Acute pancreatitis in liver transplant hospitalizations:Identifying national trends,clinical outcomes and healthcare burden in the United States

作     者：Dushyant Singh Dahiya Vinay Jahagirdar Saurabh Chandan Manesh Kumar Gangwani Nooraldin Merza Hassam Ali Smit Deliwala Muhammad Aziz Daryl Ramai Bhanu Siva Mohan Pinnam Jay Bapaye Chin-I Cheng Sumant Inamdar Neil R Sharma Mohammad Al-Haddad 

作者机构：Department of Internal MedicineCentral Michigan University College of MedicineSaginawMI 48601United States Department of Internal MedicineUniversity of Missouri-Kansas CityKansas CityMO 64110United States Division of Gastroenterology and HepatologyCHI Creighton University Medical CenterOmahaNE 68131United States Department of Internal MedicineThe University of ToledoToledoOH 43606United States Department of Internal MedicineEast Carolina UniversityGreenvilleNC 27858United States Division of Digestive DiseasesEmory University School of MedicineAtlantaGA 30322United States Division of Gastroenterology and HepatologyThe University of ToledoToledoOH 43606United States Division of Gastroenterology and HepatologyThe University of Utah School of MedicineSalt Lake CityUT 84112United States Department of Internal MedicineJohn H.Stroger Hospital of Cook CountyChicagoIL 60612United States Department of Internal MedicineRochester General HospitalRochesterNY 14621United States Department of StatisticsActuarial and Data ScienceCentral Michigan UniversityMt.PleasantMI 48859United States Division of Gastroenterology and HepatologyUniversity of Arkansas for Medical SciencesLittle RockAR 72205United States Interventional Oncology and Surgical Endoscopy ProgramsParkview Cancer InstituteFort WayneIN 46845United States Division of Gastroenterology and HepatologyIndiana University School of MedicineIndianapolisIN 46202United States 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2023年第15卷第6期

页      面：797-812页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Liver transplantation Pancreatitis Mortality Cost Length of stay 

摘      要：BACKGROUND Acute pancreatitis(AP)in liver transplant(LT)recipients may lead to poor clinical outcomes and development of severe *** We aimed to assess national trends,clinical outcomes,and the healthcare burden of LT hospitalizations with AP in the United States(US).METHODS The National Inpatient Sample was utilized to identify all adult(≥18 years old)LT hospitalizations with AP in the US from 2007–***-LT AP hospitalizations served as controls for comparative *** trends of hospitalization characteristics,clinical outcomes,complications,and healthcare burden for LT hospitalizations with AP were *** characteristics,clinical outcomes,complications,and healthcare burden were also compared between the LT and non-LT ***,predictors of inpatient mortality for LT hospitalizations with AP were *** P values≤0.05 were considered statistically *** The total number of LT hospitalizations with AP increased from 305 in 2007 to 610 in *** was a rising trend of Hispanic(16.5%in 2007 to 21.1%in 2018,P-trend=0.0009)and Asian(4.3%in 2007 to 7.4%in 2019,p-trend=0.0002)LT hospitalizations with AP,while a decline was noted for Blacks(11%in 2007 to 8.3%in 2019,P-trend=0.0004).Furthermore,LT hospitalizations with AP had an increasing comorbidity burden as the Charlson Comorbidity Index(CCI)score≥3 increased from 41.64%in 2007 to 62.30%in 2019(P-trend0.0001).We did not find statistically significant trends in inpatient mortality,mean length of stay(LOS),and mean total healthcare charge(THC)for LT hospitalizations with AP despite rising trends of complications such as sepsis,acute kidney failure(AKF),acute respiratory failure(ARF),abdominal abscesses,portal vein thrombosis(PVT),and venous thromboembolism(VTE).Between 2007–2019,6863 LT hospitalizations with AP were compared to 5649980 non-LT AP *** hospitalizations with AP were slightly older(53.5 vs 52.6 years,P=0.017)and