Wilms tumor with dilated cardiomyopathy: A case report

作     者：Saviga Sethasathien Chane Choed-Amphai Kwannapas Saengsin Lalita Sathitsamitphong Pimlak Charoenkwan Kanokkan Tepmalai Suchaya Silvilairat 

作者机构：Division of CardiologyDepartment of PediatricsFaculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand Division of Hematology and OncologyDepartment of PediatricsFaculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand Division of Pediatric SurgeryDepartment of SurgeryFaculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand 

出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)

年 卷 期：2019年第10卷第8期

页      面：293-299页

学科分类：10[医学] 

主　　题：Dilated cardiomyopathy Heart failure Hypertension Wilms tumor Case report 

摘      要：BACKGROUND Wilms tumor is the most common renal malignancy in childhood. It occurs primarily between the ages of 2 and 5 years. The usual manifestations are abdominal mass, hypertension, and hematuria. The case presented here had an unusual presentation, with dilated cardiomyopathy and hypertension secondary to the Wilms tumor. CASE SUMMARY A 3-year-old boy presented with a 5-d history of irritability, poor appetite, and respiratory distress. His presenting clinical symptoms were dyspnea, tachycardia, hypertension, and a palpable abdominal mass at the left upper quadrant. His troponin T and pro-B-type natriuretic peptide levels were elevated. Echocardiography demonstrated a dilated hypokinetic left ventricle with an ejection fraction of 29%, and a suspected left renal mass. Computed tomography scan revealed a left renal mass and multiple lung nodules. The definitive diagnosis of Wilms tumor was confirmed histologically. The patient was administered neoadjuvant chemotherapy and underwent radical nephrectomy. After surgery, radiotherapy was administered, and the adjuvant chemotherapy was continued. The blood pressure and left ventricular function normalized after the treatments. CONCLUSION Abdominal mass, dilated cardiomyopathy and hypertension can indicate Wilms tumor in pediatric patients. Chemotherapy and tumor removal achieve successful treatment.