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FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao yuan Li xi Liu Wenping Liang Yu Li Liyong Wu Zhe Wang Weihong Song The National Clinical Research center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： xiao Liang xingping Quan xiaorui Geng Yujing Huang Yonghua Zhao Lei xi Zhen yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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Ru团簇对Ni/Ni_(3)Al合金纳米线形变影响的原子模拟

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原子与分子物理学报 2025年第1期42卷 81-87页

作者：阳喜元岭南师范学院物理科学与技术学院湛江524048

镍基高温合金是制造先进航空发动机热端部件的关键材料之一,其高温力学性能直接关系到发动机运行安全和使用寿命.本文采用改进分析型嵌入原子模型(MAEAM)和分子动力学(MD)研究合金化元素钌(Ru)团簇对Ni/Ni_(3)Al纳米线形变机制的影响,... 详细信息

镍基高温合金是制造先进航空发动机热端部件的关键材料之一,其高温力学性能直接关系到发动机运行安全和使用寿命.本文采用改进分析型嵌入原子模型(MAEAM)和分子动力学(MD)研究合金化元素钌(Ru)团簇对Ni/Ni_(3)Al纳米线形变机制的影响,结果表明:在单轴拉伸应变下,纳米线的弹性模量和屈服强度随温度升高而降低.温度较低时,纳米线形变由位错产生与发射而导致晶格滑移所引起.由于晶格热振动非谐效应不明显,Ru团簇阻碍效果显著,使得晶格滑移区域仅限于Ru团簇与Ni/Ni_(3)Al相界面之间且呈非对称分布.温度较高时,纳米线的形变由位错发射而引起晶格滑移所致,但因非谐效应显著,Ru团簇无法阻碍位错运动,滑移区域在Ru团簇周围对称分布于Ni_(3)Al相中.最后从Ru团簇微观结构及其稳定性的角度进一步分析其对纳米线形变影响.

关键词： Ru团簇形变机制 Ni/Ni_(3)Al纳米线原子模拟

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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： xihang Chen Zhifeng Chen Menghua Li Weiwei Guo Shuolong yuan Liangwei Xu Chang Lin xi Shi Wei Chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

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THEORETICAL ANALYSES ON DESIGN OF SHEAR EXTRUSION DIE

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中国有色金属学会会刊：英文版 1997年第3期7卷 81-86页

作者： yuan, xi central South Univ of Technology Changsha China

ＴＨＥＯＲＥＴＩＣＡＬＡＮＡＬＹＳＥＳＯＮＤＥＳＩＧＮＯＦＳＨＥＡＲＥＸＴＲＵＳＩＯＮＤＩＥ①ＹｕａｎＸｉＤｅｐａｒｔｍｅｎｔｏｆＭａｔｅｒｉａｌｓＳｃｉｅｎｃｅａｎｄＥｎｇｉｎｅｒｉｎｇ，ＣｅｎｔｒａｌＳｏｕｔｈＵ... 详细信息

ＴＨＥＯＲＥＴＩＣＡＬＡＮＡＬＹＳＥＳＯＮＤＥＳＩＧＮＯＦＳＨＥＡＲＥＸＴＲＵＳＩＯＮＤＩＥ①ＹｕａｎＸｉＤｅｐａｒｔｍｅｎｔｏｆＭａｔｅｒｉａｌｓＳｃｉｅｎｃｅａｎｄＥｎｇｉｎｅｒｉｎｇ，ＣｅｎｔｒａｌＳｏｕｔｈＵｎｉｖｅｒｓｉｔｙｏｆＴｅｃｈｎｏ...

关键词： shape extrusion die design element deformation analysis method

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Highly interconnected macroporous MBG/PLGA scaffolds with enhanced mechanical and biological properties via green foaming strategy

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Chinese Journal of Chemical Engineering 2021年第1期34卷 426-436页

作者： Chaobo Song Jiapeng Zhang Shuang Li Shengbin Yang Eryi Lu Zhenhao xi Lian cen Ling Zhao Weikang yuan State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Stomatology of Renji Hospital School of MedicineShanghai Jiao Tong UniversityShanghai 200127China Shanghai Key Laboratory of Orthopaedic Implant Department of Orthopaedics SurgeryShanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineNo.639Zhizaoju RoadShanghai 200011China

In this study,mesoporous bioactive glass particles(MBGs) are incorporated into poly(lactic-co-glycolic acid)(PLGA) to fabricate highly interconnected macroporous composite scaffolds with enhanced mechanical and biological properties via a developed supercritical carbon dioxide(scCO_(2)) foaming method Scaffolds show favorable highly interconnected and macroporous structure through a high foaming pressure and long venting time foaming ***,scaffolds with porosity from 73% to 85%,pore size from 120 μm to 320 μm and interconnectivity of over 95% are controllably fabricated at MBG content from 0 wt% to 20 wt%.In comparison with neat PLGA scaffolds,composite scaffolds perform improved strength(up to 1.5 folds) and Young's modulus(up to 3 folds).The interconnected macroporous structure is beneficial to the ingrowth of *** importantly,composite scaffolds also provide a more promising microenvironment for cellular proliferation and adhesion with the release of bioactive ***,MBG/PLGA scaffolds developed by the green foaming strategy in this work show promising morphological,mechanical and biological features for tissue regeneration.

关键词： Scaffold Mesoporous bioactive glass Supercritical carbon dioxide Foaming Poly(lactic-co-glycolic acid)

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ON SOLUTIONS OF MATRIX EQUATION AXAT ＋ BYBT=C

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Journal of Computational Mathematics 2005年第1期23卷 17-26页

作者： yuan-beiDeng xi-yanHu ICMSEC AcademyofMathematicsandSystemSciencesChineseAcademyofSciencesBeijing100080China CollegeofMathematicsandEconometrics HunanUniversityChangsha310082China

By making use of the quotient singular value decomposition (QSVD) of a matrix pair,this paper establishes the necessary and sufficient conditions for the existence of and the expressions for the general solutions of the linear matrix equation AXA^T+BYB^T=C with the unknown X and Y, which may be both symmetric, skew-symmetric, nonnegativede finite, positive definite or some cross combinations respectively. Also, the solutions of some optimal problems are derived.

关键词： matrix equation matrix norm QSVD constrained condition optimal problem

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Kloosterman Sums and a Problem of ***

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Chinese Annals of Mathematics,Series B 2020年第3期41卷 361-370页

作者： Ping xi yuan YI School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an 710049China

A classical problem of D. H. Lehmer suggests the study of distributions of elements of Z/pZ of opposite parity to the multiplicative inverse mod p. Zhang initiated this problem and found an asymptotic evaluation of the number of such elements. In this paper, an asymptotic formula for the fourth moment of the error term of Zhang is proved,from which one may see that Zhang’s error term is optimal up to the logarithm *** method also applies to the case of arbitrary positive integral moments.

关键词： D.H.Lehmer problem Kloosterman sum Moment

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Atropoenantioselective synthesis of heterobiaryl N-oxides via dynamic kinetic resolution

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Science China Chemistry 2022年第12期65卷 2512-2516页

作者： xi yuan Jian Wang College of Chemistry and Materials Science Anhui Normal UniversityWuhu241002China School of Pharmaceutical Sciences Tsinghua UniversityBeijing100084China

A highly efficient enantioselective construction of heterobiaryl N-oxides was developed.A series of axially chiral heterobiaryl N-oxides were generated via the cascade reaction of aminobenzamides with heterobiaryl aldehydes in the presence of chiral phosphoric acids.A number of atropisomers were afforded in moderate to good yields with excellent enantioselectivities and *** results demonstrate that the heterobiaryl N-oxides can be utilized as efficient chiral ligands in asymmetric catalysis.

关键词： heterobiaryl N-oxides dynamic kinetic resolution chiral phosphoric acids atroposelectivity organocatalysis

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Sulfur dioxide sensing properties of MOF-derived ZnFe_(2)O_(4) functionalized with reduced graphene oxide at room temperature

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Rare Metals 2021年第6期40卷 1604-1613页

作者： Lan-Juan Zhou xi-xi Zhang Wen-yuan Zhang College of Control Science and Engineering China University of Petroleum(East China)Qingdao 266580China United Microelectronics center Chongqing 401332China

In this paper,ZnZnFe_(2)O_(4) nanorods were prepared using Zn/Fe metal organic framework(MOF)as precursors,and ZnZnFe_(2)O_(4)/reduced graphene oxide(rGO)was prepared by hydrothermal *** morphology and composition of the ZnZnFe_(2)O_(4)/rGO nanocomposite were characterized,and the results showed that the MOF-derived ZnZnFe_(2)O_(4) nanorods are uniformly modified on the surface of *** ZnZnFe_(2)O_(4)/rGO nanocomposite exhibits better SO_(2) gas sensing performance than the single ZnZnFe_(2)O_(4) nanorods at room *** sensing characteristics of single ZnZnFe_(2)O_(4) film sensor,single rGO film sensor and ZnZnFe_(2)O_(4)/rGO composite film sensor at SO_(2)gas concentration(1×10^(-6)-100×10^(-6))were *** response of ZnZnFe_(2)O_(4)/rGO composite sensor can reach 18.32%at room *** with single ZnZnFe_(2)O_(4) and rGO film sensors,the ZnZnFe_(2)O_(4)/rGO composite sensor has better transient response,good sensitivity and *** this work,the improvement of the sensor performance is not only due to the p-n heterostructure between ZnZnFe_(2)O_(4) nanorods and rGO nanosheets,but also to the excellent electrical properties of *** provides a new idea for the detection of SO_(2) at room temperature.

关键词： Ternary metal oxide ZnFe_(2)O_(4)nanorods Reduced graphene oxide SO_(2)gas sensor

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