Highly interconnected macroporous MBG/PLGA scaffolds with enhanced mechanical and biological properties via green foaming strategy

作     者：Chaobo Song Jiapeng Zhang Shuang Li Shengbin Yang Eryi Lu Zhenhao Xi Lian Cen Ling Zhao Weikang Yuan Chaobo Song;Jiapeng Zhang;Shuang Li;Shengbin Yang;Eryi Lu;Zhenhao Xi;Lian Cen;Ling Zhao;Weikang Yuan

作者机构：State Key Laboratory of Chemical EngineeringSchool of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Stomatology of Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Shanghai Key Laboratory of Orthopaedic ImplantDepartment of Orthopaedics SurgeryShanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineNo.639Zhizaoju RoadShanghai 200011China 

出 版 物：《Chinese Journal of Chemical Engineering》 (中国化学工程学报（英文版）)

年 卷 期：2021年第34卷第1期

页      面：426-436页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：the National Natural Science Foundation of China (Grant No. 21676083) the Fundamental Research Funds for the Central Universities 111 Project (Grant No. B20031) 

主　　题：Scaffold Mesoporous bioactive glass Supercritical carbon dioxide Foaming Poly(lactic-co-glycolic acid) 

摘      要：In this study,mesoporous bioactive glass particles(MBGs) are incorporated into poly(lactic-co-glycolic acid)(PLGA) to fabricate highly interconnected macroporous composite scaffolds with enhanced mechanical and biological properties via a developed supercritical carbon dioxide(scCO_(2)) foaming method Scaffolds show favorable highly interconnected and macroporous structure through a high foaming pressure and long venting time foaming ***,scaffolds with porosity from 73% to 85%,pore size from 120 μm to 320 μm and interconnectivity of over 95% are controllably fabricated at MBG content from 0 wt% to 20 wt%.In comparison with neat PLGA scaffolds,composite scaffolds perform improved strength(up to 1.5 folds) and Young s modulus(up to 3 folds).The interconnected macroporous structure is beneficial to the ingrowth of *** importantly,composite scaffolds also provide a more promising microenvironment for cellular proliferation and adhesion with the release of bioactive ***,MBG/PLGA scaffolds developed by the green foaming strategy in this work show promising morphological,mechanical and biological features for tissue regeneration.