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Autophagy is increased in cryptorchid testis resulting in abnormal spermatozoa

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Asian Journal of Andrology 2019年第6期21卷 570-576页

作者： Marina G Yefimova Antoine Buschiazzo Agnes Burel Marie-Therese Lavault Celine Pimentel Guilhem Jouve Sylvie Jaillard Bernard Jegou Nicolas Bourmeyster celia Ravel Univ Rennes CHU RennesLaboratoire de Biologie de la Reproduction-CECOSInsermEH ESPIrset(Institut de recherche en santeenvironnement et travail)-UMR_S 1085Rennes F-35000France Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences194223 St-PetersburgRussia Univ Rennes Biosit Platform-MRICRennes 35000France Univ Rennes CHU RennesDepartment of Gynecology Obstetric and Human ReproductionRennes 35000France Univ Rennes CHU RennesDepartment of CytogeneticIrset(Institute for Environmental and Occupational Health)-UMR_S 1085Rennes 35000France Univ Rennes InsermEH ESPIrset(Institute for Environmental and Occupational Health)-UMR_S 1085Rennes F-35000France University of Poitiers-CHU Poitiers STIM ERL 7003 CNRSPoitiers 86021France

Autophagy is invoIved in spermatogenesis by regulating germ cell *** catabolic process increases with hyperthermic conditions to prevent the accumulation of damaged *** is associated with impairment of germ cell maturation revealed by the presence of immature forms of sperm cells in *** aim of the present study was to evaluate the status of autophagy in sperm cells from cryptorchid *** samples of cryptorchid patients and normozoospermic controls were analyzed by immuno cytochemistry and electron *** protei ns,autophagy-related protein 9(ATG9)and microtubule-associated protein,lA/lB-light chain 3(LC3)were localized by immunocytochemistry on the acrosome and on the equatorial segment of sperm ***3 was also detected in the midpiece of cryptorchid sperm *** substrate p62 protein was present in the acrosome and in the postequatorial segment of sperm in control samples,but not in the cryptorchid *** electron microscopy revealed double-membrane-limited autophagosomes in postequatorial part of spermatozoa head and midpiece in cryptorchid *** degraded mitochondria were frequently discerned in autophagic *** conclusion,autophagy is increased in sperm cells from patients with cryptorchid history comparatively to *** work provides insights into the role of autophagy in the maturation and survival of human male gametes in pathological ***,regulating autophagy could represent a potential way to improve sperm quality in cryptorchid men.

关键词： autophagy cryptorchidism mitophagy spermatozoa

Molecular and phylogenetic characterization of South African H5N2 strains affecting ostriches

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Molecular and phylogenetic characterization of South African...

The Role of the Pharmacist in Pre-Exposure Prophylaxis

The 15th World Veterinary Poultry Congress

作者： celia Abolnik ARC-Onderstepoort Veterinary Institute Private Bag X5Onderstepoort Pretoria0110South Africa

＜正＞Introduction In 2004 South Africa recorded its first outbreak of highly pathogenic notifiable avian influenza （HPNAI）in forty three years when an H5N2 strain caused mortalities in ostrich flocks of the Eastern cape *** an eradication program that was followed by intensive surveillance,South Africa officially

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Pharmacology & Pharmacy 2014年第3期5卷 225-228页

作者： celia Moffat Joel Matyanga Pharmaceutical Technology Department Harare Institute of Technology Harare Zimbabwe

Pre-exposure prophylaxis is a new HIV prevention method that has shown to be effective in HIV uninfected persons at very high risk of HIV infection. It involves daily use of truvada in combination with other proven methods of HIV prevention. The aim of this paper is to discuss the various roles that pharmacists play in pre-exposure prophylaxis to maximize therapy.

关键词： HIV PrEP Role Pharmacist

Recent Advances in Superplastic Intermetallics

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Acta Metallurgica Sinica(English Letters) 1995年第Z1期8卷 405-417页

作者： NIEH Tai-Gang WADSWORTH Jeffrey (Lawrence Livermore National Laboratory, Livermore, ca 94550, USA) Lawrence Livermore National Lab Livermore United States

Superplasticity in intermetallic alloys is reviewed. Intermetallics which have been demonstrated to be superplastic include nickel-based (Ni_3Al, Ni_3Si), titanium-base (Ti_3Al, TiAl), and iron-base (Fe_3Al, FeAl) alloys. These alloys are primarily finegrained, two phase materials. But, superplasticity was also observed in some iron-base alloys which were in coarsegrained conditions. These alloys behave like Class I solid solution. The superplastic deformation mechanisms as well as microstructural characteristics are discussed. The superplastic forming of intermetallics is also briefly addressed.

关键词： Superplasticity microstructure grain size boundary sliding

Benign intratesticular schwannoma:a rare finding

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Asian Journal of Andrology 2006年第1期8卷 101-103页

作者： Maria Chiara Sighinolfi Alessandro Mofferdin Stefano S.De Stefani Antonio celia Salvatore Micali Giovanni Saredi Giulio Rossi Riccardo Valli Giampaolo Bianchi Division of Urology Department of Pathology Section of Anatomic Pathology University of Modena 41100 ModenaItaly

Schwannoma is a peripheral nerve tumour, occasionally located in the genitourinary tract. We described an extremely rare case of intratesticular neurinoma in a 79-year-old patient. （Asian JAndrol 2006 Jan; 8： 101-103）

关键词： schwannoma Schwann cells testicular neoplasm S 100 protein

Changes in expression of inhibitory substances in the intramural neurons of the stomach following streptozotocininduced diabetes in the pig

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World Journal of Gastroenterology 2017年第33期23卷 6088-6099页

作者： Michal Bulc Katarzyna Palus Lukasz Zielonka Magdalena Gajecka Jaroslaw całka Department of Clinical Physiology Faculty of Veterinary Medicine University of Warmia and Mazury Department of Veterinary Prevention and Feed Hygiene Faculty of Veterinary MedicineUniversity of Warmia and Mazury in Olsztyn

AIM Influence of chronic hyperglycemia on chemical coding of enteric neurons in stomach using pig as a model for human diabetic *** Ten pigs were divided into two groups: diabetic(D group,n = 5) and control(C group,n = 5). Pigs constituting the experimental group were given streptozotocin(150 mg/kg). Animals were euthanized six weeks after the induction of diabetes. The samples of stomach were collected from animals of both groups. The cryostat sections were processed for double immunofluorescence staining using primary antisera directed towards pan-neuronal marker(Hu C/D) proteins and/or neuronal isoform of nitric oxide synthase(n NOS),vasoactive intestinal peptide(VIP) and galanin(GAL). RESULTS In the control group in the myenteric ganglia(MG) of the corpus we have noted 22.28% ± 1.19% of n NOS positive neurons,while in diabetic group we have found 40.74% ± 2.22% of n NOS immunoreactive perikarya(increase by 82.85 %). In turn in the pylorus we have observed 15.91% ± 0.58% n NOS containing neurons in control animals and 35.38% ± 1.54% in the diabetes group(increase by 122.37%). In the MG of the antrum and submucosal ganglion(SG) in the corpus hyperglycemia did not cause statistically significant changes. With regard to VIP-positive cell bodies in the antrum MG in the control animals we have noted 18.38 ± 1.39% and 40.74% ± 1.77% in the experimental group(increase by 121.65%). While in the corpus we have observed 23.20% ± 0.23% in the control and 30.93% ± 0.86% in the diabetes group(increase by 33.31%). In turn in the pylorus VIP positive cells bodies constituted 23.64% ± 1.56% in the control group and 31.20% ± 1.10% in the experimental group(increase by 31.97%). In the submucosal ganglion in the corpus we have noted 43.61% ± 1.06% in the control animals and 37.00% ± 1.77% in the experimental group(decrease by 15.15%). Expression of GAL-positive perikarya showed statistically significant changes only in the MG of the antrum and pylorus. In the antr

关键词： Immunohistochemistry Inhibitory neurons Streptozotocin Hyperglycemia Pig

A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells

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Cellular & Molecular Immunology 2023年第12期20卷 1499-1512页

作者： Leticia Martín-Cruz Marcos Viñuela Ioanna Kalograiaki Alba Angelina Paola Oquist-Phillips Irene Real-Arévalo Francisco Javier cañada JoséIgnacio Tudela Luis Moltó Jesús Moreno-Sierra JoséLuis Subiza Oscar Palomares Department of Biochemistry and Molecular Biology School of ChemistryComplutense University of MadridMadridSpain Inmunotek Alcaláde HenaresMadridSpain Fundación Investigación Hospital Clínico San carlos Martin Lagos s/n28040MadridSpain Centro de Investigaciones Biológicas Margarita Salas CSICRamiro de Maetzu 928040MadridSpain CIBER de Enfermedades Respiratorias(CIBERES)Avda Monforte de Lemos3-528029MadridSpain Servicio de Urología Hospital Clínico San CarlosUniversidad Complutense de MadridMartín Lagos s/n28040MadridSpain

Functional Tregs play a key role in tumor development and progression,representing a major barrier to anticancer *** mechanisms by which Tregs are generated in cancer and the influence of the tumor microenvironment on these processes remain incompletely ***,by using NMR,chemoenzymatic structural assays and a plethora of in vitro and in vivo functional analyses,we demonstrate that the tumoral carbohydrate A10(ca10),a cell-surface carbohydrate derived from Ehrlich’s tumor(ET)cells,is a heparan sulfate-related proteoglycan that enhances glycolysis and promotes the development of tolerogenic features in human ***10-stimulated human DCs generate highly suppressive Tregs by mechanisms partially dependent on metabolic reprogramming,PD-L1,IL-10,and ***10 also reprograms the differentiation of human monocytes into DCs with tolerogenic *** solid ET-bearing mice,we found positive correlations between ca10 serum levels,tumor size and splenic Treg *** of isolated ca10 also increases the proportion of splenic Tregs in tumor-free ***,we provide evidence supporting the presence of a circulating human ca10 counterpart(ca10H)and show,for the first time,that serum levels of ca10H are increased in patients suffering from different cancer types compared to healthy *** note,these levels are higher in prostate cancer patients with bone metastases than in prostate cancer patients without ***,we reveal novel molecular mechanisms by which heparan sulfate-related structures associated with tumor cells promote the generation of functional Tregs in *** discovery of this novel structural-functional relationship may open new avenues of research with important clinical implications in cancer treatment.

关键词： Tumoral carbohydrate A10 Heparan sulfate-related proteoglycan cancer immunology Dendritic cell Regulatory T cell

北祁连山高压变质带的变形和变质特征及其对俯冲带折返的意义

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岩石学报 2009年第9期25卷 2235-2246页

作者：曹毅宋述光 ca0 Peking Univ MOE Key Lab Orogen Belts & Crustal Evolut Dept Geol Beijing 100871 Peoples R China

北祁连造山带是早古生代大洋板块"冷"俯冲的典型地区,形成了一系列高压低温变质的岩石组合。基性榴辉岩是俯冲洋壳变质的产物,根据其结构构造特征可以划分为(1)粒状榴辉岩,峰期变质矿物组合为Grt+Omp+Phn+Rut±Lws,硬柱石呈包裹体和假... 详细信息

北祁连造山带是早古生代大洋板块"冷"俯冲的典型地区,形成了一系列高压低温变质的岩石组合。基性榴辉岩是俯冲洋壳变质的产物,根据其结构构造特征可以划分为(1)粒状榴辉岩,峰期变质矿物组合为Grt+Omp+Phn+Rut±Lws,硬柱石呈包裹体和假象分布于石榴石内,变质温压条件T=465～508℃,p=2.30～2.60GPa。(2)片状榴辉岩,岩石具片状构造,其共生矿物组合Omp+Czo/Ep+Phn+Gln构成透入性面理S_1和线理L_1,以及宏观和显微同斜褶皱F_1。其峰期变质温压条件为T=466～510℃,P=1.9～2.2GPa。(3)蓝片岩相退化变质榴辉岩,蓝片岩相变质矿物Gln+Ep+Phn±Ab强烈交代榴辉岩相矿物,并发生强烈D_2期变形作用,岩石形成明显的透入性面理S_2和线理L_2,以及同斜剪切褶皱F_2。蓝闪石和多硅白云母线理的统计揭示D_2期变形以斜向走滑剪切为主,与D_1期变形的榴辉岩的运动学特征大体相似。D_2同变质的温压条件为T=422～487℃,P=1.15～1.37GPa。高压变质带晚期的绿片岩相叠加和D_3期变形,形成透入性面理S_3和线理L_3,其运动特征为近于垂直构造线的逆冲剪切。结合榴辉岩变形特征,变质温压条件和同位素年代学资料,我们认为退变质的强弱与变形程度有密切关系。峰期变质后的榴辉岩经过早期绿帘石榴辉岩相到蓝片岩相斜向走滑剪切,和晚期绿片岩相逆冲,在泥盆纪早期快速折返的出露地表。

关键词：北祁连山高压变质带变形变质特征俯冲带折返 implications 榴辉岩相峰期变质温压条件 mineral assembla.e 蓝片岩相 North Qilian Mountains isotopic geochronology 走滑剪切线理绿片岩相矿物组合变质矿物 movement Early Paleozoic

LUMINANCE MEASURMENT DEVICE BASED ON DIGITAL caMERA FOR QUALITY CONTROL IN AUTOMOTIVE INDUSTRY

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LUMINANCE MEASURMENT DEVICE BASED ON DIGITAL CAMERA FOR QUAL...