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Increased plasma levels of Lp(a) enhance the development of coronary atherosclerosis

中国药理学会第十次全国学术会议

作者： LIAO Hong-bo~(1+),Yuan Hu~(1+),Ping Liu~(1*),Guo Dai-Hong~1 (1.Dep of clinical Pharmacology and Pharmacy,Center of Pharmacy,Chinese PLA General Hospital,Beijing 100853,China)

recent,studies suggest that the behavioral effects of chronic antidepressants treatment might be mediated by the stimulation of hippocampal *** aim of the present study was to examine the effect of of 3,6’- disinapoyl sucrose(DISS),a bioactive component of Polygala tenuifolia Willd,on the expression of four plasticityassociated genes,namely,the cell adhesion molecule L1(CAM-L1),laminin,CrEB,and BDNF;all of which are involved in neuronal plasticity and neurite *** rats resulted in reduction of sensitivity to reward (sucrose consumption) and a decrease in mrNA of CAM-L1,laminin,and BDNF,while also presented was observed together with decrease in protein levels of pCrEB and *** administration of DISS for 21 days at the doses of 5,10 and 20 mg·kg respectively reversed the stress-induced changes in sucrose consumption, and alterations in mrNA,protein levels,of the associated genes in *** conclusion,the increase of expression of three noradrenergic-regulated plasticity genes CAM-L1,laminin,CrEB and one neurotrophic factor BDNF in hippocampus may be one of the molecular and cellular mechanisms underlying the antidepressant action of DISS.

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Increased plasma levels of Lp(a) enhance the development of ...

两岸三地药理学与临床药理学术会议

作者： LI Ying XU Hong ZHOU Qin WANG Chang-yuan LIU Yan-xia L(?) Yuan-yuan FAN Jiang-lin SUN Hui-jun (depar.ment of clinical Pharmacology, Dalian Medical univer.ity, Dalian 116027, China)

Objective To test the hypothesis that increased plasma levels of Lp(a)may enhance the develop- ment of atherosclerosis in the setting of *** The plasma Lp(a)was analyzed by SDS-PAGE Western blotting and quantitated using specific ELISA *** total cholesterol,triglyc- erides and HDL-cholesterol were determined using Wako assay *** left coronary artery was used for the evaluation of coronary atherosclerosis(stenosis%).For quantitative study of the lesions in coronary atherosclerosis,hematoxylin-eosin and Elastica-van Gieson staining were *** study cellular compo- nents(SMC ***)and Lp(a)deposits in the lesions,immunohistochemical staining was per- formed and then image analysis system was *** Plasma total cholesterol,triglycerides,or HDL-C were not significantly different between transgenic(Trg)and nontransgenic(nonTrg)*** rabbits had 200% increase in coronary stenosis caused by *** lesions of Trg WHHL rabbits con- tained more SMCs and less macrophage than those of nonTrg WHHL *** The results sug- gest that increased plasma levels of Lp(a)enhance the development of coronary atherosclerosis.

关键词： plasma levels of Lp(a) coronary atherosclerosi

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风疹病毒母婴传播的定量PCr分析

苏州大学学报（医学版） 2005年第3期25卷 448-450页

作者：封玥姜海燕顾菊萍高锦声苏州大学遗传学教研室江苏苏州215007

目的研究风疹病毒(rubellavirus,rV)母婴传播的量化关系。方法应用荧光定量PCr方法检测23例IgM抗体阳性的孕妇及其婴儿血清中rVrNA含量。结果孕妇rVrNA含量与婴儿rVrNA含量呈正相关,当孕妇血清中病毒含量在7.93×102±2.03×102拷贝/μl... 详细信息

目的研究风疹病毒(rubellavirus,rV)母婴传播的量化关系。方法应用荧光定量PCr方法检测23例IgM抗体阳性的孕妇及其婴儿血清中rVrNA含量。结果孕妇rVrNA含量与婴儿rVrNA含量呈正相关,当孕妇血清中病毒含量在7.93×102±2.03×102拷贝/μl时,婴儿血清中没有检测到rV;当孕妇血清中rVrNA含量在3.89×103±1.10×103拷贝/μl时,婴儿血清中可以检测到rV。并且随着孕妇血清中rVrNA含量的升高,婴儿血清rVrNA含量相应增高。结论孕妇与婴儿血清中rVrNA含量呈正相关。孕妇血清中rVrNA含量在3.89×103±1.10×103拷贝/μl时可能是导致婴儿感染的阈值,这对指导临床有一定的理论意义和实用价值。

关键词：风疹病毒荧光定量多聚酶链反应 rNA

Quantification of the impact of TOF and PSF on PET images using the noise-matching concept: clinical and phantom study

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Nuclear Science and Techniques 2017年第11期28卷 258-265页

作者： M. Shekari P. Ghafarian S. Ahangari M. r. Ay depar.ment of Medical Physics and Biomedical Engineering Tehran University of Medical Sciences Tehran Iran research Center for Molecular and cellular Imaging Tehran University of Medical Sciences Tehran Iran Chronic respiratory Diseases research Center National Research Institute of Tuberculosis and Lung Diseases(NRITLD) Shahid Beheshti University of Medical SciencesTehran Iran PET/CT and Cyclotron Center Masih Daneshvari HospitalShahid Beheshti University of Medical Sciences Tehran Iran

This study was to assess quantitatively the accuracy of ^(18)F-FDG PET/CT images reconstructed by TOF+PSF and TOF only, considering the noise-matching concept to minimize probable bias in evaluating algorithm performance caused by noise. PET images of similar noise level were considered. Measurements were made on an inhouse phantom with hot inserts of Φ10–37 mm, and oncological images of 14 patients were analyzed. The PET images were reconstructed using the OSEM, OSEM+TOF and OSEM+TOF+PSF algorithms. Optimal reconstruction parameters including iteration, subset, and FWHM of post-smoothing filter were chosen for both the phantom and patient data. In terms of quantitative accuracy, the recovery coefficient(rC) was calculated for the phantom PET images. The signal-to-noise ratio(SNr),lesion-to-background ratio(LBr), and SUV_(max)were evaluated from the phantom and clinical data. The smallest hot insert(Ф10 mm) with 2:1 activity concentration ratio could be detected in the PET image reconstructed using the TOF and TOF+PSF algorithms, but not the OSEM algorithm. The relative difference for SNr between the TOF+PSF and OSEM showed significantly higher values for smaller sizes, while SNr change was smaller for Ф22–37 mm inserts both 2:1 and 4:1 activity concentration ratio. In the clinical study, SNr gains were 1.6 ± 0.53 and 2.7 ± 0.74 for the TOF and TOF+PSF, while the relative difference of contrast was 17 ± 1.05 and 41.5 ± 1.85% for the TOF only and TOF+PSF, respectively. The impact of TOF+PSF is more significant than that of TOF reconstruction, in smaller inserts with low activity concentration ratio. In the clinical PET/CT images, the use of the TOF+PSF algorithm resulted in better SNr and contrast for lesions, and the highest SUV_(max)was also seen for images reconstructed with the TOF+PSF algorithm.

关键词： Time of flight (TOF) Point spread function(PSF) Lesion detectability PET Quantification Image reconstruction SUV

Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma

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World Journal of Gastroenterology 2020年第38期26卷 5759-5783页

作者： Simmone D'souza Keith CK Lau Carla S Coffin Trushar r Patel depar.ment of Microbiology Immunologyand Infectious DiseasesCumming School of MedicineUniversity of CalgaryCalgary T2N 1N4ABCanada depar.ment of Chemistry and biochemistr. Alberta RNA Research and Training InstituteUniversity of LethbridgeLethbridge T1K3M4ABCanada

Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis,cancer,and liver *** cancer is the third leading cause of cancer-associated mortality,of which hepatocellular carcinoma(HCC)represents 90%of all primary liver *** tumors like HCC are complex and have heterogeneous tumor genomic profiles contributing to complexity in diagnosis and *** infection with hepatitis B virus(HBV),hepatitis delta virus(HDV),and hepatitis C virus(HCV)are the greatest etiological risk factors for *** to the significant role of chronic viral infection in HCC development,it is important to investigate direct(viral associated)and indirect(immune-associated)mechanisms involved in the pathogenesis of *** mechanisms used by HBV,HCV,and HDV that drive hepatocarcinogenesis include persistent liver inflammation with an impaired antiviral immune response,immune and viral protein-mediated oxidative stress,and deregulation of cellular signaling pathways by viral *** integration to promote genome instability is a feature of HBV infection,and metabolic reprogramming leading to steatosis is driven by HCV *** current review aims to provide a brief overview of HBV,HCV and HDV molecular biology,and highlight specific viral-associated oncogenic mechanisms and common molecular pathways deregulated in HCC,and current as well as emerging treatments for HCC.

关键词： Chronic viral infection Hallmarks of cancer Hepatocellular carcinoma Hepatitis B virus Hepatitis C virus Hepatitis delta virus co-infection Molecular mechanisms Viral hepatitis

Galectin-3 possible involvement in antipsychotic-induced metabolic changes of schizophrenia:A minireview

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World Journal of Diabetes 2021年第10期12卷 1731-1739页

作者： Milica M Borovcanin Katarina Vesic Milena Jovanovic Natasa r Mijailovic depar.ment of Psychiatry University of KragujevacFaculty of Medical SciencesKragujevac 34000SumadijaSerbia depar.ment of Neurology University of KragujevacFaculty of Medical SciencesKragujevac 34000SumadijaSerbia PhD Studies University of KragujevacFaculty of Medical SciencesKragujevac 34000SumadijaSerbia Clinic for Nephrology and Dialysis University Clinical Center KragujevacKragujevac 34000SumadijaSerbia depar.ment of Pharmacy University of KragujevacFaculty of Medical SciencesKragujevac 34000SumadijaSerbia

recently,specific immunometabolic profiles have been postulated in patients with schizophrenia,even before full-blown disease and independent of antipsychotic *** profiling studies offer a promising potential for elucidating the cellular and molecular pathways that may be involved in the onset and progression of schizophrenia symptoms,and co-occurrent metabolic *** view of all this,we were intrigued to explore galectin-3(Gal-3)as a glycan,and in our previous study,we measured its elevated levels in remission of *** finding may be a consequence of antipsychotic treatment and may have an impact on the onset of inflammation,the development of obesity,and the presumed cognitive changes in *** the animal study,it was shown that downregulation of Gal-3 was beneficial in insulin regulation of obesity and cognitive *** involving plasma exchange are discussed in this review,particularly in the context of Gal-3 elimination.

关键词： Galectin-3 Schizophrenia Metabolic syndrome Insulin resistance Cognition Antipsychotics

流行性乙型脑炎病毒组织培养的研究 Ⅱ.影响细胞病变作用的几种因素

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微生物学报 1960年第2期 116-125页

作者：郭煇玉中国医学科学院北京协和医院检验科

近十年来,组织培养技术有很大的发展,在研究许多病毒学的理论与实际问题中,已经成为不可缺少的方法。促进病毒组织培养发展的重要因素之一是病毒致细胞病变作用的发现。利用病毒在组织培养中引起细胞破坏或形态改变等指标,可以直接及简... 详细信息

近十年来,组织培养技术有很大的发展,在研究许多病毒学的理论与实际问题中,已经成为不可缺少的方法。促进病毒组织培养发展的重要因素之一是病毒致细胞病变作用的发现。利用病毒在组织培养中引起细胞破坏或形态改变等指标,可以直接及简便地证明病毒在组织培养中的繁殖。从理论上看来,病毒感染细胞后都使细胞产生不同程度的变化。但是影响病毒致细胞病变作用的因素是很多的。不论在宿主细胞方面,病

关键词：脑炎病毒病变肌皮 rNA病毒病毒株鸡胚

同种异体移植肾组织中CD40/CD40L的表达及其意义

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肾脏病与透析肾移植杂志 2002年第4期11卷 312-314,341页

作者：周广臣许纯孝谢叔良南京大学医学院临床学院山东大学第二附属医院泌尿外科徐州医学院附属医院泌尿外科

目的 :探讨移植肾急性排斥 (Ar)时CD4 0及其配体 (CD4 0L)表达的作用及临床意义。　方法 :采用SP免疫组织化学染色法对 10例正常肾、12例无急性排斥 (N Ar)及 2 4例Ar移植肾组织中CD4 0、CD4 0L表达进行观察 ,并结合肾间质中CD3、CD6 ... 详细信息

目的 :探讨移植肾急性排斥 (Ar)时CD4 0及其配体 (CD4 0L)表达的作用及临床意义。　方法 :采用SP免疫组织化学染色法对 10例正常肾、12例无急性排斥 (N Ar)及 2 4例Ar移植肾组织中CD4 0、CD4 0L表达进行观察 ,并结合肾间质中CD3、CD6 8细胞数进行分析。　结果 :Ar组肾间质CD3、CD6 8细胞数较N Ar组和正常肾明显增高 ,与此相一致的是间质CD4 0 + 、CD4 0L+ 细胞数也较N Ar组明显增高。Ar肾组织中CD4 0 /CD4 0L表达分布不同 ,间质淋巴细胞以表达CD4 0为主 ,CD4 0L表达以肾实质细胞表达为主。　结论 :CD4 0 /CD4 0L在Ar移植肾组织中的原位表达及其分布特点可能与其参与Ar的病理损伤机制有关。

关键词：同种异体移植肾组织 CD40 急性排斥反应共刺激分子 CD40配体免疫组织化学

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“生精胶囊”对大鼠的生精作用的研究

四川生理科学杂志 1995年第1期17卷 13-16页

作者：季如莲四川省中医药研究院临床所中药研究室成都610031

本文用病理学的计数方法研究了“生精胶囊”对大鼠的生精作用。结果表明“生精胶囊”能明显增加睾丸曲细精管内生殖细胞数目、睾丸内精子数目、曲细精管数量及其直径和曲细精管内细胞层数,增加精子活率而对初级精母细胞直径及精子活动... 详细信息

本文用病理学的计数方法研究了“生精胶囊”对大鼠的生精作用。结果表明“生精胶囊”能明显增加睾丸曲细精管内生殖细胞数目、睾丸内精子数目、曲细精管数量及其直径和曲细精管内细胞层数,增加精子活率而对初级精母细胞直径及精子活动力无明显影响。为临床该药治疗“男性不育少精症”提供了科学依据。

关键词：生精胶囊生精作用少精症

Excretion of urinary glycosaminoglycans in type 2 diabetic nephropathy

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Excretion of urinary glycosaminoglycans in type 2 diabetic n...