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Going straight for the gut:gut-brain axis pathology and treatment of Parkinson's disease

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Neural Regeneration Research 2024年第10期19卷 2111-2112页

作者： Dominique Ebedes cesar V.Borlongan University of South Florida Morsani College of Medicine TampaFLUSA Center of Excellence for Aging and Brain Repair Department of Neurosurgery and Brain RepairUniversity of South Florida Morsani College of MedicineTampaFLUSA

This perspective focuses on the recent literature regarding the role of the gut-brain axis(GBA) in fecal microbiota transplantation(FMT) and stem cell therapy(SCT) in Parkinson's disease(PD).PD is the second most common neurodegenerative disease in the United States,yet therapies remain *** research suggests that the GBA may play a role in the pathogenesis of *** FMT as well as SCT offer promising new avenues for PD *** bing the interactions between FMT and SCT with the GBA may reveal novel therapeutics for PD.

关键词： straight pathology pathogenesis

Distribution of action movements （DAM）： a descriptor for human action recognition

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Frontiers of Computer Science 2015年第6期9卷 956-965页

作者： Franco RONCHETTI Facundo QUIROGA Laura LANZARINI cesar ESTREBOU Instituto de Investigacion en Informatica III-LIDI Facultad de Informatica Universidad Nacional de La Plata La Plata B 1900AWX Argentina

Human action recognition from skeletal data is an important and active area of research in which the state of the art has not yet achieved near-perfect accuracy on many well- known datasets. In this paper, we introduce the Distribution of Action Movements Descriptor, a novel action descriptor based on the distribution of the directions of the motions of the joints between frames, over the set of all possible mo- tions in the dataset. The descriptor is computed as a normal- ized histogram over a set of representative directions of the joints, which are in turn obtained via clustering. While the descriptor is global in the sense that it represents the overall distribution of movement directions of an action, it is able to partially retain its temporal structure by applying a window- ing scheme. The descriptor, together with performs several state-of-the-art known datasets. a standard classifier, out- techniques on many well-

关键词： human action recognition descriptor Prob-SOM MSRC12 Action3D

Exploring the reproductive ecology of the tropical semifossorial snake Ninia atrata

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Zoological Research 2020年第2期41卷 157-171页

作者： Teddy Angarita-Sierra cesar Alejandro Lopez-Hurtado Tropical Organism Biology Research Group Universidad Nacional de ColombiaBogota111321Colombia Yoluka ONG Fundacion de Investigacion en Biodiversidad y ConservacionBogota110931Colombia Vicerrectoria de Investigacion Universidad Manuela BeltranBogota110231Colombia

Based on histological analyses and field studies,this research describes the reproductive ecology of a population of Ninia atrata snakes inhabiting an oil palm ***,through a multivariate approach,we explored the main drivers of reproductive output in *** showed that prey abundance and food intake were crucial variables contributing to reproductive *** linear regression models showed that neonates had high sensitivity(R2=55.29%)to extreme changes in climate,which was strongly related to slug and snail abundance variability and microhabitat *** cycles were markedly different between the sexes,being continuous in males and cyclical in *** this variation,reproductive cycles at the population level were seasonal *** recruitment of neonates all year,multiple clutches,high mating frequency,and continuous sperm production characterized the reproductive phenology of *** addition,a significant number of previtellogenic females presented oviductal sperm as well as uterine scars,suggesting a high precocity in the *** main drivers of reproductive output also differed between the *** females,clutch size and secondary follicle variability were highly related to stomach bolus volume,fat body area,and body *** males,height of piles of palm leaves and body mass,rather than intrinsic reproductive traits,were the main drivers of sperm ***,in both cases,the relationship between body mass,prey abundance,and food intake suggests that *** follows the income breeding strategy to compensate for reproductive costs and to maximize fitness.

关键词： Continuous male reproduction Clutch mass Income breeding Iteroparity Spermatogenesis Oogenesis Reproductive effort El Nino-Southern Oscillation(ENSO)

Regulation of multidrug resistance by microRNAs in anti-cancer therapy

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Acta Pharmaceutica Sinica B 2017年第1期7卷 38-51页

作者： Xin An cesar Sarmiento Tao Tan Hua Zhu State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Surgery Davis Heart and Lung Research InstituteThe Ohio State University Wexner Medical Center

Multidrug resistance(MDR) remains a major clinical obstacle to successful cancer *** diverse mechanisms of MDR have been well elucidated, such as dysregulation of drugs transporters, defects of apoptosis and autophagy machinery, alterations of drug metabolism and drug targets, disrupti on of redox homeostasis, the exact mechanisms of MDR in a specific cancer patient and the cross-talk among these different mechanisms and how they are regulated are poorly *** RNAs(mi RNAs) are a new class of small noncoding RNAs that could control the global activity of the cell by post-transcriptionally regulating a large variety of target genes and proteins *** evidence shows that mi RNAs play a key regulatory role in MDR through modulating various drug resistant mechanisms mentioned above, thereby holding much promise for developing novel and more effective individualized therapies for cancer treatment. This review summarizes the various MDR mechanisms and mainly focuses on the role of mi RNAs in regulating MDR in cancer treatment.

关键词： Multidrug resistance miRNA Cancer Therapy Autophagy Redox Homeostasis

Analysis of three-dimensional vortexes below the free surface in a continuous casting mold

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International Journal of Minerals,Metallurgy and Materials 2011年第4期18卷 397-406页

作者： cesar A.Real-Ramirez Jesus I.Gonzalez-Trejo Universidad Autonoma Metropolitana-Azcapotzalco.San Pablo 180 02200Mexico CityMexico

To study fluctuations of the free surface of liquid steel in the mold,two different models with the same casting conditions but different thicknesses were employed to analyze the hydrodynamic behavior at the top of the *** first model was a standard thickness slab,and the second had a thickness three times *** is found with the second model that above the plane formed by the steel jets,it is possible to observe four three-dimensional vortexes that interact with the submerged entry nozzle（SEN）and mold *** using a biphasic model to simulate the interface between the liquid and air inside the mold,the flow asymmetry and the fluctuations of the free surface can be clearly observed.

关键词： continuous casting molds flow patterns three dimensional vortes mathematical models computer simulation

Fuzzy C-means Rule Generation for Fuzzy Entry Temperature Prediction in a Hot Strip Mill

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Journal of Iron and Steel Research International 2016年第2期23卷 116-123页

作者： Jose Angel BARRIOS cesar VILLANUEVA Alberto CAVAZOS Rafael COLAS Mechanical and Electrical Engineering Faculty Autonomous University of Nuevo LeonSan Nicolas de los Garza 66451Nuevo LeonMexico Hot Rolling Department Ternium ChurubuscoMonterrey 64000Nuevo LeonMexico

Variable estimation for finishing mill set-up in hot rolling is greatly affected by measurement uncertainties, variations in the incoming bar conditions and product changes. The fuzzy C-means algorithm was evaluated for rule base generation for fuzzy and fuzzy grey-box temperature estimation. Experimental data were collected from a real- life mill and three different sets were randomly drawn. The first set was used for rule-generation, the second set was used for training those systems with learning capabilities, while the third one was used for validation. The perform- ance of the developed systems was evaluated by five performance measures applied over the prediction error with the validation set and was compared with that of the empirical rule-base fuzzy systems and the physical model used in plant. The results show that the fuzzy C-means generated rule-bases improve temperature estimation; however, the best results are obtained when fuzzy C-means algorithm, grey-box modeling and learning functions are combined. Application of fuzzy C-means rule generation brings improvement on performance of up to 72%.

关键词： gray-box modeling ANFIS hot rolling temperature estimation fuzzy C-means rule base generation

Neurovascular unit permeability in neuroinflammatory diseases:a common pathologic and therapeutic target?

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Neural Regeneration Research 2023年第8期18卷 1715-1716页

作者： Molly Monsour cesar V.Borlongan University of South Florida Morsani College of Medicine TampaFLUSA Department of Neurosurgery and Brain Repair University of South FloridaMorsani College of MedicineTampaFLUSA

Deleterious inflammatory cell invasion has been implicated in neurological diseases,partly manifesting as a leaky blood-central nervous system ba rrier(BCNSB)(Huang et al.,2021).Uncovering the perturbations of the neurovascular unit(NVU)may reveal the role of detrimental proinflammatory cells and signaling molecules in disrupting the central nervous system immuneprivileged environment.

关键词： invasion inflammatory diseases

Modern data sources and techniques for analysis and forecast of road accidents:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第4期7卷 432-446页

作者： Camilo Gutierrez-Osorio cesar pedraza Departamento de Ingeniena de Sistemas e Industrial Universidad Nacional de ColombiaBogotaColombia

Road accidents are one of the most relevant causes of injuries and death worldwide,and therefore,they constitute a significant field of research on the use of advanced algorithms and techniques to analyze and predict traffic accidents and determine the most relevant elements that contribute to road *** research of road accident prediction aims to respond to the challenge of offer tools to generate a more secure mobility environment,and ultimately,save *** paper aims to provide an overview of the state of the art in the prediction of road accidents through machine learning algorithms and advanced techniques for analyzing information,such as convolutional neural networks and long short-term memory networks,among other deep learning ***,in this article,a compendium and study of the most used data sources for the road accident forecast is *** a classification is proposed according to its origin and characteristics,such as open data,measurement technologies,onboard equipment and social media *** the analysis of the information,the different algorithms employed to make predictions about road accidents are listed and compared,as well as their applicability depending on the types of data being analyzed,along with the results obtained and their ease of interpretation and *** best results reported by the authors are obtained when two or more analytic techniques are combined,in such a way that analysis of the obtained results is *** the future challenges in road traffic forecasting lies the enhancement of the scope of the proposed models and predictions by the incorporation of heterogeneous data sources,that include geo spatial data,information from traffic volume,traffic statistics,video,sound,text and sentiment from social media,that many authors concur that can improve the precision and accuracy of the analysis and predictions.

关键词： Traffic engineering Data analysis Machine learning Road accident forecasting Traffic accident prediction

Surgical Complications and Evolution of Grafts in Children with Renal Transplantation at Cayetano Heredia National Hospital

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Open Journal of Nephrology 2013年第3期3卷 124-127页

作者： Roberto sanchez Reyner Loza cesar Loza Luis Zegarra Renal Transplant Unit Cayetano Heredia Hospital Lima Peru Surgery and Urology Unit Department of Surgery Cayetano Heredia Hospital Lima Peru

Objective: This study aims to determine surgical complications and graft outcome in children undergoing renal transplantation at Cayetano Heredia National Hospital (CHNH). Materials and Methods: A case study series focused on the incidence of surgical complications and graft outcome in pediatric patients with end stage renal disease (ESRD) who underwent renal transplant (RT) between December 2007 and March 2011. Results: The study described 29 pediatric transplant patients whose average age was 13.69 ± 3.38 (6.2-17.9) years. The etiology of end stage renal disease (ESRD) was renal hypoplasia in 12 patients (41.38%), primary glomerulopathy in 10 patients (34.48%), obstructive uropathy in 4 patients (13.79%), vasculitis in 2 patients (6.9%) and hemolytic uremic syndrome (HUS) in 1 (3.45%) patient. There were 11 surgical complications (34.48%): 2 cases of arterial thrombosis, 3 cases of urinary fistula, 3 of lymphocele, 1 of venous thrombosis, urinoma and perineal collection. The follow-up time was 15.84 ± 12.19 months. Graft survival at 12, 24, and 40 months was 89.29%, 77.16% and 77.16%, respectively. Conclusion: Surgical complications and graft survival in pediatric renal transplantation in our series did not differ from other published series.

关键词： Children Terminal Chronic Renal Disease Renal Transplantation Surgical Complications