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Warburg effect mimicking inborn errors of metabolism in childhood hematologic malignancies:A case-based systematic review

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World Journal of Clinical Pediatrics 2023年第5期12卷 350-358页

作者： Khanittha Permtawee Maliwan Tengsujaritkul chane choed-amphai Supapitch Chanthong Kanittha Mankhemthong Lalita Sathitsamitphong Rungrote Natesirinilkul Pimlak Charoenkwan Department of Pediatrics Faculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand Department of Pediatrics Nakornping HospitalChiang Mai 50180Thailand

BACKGROUND Type B lactic acidosis and hypoglycemia can occur in various pediatric *** young children with a history of fasting preceding these metabolic derangements,inborn errors of metabolism should be primarily ***,the Warburg effect,a rare metabolic complication,can also manifest in children with hematologic *** a few reports of this condition in children have been published in the *** To identify the clinical course,treatment strategies,and outcomes of childhood hematologic malignancies with type B lactic *** We performed a comprehensive search of the PubMed,Scopus,and Cochrane databases without any time restriction but limited to English language *** databases were last accessed on July 1st,*** A total of 20 publications were included in the analysis,all of which were case reports or case *** higher quality evidence was *** children with hematologic malignancies and Warburg effect,there were 14 cases of acute lymphoblastic leukemia and 6 cases of non-Hodgkin’s lymphoma including our illustrative *** acidosis occurred in 55%of newly diagnosed cases and 45%of relapsed *** mean age was 10.3±4.5 years,and 80%of cases were *** mean serum lactate was 16.9±12.6 mmol/L,and 43.8%of the cases had concomitant *** acidosis initially subsided in 80%of patients receiving chemotherapy compared to 60%in the contrast *** mortality rate of newly diagnosed cases was 45.5%,while the relapsed cases represented a 100%mortality *** 8 patients reported before 2001 died from disease-related ***,patients described in reports published between 2003 and 2023 had a 54.5%rate of complete *** This complication has historically led to fatal outcome;however,patients who received chemotherapy showed a more favorable ***,it is crucial to promptly initiate specific treatment in this context.

关键词： Warburg effect Lactic acidosis type B Inborn errors of metabolism Leukemia Lymphoma Children

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Wilms tumor with dilated cardiomyopathy: A case report

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World Journal of Clinical Oncology 2019年第8期10卷 293-299页

作者： Saviga Sethasathien chane choed-amphai Kwannapas Saengsin Lalita Sathitsamitphong Pimlak Charoenkwan Kanokkan Tepmalai Suchaya Silvilairat Division of Cardiology Department of PediatricsFaculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand Division of Hematology and Oncology Department of PediatricsFaculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand Division of Pediatric Surgery Department of SurgeryFaculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand

BACKGROUND Wilms tumor is the most common renal malignancy in childhood. It occurs primarily between the ages of 2 and 5 years. The usual manifestations are abdominal mass, hypertension, and hematuria. The case presented here had an unusual presentation, with dilated cardiomyopathy and hypertension secondary to the Wilms tumor. CASE SUMMARY A 3-year-old boy presented with a 5-d history of irritability, poor appetite, and respiratory distress. His presenting clinical symptoms were dyspnea, tachycardia, hypertension, and a palpable abdominal mass at the left upper quadrant. His troponin T and pro-B-type natriuretic peptide levels were elevated. Echocardiography demonstrated a dilated hypokinetic left ventricle with an ejection fraction of 29%, and a suspected left renal mass. Computed tomography scan revealed a left renal mass and multiple lung nodules. The definitive diagnosis of Wilms tumor was confirmed histologically. The patient was administered neoadjuvant chemotherapy and underwent radical nephrectomy. After surgery, radiotherapy was administered, and the adjuvant chemotherapy was continued. The blood pressure and left ventricular function normalized after the treatments. CONCLUSION Abdominal mass, dilated cardiomyopathy and hypertension can indicate Wilms tumor in pediatric patients. Chemotherapy and tumor removal achieve successful treatment.

关键词： Dilated cardiomyopathy Heart failure Hypertension Wilms tumor Case report

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