutions consist in increasing the sampling time and using zero-padding to improve the frequency resolution of the ***,these solutions intensify the complexity and amount of *** contradiction between the acquisition accuracy and the computational load leads us to research for a more simple and effective algorithm,which achieves fine acquisition by a look-up *** coarse acquisition using the parallel frequency acquisition(PFA)algorithm,the proposed algorithm optimizes the Doppler shift estimation through the look-up table method based on the FFT results to improve the acquisition accuracy of the Doppler shift with a minimal additional computing *** the Doppler shift is within the queryable range of the table,the proposed algorithm can improve the Doppler shift estimation accuracy to 50 Hz for the BeiDou B1I signal.

关键词： fine acquisition fast Fourier transform(FFT) table look-up parallel frequency acquisition(PFA) BeiDou

Phase Transitions in Neutron Stars Within Modified Quark-Meson Coupling Model

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Communications in Theoretical Physics 2008年第7期50卷 180-186页

作者： MA chang-Qun gao Chun-Yuan School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking University Beijing 100871 China

K^- condensation and quark deconfinement phase transitions in neutron stars are investigated. We use the modified quark-meson coupling model for hadronic phase and the MIT bag model for quark phase. With the equation of state （EOS） solved self-consistently, we discuss the properties of neutron stars. We find that the EOS of pure hadron matter with condensed K- phase should be ruled out by the redshift for star EX00748-676, while EOS containing unpaired quark matter phase with B1/4 being about 180 MeV could be consistent with both this observation and the best measured mass of star PSR 1913 ＋ 16. But if the recent inferred massive star among Terzan 5 with M 〉 1.68M is confirmed, all the present EOSes with condensed phase and deconfined phase would be ruled out.

关键词： neutron star modified quark-meson coupling model nuclear matter quark matter

Fermion Entropy of Vaidya-Bonner Black Hole

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Chinese Physics Letters 2001年第9期18卷 1167-1169页

作者： gao chang-Jun SHEN You-Gen Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030 National Astronomical Observatories Chinese Academy of SciencesBeijing 100012 Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100080

Using the membrane model which is based on the brick-wall model, we have calculated the free energy and entropy of the Vaidya-Bonner black hole due to fermion fields. The result shows that the entropy of the Vaidya-Bonner black hole is exactly proportional to the area of its event horizon. The relationship between the entropy and event horizon in such a non-static case is just the same as that in a static or stationary cases.

关键词： horizon entropy Vaidya

On static and spherically symmetric solutions of Starobinsky model

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Research in Astronomy and Astrophysics 2018年第12期18卷 131-136页

作者： Shuang Yu chang-Jun gao Ming-Jun Liu Key Laboratory of Computational Astrophysics National Astronomical Observatories Chinese Academy of Sciences School of Astronomy and Space Sciences University of Chinese Academy of Sciences Department of Astronomy School of Physics Peking University

We investigate the problem of static and spherically symmetric solutions in the Starobinsky gravity *** extending the Lichnerowicz and Israel theorems, William Nelson has demonstrated that the Schwarzschild solution is the unique static, spherically symmetric and asymptotically flat black hole solution in the Starobinsky ***, Hong Lüet *** that there are sign errors in the proof of *** raises the problem of whether Nelson’s proof is correct or *** order to answer this question, we explore the corresponding solutions by using the Taylor series expansion *** find that Nelson’s conclusion is indeed correct despite the flaw in the proof.

关键词： black hole physics:gravitation

MULTILAYERS AND POLY(ALLYLAMINE HYDROCHLORIDE)-GRAFTPOLY(ETHYLENE GLYCOL) MODIFIED BOVINE SERUM ALBUMIN NANOPARTICLES:IMPROVED STABILITY AND pH-RESPONSIVE DRUG DELIVERY

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Chinese Journal of Polymer Science 2012年第5期30卷 719-726页

作者： Li-li Xie 仝维鋆 Jian-quan Xu chang-you gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang University

To improve the colloidal stability of bovine serum albumin （BSA） nanoparticles （hiPs） in diverse mediums, poly（allylamine hydrochloride）（PAH）/sodium poly（4-styrene sulfonate）（PSS） multilayers and poly（allylamine hydrochloride）-graft-poly（ethylene glycol）（PAH-g-PEG） coating were coated on the surface of BSA NPs. Stabilities of the BSA NPs in diverse mediums with different surfaces were detected by dynamic light scattering （DLS）. Multilayers and PAH-g-PEG coated BSA NPs can be well dispersed in various mediums with a narrow polydispersity index （PDI）. The BSA NPs with the highest surface density of PEG show the best stability. The multilayers and PAH-g-PEG coating do not deter the pH-dependent loading and release property of BSA NPs. At pH 9, the encapsulation efficiency of doxorubicin reaches almost 99%, and the release rate at pH 5.5 is significantly higher than that at pH 7.4.

关键词： BSA nanoparticle PEG LBL Drug delivery pH-responsive.

Ag^(+)、Zn^(2+)、Cr^(3+)改性Y型分子筛吸附脱除喹啉的模拟计算研究

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原子与分子物理学报 2025年第1期42卷 61-68页

作者：孙潇镝唐克高畅富添王聚财洪新辽宁工业大学化学与环境工程学院锦州121001 葫芦岛市应急管理局葫芦岛125000

首先考察了吸附时间对三种改性Y型分子筛AgY、ZnY、CrY吸附脱除模拟燃料中喹啉的影响,结果发现三种分子筛对喹啉的吸附容量和去除率大小顺序均为:AgY>CrY>ZnY.运用Materials Studio软件,采用巨正则蒙特卡洛(GCMC)和密度泛函理论(DFT)对... 详细信息

首先考察了吸附时间对三种改性Y型分子筛AgY、ZnY、CrY吸附脱除模拟燃料中喹啉的影响,结果发现三种分子筛对喹啉的吸附容量和去除率大小顺序均为:AgY>CrY>ZnY.运用Materials Studio软件,采用巨正则蒙特卡洛(GCMC)和密度泛函理论(DFT)对改性Y型分子筛吸附喹啉机理进行了模拟计算研究,得出以下结论:模拟计算AgY、ZnY、CrY的比表面积和孔体积与其低温N2吸附-脱附表征结果基本一致,并且发现改性Y型分子筛的吸附脱氮能力与比表面积和孔体积关系不大;以Fukui函数为基础,采用Mulliken和Hirshfeld两种布局数分析方法模拟计算了三种改性Y型分子筛的相对亲电性并分析Lewis酸强弱,其Lewis酸大小顺序为:AgY>CrY>ZnY;对三种改性分子筛进行了前线轨道分析,其化学吸附活性大小为AgYCrY>ZnY,模拟计算所得各种结果与实验结果顺序完全一致.

关键词： Y型分子筛改性吸附喹啉模拟

Activation of Dopamine D2 Receptors Alleviates Neuronal Hyperexcitability in the Lateral Entorhinal Cortex via Inhibition of HCN Current in a Rat Model of Chronic Inflammatory Pain

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Neuroscience Bulletin 2022年第9期38卷 1041-1056页

作者： Shi-Hao gao Yong Tao Yang Zhu Hao Huang Lin-Lin Shen chang-Yue gao Department of Rehabilitation Daping HospitalArmy Medical UniversityChongqing400042China Department of Respiratory and Critical Care Medicine Xinqiao HospitalArmy Medical UniversityChongqing400037China Army 953 Hospital Army Medical UniversityShigatse857000China

Functional changes in synaptic transmission from the lateral entorhinal cortex to the dentate gyrus(LEC-DG)are considered responsible for the chronification of ***,the underlying alterations in fan cells,which are the predominant neurons in the LEC that project to the DG,remain ***,we investigated possible mechanisms using a rat model of complete Freund’s adjuvant(CFA)-induced inflammatory *** found a substantial increase in hyperpolarization-activated/cyclic nucleotide-gated currents(Ih),which led to the hyperexcitability of LEC fan cells of CFA *** phenomenon was attenuated in CFA slices by activating dopamine D2,but not D1,*** activation of the ventral tegmental area-LEC projection had a D2 receptor-dependent analgesic ***-LEC microinjection of a D2 receptor agonist also suppressed CFA-induced behavioral hypersensitivity,and this effect was attenuated by pre-activation of the *** findings suggest that down-regulating the excitability of LEC fan cells through activation of the dopamine D2 receptor may be a strategy for treating chronic inflammatory pain.

关键词： Inflammatory pain Lateral entorhinal cortex Neuronal hyperexcitability Dopamine D2 receptor HCN current