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The higher-order topological pumping explored in the 2D acoustic crystal

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 127-133页

作者： yanqiu Wang Bin Liang Jianchun Cheng Key Laboratory of Modern Acoustics Ministry of EducationInstitute of AcousticsDepartment of PhysicsNanjing UniversityNanjing 210093China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

The topological pumping has been instrumental in advancing our understanding of topological phase transitions in various physical systems,which can be extended to uncover intriguing higher-order topological phases in the lower-dimensional ***,we propose a theoretical exploration of topological dipole pumping on an acoustic square superlattice by cyclically modulating intracell couplings,which shares the topological nature of an extended three-dimensional system with chiral hinge *** the multipole chiral numbers,we characterize the higher-order topological phases that arise during the *** evolution of topological phase transitions is verified by numerical simulations and shows corner states are transferred across the *** findings can inspire the construction of chiral hinge states in artificial crystals,opening up new possibilities for the design of devices allowing the unidirectional propagation of sound.

关键词： topological phases of matter Thouless pumping acoustic metamaterial

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MKK4 inhibitor:the hope for liver failure prevention and potential small liver graft transplantation

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Chinese Journal of Natural Medicines 2024年第6期22卷 483-485页

作者： ZHANG yanqiu ZHANG Hao Jiangsu Key Laboratory of Bioactive Natural Product Research Department of Natural Medicinal ChemistryChina Pharmaceutical UniversityNanjing 210009China

Liver regeneration represents a fascinating concept that spans from ancient mythology to modern medical *** Greek mythology,Prometheus,a hero who defied Zeus by stealing fire and giving it to humanity,was subjected to a severe *** was bound to a rock where,each day,an eagle would feast on his liver,which would then miracu-lously regenerate *** myth underscores the liver’s unique regenerative abilities,a feature that is not just le-gendary but also scientifically recognized.

关键词： Liver regeneration Partial hepatectomy MKK4 Drug discovery and development First-in-human phase I trial

Classification and spectrum optimization method of grease based on infrared spectrum

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Friction 2024年第6期12卷 1154-1164页

作者： Xin FENG yanqiu XIA Peiyuan XIE Xiaohe LI School of Energy Power and Mechanical Engineering North China Electric Power UniversityBeijing 102206China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

The infrared(IR)absorption spectral data of 63 kinds of lubricating greases containing six different types of thickeners were obtained using the IR *** Kohonen neural network algorithm was used to identify the type of the lubricating *** results show that this machine learning method can effectively eliminate the interference fringes in the IR spectrum,and complete the feature selection and dimensionality reduction of the high-dimensional spectral *** 63 kinds of greases exhibit spatial clustering under certain IR spectrum recognition spectral bands,which are linked to characteristic peaks of lubricating greases and improve the recognition accuracy of these *** model achieved recognition accuracy of 100.00%,96.08%,94.87%,100.00%,and 87.50%for polyurea grease,calcium sulfonate composite grease,aluminum(Al)-based grease,bentonite grease,and lithium-based grease,*** on the different IR absorption spectrum bands produced by each kind of lubricating grease,the three-dimensional spatial distribution map of the lubricating grease drawn also verifies the accuracy of classification while recognizing the *** paper demonstrates fast recognition speed and high accuracy,proving that the Kohonen neural network algorithm has an efficient recognition ability for identifying the types of the lubricating grease.

关键词： grease infrared(IR)spectroscopy layered Kohonen network species recognition spectrum band optimization

Prediction of Lubricant Physicochemical Properties Based on Gaussian Copula Data Expansion

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 161-174页

作者： Feng Xin Yang Rui Xie Peiyuan Xia yanqiu School of Energy Power and Mechanical Engineering North China Electric Power UniversityBeijing 102206China

The composition of base oils affects the performance of lubricants made from *** paper proposes a hybrid model based on gradient-boosted decision tree(GBDT)to analyze the effect of different ratios of KN4010,PAO40,and PriEco3000 component in a composite base oil system on the performance of *** study was conducted under small laboratory sample conditions,and a data expansion method using the Gaussian Copula function was proposed to improve the prediction ability of the hybrid *** study also compared four optimization algorithms,sticky mushroom algorithm(SMA),genetic algorithm(GA),whale optimization algorithm(WOA),and seagull optimization algorithm(SOA),to predict the kinematic viscosity at 40℃,kinematic viscosity at 100℃,viscosity index,and oxidation induction time performance of the *** results showed that the Gaussian Copula function data expansion method improved the prediction ability of the hybrid model in the case of small *** SOA-GBDT hybrid model had the fastest convergence speed for the samples and the best prediction effect,with determination coefficients(R^(2))for the four indicators of lubricants reaching 0.98,0.99,0.96 and 0.96,***,this model can significantly reduce the model’s prediction error and has good prediction ability.

关键词： base oil data augmentation machine learning performance prediction seagull algorithm

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Tribological properties of Al-GNP composites at elevated temperature

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Friction 2024年第5期12卷 1028-1041页

作者： Sunil POUDEL Rizwan BAJWA Yongde XIA Zakir KHAN Yi ZHANG yanqiu ZHU College of Engineering Mathematics and Physical SciencesUniversity of ExeterExeterEX44QFUK European Technical Centre Daido Metal Co.Ltd.Iliminster SomersetTA199PHUK

Lighter and more powerful next generation vehicles and other rotary machinery demand bearings to operate in harsher conditions for higher efficiency,and the continuous development of advanced low-wear and friction materials is thus becoming even more important to meet these *** aluminium composites reinforced with high performance lubricate phases such as graphene nanoplatelets(GNPs)are very promising and have been vigorously *** maintaining a low coefficient of friction(COF)and offering great strength against wear due to their self-lubricating capability,the solid lubricant like GNPs protect the bearing surface from wear damage and prevent change in metallurgical properties during temperature *** paper first studies the high-temperature tribological performance of aluminium matrix composites reinforced with GNP,consolidated via powder metallurgy,then elucidates their tribological *** report that the best tribological performance is achieved by the composite containing 2.0 wt%GNP,with an extraordinarily low COF of 0.09 and a specific wear rate of 3.5×10^(−2)mm^(3)·N^(−1)·m^(−1),which represent 75%and 40%reduction respectively,against the plain aluminium consolidated under identical *** in-track and out-of-track Raman analysis have confirmed the role of GNPs in creating a tribofilm on the counterpart surface which contributed to the excellent performance.

关键词： nanocomposite graphene nanoplatelet(GNP) tribology powder metallurgy

Leveraging diverse cell-death patterns to predict the clinical outcome of immune checkpoint therapy in lung adenocarcinoma:Based on muti-omics analysis and vitro assay

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Oncology Research 2024年第2期32卷 393-407页

作者： HONGYUAN LIANG yanqiu LI YONGGANG QU LINGYUN ZHANG Department of Radiology Shengjing Hospital of China Medical UniversityShenyangChina Department of Nephrology The First Affiliated Hospital of China Medical UniversityShenyangChina Department of Clinical Medicine China Medical UniversityShenyangChina Department of Medical Oncology The First Hospital of China Medical UniversityShenyangChina

Advanced LUAD shows limited response to treatment including immune *** the development of sequencing omics,it is urgent to combine high-throughput multi-omics data to identify new immune checkpoint therapeutic response *** GSE72094(n=386)and GSE31210(n=226)gene expression profile data in the GEO database,we identified genes associated with lung adenocarcinoma(LUAD)death using tools such as“edgeR”and“maftools”and visualized the characteristics of these genes using the“circlize”R *** constructed a prognostic model based on death-related genes and optimized the model using LASSO-Cox regression *** calculating the cell death index(CDI)of each individual,we divided LUAD patients into high and low CDI groups and examined the relationship between CDI and overall survival time by principal component analysis(PCA)and Kaplan-Meier *** also used the“ConsensusClusterPlus”tool for unsupervised clustering of LUAD subtypes based on model *** addition,we collected data on the expression of immunomodulatory genes and model genes for each cohort and performed tumor microenvironment *** also used the TIDE algorithm to predict immunotherapy responses in the CDI ***,we studied the effect of PRKCD on the proliferation and migration of LUAD cells through cell culture *** study utilized the TCGA-LUAD cohort(n=493)and identified 2,901 genes that are differentially expressed in patients with *** KEGG and GO enrichment analysis,these genes were found to be involved in a wide range of biological *** study also used univariate Cox regression models and LASSO regression analyses to identify 17 candidate genes that were best associated with mortality prognostic risk *** comparing the overall survival(OS)outcomes of patients with different CDI values,it was found that increased CDI levels were significantly associated with lower OS *** addition,the study used unsupervised cluster analysis to d

关键词： Lung adenocarcinoma Programmed cell death Iron-death Drug sensitivity Cancer therapy

Identification of Lubricating Oil Additives Using XGBoost and Ant Colony Optimization Algorithms

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China Petroleum Processing & Petrochemical Technology 2024年第2期26卷 158-167页

作者： Xia yanqiu Cui Jinwei Xie Peiyuan Zou Shaode Feng Xin School of Energy Power and Mechanical Engineering North China Electric Power UniversityBeijing 102206China

To address the problem of identifying multiple types of additives in lubricating oil,a method based on midinfrared spectral band selection using the eXtreme Gradient Boosting(XGBoost)algorithm combined with the ant colony optimization(ACO)algorithm is *** XGBoost algorithm was used to train and test three additives,T534(alkyl diphenylamine),T308(isooctyl acid thiophospholipid octadecylamine),and T306(trimethylphenol phosphate),separately,in order to screen for the optimal combination of spectral bands for each *** ACO algorithm was used to optimize the parameters of the XGBoost algorithm to improve the identification *** this process,the support vector machine(SVM)and hybrid bat algorithms(HBA)were included as a comparison,generating four models:ACO-XGBoost,ACO-SVM,HBA-XGboost,and *** results showed that all four models could identify the three additives efficiently,with the ACO-XGBoost model achieving 100%recognition of all three *** addition,the generalizability of the ACO-XGBoost model was further demonstrated by predicting a lubricating oil containing the three additives prepared in our laboratory and a collected sample of commercial oil currently in use。

关键词： lubricant oil additives fourier transform infrared spectroscopy type identification ACO-XGBoost combinatorial algorithm

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MKK4 inhibitor: the hope for liver failure prevention and potential small liver graft transplantation

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Chinese Journal of Natural Medicines 2024年第06期 483-485页

作者： ZHANG yanqiu ZHANG Hao Jiangsu Key Laboratory of Bioactive Natural Product Research Department of Natural Medicinal Chemistry China Pharmaceutical University

Liver regeneration represents a fascinating concept that spans from ancient mythology to modern medical science. In Greek mythology, Prometheus, a hero who defied Zeus by stealing fire and giving it to humanity, was s...

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The Effects of Mindfulness-Based Interventions on Symptoms of Mild Traumatic Brain Injury:A Systematic Review

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International Journal of Mental Health Promotion 2024年第6期26卷 417-428页

作者： Qiqi Feng Zhijian Huang yanqiu Wang Bin Wang School of Physical Education and Sports Central China Normal UniversityWuhan430079China School of Physical Education Hubei UniversityWuhan430062China

Mindfulness-based interventions(MBIs)are emerging non-pharmacological treatments for mild traumatic brain injury(mTBI).In this systematic review,the authors aimed to evaluate the potential efficacy of MBIs to provide recommendations for treating patients with *** searched of the English literature on MBIs for patients with mTBI as of 01 September,2023,using the PubMed,Web of Science,PsycINFO,and Scopus *** author performed data extraction and quality scoring of the included literature according to the proposed protocol,and another conducted the *** review was not registered.A total of 11 studies met the final inclusion criteria,5 of which involved military personnel(veterans).MBIs covered in this review include goal-oriented attention self-regulation(GOALS),mindfulness-based stress reduction(MBSR),acceptance and commitment therapy(ACT),and so *** shows that MBSR mainly reduces mental fatigue symptoms in mTBI patients,and GOALS tend to improve their cognitive *** effect of MBIs on psychological symptoms needs further *** studies,such as mindfulness-based group therapy and intervention studies targeting mTBI military personnel,are relatively *** have specific effects on mental fatigue and cognitive dysfunction in patients with ***,the effect on psychological distress and the sustained effectiveness across all symptoms still need further *** the particularity of military personnel suffering from mTBI,researchers need to do more intervention studies targeting mTBI military ***,the design of future MBIs trials for mTBI patients’needs to take into account all the factors,such as different populations and severity of traumatic brain injury,to verify the effectiveness of MBIs in alleviating mTBI symptoms and explore the mechanism of intervention.

关键词： Mindfulness traumatic brain injury mild