MKK4 inhibitor:the hope for liver failure prevention and potential small liver graft transplantation

作     者：ZHANG Yanqiu ZHANG Hao ZHANG Yanqiu;ZHANG Hao

作者机构：Jiangsu Key Laboratory of Bioactive Natural Product ResearchDepartment of Natural Medicinal ChemistryChina Pharmaceutical UniversityNanjing 210009China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2024年第22卷第6期

页      面：483-485页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.82074068,82373912,82300685) the National Key R&D Program of China(No.2023YFD1601400) the Fundamental Research Funds for the Central Universities(No.2632022YC04) Jiangsu Outstanding Youth Fund Project(No.BK20231535) the Natural Science Foundation of Jiangsu Province(No.BK20221052) the Jiangsu Funding Program for Excellent Postdoctoral Talent(No.2022ZB286) 

主　　题：Liver regeneration Partial hepatectomy MKK4 Drug discovery and development First-in-human phase I trial 

摘      要：Liver regeneration represents a fascinating concept that spans from ancient mythology to modern medical *** Greek mythology,Prometheus,a hero who defied Zeus by stealing fire and giving it to humanity,was subjected to a severe *** was bound to a rock where,each day,an eagle would feast on his liver,which would then miracu-lously regenerate *** myth underscores the liver’s unique regenerative abilities,a feature that is not just le-gendary but also scientifically recognized.