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The KDM4B–CCAR1–MED1 axis is a critical regulator of osteoclast differentiation and bone homeostasis

Bone Research 2021年第3期9卷 323-335页

作者： Sun-Ju Yi You-Jee Jang hye-Jung Kim Kyubin Lee hyerim Lee Yeojin Kim Junil Kim Seon young hwang Jin Sook Song hitoshi Okada Jae-Il Park Kyuho Kang Kyunghwan Kim Department of Biological Sciences and Biotechnology Chungbuk National UniversityCheongjuChungbukRepublic of Korea Korea Basic Science Institute Gwangju Center at Chonnam National UniversityGwangjuRepublic of Korea New Drug Development Center KBIO Osong Medical Innovation FoundationCheongjuChungbukRepublic of Korea Data Convergence Drug Research Center Therapeutics&Biotechnology DivisionKorea Research Institute of Chemical TechnologyDaejeonRepublic of Korea Department of Biochemistry Kindai University Faculty of MedicineOsakasayamaOsakaJapan

Bone undergoes a constant and continuous remodeling process that is tightly regulated by the coordinated and sequential actions of bone-resorbing osteoclasts and bone-forming *** studies have shown that histone demethylases are implicated in osteoblastogenesis;however,little is known about the role of histone demethylases in osteoclast ***,we identified KDM4B as an epigenetic regulator of osteoclast *** of KDM4B significantly blocked the formation of tartrate-resistant acid phosphatase-positive multinucleated *** with myeloid-specific conditional knockout of KDM4B showed an osteopetrotic phenotype due to osteoclast *** analysis revealed that KDM4B physically and functionally associates with CCAR1 and MED1 in a *** genome-wide chromatin immunoprecipitation(chIP)-sequencing,we revealed that the KDM4B–CCAR1–MED1 complex is localized to the promoters of several osteoclast-related genes upon receptor activator of NF-κB ligand *** demonstrated that the KDM4B–CCAR1–MED1 signaling axis induces changes in chromatin structure(euchromatinization)near the promoters of osteoclast-related genes through h3K9 demethylation,leading to NF-κB p65 recruitment via a direct interaction between KDM4B and ***,small molecule inhibition of KDM4B activity impeded bone loss in an ovariectomized mouse *** together,our findings establish KDM4B as a critical regulator of osteoclastogenesis,providing a potential therapeutic target for osteoporosis.

关键词： formation. critical MED1

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Preparation and characterization of Urea-gypsum by Solid-phase Ball Milling

Preparation and Characterization of Urea-gypsum by Solid-pha...

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2011 IEEE International Conference on Waste Recycling,Ecology and Environment(ICWREE 2011)

作者： Yuequan DENG1 chunfeng XU2* Faqing DONG1 Peng FU1 Jianghong hE1 1 School of Material and Engineering Southwest University of Science and Technology Mianyang china 2 Water Quality Inspection Center Mianyang Water (Group) Co mpany Limited M ianyang ch ina No. 216 changhong Road Mianyang City Sichuan Pro. 621002

Urea-gypsum was prepared by solid-phase ball milling from g ypsum and urea as the material. The technological conditions were optimized by the orthogonal design;the dynamic characteristics of solid phase reaction were studied by Kissinger equation, and the urea-gypsum was characterized by XRD, FTIR, S EM and TG-DSC. The results showed that the optimum technical conditions are as follows: reaction temperature 55 ℃ , reaction time 40 min, ball-feed ratio 6:1, rotational speed 600 r min-1, and in this condition the average conversion of reaction can reach 89.38%;the relationship between the reaction rate constant KK and temperature T can be described by the formula as KK=1.5×109exp[（71.70×103）/RT];urea-gypsum prepared by solid-phase ball milling of platelike structure belongs to triclinic, and the characteristic abs orptions of IR are the stretching vibrations of N-h, C=O, C-N, S-O and deformation vibration of N-h, and the decomposition temperature of urea-gypsum is 200-220 ℃ .This paper provides a preparation for urea-gypsum with high efficiency and energy saving effective, which could improve the nitrogen use efficiency effective, reduce the agricultural nitrogen emission, and increase the crops yield, and this also open up a new technology for large-scale utilization of industrial waste such as phosphog ypsum and desulphogypsum.

关键词： urea-gypsum solid-phase ball milling preparation characterization

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固相微萃取和气相色谱-质谱联用分析罗汉果浸膏的挥发性成分

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新乡医学院学报 2004年第1期21卷 26-28页

作者：董丽王翔新乡医学院化学教研室河南新乡453003 新乡制药股份有限公司河南新乡453002

目的　对罗汉果浸膏的挥发性成分进行分离分析鉴定。方法　采用固相微萃取和气相色谱 -质谱联用技术 ,在固相微萃取实验中使用 85μm聚丙烯酸酯作为萃取纤维 ,并对萃取时间、萃取温度、离子强度、解吸时间等实验条件进行优化 ,应用峰面... 详细信息

目的　对罗汉果浸膏的挥发性成分进行分离分析鉴定。方法　采用固相微萃取和气相色谱 -质谱联用技术 ,在固相微萃取实验中使用 85μm聚丙烯酸酯作为萃取纤维 ,并对萃取时间、萃取温度、离子强度、解吸时间等实验条件进行优化 ,应用峰面积归一化法测定各组分的相对含量。结果　在 hP-5MS柱共鉴定出 3 8种化合物 ,主要成分为β-大马酮、β-二氢大马酮、糠醛、苯甲酸苄酯等。

关键词：罗汉果浸膏固相微萃取挥发性成分气相色谱-质谱

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新疆野生菊苣生物学特性的初步研究

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石河子大学学报（自然科学版） 2003年第1期7卷 55-58页

作者：张霞王绍明惠俊爱张玲石河子大学生物工程学院新疆石河子832003

新疆是野生菊苣在我国的主要自然分布区之一,在北疆地区野生菊苣每年3月底至4月初萌芽,5月中旬抽茎,花期6～10月,6月中旬始花,7月上旬至7月中旬为盛花期,种子在授粉后20天发育成熟,此时种子发芽率及千粒重均达到最高,最佳种子收获期为... 详细信息

新疆是野生菊苣在我国的主要自然分布区之一,在北疆地区野生菊苣每年3月底至4月初萌芽,5月中旬抽茎,花期6～10月,6月中旬始花,7月上旬至7月中旬为盛花期,种子在授粉后20天发育成熟,此时种子发芽率及千粒重均达到最高,最佳种子收获期为盛花期后20至30天;种子深褐色,水分含量为18 08%;种子无休眼期,8～9月萌发。菊苣基生叶总蛋白质含量为18%,含有17种氨基酸,总量为14 43%。菊苣生境适应范围广,土壤条件中性偏碱,并可分布至轻度盐渍化土壤。

关键词：新疆野生菊苣生物学特性野生蔬菜饲用植物种子发芽率花期种子干粒重

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World Journal of Gastroenterology 2005年第47期11卷 7494-7498页

作者： Shih-chao Kang Shinn-Jang hwang Shiang-ho Lee Full-young chang Shou-Dong Lee Division of Family Medicine I-Lan HospitalDepartment of HealthI-LanTaiwanChina Department of Family Medicine Taipei Veterans General Hospital and National Yang-Ming University School of MedicineTaipeiTaiwanChina Shiang-ho Clinic TaipeiTaiwanChina Division of Gastroenterology Department of MedicineTaipei Veterans General Hospital and National Yang-Ming University School of MedicineTaipeiTaiwanChina

AIM. To evaluate health-related quality of life （hRQOL） in chinese patients with chronic hepatitis C （ch-C）, and the impact of antiviral treatment. METhODS： Short Form 36 （SF-36） health-related Quality of Life Questionnaires to interview ch-C patients, and age- and sex-matched control subjects at outpatient clinics of a medical center in Taiwan were used. Data were transformed to scores for comparisons of eight major SF-36 domains. We also enrolled consecutive ch-C patients who completed one course of antiviral treatment （interferon α with ribavirin）, and measured the hRQOL before, at the 12m wk of treatment, at the end of treatment, and at mo 6, after stopping the treatment to evaluate the impact of antiviral treatment. RESULTS： A total of 371 outpatients were enrolled, including 182 with ch-C and 189 age- and sex-matched subjects without ch-C. ch-C subjects had obviously lower educational status （P〈0.01）. Mean scores of domains in general health, physical functioning, role-physical, role-emotional, vitality, and mental health of the SF-36 were significantly lower in subjects with ch-C than those without ch-C （P〈0.05）. In an analysis of 47 ch-C patients who received and completed the whole course of antiviral treatment, mean scores of all domains were significantly lower at wk 12 of treatment compared to baseline. The scores returned to pretreatment values by the end of treatment, but were significantly increased at mo 6 after stopping the treatment. Among the 47 ch-C patients, 21 had sustained responses and 26 had nonsustained responses to antiviral treatment. Compared to pretreatment values, subjects with sustained responses had significantly lower social functioning scores at wk 12 of treatment, and scores for all SF-36 domains returned to pretreatment values, and increased significantly at mo 6 after stopping the treatment. For non-sustained virological responders, scores of all SF-36 domains significantly decreased at wk 12 of treatment, and did not increa

关键词： hepatitis C Quality of life Questionnaire

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城市机动车尾气污染特征与防治对策

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四川环境 2002年第3期21卷 90-92页

作者：李连山焦桂枝陈寒玉平顶山工学院河南平顶山467001

通过对平顶山市主要交通道口空气中NOx、CO、NO2 、Pb的调查 ,分析了城市机动车尾气污染的特征 ,并提出了减少与控制机动车尾气排放。

关键词：城市机动车尾气污染防治对策

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从世界平面发展史谈现代平面设计的民族化和国际化

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西安建筑科技大学学报（社会科学版） 2003年第3期22卷 47-49页

作者：樊海燕陶安惠西安建筑科技大学艺术学院陕西西安710055 陕西师范大学出版社陕西西安710062

随着市场经济的逐步发展 ,平面设计的国际化趋势日益凸显。在这过程中 ,平面设计又因国际化而出现了趋同化 ,其原因就在于忽略了平面设计本身的民族化特点。本文从世界平面设计的发展史角度论述了平面设计初期的民族化特点 ,以及在日益... 详细信息

随着市场经济的逐步发展 ,平面设计的国际化趋势日益凸显。在这过程中 ,平面设计又因国际化而出现了趋同化 ,其原因就在于忽略了平面设计本身的民族化特点。本文从世界平面设计的发展史角度论述了平面设计初期的民族化特点 ,以及在日益发展的国际化过程中。

关键词：面设计国际化民族化

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Risk of complications and urinary incontinence following cytoreductive prostatectomy： a multi-institutional study

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Asian Journal of Andrology 2018年第1期20卷 9-14页

作者： Dae Keun Kim Jaspreet Singh Parihar young Suk Kwon Sinae Kim Brian Shinder Nara Lee Nicholas Farber Thomas Ahlering Douglas Skarecky Bertram Yuh Nora Ruel Wun-lae Kim Koon ho Rha Isaac Yi Kim Department of Urology CHA Seoul Station Medical Center CHA University CHA Medical School Seou104637 Korea Department of Urology School of Medicine Graduate School Hanyang University Seou104763 Korea Section of Urologic Oncology Rutgers Cancer Institute of New Jersey and Division of Urology Rutgers Robert Wood Johnson Medical School Rutgers The State University of New Jersey New Brunswick 08901 USA Department of Biostatistics Rutgers School of Public Health The State University of New Jersey New Brunswick NJ Piscataway 08854 USA Department of Internal Medicine Rutgers Robert Wood Johnson Medical School Rutgers The State University of New Jersey New Brunswick 08901 USA Department of Urology University of California Irvine School of Medicine Orange 92687 USA Division of Urology and UroLogic Oncology City of Hope National Medical Center Duarte 91010 USA Department of Urology Chungbuk National University College of Medicine Cheongju 28644 Korea Department of Urology and Urological Science Institute College of Medicine Yonsei University Seou103722. Korea

Emerging evidence has suggested that cytoreductive prostatectomy （CRP） allows superior oncologic control when compared to current standard of care androgen deprivation therapy alone. however, the safety and benefit of cytoreduction in metastatic prostate cancer （mPCa） has not been proven. Therefore, we evaluated the incidence of complications following CRP in men newly diagnosed with mPCa. A total of 68 patients who underwent CRP from 2006 to 2014 at four tertiary surgical centers were compared to 598 men who underwent radical prostatectomy for clinically localized prostate cancer （PCa）. Urinary incontinence was defined as the use of any pad. CRP had longer operative times （200 min vs 140 min, P 〈 0.0001） and higher estimated blood loss （250 ml vs 125 ml, P 〈 0.0001） compared to the control group. however, both overall （8.82% vs 5.85%） and major complication rates （4.41% vs 2.17%） were comparable between the two groups. Importantly, urinary incontinence rate at 1-year after surgery was significantly higher in the CRP group （57.4% vs 90.8%, P 〈 0.0001）. Univariate logistic analysis showed that the estimated blood loss was the only independent predictor of perioperative complications both in the unadjusted model （OR： 1.18; 95% ch 1.02-1.37; P= 0.025） and surgery type-adjusted model （OR： 1.17; 95% ch 1.01-1.36; P= 0.034）. In conclusion, CRP is more challenging than radical prostatectomy and associated with a notably higher incidence of urinary incontinence. Nevertheless, CRP is a technically feasible and safe surgery for selecting PCa patients who present with node-positive or bony metastasis when performed by experienced surgeons. A prospective, multi-institutional clinical trial is currently underway to verify this concept.

关键词： cytoreductive surgical procedures metastatic prostate cancer outcome radical prostatectomy

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兰西拉光缆通信干线开通

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通讯世界 1998年第9期 6-11页

作者： The communication artery conniving north--west and south--Wed ch-ina is one of the State Projectsunder the 9gth FYP (Five--year--Plan). The project’s main section, running from Lanzhou across Xining toLhasa, the capital of Tibet, has been completed in Aug

The communication artery conniving north--west and south--Wed ch-ina is one of the State Projectsunder the 9gth FYP (Five--year--Plan). The project’s main section, running from Lanzhou across Xining toLhasa, the capital of Tibet, has been completed in August, four months ahead of schedule. The cable is2754 km long, traversing 3 provincial areas and 23 counties and cities, capable of offering 21330 tollcircuits at the initial stabs of operation. The total project investment costs about 612 mil yuan. Theproject has been identified as one of the rare engineering f6ats with such difficult terrain and utmostimplementation difficulties ever encountered in the history of telecommunications constructions at homeas well as abroad.

关键词：光缆通信干线开通拉萨日光城西藏

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钻头优选的属性层次模型及应用

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石油学报 2001年第6期22卷 82-85页

作者：毕雪亮阎铁张书瑞大庆石油学院石油工程系黑龙江安达151400 大庆石油管理局钻井一公司黑龙江大庆163411

在属性测度的基础上 ,通过分析判断准则和属性判断矩阵 ,建立了属性层次模型。该模型将属性识别理论和层次分析方法结合在一起 ,是一种新的无结构决策方法。将该方法应用于钻头优选技术中 ,研究了属性层次模型进行钻头优选的步骤和层次... 详细信息

在属性测度的基础上 ,通过分析判断准则和属性判断矩阵 ,建立了属性层次模型。该模型将属性识别理论和层次分析方法结合在一起 ,是一种新的无结构决策方法。将该方法应用于钻头优选技术中 ,研究了属性层次模型进行钻头优选的步骤和层次结构。结合大庆油田深井的钻井实际 ,基于该油田深井钻井使用数据库 ,利用所建立的模型对大庆油田的深井钻头进行了优选 ,以尚志地区为例进行了实际分析 ,给出了该地区钻头优选方案。

关键词：属性层次分析识别判断矩阵钻头优选(优化) 钻井

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