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Role of neutrophil-to-lymphocyte and platelet-tolymphocyte ratios in Peyronie’s disease: a new diagnostic approach to predict the stage of the disease?

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Asian Journal of Andrology 2021年第3期23卷 325-329页

作者： Esther Garda Rojo Borja Garda Gomez Rocio Santos-Perez de la Blanca celeste manfredi Manuel Alonso Isa Jose Medina Polo Alfredo Rodriguez Antolin Javier Romero Otero Department of Urology Research Institute Hospital 12 de Octubre(Imasl2)Madrid 29041Spain Department of Urology University Hospital HM MonteprfncipeMadrid 28668Spain.

Neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)have been associated with multiple entities and several types of *** can be assumed as markers of inflammatory *** objective of this study is to evaluate the NLR and PLR in Peyronie’s disease(PD)and to establish a comparison of its values in the acute and chronic *** recruited patients with PD from March 2018 to March *** patients enrolled underwent medical and sexual history as well as a physical *** values of blood count of each patient were collected both in the acute and chronic *** test was used to compare the acute and chronic stage ***-Wallis test was carried out to evaluate the impact of treatments on the *** identify cutoff values,we used sensibility and specificity tables and receiver operating characteristic(ROC)curves.A total of 120 patients were *** mean age was 55.85(range:18-77)years and the mean penile curvature was 48.43°(range:10°-100°).In the acute stage,the mean NLR was 2.35 and the mean PLR was *** ratios,in the chronic stage,were 1.57 and 100.00,*** significant differences between acute and stable stages for both indices were found(NLR:P<0.0001;PLR:P=0.0202).The optimal cutoff for classification in acute or stable stage was 2 for NLR and 102 for *** to our results,with an ordinary blood count,we could have important indications regarding the disease stage of the patient,and consequently on the most appropriate type of therapy to choose.

关键词： diagnosis inflammation neutrophil-to-lymphocyte ratio Peyronie^disease platelet-to-lymphocyte ratio

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Intraplaque injections of hyaluronic acid for the treatment of stable-phase Peyronie’s disease:a retrospective single-center experience

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Asian Journal of Andrology 2024年第3期26卷 268-271页

作者： Simone Cilio Roberto La Rocca Giuseppe Celentano Claudio Marino Massimiliano Creta Gianluigi Califano celeste manfredi Giorgio Ivan Russo Afonso Morgado Marco Falcone Marco Capece YAU Working Group Sexual and Reproductive Health Department of Neurosciences Reproductive Sciences and OdontostomatologyUrology UnitUniversity of Naples“Federico II”Naples 80131Italy Urology Unit Department of WomenChild and General and Specialized Surgery“Luigi Vanvitelli”UniversityNaples 80131Italy Urology Section Department of SurgeryUniversityof CataniaCatania 95131Italy Department of Urology Centro Hospitalar Universitário São JoãoPorto 4200-319Portugal Urology Clinic-A.O.U.“Cittàdella Salute edella Scienza”-Molinette Hospital University of TurinTurin 10100Italy 不详

Peyronie’s disease(PD)is a condition of penile connective tissue affecting up to 10%of men *** the complexity ofits management,nonsurgical treatments,such as intraplaque injections,are gaining *** current literature shows dataon the efficacy of intraplaque injections of hyaluronic acid(HA)mainly in acute-phase ***,data on injections of HA instable-phase PD are *** for this retrospective study were derived from a prospectively maintained database of privatepatients presenting at a private medical practice affiliated to the University of Naples“Federico II”(Naples,Italy)with stable-phasePD between January 2020 and March *** underwent a standard protocol of three injections,each administered at atwo-week *** the intervals,patients performed vacuum device therapy,penile stretching,and modeling *** compiled the Peyronie’s Disease Questionnaire(PDQ)and Global Assessment of Peyronie’s Disease(GAPD)at baselineand 2 weeks after the third injection.A penile Doppler ultrasound was performed 2 weeks after the last injection to record thefinal ***,we recruited 62 patients with stable-phase PD and a mean(±standard deviation[s.d.])curvature of52.7°(±9.7°).After 6 weeks,eight(12.9%)patients did not experience any curvature *** remaining 54 patientshad a final mean(±s.d.)curvature of 40.3°(±9.1°)with P<0.001,compared to that before *** found improvement inall PDQ domains(all P≤0.01),and 50(80.6%)patients reported subjective improvement of the penile curvature according to *** conclusion,we demonstrated that after three injections of HA administered according to the adopted protocol,patientswith stable-phase PD could experience significant improvements in penile curvature,and physical and psychological consequencesof the disease without significantly relevant side effects.

关键词： hyaluronic acid intraplaque injection Peyronie’s disease stable-phase therapy

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Hyper accuracy three-dimensional virtual anatomical rainbow model facilitates surgical planning and safe selective clamping during robot-assisted partial nephrectomy

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Asian Journal of Urology 2024年第4期11卷 660-665页

作者： Francesco Ditonno Antonio Franco celeste manfredi Daniele Amparore Enrico Checcucci Marco De Sio Alessandro Antonelli Cosimo De Nunzio Cristian Fiori Francesco Porpiglia Riccardo Autorino Department of Urology Rush UniversityChicagoILUSA Department of Urology Azienda Ospedaliera Universitaria Integrata VeronaUniversity of VeronaVeronaItaly Department of Urology Sant'Andrea HospitalSapienza UniversityRomeItaly Unit of Urology Department of WomanChild and General and Specialized SurgeryUniversity of Campania“Luigi Vanvitelli”NaplesItaly Division of Urology Department of OncologyUniversity of TurinSan Luigi Gonzaga HospitalOrbassanoTurinItaly

ObjectiveTo highlight the role of hyper accuracy three-dimensional(3D)reconstruction in facilitating surgical planning and guiding selective clamping during robot-assisted partial nephrectomy(RAPN).MethodsA transperitoneal RAPN was performed in a 62-year-old male patient presenting with a 4 cm right anterior interpolar renal mass(R.E.N.A.L nephrometry score 7A).An abnormal vasculature was observed,with a single renal vein and two right renal arteries originating superiorly to the vein and anterior,when dividing in their segmental *** to the hyper accuracy 3D(HA3D^(®))rainbow model(MEDICS Srl,Turin,Italy),one branch belonging to one of the segmental arteries was feeding the *** allowed for an accurate prediction of the area vascularized by each arterial *** 3D model was included in the intraoperative console view during the whole procedure,using the TilePro feature.A step-by-step explanation of the procedure is provided in the video attached to the present *** operative time was 90 min with a warm ischemia time on selective clamping of 13 *** blood loss was 180 *** intraoperative complication was encountered and no drain was placed at the end of the *** patient was discharged on postoperative Day 2,without any early postoperative *** final pathology report showed a pathological tumor stage 1 clear cell renal cell carcinoma with negative surgical *** present study and the attached video illustrate the value of 3D rainbow model during the planning and execution of a RAPN with selective *** shows how the surgeon can rely on this model to be more efficient by avoiding unnecessary surgical steps,and to safely adopt a“selective”clamping strategy that can translate in minimal functional impact.

关键词： Hyper accuracy three-dimensional rainbow model Augmented reality Clear cell renal cell carcinoma Robot-assisted partial nephrectomy Selective clamping

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New frontiers in focal therapy for prostate cancer:Prostate-specific membrane antigen positron emission tomography/magnetic resonance imaging

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World Journal of Clinical Oncology 2021年第2期12卷 61-68页

作者： celeste manfredi Esau Fernandez-Pascual Estefanía Linares-Espinós Felipe Couñago Juan Ignacio Martínez-Salamanca Department of Woman Child and General and Specialized SurgeryUrology UnitUniversity of Campania“Luigi Vanvitelli”Naples 81110Italy Department of Urology Hospital Universitario La PazMadrid 28046Spain LYX Institute of Urology Facultad de MedicinaUniversidad Francisco de VitoriaPozuelo de Alarcón 28223MadridSpain Radiation Oncology Hospital Universitario Quirónsalud MadridPozuelo de Alarcón 28223MadridSpain Department of Urology Hospital Universitario Puerta Hierro-MajadahondaMajadahonda 28222MadridSpain

Imaging has a central role in the context of focal therapy(FT)for prostate cancer(PCa).Prostate-specific membrane antigen(PSMA)positron emission tomography/magnetic resonance imaging(PET/MRI)is a novel imaging modality that combines the morpho-functional information of MRI with the molecular characterization of *** papers reported the potential advantages of PSMA PET/MRI in different clinical *** evidence on PSMA PET/MRI is available in the setting of *** PET/MRI can be an effective imaging modality for detecting primary PCa and seems to provide accurate local staging of primary *** PET/MRI also shows high performance for restaging and detecting tumor *** higher soft-tissue contrast and the reduction of ionizing radiation are the main advantages reported in the literature compared to PET/computed *** PET/MRI could represent a turning point in the management of patients with PCa in the context of *** studies are needed to confirm its applications in this specific clinical setting.

关键词： Prostate-specific membrane antigen Positron emission tomography/magnetic resonance imaging Prostate cancer Focal therapy High-intensity focused ultrasound Cryotherapy

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The role of MRI in modifying surgical management of colorectal liver metastases:a lesson from the CAMINO trial

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 837-840页

作者： Marco Palucci celeste Del Basso Fabio Giannone Robotic Oncological and HPB SurgeryAOU SS Antonio e Biagio e Cesare ArrigoAlessandriaItaly

The CAMINO trial by Görgec et al.(1)assessed the added diagnostic value of contrast-enhanced(CE)magnetic resonance imaging(MRI)using gadoxetic acid and diffusion-weighted imaging for patients with colorectal liver metastases(CRLMs)scheduled for curative treatment(surgical resection,thermal ablation,or both).The study explored how often liver(MRI)changes therapeutic strategy compared to using only a CE computed tomography(CT)*** MRI’s widespread use in staging for CRLMs,guidelines remain vague,leaving decisions to the surgeon’s preference and expertise.

关键词： Magnetic resonance imaging(MRI) colorectal liver metastasis(CRLM) CAMINO trial

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Leishmaniasis in the knee area

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Asian Pacific Journal of Tropical Medicine 2010年第4期3卷 330-331页

作者： Bava Amadeo Javier Rossi Maria Laura Seley celeste Troncoso Alcides Department of Micology La Plata University Department of Microbiology Parasitology and Infectious DiseasesSchool of MedicineBuenos Aires University

Leishmaniasis is a parasitic infection caused by species leishmaniae,which can produce two types of manifestations:visceral and *** south America cutaneous leishmaniasis is more common than visceral leishmaniasis.A case of primary cutaneous leishmaniasis from Bolivia is presented for its *** patient of our case showed an ulcerated lesion of the knee. Montenegro’s intradermal test was ***-stained touch preparation of the skin biopsy revealed amastigotes inside macrophages,consistent with *** patient was treated with meglumine antimoniate intramuscular(20 mg of Sb+/kg/day) three weeks,with complete cicatrization of the lesion.

关键词： Cutaneous leishmaniasis Skin ulcers Leishmania

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IGF1-PI3K-induced physiological cardiac hypertrophy:Implications for new heart failure therapies,biomarkers,and predicting cardiotoxicity

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Journal of Sport and Health Science 2021年第6期10卷 637-647,I0001页

作者： Sebastian Bass-Stringer celeste M.K.Tai Julie R.McMullen Baker Heart and Diabetes Institute MelbourneVIC 3004Australia Department of Physiology Anatomy and MicrobiologyLa Trobe UniversityBundooraVIC 3086Australia Department of Diabetes Central Clinical SchoolMonash UniversityMelbourneVIC 3004Australia Department of Physiology and Department of Medicine Alfred Hospital Monash UniversityMelbourneVIC 3004Australia

Heart failure represents the end point of a variety of cardiovascular *** is a growing health burden and a leading cause of death *** date,limited treatment options exist for the treatment of heart failure,but exercise has been well-established as one of the few safe and effective interventions,leading to improved outcomes in ***,a lack of patient adherence remains a significant barrier in the implementation of exercise-based therapy for the treatment of heart *** insulin-like growth factor 1(IGF1)phosphoinositide 3-kinase(PI3K)pathway has been recognized as perhaps the most critical pathway for mediating exercisedinduced heart growth and ***,we discuss how modulating activity of the IGF1PI3K pathway may be a valuable approach for the development of therapies that mimic the protective effects of exercise on the *** outline some of the promising approaches being investigated that utilize PI3K-based therapy for the treatment of heart *** discuss the implications for cardiac pathology and cardiotoxicity that arise in a setting of reduced PI3K ***,we discuss the use of animal models of cardiac health and disease,and genetic mice with increased or decreased cardiac PI3K activity for the discovery of novel drug targets and biomarkers of cardiovascular disease.

关键词： Cardiac protection Cardiotoxicity Exercise Heart failure IGF1 PI3K Therapies

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PSA as the driving biomarker to manage low-and intermediate-risk prostate cancer patients in clinical practice

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Asian Journal of Andrology 2024年第6期26卷 567-568页

作者： Enrico Ricevuto celeste Morgani Fabrizia Seri Gemma Bruera Oncology Territorial Care Unit S.Salvatore HospitalUniversity of L’AquilaL’Aquila 67100Italy Department of Biotechnological and Applied Clinical Sciences University of L’AquilaL’Aquila 67100Italy

Prostate cancer risk stratification relies on several clinical factors. Low-risk patients, characterized by T1–T2a stage, Gleason score (GS) ≤6, and prostate-specific antigen (PSA) <10 ng ml−1, exhibit an excellent prognosis and are suitable for active surveillance (AS). Regular monitoring is essential for these patients, including PSA tests every 3–6 months, annual digital rectal exams (DRE), and prostate biopsies every 6–12 months, followed by less frequent biopsies every 2–5 years. Epstein criteria, which consider GS ≤6, PSA density (PSAD) <0.15 ng ml−2, limited tumor involvement in cores, and absence of high-risk features, help predict pathologic and biochemical relapse-free survival and guide AS management.

关键词： patients clinical cancer

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Shaping the future of pediatric liver health:unraveling the impact of the new metabolic-associated fatty liver disease definition

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Hepatobiliary Surgery and Nutrition 2023年第4期12卷 611-615页

作者： Stefano Ciardullo Michela Vergani celeste Ronchetti Gianluca Perseghin Department of Medicine and Surgery University of Milano BicoccaMilanItaly Department of Medicine and Rehabilitation Policlinico di MonzaMonzaItaly

Liver steatosis(i.e.,excessive triglyceride accumulation within the hepatocyte)is a very common finding in both the adult and pediatric *** the latter,epidemiologic data using validated diagnostic techniques(either liver biopsy or ultrasound-based technologies)have shown an alarmingly high prevalence,paralleling the ever-increasing rates of overweight and obesity.

关键词： Nonalcoholic fatty liver disease(NAFLD) metabolic-associated fatty liver disease(MAFLD) pediatrics definition fatty liver

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Effects of obesity on breast size,thoracic spine structure and function,upper torso musculoskeletal pain and physical activity in women

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Journal of Sport and Health Science 2020年第2期9卷 140-148页

作者： Julie R.Steele celeste E.Coltman Deirdre E.McGhee Biomechanics Research Laboratory School of MedicineUniversity of WollongongWollongongNSW 2522Australia Research Institute for Sport and Exercise Faculty of HealthUniversity of CanberraCanberraACT 2601Australia

Purpose:This study investigated the effects of obesity on breast size,thoracic spine structure and function,upper torso musculoskeletal pain and physical activity participation in women living independently in the ***:A total of 378 women were divided into 3 groups(Not Overweight:body mass index(BMI)=22.5±0.2 kg/m^2(mean±SE);Overweight:BMI=27.4±0.3 kg/m^2;Obese:BMI=35.4±0.3 kg/m^2).Outcome variables of breast volume(mL),thoracic flexion torque(N·m),thoracic kyphosis(degrees),upper torso musculoskeletal pain(score) and time spent in physical activity(min) were calculated and compared among the 3 groups,adjusting for between-group differences in ***:There was a significant main effect of BMI on all outcome *** classified as Obese displayed significantly larger breasts,had greater thoracic flexion torques and reported less time participating in physical activity relative to the participants who were classified as Not Overweight and *** in the Obese group also displayed significantly more thoracic kyphosis and reported significantly more upper torso musculoskeletal pain compared to their counterparts who were classified as Not ***:This study is the first to demonstrate that increased obesity levels were associated with compromised kyphosis and loading of the thoracic spine,as well as increased symptoms of upper torso musculoskeletal pain and reduced time spent in physical activity in women living in the *** recommend further research to determine whether evidence-based interventions designed to reduce the flexion torque generated on the thoracic spine can improve these symptoms of upper torso musculoskeletal pain and the ability of women with obesity to participate in physical activity.

关键词： Breast volume Obesity Thoracic kyphosis Upper torso loading

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