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Tracking Source Variations of Inhalation Cancer Risks and Ozone Formation Potential in Hong Kong over Two Decades(2000−2020)Using Toxic Air Pollutant Monitoring Data

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Environment & Health 2024年第6期2卷 411-421页

作者： Yee Ka Wong Wai Wai chan Dasa Gu Jian Zhen Yu Alexis K.H.Lau Division of Environment and Sustainability The Hong Kong University of Science and TechnologyKowloonHong Kong 000000China Institute for the Environment The Hong Kong University of Science and TechnologyKowloonHong Kong 000000China Institute for the Environment and Department of Chemistry The Hong Kong University of Science and TechnologyKowloonHong Kong 000000China Institute for the Environment and Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyKowloonHong Kong 000000China

Toxic air pollutants(TAPs)are a class of airborne chemicals known or suspected to cause serious health *** study,applying positive matrix factorization and inhalation unit risk estimates of TAPs,quantifies the changes in significant sources contributing to inhalation cancer risks(ICRs)from 2000 to 2020 in Hong Kong,*** ICR decreased from 1701 to 451 cases per million between 2000−2004 and 2016−2020,largely attributed to the reduction in diesel particulate matter(DPM),gasoline and solvent use-related volatile organic compounds(VOCs),and coal/biomass combustion-related polycyclic aromatic hydrocarbons and metal(loid)*** regional contribution of VOCs associated with industrial and halogenated solvent sources increased substantially,representing the largest non-DPM ICR contributor(37%)in 2016−2020,stressing the need for a more comprehensive risk evaluation across the fast-growing and densely populated Greater Bay Area(GBA).ICRs in Hong Kong and the GBA will likely remain over 100 cases per million by *** contributions to ozone formation potential of VOC/carbonyl sources were quantified,which show a notable shift from being solvent/gasoline-dominant in 2000−2004 to being more evenly shared by various sources in 2016−*** a similar TAP monitoring network in the GBA is anticipated to provide the monitoring data needed to facilitate the development of more informed air quality management strategies.

关键词： toxic air pollutant hazardous air pollutant health risk assessment source apportionment ozone formation potential air quality management

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Absence of enhancement in a lesion does not preclude primary central nervous system T-cell lymphoma:A case report

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World Journal of Clinical Cases 2024年第2期12卷 374-382页

作者： chan-Seop Kim Chi-Hoon Choi Kyung Sik Yi Yook Kim Jisun Lee chang Gok Woo Young Hun Jeon Department of Radiology Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644Chungcheongbuk-doSouth Korea Department of Pathology Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644Chungcheongbuk-doSouth Korea Department of Radiology Seoul National University HosptialSeoul 03080South Korea

BACKGROUND Primary central nervous system lymphoma(PCNSL)is a non-Hodgkin lymphoma that originates in the central nervous system(CNS)and is exclusively limited to the *** most PCNSLs are diffuse large B-cell lymphomas,primary CNS T-cell lymphomas(PCNSTLs)are *** typically demonstrate some degree of enhancement on contrast-enhanced magnetic resonance imaging(MRI).To the best of our knowledge,non-enhancing PCNSTL has not been reported *** SUMMARY A 69-year-old male presented to the neurology department with complaints of mild cognitive impairment and gradual onset of left lower leg weakness over a span of two *** MRI showed asymmetric T2-hyperintense lesions within the *** enhancement was observed on the contrast-enhanced T1 *** initial diagnosis was neuro-Behçet’s *** high-dose steroid therapy,no alterations in the lesions were identified on initial *** patient’s symptoms deteriorated *** MRI performed one month after the initial scan revealed an increased lesion ***,brain biopsy confirmed the diagnosis of *** patient underwent definitive combined ***,the patient developed bacteremia and died of septic shock approximately three months after *** The absence of enhancement in the lesion did not rule out PCNSTL.A biopsy approach is advisable for pathological confirmation.

关键词： Central nervous system neoplasms Non-Hodgkin Lymphoma T-cell Lymphoma Primary central nervous system lymphoma Primary central nervous system T-cell lymphoma Case report

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Polysaccharide of Alocasia cucullata Exerts Antitumor Effect by Regulating Bcl-2, Caspase-3 and ERK1/2 Expressions during Long-Time Administration

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Chinese Journal of Integrative Medicine 2024年第1期30卷 52-61页

作者： ZHOU Qi-chun XIAO Shi-lin LIN Ru-kun LI chan CHEN Zhi-jie CHEN Yi-fei LUO Chao-hua MO Zhi-xian LIN Ying-bo School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou(510515)China Clinical and Basic Research Team of TCM Prevention and Treatment of Non-Small Cell Lung Cancer the Second Clinical College of Guangzhou University of Chinese MedicineGuangzhou(510120)China Department of Chinese Medicine Zhujiang Hospital Affiliated to Southern Medical UniversityGuangzhou(510282)China Department of Pharmacy Jiangmen Central HospitalJiangmen(529000)China

Objective: To study the in vitro and in vivo antitumor effects of the polysaccharide of Alocasia cucullata(PAC) and the underlying mechanism. Methods: B16F10 and 4T1 cells were cultured with PAC of 40 μg/m L, and PAC was withdrawn after 40 days of administration. The cell viability was detected by cell counting kit-8. The expression of Bcl-2 and Caspase-3 proteins were detected by Western blot and the expressions of ERK1/2 mRNA were detected by quantitative real-time polymerase chain reaction(qRT-PCR). A mouse melanoma model was established to study the effect of PAC during long-time administration. Mice were divided into 3 treatment groups: control group treated with normal saline, positive control group(LNT group) treated with lentinan at 100 mg/(kg·d), and PAC group treated with PAC at 120 mg/(kg·d). The pathological changes of tumor tissues were observed by hematoxylin-eosin staining. The cell apoptosis of tumor tissues was detected by TUNEL staining. Bcl-2 and Caspase-3 protein expressions were detected by immunohistochemistry, and the expressions of ERK1/2, JNK1 and p38 mRNA were detected by qRT-PCR. Results: In vitro, no strong inhibitory effects of PAC were found in various tumor cells after 48 or 72 h of administration. Interestingly however, after 40 days of cultivation under PAC, an inhibitory effect on B16F10 cells was found. Correspondingly, the long-time administration of PAC led to downregulation of Bcl-2 protein(P <0.05), up-regulation of Caspase-3 protein(P<0.05) and ERK1 mRNA(P<0.05) in B16F10 cells. The above results were verified by in vivo experiments. In addition, viability of B16F10 cells under long-time administration culture in vitro decreased after drug withdrawal, and similar results were also observed in 4T1 cells. Conclusions: Long-time administration of PAC can significantly inhibit viability and promote apoptosis of tumor cells, and had obvious antitumor effect in tumor-bearing mice.

关键词： polysaccharide of Alocasia cucullata tumor cells Bcl-2 Caspase-3 ERK1/2 Chinese medicine

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A converged ubiquitin-proteasome pathway for the degradation of TOC and TOM tail-anchored receptors

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Journal of Integrative Plant Biology 2024年第5期66卷 1007-1023页

作者： Meijing Yang Shuai Chen Shey-Li Lim Lang Yang Jia Yi Zhong Koon Chuen chan Zhizhu Zhao Kam-Bo Wong Junqi Wang Boon Leong Lim School of Biological Sciences University of Hong KongPokfulam 999077Hong KongChina Department of Biology Southern University of Science and TechnologyShenzhen 518055China School of Biomedical Engineering Shenzhen UniversityShenzhen 518060China School of Life Sciences The Chinese Universityof Hong KongShatin 999077HongKongChina State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongShatin 999077Hong KongChina HKU Shenzhen Institute of Research and Innovation Shenzhen 518052China

In plants,thousands of nucleus-encoded proteins translated in the cytosol are sorted to chloroplasts and mitochondria by binding to specific receptors of the TOC(translocon on the outer chloroplast membrane)and the TOM(translocon on the outer mitochondrial membrane)complexes for import into those *** degradation pathways for these receptors are ***,we discovered a converged ubiquitin-proteasome pathway for the degradation of Arabidopsis thaliana TOC and TOM tail-anchored *** receptors are ubiquitinated by E3 ligase(s)and pulled from the outer membranes by the AAA+adenosine triphosphatase CDC48,after which a previously uncharacterized cytosolic protein,transmembrane domain(TMD)-binding protein for tail-anchored outer membrane proteins(TTOP),binds to the exposed TMDs at the C termini of the receptors and CDC48,and delivers these complexes to the 26S proteasome.

关键词： 26S proteasome CDC48 SP1 TOC TOM ubiquitination

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Predictive Ability of Hypertriglyceridemic Waist,Hypertriglyceridemic Waist-to-Height Ratio,and Waist-to-Hip Ratio for Cardiometabolic Risk Factors Clustering Screening among Chinese Children and Adolescents

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Biomedical and Environmental Sciences 2024年第3期37卷 233-241页

作者： XIAO Tian Li YUAN Shu Qian GAO Jing Yu Julien SBaker YANG Yi De WANG Xi Jie ZHENG chan Juan DONG Yan Hui ZOU Zhi Yong Key Laboratory of Molecular Epidemiology of Hunan Province School of MedicineHunan Normal UniversityChangsha 410081HunanChina The Institute of Interdisciplinary Studies Hunan Normal UniversityChangsha 410013HunanChina Chenzhou First People's Hospital Chenzhou 423000HunanChina Centre for Health and Exercise Science Research Hong Kong Baptist UniversityKowloon TongHong Kong 999077China Department of Sport Physical Education and HealthHong Kong Baptist UniversityKowloon TongHong Kong 999077China Vanke School of Public Health Tsinghua UniversityBeijing 100084China Institute of Child and Adolescent Health School of Public HealthPeking University Health Science CenterBeijing 100191China

Objective Hypertriglyceridemic waist(HW),hypertriglyceridemic waist-to-height ratio(HWHtR),and waist-to-hip ratio(WHR)have been shown to be indicators of cardiometabolic risk ***,it is not clear which indicator is more suitable for children and *** aimed to investigate the relationship between HW,HWHtR,WHR,and cardiovascular risk factors clustering to determine the best screening tools for cardiometabolic risk in children and *** This was a national cross-sectional *** and biochemical variables were assessed in approximately 70,000 participants aged 6–18 years from seven provinces in ***,physical activity,dietary intake,and family history of chronic diseases were obtained through ***,χ2 and logistic regression analysis was *** A significant sex difference was observed for HWHtR and WHR,but not for HW *** risk of cardiometabolic health risk factor clustering with HW phenotype or the HWHtR phenotype was significantly higher than that with the non-HW or non-HWHtR phenotypes among children and adolescents(HW:OR=12.22,95%CI:9.54-15.67;HWHtR:OR=9.70,95%CI:6.93-13.58).Compared with the HW and HWHtR phenotypes,the association between risk of cardiometabolic health risk factors(CHRF)clustering and high WHR was much weaker and not significant(WHR:OR=1.14,95%CI:0.97-1.34).Conclusion Compared with HWHtR and WHR,the HW phenotype is a more convenient indicator with higher applicability to screen children and adolescents for cardiovascular risk factors.

关键词： Hypertriglyceridemic waist Waist-to-hip ratio Children and adolescents China Hypertriglyceridemic waist-to-height ratio Cardiovascular risk factors

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陈白一工笔画的时代转向

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美术 2024年第8期 48-51,2页

作者：孙婵湖南美术馆

当代工笔画名家陈白一,长期致力于工笔画的艺术创新与题材开拓,努力融合人民情感、时代事件与工笔技法。20世纪50年代以来,他系统地继承了中国传统的工笔画技法,用传统绘画形式来描绘时代事件,创作了《朝鲜少年崔莹会见罗盛教双亲》《... 详细信息

当代工笔画名家陈白一,长期致力于工笔画的艺术创新与题材开拓,努力融合人民情感、时代事件与工笔技法。20世纪50年代以来,他系统地继承了中国传统的工笔画技法,用传统绘画形式来描绘时代事件,创作了《朝鲜少年崔莹会见罗盛教双亲》《共产主义战士欧阳海》《考古新发现》等优秀作品。80年代开始,陈白一的创作有了新的转向,不仅关注人民情,而且融入生活味,画面刻画了大量湘西少数民族的细节与情韵,生动展现出中华民族生命气质的独特面相。

关键词：陈白一工笔画新年画湖南美术

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Neighboring effect in single-atom catalysts for the electrochemical carbon dioxide reduction reaction

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eScience 2024年第1期4卷 1-16页

作者： Hon Ho Wong Mingzi Sun Tong Wu Cheuk Hei chan Lu Lu Qiuyang Lu Baian Chen Bolong Huang Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARChina Research Centre for Carbon-Strategic Catalysis The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARChina

Although single-atom catalysts(SACs)have attracted enormous attention for their applications in the electrochemical reduction of CO_(2)(CO_(2)RR)due to their extraordinary catalytic activity and well-defined active centers,neighboring effects and their influence on the electrochemical performance of SACs have not been well *** this review,we present a summary of the neighboring effects on SACs for the CO_(2)RR process,where the surrounding atoms not only induce electronic modulation of the metal atom but also participate in the CO_(2)*** theoretical and experimental studies have pointed out that the neighboring sites of the anchored metal center can provide second active/adsorption locations during the catalytic process,enhancing CO_(2)RR performance *** review supplies advanced insights into the significant roles and impacts of neighboring effects on the catalytic process,which also benefit the development of advanced SACs to achieve efficient electrocatalysis.

关键词： Carbon dioxide reduction Neighboring effect Atomic catalysts Electronic modulations Active sites

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Circadian rhythm dysfunction and psychopathology in the offspring of parents with bipolar disorder:a highrisk study in the Chinese population

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General Psychiatry 2024年第3期37卷 388-400页

作者： Binbin Lei Hongliang Feng Lulu Yang Jing Wang Jie Chen Weidong Song Chao Jiang Kun Zhang Qunfeng Wang Jessie Chi Ching Tsang Ngan Yin chan Yaping Liu Joey W.Y.chan Jiyang Pan Bin Zhang Tao Li Kathleen Ries Merikangas Jihui Zhang Yun Kwok Wing Guangdong Cardiovascular Institute Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdongChina Guangdong Mental Health Center Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdongChina Li Chiu Kong Family Sleep Assessment Unit Department of PsychiatryFaculty of MedicineThe Chinese University of Hong KongHong KongChina Center for Sleep and Circadian Medicine The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Psychiatry Faculty of MedicineThe Chinese University of Hong KongNew TerritoriesHong KongChina Key Laboratory of Neurogenetics and channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou Medical UniversityGuangzhouGuangdongChina Shenzhen Nanshan Center for Chronic Diseases Control(Shenzhen Nanshan Mental Health Center) ShenzhenChina Department of Clinical Psychology Shenzhen Fuyong People's HospitalShenzhenChina Department of Mental Illness Prevention and Treatment Shenzhen Longgang Center for Chronic Diseases ControlShenzhenChina Department of Neurology Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina Sleep Medical Center The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdongChina Department of Psychiatry Nanfang HospitalSouthern Medical UniversityGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired IntelligenceGuangzhouGuangdongChina Department of Neurobiology Affiliated Mental Health Center&Hangzhou Seventh People's HospitalZhejiang University School of MedicineHangzhouZhejiangChina Genetic Epidemiology Research Branch Intramural Research ProgramNational Institute of Mental HealthBethesdaMarylandUSA

Background Understanding the evolution of circadian rhythm dysfunction and psychopathology in the high-risk population has important implications for the prevention of bipolar ***,some of the previous studies on the emergence of psychopathologies and circadian dysfunction among high-risk populations were inconsistent and *** To examine the prevalence rates of sleep and circadian dysfunctions,mental disorders and their symptoms in the offspring of parents with(O-BD)and without bipolar disorder(O-control).Methods The study included 191 O-BD and 202 O-control subjects aged 6-21 years from the Greater Bay Area,*** diagnoses and symptoms of sleep/circadian rhythm and mental disorders were assessed by the Diagnostic Interview for Sleep Patterns and Disorders,and the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version,*** estimating equations and shared frailty proportional hazards models of survival analysis were applied to compare the outcomes in the *** Adjusting for age,sex and region of recruitment,there was a significantly higher risk of delayed sleep phase symptoms(9.55%vs 2.58%,adjusted OR:4.04)in O-BD than in O-control.O-BD had a nearly fivefold higher risk of mood disorders(11.70%vs 3.47%,adjusted OR:4.68)and social anxiety(6.28%vs 1.49%,adjusted OR:4.70),a fourfold higher risk of depressive disorders(11.17%vs 3.47%,adjusted OR:3.99)and a threefold higher risk of mood symptoms(20.74%vs 10.40%,adjusted OR:2.59)than *** analysis revealed that O-BD children(aged under 12 years)had a nearly 2-fold higher risk of any mental and behavioural symptoms than O-control,while there was a nearly 4-fold higher risk of delayed sleep phase symptoms,a 7.5-fold higher risk of social anxiety and a 3-fold higher risk of mood symptoms in O-BD adolescents(aged 12 years and over).Conclusions There was an increase in delayed sleep phase symptoms in O-BD

关键词： prevention dysfunction bipolar

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Comparing 11 early warning scores and three shock indices in early sepsis prediction in the emergency department

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World Journal of Emergency Medicine 2024年第4期15卷 273-282页

作者： Rex Pui Kin Lam Zonglin Dai Eric Ho Yin Lau Carrie Yuen Ting Ip Ho Ching chan Lingyun Zhao Tat ChiTsang Matthew Sik Hon Tsui Timothy Hudson Rainer Department of Emergency Medicine School of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina

BACKGROUND:This study aimed to evaluate the discriminatory performance of 11 vital sign-based early warning scores(EWSs)and three shock indices in early sepsis prediction in the emergency department(ED).METHODS:We performed a retrospective study on consecutive adult patients with an infection over 3 months in a public ED in Hong *** primary outcome was sepsis(Sepsis-3 definition)within 48 h of ED *** c-statistics and the DeLong test,we compared 11 EWSs,including the National Early Warning Score 2(NEWS2),Modified Early Warning Score,and Worthing Physiological Scoring System(WPS),etc.,and three shock indices(the shock index[SI],modified shock index[MSI],and diastolic shock index[DSI]),with Systemic Inflammatory Response Syndrome(SIRS)and quick Sequential Organ Failure Assessment(qSOFA)in predicting the primary outcome,intensive care unit admission,and mortality at different time ***:We analyzed 601 patients,of whom 166(27.6%)developed ***2 had the highest point estimate(area under the receiver operating characteristic curve[AUROC]0.75,95%CI 0.70-0.79)and was significantly better than SIRS,qSOFA,other EWSs and shock indices,except WPS,at predicting the primary ***,the pooled sensitivity and specificity of NEWS2≥5 for the prediction of sepsis were 0.45(95%CI 0.37-0.52)and 0.88(95%CI 0.85-0.91),*** discriminatory performance of all EWSs and shock indices declined when used to predict mortality at a more remote time ***:NEWS2 compared favorably with other EWSs and shock indices in early sepsis prediction but its low sensitivity at the usual cut-off point requires further modification for sepsis screening.

关键词： Sepsis Emergency department Clinical prediction rule Early warning score Shock index

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Preparation of multicolor carbon dots with thermally turn-on fluorescence for multidimensional information encryption

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Chinese Chemical Letters 2024年第1期35卷 343-347页

作者： chan Wang Jianfeng Huang Yimin He Guoxia Ran Qijun Song Key Laboratory of Synthetic and Biological Colloids Ministry of EducationInternational Joint Research Center for Photoresponsive Molecules and MaterialsSchool of Chemical&Material EngineeringJiangnan UniversityWuxi 214122China Department of Radiation Oncology Affiliated Hospital of Jiangnan UniversityWuxi 214122China

Carbon dots(CDs)with superior fluorescence properties have attracted a growing number of research interests in ***,the preparation of CDs with thermally turn-on fluorescence and full-color-emitting in visible spectrum is still a big challenge due to the complicated reaction mechanism in the formation of ***,a simple precursor-oriented strategy for the preparation of multicolor CDs with heat-stimuli turn-on fluorescence is *** experimental characterizations and theoretical calculations revealed that the emission wavelength of CDs can be readily tuned from 460 nm to 654 nm with selected precursors,which was ascribed to the extent of conjugated sp2-domains(core states)and the amount of oxygen-and nitrogen-containing groups bound to sp2-domains(surface states).After simply mixing two or three kinds of CDs,a full-color range of fluorescence emission was realized,and the CDs-based fluorescence inks were successfully ***,all the printed patterns from the inkjet exhibited a thermal-induced enhancement in *** this basis,combining CDs with heating-induced“turn-off”fluorescence materials can lead to multidimensional and multistage *** results demonstrate that the thermochromic and photochromic CDs with much more enhanced security exhibit promising application in data storage and encryption.

关键词： Carbon dots Precursor-oriented structure Full-color fluorescence Turn-on thermosensitivity Advanced anti-counterfeiting

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