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The growth of the South American kraft pulp industry based on the utilization of plantation forests

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The growth of the South American kraft pulp industry based o...

Columnar joints in the Patino Formation sandstones, Eastern Paraguay： a dynamic interaction between dyke intrusion, quartz dissolution and cooling-induced fractures

2005中国造纸学会学术报告会

作者： celso Foelkel

＜正＞Summary: Since the early 70’s, the growth of South America, mainly Brazil and Chile, as producers of kraft pulp to supply domestic and international markets, is being very fast and consistent. More recently, other countries in the continent have acquired the technology and capability to develop fast-growing trees in plantations forests. Uruguay and Argentina are showing high potential to become important market pulp producers in the world scene. Bleached kraft pulp is very competitive thanks to the low wood cost, the quality of this wood, and the right technology, both at the industrial and in the forest sites. The main reasons for this success are being the eucalyptus and pines, whose forests, woods, pulping, bleaching and product quality are admired and requested by the most strict markets, everywhere. Bleached Eucalyptus kraft market pulps coming from Brazil are well-known not only because quality and supply reliability, but because the admirable competitiveness in a so taught business segment. From Chile, the success stays more in the side of Pinus radiata pulp, although Eucalyptus also shows an important growth in the country. This paper intends to show the driving forces for these achievements, from forestry to market pulp manufacturing. This life experience will enable the readers to understand this successful business and to eventually take part on it. Since this story of success is based on plantation forests, the final part of this paper intends to show the fundamental issues that are being considered to have a productive and environmentally friendly forestry business.

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Episodes 2008年第3期31卷 302-308页

作者： Victor Fernandez Velazquez Paulo Cesar Fonseca Giannini Claudio Riccomini Alethea Ernandes Martins Sallun Jorge Hachiro celso de Barros Gomes eseola de Artes Ciencias e Humanidades Universidade de Sao Paulo Rua Arlindo Betio 1000 03828-080 Sao Paulo Brasil Instituto de Geociencias Universidade de Sao Paulo Rua do Lago 562 05508-080 Sao Paulo Brasil Insfituto Geolegico Secretaria do Meio Ambiente Av. Miguel Estefano 3900 04301-903 Sao Paulo Brasil.

The Patiho Formation sandstones, which crop out in Aregud neighborhood in Eastern Paraguay and show columnar joints near the contact zone with a nephelinite dyke, have as their main characteristics the high pro- portion of syntaxial quartz overgrowth and a porosity originated from different processes, initially by dissolu- tion and later by partial filling and fracturing. Features like the presence of floating grains in the syntaxial cement, the transitional interpenetrative contact between the silica-rich cement and grains as well as the intense fracture porosity are strong indications that the cement has been formed by dissolution and reprecipita- tion of quartz from the framework under the effect of thermal expansion followed by rapid contraction. The increase of the silica-rich cement towards the dyke in association with the orthogonal disposition of the columns relative to dyke walls are indicative that the igneous body may represent the main heat source for the interstitial aqueous solutions previously existing in the sediments. At macroscopic scale, the increasing of inter- nal tensions in the sandstones is responsible for the nucleation of polygons, leading to the individualization of prisms, which are interconnected by a system of joints, formed firstly on isotherm surfaces of low tem- perature and later on successive adjacent planes towards the dyke heat source.

关键词：柱状连接砂岩巴拉圭南美洲动力学

Searching for nuclear export elements in hepatitis D virus RNA

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World Journal of Virology 2013年第3期2卷 123-135页

作者： Natália Freitas celso Cunha Department of Microbiology Molecular Genetics and Immunology Kansas University Medical Center Rainbow Boulevard Kansa KS 66160 United States Medical Microbiology Unit Center for Malaria and Tropical Diseases Institute of Hygiene and Tropical Medicine Nova University of Lisbon 1349-008 Lisbon Portugal

AIM: To search for the presence of cis elements in hepatitis D virus(HDV) genomic and antigenomic RNA capable of promoting nuclear export. METHODS: We made use of a well characterized chloramphenicol acetyl-transferase reporter system based on plasmid p DM138. Twenty c DNA fragments corresponding to different HDV genomic and antigenomic RNA sequences were inserted in plasmid pD M138, and used in transfection experiments in Huh7 cells. The relative amounts of HDV RNA in nuclear and cytoplasmic fractions were then determined by realtime polymerase chain reaction and Northern blotting. The secondary structure of the RNA sequences that displayed nuclear export ability was further predicted using a web interface. Finally, the sensitivity to leptomycin B was assessed in order to investigate possible cellular pathways involved in HDV RNA nuclear ***: Analysis of genomic RNA sequences did not allow identifying an unequivocal nuclear export element. However, two regions were found to promote the export of reporter m RNAs with efficiency higher than the negative controls albeit lower than the positive control. These regions correspond to nucleotides 266-489 and 584-920, respectively. In addition, when analyzing antigenomic RNA sequences a nuclear export element was found in positions 214-417. Export mediated by the nuclear export element of HDV antigenomic RNA is sensitive to leptomycin B suggesting a possible role of CRM1 in this transport pathway. CONCLUSION: A cis-acting nuclear export element is present in nucleotides 214-417 of HDV antigenomic RNA.

关键词： Hepatitis D virus Genomic RNA Antigenomic RNA Nuclear export Nuclear export element

Update on the management and treatment of viral hepatitis

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World Journal of Gastroenterology 2021年第23期27卷 3249-3261页

作者： Patricia Holanda Almeida celso E L Matielo Lilian A Curvelo Rodrigo A Rocco Guilherme Felga Bianca Della Guardia Yuri L Boteon Liver Unit Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Instituto Israelita de Ensino e Pesquisa Albert Einstein Faculdade Israelita de Ciências da Saúde Albert EinsteinSão Paulo 05652-900Brazil

This review aims to summarize the current evidence on the treatment of viral hepatitis,focusing on its clinical ***,future treatment options and areas of potential research interest are *** and Scopus databases were searched for primary studies published within the last ten *** included hepatitis A virus,hepatitis B virus(HBV),hepatitis C virus,hepatitis D virus(HDV),hepatitis E virus,and *** reported in the studies were summarized,tabulated,and *** advances in viral hepatitis treatment were accomplished,such as the advent of curative therapies for hepatitis C and the development and improvement of hepatitis A,hepatitis B,and hepatitis E *** that cure hepatitis B,going beyond viral suppression,are so far unavailable;however,targeted antiviral drugs against HBV(immunomodulatory therapies and gene silencing technologies)are promising approaches to eradicating the ***,high vaccination coverage and large-scale test-and-treat programmes with high screening rates may eliminate viral hepatitis and mitigate their burden on health *** development of curative hepatitis C treatment renewed the enthusiasm for curing hepatitis B,albeit further investigation is *** therapeutic options targeting HDV life cycle are currently under clinical investigation.

关键词： Viral hepatitis Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus

Intestinal anti-inflammatory activity of Ground Cherry(Physalis angulata L.)standardized CO2 phytopharmaceutical preparation

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World Journal of Gastroenterology 2017年第24期23卷 4369-4380页

作者： luiz domingues almeida junior ana elisa valencise quaglio celso acácio rodrigues de almeida costa Luiz Claudio Di Stasi laboratory of phytomedicines pharmacology and biotechnology(phytopharmatech)department of pharmacologyinstitute of biosciencesuniversidade estadual paulista unespbotucatusao paulocep 18618-970

AIM To investigate the effects of Ground Cherry(Physalis angulata L.)standardized supercritical CO_2 extract in trinitrobenzenesulphonic acid(TNBS)model of rat intestinal *** The animals were divided into groups that received vehicle or *** extract(PACO_2)orally at the doses 25,50 and 100 mg/kg daily by 5 d before TNBS *** effects of PACO_2 were assessed by macroscopic analysis,biochemical determinations of the levels of myeloperoxidase(MPO),alkaline phosphatase(ALP),glutathione and cytokines(such as INF-γ,IL-1β,IL-6,IL-10 and TNF-α),gene expression evaluation(including Hsp70,heparanase,NF-κB,mitogenactivated protein kinases(Mapk)1,3,6 and 9,and the mucins genes Muc 1,2,3 and 4)and histopathological studies using optical,and electronic(transmission and scanning)*** PACO2 extract promoted a significant reduction in MPO and ALP activities,reducing oxidative stress and neutrophil *** effects were accompanied by significant reduction of colonic levels of IFN-γand IL-6 and down-regulation of heparanase,Hsp70,Mapk3,Mapk9,Muc1 and Muc2 genes expression when compared with TNBS-control *** addition,protective effects were also evidenced by reduced neutrophil infiltration,recovery of cell architecture and replacement of mucin by histopathological and ultrastructural *** Physalis angulata supercritical CO2 extract is an intestinal anti-inflammatory product that modulates oxidative stress,immune response and expression of inflammatory mediators,with potentially utility for treating inflammatory bowel disease.

关键词： Intestinal disease Inflammatory bowel disease Physalis angulata L.trinitrobenzenesulphonic acid

Naturotherapies Based on Minerals

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Geomaterials 2013年第1期3卷 1-14页

作者： celso de Sousa Figueiredo Gomes GeoBioTec Research Center of the Foundation for Science and Technology University of Aveiro Aveiro Portugal

Since the antiquity, and on an empirical basis, man has accumulated experience on the benefits and risks of minerals (such as, special clay, mud and sand) and other mineral resources (such as, salt, sea water, spring water, underground water, volcanic emissions and dust) on human health. Man and minerals are chemical systems sharing a common composition, comprising major, minor and trace chemical elements, such as, oxygen, hydrogen, carbon, sulphur, phosphor, calcium, magnesium, sodium, potassium, iron, silicon, zinc, selenium, copper, manganese and fluorine, all essential to life, to a high standard of living and to the formation of minerals;in the natural environment where man lives minerals and chemical elements are omnipresent, therefore, interactions are expected to occur and to condition man’s life and his standard of living, in turn highly determined by our health state. Examples of the properties and medicinal use of certain types of special clay, certain types of special sand, and certain types of special natural mineral water, thermal or not, in the treatment of particular types of health affections will be disclosed.

关键词： Minerals Human Health Naturotherapy Oligotherapy Pelotherapy Psammotherapy Mineral Water Drinking Cure

Nanoparticle-encapsulated retinoic acid for the modulation of bone marrow hematopoietic stem cell niche

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Bioactive Materials 2024年第4期34卷 311-325页

作者： Emanuel Quartin Susana Rosa Sara Gonzalez-Anton Laura Mosteo Lopez Vitor Francisco Delfim Duarte Cristina Lo celso Ricardo Pires das Neves Lino Ferreira CNC-Center for Neuroscience and Cell Biology CIBB-Centre for Innovative Biomedicine and BiotechnologyUniversity of Coimbra3004-517CoimbraPortugal IIIUC-Institute of Interdisciplinary Research University of Coimbra3004-517CoimbraPortugal Faculty of Medicine University of Coimbra3004-517CoimbraPortugal Department of Life Sciences Imperial College LondonSouth Kensington CampusThe Francis Crick InstituteLondonUK Haematopoietic Stem Cell Laboratory The Francis Crick InstituteLondonUK Instituto de Investigação e Inovação em Saúde(i3S) University of PortoPortoPortugal Department of Biomedicine Faculdade de Medicina da Universidade do Porto(FMUP)PortoPortugal Department of Onco-Hematology Instituto Português de Oncologia(IPO)-PortoPortoPortugal

More effective approaches are needed in the treatment of blood cancers,in particular acute myeloid leukemia(AML),that are able to eliminate resistant leukemia stem cells(LSCs)at the bone marrow(BM),after a chemotherapy session,and then enhance hematopoietic stem cell(HSC)engraftment for the re-establishment of the HSC ***,we investigate whether light-activatable nanoparticles(NPs)encapsulating all-trans-retinoic acid(RA^(+)NPs)could solve both *** in vitro results show that mouse AML cells transfected with RA^(+)NPs differentiate towards antitumoral M1 macrophages through RIG.1 and OASL gene *** in vivo results further show that mouse AML cells transfected with RA^(+)NPs home at the BM after transplantation in an AML mouse *** photo-disassembly of the NPs within the grafted cells by a blue laser enables their differentiation towards a macrophage *** macrophage activation seems to have systemic anti-leukemic effect within the BM,with a significant reduction of leukemic cells in all BM compartments,of animals treated with RA^(+)NPs,when compared with animals treated with empty *** a separate group of experiments,we show for the first time that normal HSCs transfected with RA^(+)NPs show superior engraftment at the BM niche than cells without treatment or treated with empty *** is the first time that the activity of RA is tested in terms of long-term hematopoietic reconstitution after transplant using an in situ activation approach without any exogenous priming or genetic conditioning of the transplanted ***,the approach documented here has the potential to improve consolidation therapy in AML since it allows a dual intervention in the BM niche:to tackle resistant leukemia and improve HSC engraftment at the same time.

关键词： Light Nanoparticles Retinoic acid Leukemia M1 macrophages Drug delivery

Thermal lens analysis in a diode-pumped 10 Hz 100 mJ Yb:YAG amplifier

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High Power Laser Science and Engineering 2020年第2期8卷 24-31页

作者： Victor Hariton celso Paiva Joao Hugo Pires Mario Galletti Goncalo Figueira GoLP/Instituto de Plasmas e Fusao Nuclear Instituto Superior TécnicoUniversidade de LisboaAv.Rovisco Pais1049-001 LisbonPortugal Central Laser Facility Science and Technology Facilities CouncilRutherford Appleton LaboratoryHarwell Science and Innovation CampusDidcot OX110QXUK

We address the power scaling issue in end-pumped laser rod amplifiers by studying,experimentally and numerically,the magnitude of thermal lensing in a high-energy diode-pumped Yb:YAG *** spatio-temporal temperature profile of the gain medium and the focal length of the induced thermal lens are determined *** influence of the repetition rate and pumping power on the temperature distribution is *** measurements covered repetition rates between 1 and 10 Hz and up to 4 kW pumping power.

关键词： diode-pumped lasers high-energy laser amplifiers thermal effects in lasers ytterbium-doped laser media

Using Condensed Water of Air Conditioners for Toilet Flushing： A Case Study in Brazil

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Journal of Civil Engineering and Architecture 2013年第1期7卷 98-104页

作者： celso Silva Bastos Joao Luiz Calmon Postgraduate Program in Civil Engineering Technology Center Federal University of Espirito Santo Vit6ria 29000-000 Brazil

Within the concept of sustainable construction, with sensible and conscious use of finite natural resources, every effort to save and reuse raw-materials is considered an important step to be adopted in buildings, from project, implantation and construction to operation and maintenance throughout their lifecycle. This study aims at showing the application of a system that reuses condensed water drained from air-conditioner evaporators （which are usually disposed of）, and a plan to use this water for toilet flushing, reducing consumption of treated water bought from water companies. The authors verified that each air-conditioner specified in the project of a commercial building--used as reference here--produces 4.8 L of water per hour of operation. This result in a daily accumulated volume of 4,290 L, which represents a significant part of the amount needed to supply all the toilets in the building. A water capture system located at a strategic intermediate floor would be able to store this water and pump it into a special reservoir on the roof of the building, to be distributed into toilet flush pipes. By applying this technology, the authors seek to considerably reduce the expected treated water consumption and consequently decrease water bill costs.

关键词： Water reuse air-conditioner toilet flush.