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Fine-mapping and validation of the genomic region underpinning pear red skin colour

Horticulture Research 2019年第1期6卷 1607-1613页

作者： Satish Kumar Chris Kirk cecilia hong deng Claudia Wiedow Mengfan Qin Richard Espley Jun Wu Lester Brewer The New Zealand Institute for Plant and Food Research Limited Hawkes Bay Research CentreHavelock NorthNew Zealand The New Zealand Institute for Plant and Food Research Limited Palmerston North Research CentrePalmerston NorthNew Zealand The New Zealand Institute for Plant and Food Research Limited Mount Albert Research CentreAucklandNew Zealand Centre of Pear Engineering Technology Research Nanjing Agricultural University210095 NanjingChina The New Zealand Institute for Plant and Food Research Limited Motueka Research CentreMotuekaNew Zealand

Red skin colour is an important target trait in various pear breeding *** this study,the genetic control of red skin colour was investigated in an interspecific population derived using the descendants of the red sport European pear cultivar‘Max Red Bartlett’(MRB)and the red-blushed Chinese pear cultivar‘Huobali’.Approximately 550 seedlings from nine families were phenotyped for red skin over-colour coverage(Ocolcov)and the intensity of red over-colour(Ocolint)on a 0–9 scale,and genotyped using ***-wide association analyses were conducted using 7500 high-quality single nucleotide polymorphisms(SNPs).Genomic regions on linkage groups(LG)4 and 5 were found to be associated,and the best SNP(S578_25116)on LG4 accounted for~15%of phenotypic variation in Ocolcov and *** association of S578_25116 with Ocolcov and Ocolint was successfully validated in a sample of~200 European and Asian pear *** association with red skin at locus S578_25116 was not present in Asian pear accessions,suggesting its close proximity to the MRB’s Cardinal *** putative candidate genes,including MYB transcription factors(PCP027962 and PCP027967),were identified in the quantitative trait locus region on LG4 and await functional validation.

关键词： cultivar breeding colour

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The IAA-and ABA-responsive transcription factor CgMYB58 upregulates lignin biosynthesis and triggers juice sac granulation in pummelo

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Horticulture Research 2020年第1期7卷 846-859页

作者： Meiyan Shi Xiao Liu Haipeng Zhang Zhenyu He hongbin Yang Jiajing Chen Jia Feng Wenhui Yang Youwu Jiang Jia-Long Yao cecilia hong deng Juan Xu Key Laboratory of Horticultural Plant Biology Ministry of EducationWuhanHubei 430070China The New Zealand Institute for Plant and Food Research Limited Private Bag 92169Auckland 1142New Zealand

In citrus,lignin overaccumulation in the juice sac results in granulation and an unpleasant fruit texture and *** integrating metabolic phenotyping and transcriptomic analyses,we found 702 differentially expressed genes(DEGs),including 24 transcription factors(TFs),to be significantly correlated with lignin ***58 was further identified as a critical R2R3 MYB TF involved in lignin overaccumulation owing to its high transcript levels in Huanong Red-fleshed pummelo(HR,Citrus grandis)*** expression of CgMYB58 led to an increase in the lignin content in the pummelo fruit mesocarp,whereas its stable overexpression significantly promoted lignin accumulation and upregulated 19 lignin biosynthetic *** these genes,CgPAL1,CgPAL2,Cg4CL1,and CgC3H were directly modulated by CgMYB58 through interaction with their promoter ***,we showed that juice sac granulation in pummelo fruits could be affected by indole-3-acetic acid(IAA)and abscisic acid(ABA)*** HR pummelo,ABA significantly accelerated this granulation,whereas IAA effectively inhibited this *** together,these results provide novel insight into the lignin accumulation mechanism in citrus *** also revealed the theoretical basis via exogenous IAA application,which repressed the expression of CgMYB58 and its target genes,thus alleviating juice sac granulation in orchards.

关键词： integrating treatment citrus

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Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury:state of the art and future perspectives

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Neural Regeneration Research 2025年第11期20卷 3151-3171页

作者： Fatima Aldali Chunchu deng Mingbo Nie hong Chen Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal *** nerve injury results in movements or sensation impairments,and represents a serious public health *** severed peripheral nerves have been effectively joined and various therapies have been offered,recovery of sensory or motor functions remains limited,and efficacious therapies for complete repair of a nerve injury remain *** emerging field of mesenchymal stem cells and their exosome-based therapies hold promise for enhancing nerve regeneration and *** stem cells,as large living cells responsive to the environment,secrete various factors and *** latter are nano-sized extracellular vesicles containing bioactive molecules such as proteins,microRNA,and messenger RNA derived from parent mesenchymal stem *** have pivotal roles in cell-to-cell communication and nervous tissue function,offering solutions to changes associated with cell-based *** ongoing investigations,mesenchymal stem cells and mesenchymal stem cell-derived exosome-based therapies are in the exploratory stage.A comprehensive review of the latest preclinical experiments and clinical trials is essential for deep understanding of therapeutic strategies and for facilitating clinical *** review initially explores current investigations of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in peripheral nerve injury,exploring the underlying ***,it provides an overview of the current status of mesenchymal stem cell and exosomebased therapies in clinical trials,followed by a comparative analysis of therapies utilizing mesenchymal stem cells and ***,the review addresses the limitations and challenges associated with use of mesenchymal stem cell-derived exosomes,offering potential solutions and guiding future directions.

关键词： clinical trials exosome extracellular vesicles mesenchymal stem cells nerve regeneration peripheral nerve injury pre-clinical experiments

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Distributed Oblivious Function Evaluation and Its Applications

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Journal of Computer Science & Technology 2004年第6期19卷 942-947页

作者： hong-DaLi XiongYang deng-GuoFeng BaoLi StateKeyLabofInformationSecurity GraduateSchoolofChineseAcademyofSciencesBeijing100039P.R.China CollegeofEconomyandTrade SouthChinaUniversityofTropicalAgricultureSanya571737P.R.China

This paper is about distributed oblivious function evaluation (DOFE). In this setting one party (Alice) has a functionf(x), and the other party (Bob) with an input α wants to learnf(α) in an oblivious way with the help of a set of servers. What Alice should do is to share her secret functionf(x) among the servers. Bob obtains what he should get by interacting with the servers. This paper proposes the model and security requirements for DOFE and analyzes three distributed oblivious polynomial evaluation protocols presented in the paper. Keywords oblivious function evaluation - oblivious polynomial evaluation - secure multiparty computation - distributed - information security The research is supported by the National Basic Research 973 Program of China under Grant No. 1999035802 and the National Natural Science Foundation of China under Grant No.60273029.hong-Da Li was born in 1960. He received the Ph.D. degree from Northwestern Polytechnical University in 2001. His current research interests are cryptology and cryptographic protocol.Xiong Yang received the B.S. degree in mathematics from Yan'an University, China, in 1984. He is an associate professor in College of Economy and Trade at South China University of Tropical Agriculture. His research interest is information security.deng-Guo Feng was born in 1963. He is now a Ph.D. supervisor. His research interests focus on information security.Bao Li was born in 1965. He received the Ph.D. degree in cryptography in 1995 from Xidian University. His research interests include cryptographic protocols and public key cryptosystems.

关键词： oblivious function evaluation oblivious polynomial evaluation secure multiparty computation distributed information security

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A global analysis of CO_(2)and non-CO_(2)GHG emissions embodied in trade with Belt and Road Initiative countries

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Ecosystem Health and Sustainability 2020年第1期6卷 18-37,17页

作者： Jing Hou Xu deng cecilia Han Springer Fei Teng Institute of Energy Environment and EconomyTsinghua UniversityBeijingChina Belfer Center for Science and International Affairs Harvard Kennedy SchoolCambridgeMAUSA

Introduction:The Belt and Road Initiative(BRI)is an important cooperative framework that increasingly affects the global economy,trade,and emission ***,most existing studies pay insufficient attention to consumption-based emissions,embodied emissions,and non-CO_(2) greenhouse gases(GHGs).This study constructs a GHG emissions database to study the trends and variations in production-based,consumption-based,and embodied emissions associated with BRI ***:We find that the per capita GHG emissions of BRI countries are lower than the global average but show significant variation within this *** also find that trade-embodied emissions between BRI countries and China are *** a group,BRI countries are anet exporter of GHGs,with a global share of net export emissions of about 20%.In 2011,nearly 80%of GHG export emissions from BRI countries flowed to non-BRI countries,and nearly 15%flowed to China;about 57%of GHG import emissions were from non-BRI countries,and about 38%were from ***:Therefore,this study concludes that the BRI should be used to coordinate climate governance to accelerate and strengthen the dissemination and deployment of low-emissions technologies,strategies,and policies within the BRI so as to avoid a carbon-intensive lock-in effect.

关键词： Belt and Road Initiative(BRI) China consumption-based emissions non-CO_(2)greenhouse gas(NCO2) embodied emissions global multi-regional input-output model(MRIO)

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A practical path guiding method for participating media

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Computational Visual Media 2020年第1期6卷 37-51页

作者： hong deng Beibei Wang Rui Wang Nicolas Holzschuch Nanjing University of Science and Technology Nanjing 210094China State Key Lab of CAD&CG Zhejiang UniversityHangzhou 310058China Univ.Grenoble-Alpes InriaCNRSGrenoble INPLJK38000 GrenobleFrance

Rendering translucent materials is costly:light transport algorithms need to simulate a large number of scattering events inside the material before reaching *** cost is especially high for materials with a large albedo or a small mean-freepath,where higher-order scattering effects *** simple terms,the paths get lost in the *** guiding has been proposed for surface rendering to make convergence faster by guiding the sampling *** this paper,we introduce a path guiding solution for translucent *** learn an adaptive approximate representation of the radiance distribution in the volume and use it to sample the scattering direction,combining it with phase function sampling by resampled importance *** proposed method significantly improves the performance of light transport simulation in participating media,especially for small lights and media with refractive *** method can handle any homogeneous participating medium,with high or low scattering,with high or low absorption,and from isotropic to highly anisotropic.

关键词： Monte Carlo ray tracing path guiding volume light transport participating media rendering

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Parameter effects on high-speed UAV ground directional stability using bifurcation analysis

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Chinese Journal of Aeronautics 2021年第11期34卷 1-14页

作者： Qiaozhi YIN Xiaohui WEI hong NIE Jian deng State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China Key Laboratory of Fundamental Science for National Defense-Advanced Design Technology of Flight Vehicle Nanjing University of Aeronautics and AstronauticsNanjing 210016China MIIT Key Laboratory of Multifunctional Lightweight Materials and Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

A loss of ground directional stability can trigger a high-speed Unmanned Aerial Vehicle(UAV)to veer off the *** order to investigate the combined effects of the key structural and operational parameters on the UAV ground directional stability from a global perspective,a fully parameterized mathematical high-speed UAV ground nonlinear dynamic model is developed considering several nonlinear *** bifurcation analysis procedure of a UAV ground steering system is introduced,following which the simulation efficiency is greatly improved comparing with the time-domain simulation *** the numerical continuation method is employed to investigate the influence of the nose wheel steering angle and the global stability region is *** bifurcation parameter plane is divided into several parts with different stability properties by the saddle nodes and the Hopf bifurcation *** find that the UAV motion states will never cross the bifurcation curve in the nonlinear ***,the dual-parameter bifurcation analyses are presented to give a complete description of the possible steering *** is also found that BT bifurcation appears when the UAV initial rectilinear velocity and the tire frictional coefficient *** addition,results indicate that the influence of tire frictional coefficient has an opposite trend to the influence of initial rectilinear ***,using bifurcation analysis method to identify the parameter regions of a UAV nonlinear ground dynamic system helps to improve the development efficiency and quality during UAV designing phase.

关键词： Bifurcation analysis Ground directional stability High-speed UAV Nonlinear system Numerical continuation

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Study on modal characteristics and vibration reduction of an aircraft rotor–stator brake-induced squeal system

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Acta Mechanica Sinica 2020年第6期36卷 1350-1359,I0004页

作者： Qiaozhi Yin Xiaohui Wei hong Nie Jian deng State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China Key Laboratory of Fundamental Science for National Defense-Advanced Design Technology of Flight Vehicle Nanjing University of Aeronautics and AstronauticsNanjing210016China Nanjing Center for Multifunctional Lightweight Materials and Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China

Based on the modal coupling theory,the rotor and stator contact stiffness and axial relative velocity are considered to build an electric aircraft brake dynamic system model in this *** the complex modal analysis and transient dynamic analysis methods are used to study the aircraft brake squeal performance and vibratory *** unstable vibration modes indicate that the out-of-plane vibration plays an important role and the feed-in energy is larger than the output energy in the brake rotor–stator module so that brake squeal takes *** the influences of the contact stiffness,friction damping and frictional coefficient on the brake squeal system are carried out,laying the foundation for the three proposed vibration suppression *** show that the coefficient negative-slope condition will intensify the ***,a linear relationship between the squeal factor and the frictional coefficient is obtained to provide a guidance to predict squeal stability under more *** reduction design shows that adding a damping layer to the brake mechanism and chamfering the edge of braking stators both can reduce brake squeal effectively,while slotting braking stators is invalid in aircraft braking system.

关键词： Aircraft rotor-stator bake-induced vibration Brake squeal-Vibration stability Modal coupling Vibration suppression

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Gravitational field around black hole induces photonic spin-orbit interaction that twists light

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Frontiers of physics 2017年第5期12卷 87-90页

作者： deng Pan hong-Xing Xu School of Physics and Technology Wuhan University Wuhan 430072 China

The spin-orbit interaction （SOI） of light has been intensively studied in nanophotonics because it enables sensitive control of photons＇ spin degree of freedom and thereby the trajectories of the photons, which is useful for applications such as signal encoding and routing. A recent study [Phys. Rev. Lett. 117, 166803 （2016）] showed that the SOI of photons manifests in the presence of a gradient in the permittivity of the medium through which the photons propagate; this enhances the scattering of circularly polarized light and results in the photons propagating along twisted trajectories. Here we theoretically predict that, because of the equivalence between an inhomogeneous dielectric medium and a gravitational field demonstrated in transformation optics, a significant SOI is induced onto circularly polarized light passing by the gravitational lens of a black hole. This leads to： i） the photons to propagate along chiral trajectories if the size of the black hole is smaller than the wavelength of the incident photons; ii） the resulting image of the gravitational lens to manifest an azimuthal rotation because of these chiral trajectories. The findings open for a way to probe for and discover subwavelength-size black holes using circularly polarized light.

关键词： spin-orbit interation black hole gravitational lens optical angular momentum

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Drug-delivery and multifunction possibilities of hypocrellin photosensitizers

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Journal of Innovative Optical Health Sciences 2015年第1期8卷 27-39页

作者： hong deng Jie Xie Jingquan Zhao Beijing National Laboratory for Molecular Sciences(BNLMS)Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences P.O.Box 101No.21st North Street ZhongguancunBeijing 100190P.R.China

Photodynamic therapy(PDT)has been a routine treatment of tumors and some microvascular diseases,but clinically available photosensitizers are still *** all kinds of photo-sensitizers,hypocellins possess the most characteristics of ideal photosensitizers,such as,high photo-activity but low dark toxicity,fast clearance from *** review is focused on two main topics,drug-delivery problem of hypocrellins and how the environment-sensitive fluorescence of bypecrellins was used for recognition of various ***-delivery of hypocrellins was mainly achieved in two strategies一preparing the drugdelivery vehicles and finding quantitatively amphiphilic *** fAuorescence originated from the intramolecular proton transfer is very distinct from other kinds of ***,it was proved that quan-titative hypocrellin ftuorescence could not only reoognize various biomolecules,including proteins,polysaocharides and lipids,but also distinguish the specific binding from nonspedifie binding with some kind of ***,hypocrellin fluorescence was pH *** is known that tumor cells or tses have the features of a large amount of lipid,neonatal collagen,over expression of polysaccharides,and lower pH values compared to normal *** to the relative but not absolute specifcity,further studies on quantitative recognition of various biomolecules at a cellular level,may find a new clue to treat tumors by joint usage of photodynamic diagnosis(PDD)and PDT.

关键词： Hypocrellins photodynamie therapy drug delivery biomolecular recognition

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