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Drug Combination Therapy 2022年第1期4卷 1-9页

作者： Nishant Thakur Bhupinder Kaur Manish Goswami chandan sharma University Institute of Pharma Sciences Chandigarh UniversityGharuanMohaliPunjab140413India Saraswati College of Pharmacy GharuanMohaliPunjab140413India

Aim:Thiocolchicoside is a sulfur derivative of the colchicine widely used as the skeletal muscle relaxant in variety of muscle related *** of the Thiocolchicoside is screened with the Eudragit RLPO,Eudragit L-100 and Eudragit E-100 for checking its suitability for formulating as transdermal drug delivery ***:The binary mixtures of the drug and polymers were placed in the Petri plates and the temperature and humidity were adjusted at 40℃±2℃ and 75%relative *** drug and polymer mixture were examined on the FTIR and DSC for detection of any possible physical and chemical ***:Eudragit E100 and L100showed no significant interaction with the Thiocolchicoside and that was justified with differential scanning calorimetryand Fourier transform ***,Eudragit RLPO showed a slight interaction with the drug during the compatibility studies.

关键词： Thiocolchicoside Relative humidity Eudragit Compatibility Fourier transform infrared Differential scanning calorimetry

Impact of frailty on endoscopic retrograde cholangiopancreatography outcomes in nonagenarians:A United States national experience

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World Journal of Gastrointestinal Endoscopy 2024年第3期16卷 148-156页

作者： Sanket Dhirubhai Basida Dushyant Singh Dahiya Muhammad Nadeem Yousaf Brinda Basida Bhanu Siva Mohan Pinnam Manesh Kumar Gangwani Hassam Ali Sahib Singh Yash R Shah Daksh Ahluwalia Mihir Prakash Shah Saurabh chandan Neil R sharma Shyam Thakkar Department of Internal Medicine University of Missouri-ColumbiaColumbiaMO 65212United States Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Division of Gastroenterology and Hepatology University of MissouriColumbiaMO 65212United States Department of Rheumatology Medical College of GeorgiaAugusta UniversityNorth AugustaGA 30912United States Department of Internal Medicine John H.Stroger Hospital of Cook CountyChicagoIL 60612United States Department of Internal Medicine The University of ToledoToledoOH 43606United States Division of Gastroenterology and Hepatology East Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Internal Medicine Sinai HospitalBaltimoreMD 21215United States Department of Internal Medicine Trinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Division of Gastroenterology and Hepatology Creighton University School of MedicineOmahaNE 68131United States Division of Interventional Oncology&Surgical Endoscopy GI Oncology Tumor Site TeamParkview Cancer InstituteParkview HealthFort WayneIN 46845United States Section of Gastroenterology&Hepatology West Virginia University School of MedicineMorgantownWV 26505United States

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is an essential therapeutic tool for biliary and pancreatic *** and elderly patients,especially those aged≥90 years are generally considered a higher-risk population for ERCP-related *** To investigate outcomes of ERCP in the Non-agenarian population(≥90 years)concerning *** This is a cohort study using the 2018-2020 National Readmission *** aged≥90 were identified who underwent ERCP,using the international classification of diseases-10 code with clinical *** Hopkins’s adjusted clinical groups frailty indicator was used to classify patients as frail and *** primary outcome was mortality,and the secondary outcomes were morbidity and the 30 d readmission rate related to *** used univariate and multivariate regression models for *** A total of 9448 patients were admitted for any indications of *** and non-frail patients were 3445(36.46%)and 6003(63.53%)*** for ERCP were Choledocholithiasis(74.84%),Biliary pancreatitis(9.19%),Pancreatico-biliary cancer(7.6%),Biliary stricture(4.84%),and Cholangitis(1.51%).Mortality rates were higher in frail group[adjusted odds ratio(aOR)=1.68,P=0.02].The Intra-procedural complications were insigni-ficant between the two groups which included bleeding(aOR=0.72,P=0.67),accidental punctures/lacerations(aOR=0.77,P=0.5),and mechanical ventilation rates(aOR=1.19,P=0.6).Post-ERCP complication rate was similar for bleeding(aOR=0.72,P=0.41)and post-ERCP pancreatitis(aOR=1.4,P=0.44).Frail patients had a longer length of stay(6.7 d vs 5.5 d)and higher mean total charges of hospitalization($78807 vs$71392)compared to controls(P<0.001).The 30 d all-cause readmission rates between frail and non-frail patients were similar(P=0.96).CONCLUSION There was a significantly higher mortality risk and healthcare burden amongst nonagenarian frail patients undergoing ERCP compared

关键词： Endoscopic retrograde cholangiopancreatography Nonagenarians Frailty Mortality Healthcare burden

Recent advances in imaging techniques of renal masses

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World Journal of Radiology 2022年第6期14卷 137-150页

作者： Ankita Aggarwal chandan J Das Sanjay sharma Department of Radiology Vardhman Mahavir Medical College&Safdarjung HospitalDelhi 110029India Chandan Department of Radiodiagnosis and Interventional Radiology All India Institute of Medical SciencesDelhi 110029India Department of Radiology(RPC) All India Institute of Medical SciencesNew Delhi 110029India

Multiphasic multidetector computed tomography(CT)forms the mainstay for the characterization of renal masses whereas magnetic resonance imaging(MRI)acts as a problem-solving tool in some ***,a few of the renal masses remain indeterminate even after evaluation by conventional imaging *** overcome the deficiency in current imaging techniques,advanced imaging methods have been devised and are being *** review will cover the role of contrast-enhanced ultrasonography,shear wave elastography,dual-energy CT,perfusion CT,MR perfusion,diffusion-weighted MRI,blood oxygen leveldependent MRI,MR spectroscopy,positron emission tomography(PET)/prostate-specific membrane antigen-PET in the characterization of renal masses.

关键词： Advanced imaging techniques Renal mass Contrast-enhanced ultrasonography renal Shear wave elastography

Acute pancreatitis in liver transplant hospitalizations:Identifying national trends,clinical outcomes and healthcare burden in the United States

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World Journal of Hepatology 2023年第6期15卷 797-812页

作者： Dushyant Singh Dahiya Vinay Jahagirdar Saurabh chandan Manesh Kumar Gangwani Nooraldin Merza Hassam Ali Smit Deliwala Muhammad Aziz Daryl Ramai Bhanu Siva Mohan Pinnam Jay Bapaye Chin-I Cheng Sumant Inamdar Neil R sharma Mohammad Al-Haddad Department of Internal Medicine Central Michigan University College of MedicineSaginawMI 48601United States Department of Internal Medicine University of Missouri-Kansas CityKansas CityMO 64110United States Division of Gastroenterology and Hepatology CHI Creighton University Medical CenterOmahaNE 68131United States Department of Internal Medicine The University of ToledoToledoOH 43606United States Department of Internal Medicine East Carolina UniversityGreenvilleNC 27858United States Division of Digestive Diseases Emory University School of MedicineAtlantaGA 30322United States Division of Gastroenterology and Hepatology The University of ToledoToledoOH 43606United States Division of Gastroenterology and Hepatology The University of Utah School of MedicineSalt Lake CityUT 84112United States Department of Internal Medicine John H.Stroger Hospital of Cook CountyChicagoIL 60612United States Department of Internal Medicine Rochester General HospitalRochesterNY 14621United States Department of Statistics Actuarial and Data ScienceCentral Michigan UniversityMt.PleasantMI 48859United States Division of Gastroenterology and Hepatology University of Arkansas for Medical SciencesLittle RockAR 72205United States Interventional Oncology and Surgical Endoscopy Programs Parkview Cancer InstituteFort WayneIN 46845United States Division of Gastroenterology and Hepatology Indiana University School of MedicineIndianapolisIN 46202United States

BACKGROUND Acute pancreatitis(AP)in liver transplant(LT)recipients may lead to poor clinical outcomes and development of severe *** We aimed to assess national trends,clinical outcomes,and the healthcare burden of LT hospitalizations with AP in the United States(US).METHODS The National Inpatient Sample was utilized to identify all adult(≥18 years old)LT hospitalizations with AP in the US from 2007–***-LT AP hospitalizations served as controls for comparative *** trends of hospitalization characteristics,clinical outcomes,complications,and healthcare burden for LT hospitalizations with AP were *** characteristics,clinical outcomes,complications,and healthcare burden were also compared between the LT and non-LT ***,predictors of inpatient mortality for LT hospitalizations with AP were *** P values≤0.05 were considered statistically *** The total number of LT hospitalizations with AP increased from 305 in 2007 to 610 in *** was a rising trend of Hispanic(16.5%in 2007 to 21.1%in 2018,P-trend=0.0009)and Asian(4.3%in 2007 to 7.4%in 2019,p-trend=0.0002)LT hospitalizations with AP,while a decline was noted for Blacks(11%in 2007 to 8.3%in 2019,P-trend=0.0004).Furthermore,LT hospitalizations with AP had an increasing comorbidity burden as the Charlson Comorbidity Index(CCI)score≥3 increased from 41.64%in 2007 to 62.30%in 2019(P-trend<0.0001).We did not find statistically significant trends in inpatient mortality,mean length of stay(LOS),and mean total healthcare charge(THC)for LT hospitalizations with AP despite rising trends of complications such as sepsis,acute kidney failure(AKF),acute respiratory failure(ARF),abdominal abscesses,portal vein thrombosis(PVT),and venous thromboembolism(VTE).Between 2007–2019,6863 LT hospitalizations with AP were compared to 5649980 non-LT AP *** hospitalizations with AP were slightly older(53.5 vs 52.6 years,P=0.017)and

关键词： Liver transplantation Pancreatitis Mortality Cost Length of stay

Assay method for quality control and stability studies of a new antimalarial agent (CDRI 99/411)

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Journal of Pharmaceutical Analysis 2013年第5期3卷 335-340页

作者： Kiran Khandelwal Shakti Deep Pachauri Sofa Zaidi Pankaj Dwivedi Ashok Kumar sharma chandan Singh Anil Kumar Dwivedi Division of Pharmaceutics CSIR-Central Drug Research Institute Division of Medicinal and Process Chemistry CSIR-Central Drug Research Institute

CDRI compound no. 99/411 is a potent 1,2,4-trioxane antimalarial candidate drug under development at our Institute. An HPLC method for determination of CDRI 99/411 with its starting material and intermediates has been developed and validated for in process quality control and stability studies. The analytical performance parameters such as linearity, precision, accuracy, specificity, limit of detection （LOD） and lower limit of quantification （LLOQ） were determined according to International Conference on Harmonization ICH Q2（R1） guidelines. HPLC separation was achieved on a RP-select B Lichrosphere~ column （250 mm x 4 ram, 5 lam, Merck） using water containing 0.1% glacial acetic acid and acetonitrile as the mobile phase in a gradient elution. The eluents were monitored by a photo diode array detector at 245 and 275 nm. Based on signal to noise ratio of 3 and 10 the LOD of CDRI 99/411 was 0.55 μg/mL, while the LLOQ was 1.05 μg/mL. The calibration curves were linear in the range of 1.05- 68 μg/mL. Precision of the method was determined by inter- and intra-assay variations within the acceptable range.

关键词： HPLC Trioxane Process quality control Stability

Diffusion weighted imaging: Technique and applications

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World Journal of Radiology 2016年第9期8卷 785-798页

作者： Vinit Baliyan chandan J Das Raju sharma Arun Kumar Gupta Department of Radiology All India Institute of Medical Sciences

Diffusion weighted imaging(DWI) is a method of signal contrast generation based on the differences in Brownian motion. DWI is a method to evaluate the molecular function and micro-architecture of the human body. DWI signal contrast can be quantified by apparent diffusion coefficient maps and it acts as a tool for treatment respon-se evaluation and assessment of disease progression. Ability to detect and quantify the anisotropy of diffusion leads to a new paradigm called diffusion tensor imaging(DTI). DTI is a tool for assessment of the organs with highly organised fibre structure. DWI forms an integral part of modern state-of-art magnetic resonance imaging and is indispensable in neuroimaging and oncology. DWI is a field that has been undergoing rapid technical evolution and its applications are increasing every day. This review article provides insights in to the evolution of DWI as a new imaging paradigm and provides a summary of current role of DWI in various disease processes.

关键词： Diffusion weighted imaging Diffusion tensor imaging Onco-imaging Neuro-imaging

The Synthesis of Gold Nanoparticles Using <i>Amaranthus spinosus</i>Leaf Extract and Study of Their Optical Properties

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Advances in Materials Physics and Chemistry 2012年第4期2卷 275-281页

作者： Ratul Kumar Das Nayanmoni Gogoi Punuri Jayasekhar Babu Pragya sharma chandan Mahanta Utpal Bora Bioengineering Research Laboratory Department of Biotechnology Indian Institute of Technology Guwahati Guwahati India Biotech Hub Centre for the Environment Indian Institute of Technology Guwahati Guwahati India Department of Civil Engineering Indian Institute of Technology Guwahati Guwahati India

We report here the application of a medicinally important plant Amaranthus spinosus for the synthesis of gold nanoparticles (AuNPs). Different concentrations of ethanolic leaf extract of the plant were reacted with aqueous solution of HAuCl4·4H2O under mild reaction conditions. Synthesis of AuNPs was confirmed from the UV-Vis study of surface plasmon resonance property of the colloidal solution. Transmission electron microscopy (TEM) revealed particles as spherical and triangular in shape. X-ray diffraction (XRD) confirmed the crystalline nature of AuNPs with average size of 10.74 nm as determined by Debye-Scherrer’s Equation. Fourier transform infra-red (FT-IR) analysis of leaf extract and lyophilized AuNPs showed the presence of various functional groups present in diverse phytochemicals. Energy dispersive X-ray (EDX) of purified AuNPs confirmed the formation of AuNPs and surface adsorption of biomolecules. We further investigated the toxicity of the synthesized AuNPs and found non toxic to the cancer cell lines and could be used for biomedical applications.

关键词： Gold Nanoparticles Leaf Extract Anti-Oxidant Amaranthus spinosus Crystal Growth

The keystone-design perforator-based flap for leg defects: a synthesis of philosophies

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Plastic and Aesthetic Research 2014年第1期1卷 70-74页

作者： Jerry R.John Jyoshid R.Balan Satyaswarup Tripathy Ramesh Kumar sharma chandan Jadhav Department of Plastic Surgery Post Graduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India Department of Plastic Surgery Sushruta Institute of Plastic SurgeryElite HospitalsThrissur 680007KeralaIndia.

Aim:The classical keystone-design flap,although elegantly employed for various trunk defects,has limited movement on the *** study aims to modify the keystone–design flaps for leg ***:A keystone-design flap,in which perforators are identified and dissected,is described specifically for elliptical defects overlying the ***:It retains the unique advantages of both the perforator island flap concept as well as the keystone-design ***:The technique as well as the possibilities of raising such flaps over various areas of the leg is outlined.

关键词： Flap keystone leg defect lower extremity reconstruction perforator island flap

非发酵乳清荔枝保健饮品的开发和贮存稳定性(摘选)

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农业工程 2012年第5期2卷 76-78页

作者： Vishal Kumar P D sharma chandan Kumar Man Mohan Deo 拉金德拉农业大学加工与食品工程学院

利用乳清和荔枝汁生产乳清荔枝保健饮品并分析了其理化特性和耐贮性。根据初步试验确定了4个指标,分别为糖5%和7.5%、荔枝果肉6%和8%、果胶0.7%,将产品在(7±1)℃下贮藏35d,期间每7d测定一次理化性质、微生物和感官品质。试验结果表明,... 详细信息

利用乳清和荔枝汁生产乳清荔枝保健饮品并分析了其理化特性和耐贮性。根据初步试验确定了4个指标,分别为糖5%和7.5%、荔枝果肉6%和8%、果胶0.7%,将产品在(7±1)℃下贮藏35d,期间每7d测定一次理化性质、微生物和感官品质。试验结果表明,贮藏期间可溶性固形物、总酸度、还原糖和总糖含量增加,pH值和总固体量降低,而脂肪和蛋白质含量没有改变。水活度低于0.80,细菌数小于30000cfumL,均在食品安全可接受的范围内。所有样品在贮藏35d后接受感官评定,其中5%糖、8%果肉的处理组合感官得分最高。

关键词：乳清储存理化性质微生物特性感官

Perfusion computed tomography in renal cell carcinoma

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World Journal of Radiology 2015年第7期7卷 170-179页

作者： chandan J Das Usha Thingujam Ananya Panda Sanjay sharma Arun Kumar Gupta Department of Radiology All India Institute of Medical Sciences

Various imaging modalities are available for the diagnosis, staging and response evaluation of patients with renal cell carcinoma(RCC). While contrast enhanced computed tomography(CT) is used as the standard of imaging for size, morphological evaluation and response assessment in RCC, a new functional imaging technique like perfusion CT(p CT), goes down to the molecular level and provides new perspectives in imaging of RCC. p CT depicts regional tumor perfusion and vascular permeability which are indirect parameters of tumor angiogenesis and thereby provides vital information regarding tumor microenvironment. Also response evaluation using p CT may predate the size criteria used in Response Evaluation Criteria in Solid Tumors, as changes in the perfusion occurs earlier following tissue kinase inhibitors before any actual change in size. This may potentially help in predicting prognosis, better selection of therapy and more accurate and better response evaluation in patients with RCC. This article describes the techniques and role of p CT in staging and response assessment in patients with RCCs.

关键词： Angiogenesis Anti-angiogenic therapy Perfusion computed tomography Renal cell carcinoma