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界面微分电容法单晶硅表面单分子膜质量的检测

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应用化学 2002年第6期19卷 539-543页

作者：孙乔玉,catherine henry de villeneuve,力虎林,Philippe Allongueb 兰州大学化学化工学院 Laboratoire de Physiquedes Liquideset Electrochimie CNRS-UPR15conventionnéeaveclUniversitéP&MCurie 4placeJussieu Tour22 75005Paris France Laboratoire de Physiquedes Liquideset Electrochimie 兰州大学化学化工学院 Laboratoire de Phys

用界面电容分析法 ,研究了影响烯烃类分子在氢结尾的硅 (1 1 1 )表面上通过 Si— C键嫁接有机单分子膜的某些因素和有机单分子膜对硅表面氧化的钝化作用 .指出嫁接反应条件或嫁接分子的反应活性的差异都会影响所形成的单分子膜的质量 ;... 详细信息

用界面电容分析法 ,研究了影响烯烃类分子在氢结尾的硅 (1 1 1 )表面上通过 Si— C键嫁接有机单分子膜的某些因素和有机单分子膜对硅表面氧化的钝化作用 .指出嫁接反应条件或嫁接分子的反应活性的差异都会影响所形成的单分子膜的质量 ;在所选择的反应条件下 ,由于烯烃修饰的硅表面上嫁接分子所占的体积分数约为 0 .90 ,故只能对硅表面的氧化产生有限的钝化作用 .另外 ,系统测量了不同链长的烯烃分子形成的有机单分子膜的电容特性参数

关键词：硅表面有机嫁接单分子膜界面微分电容分析

Treatment of prolonged clonidine-induced autonomic instability with midodrine:a case report about a new approach or a cautionary tale?

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Emergency and Critical Care Medicine 2023年第4期3卷 194-197页

作者： Saada Malouf catherine henry Lara Pemberton Joe-Anthony Rotella department of Emergency Medicine Northern HealthEppingAustralia SPECTRE(Substance Use PsychiatryEnvenomationClinical Toxicologistand REcreational substances)UnitNorthern HealthEppingAustralia Melbourne Medical School University of MelbourneParkvilleAustralia

Background:Clonidine is a centrally acting a2 adrenergic and imidazoline-1 receptor agonist that can cause somnolence,bradycardia,and hypotension within several hours of *** well-described but observed by us locally is the observation that patients presenting after large overdoses including clonidine can have prolonged autonomic *** a result,they may require many days in hospital before *** have previously used midodrine as an indirect antagonist with good effect;however,there are no previous reports of its use for this *** presentation:We present the case of a young female patient who developed prolonged autonomic instability following a large overdose of clonidine(coingested with smaller doses of escitalopram+lisdexamfetamine)that was treated with midodrine but complicated by a type 2 non-ST segment elevated myocardial ***:Midodrine seems to ameliorate this protracted instability and may provide a means to decrease hospital length of stay in appropriate individuals.

关键词： Autonomic Case report Clonidine Instability Midodrine Overdose

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醇类在Si-H表面形成单分子膜的特性

应用化学 2003年第6期20卷 557-561页

作者：孙乔玉黄吉儿 C.henry de villeneuve 力虎林 P.Allongue 兰州大学化学化工学院兰州730000 Laboratoire de Physique des Liquides et Electrochimie

以界面电容分析法为主并结合XPS、AFM技术研究了醇类分子在Si(111) H表面上形成的有机单分子膜的特性。并探讨了嫁接反应中影响单分子膜特性的某些因素和单分子膜的稳定性及其对硅表面氧化的钝化作用。在所选择的反应条件下 ,不同链长... 详细信息

以界面电容分析法为主并结合XPS、AFM技术研究了醇类分子在Si(111) H表面上形成的有机单分子膜的特性。并探讨了嫁接反应中影响单分子膜特性的某些因素和单分子膜的稳定性及其对硅表面氧化的钝化作用。在所选择的反应条件下 ,不同链长醇分子修饰的硅表面上 ,嫁接分子所占体积分数约为 80 % ,平带电位约为 - 1 0 0V(vs .SSE)。研究表明。

关键词： Si(111)-H表面单分子膜醇类

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硅表面嫁接有机单分子膜的研究近况

应用化学 2002年第6期19卷 511-516页

作者：孙乔玉,黄吉儿,catherine henry de villeneuveb,力虎林,hilippe Allongueb 兰州大学化学化工学院 Laboratoire de Physiquedes Liquideset Electrochimie CNRS-UPR15conventionnéeaveclUniversitéP&MCurie France 兰州大学化学化工学院 Laboratoire de Physiquedes Liquideset Electrochimie 兰州大学化学化工学院 Laboratoire de Physiquedes Liq

由于在微电子、化学 /生物化学传感器、纳米技术及太阳能等领域具有潜在的应用价值 ,通过 Si— C键在硅表面上直接嫁接有机单分子膜 ,已成为近几年新开展的研究热点 .对这一研究领域进行了概要综述

关键词：硅有机单分子膜嫁接综述

Implementing physically active learning:Future directions for research,policy,and practice

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Journal of Sport and Health Science 2020年第1期9卷 41-49,F0003页

作者： Andy Daly-Smith Thomas Quarmby Victoria S.J.Archbold Ash C.Routen Jade L.Morris catherine Gammon John B.Bartholomew Geir Kare Resaland Bryn Llewellyn Richard Allman henry Dorling School of Sport Leeds Beckett UniversityLeedsLS63QSUK School of Sport Exercise and Health SciencesLoughborough UniversityE152GZUK School of Health Promotion and Human Performance Eastern Michigan UniversityYpsilantiMI 48197USA Centre for Diet and Activity Research MRC Epidemiology UnitUniversity of CambridgeCambridgeCB21TNUK department of Kinesiology and Health Education The University of Texas at AustinAustinTX 78705USA Center for Physically Active Learning Faculty of EducationArts and SportsWestern Norway University of Applied SciencesSogndal5020 BergenNorway Tagtiv8 Ltd and Move&Learn LeedsWF27BSUK School of Sport Health and Social ScienceSolent UniversitySouthamptonSO 14 ORTUK

Purpose:To identify co-produced multi-stakeholder perspectives important for successful widespread physically active learning(PAL) adoption and ***:A total of 35 stakeholders(policymakers n=9;commercial education sector,n=8;teachers,n=3;researchers,n=15) attended a design thinking PAL *** formed 5 multi-disciplinary groups with at least 1 representative from each stakeholder *** group,facilitated by a researcher,undertook 2 tasks:(1) using Post-it Notes,the following question was answered:within the school day,what are the opportunities for learning combined with movement?and(2) structured as a washing-line task,the following question was answered:how can we establish PAL as the norm?All discussions were audio-recorded and *** analyses were conducted by 4 *** the analyses were complete,the main themes and subthemes were assigned to 4 predetermined categories:(1) PAL design and implementation,(2) priorities for practice,(3) priorities for policy,and(4) priorities for ***:The following were the main themes for PAL implementation:opportunities for PAL within the school day,delivery environments,learning approaches,and the intensity of *** main themes for the priorities for practice included teacher confidence and competence,resources to support delivery,and community of *** main themes for the policy for priorities included self-governance,the Office for Standards in Education,Children’s Services,and Skill,policy investment in initial teacher training,and curriculum *** main themes for the research priorities included establishing a strong evidence base,school-based PAL implementation,and a whole-systems ***:The present study is the first to identify PAL implementation factors using a combined multi-stakeholder *** achieve wider PAL adoption and implementation,future interventions should be evidence based and address implementation factors

关键词： Children Physical activity Physically active learning Policy School

Moving interdisciplinary science forward:integrating participatory modelling with mathematical modelling of zoonotic disease in Africa

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Infectious Diseases of Poverty 2016年第1期5卷 149-160页

作者： catherine Grant Giovanni Lo Iacono Vupenyu Dzingirai Bernard Bett Thomas R.A.Winnebah Peter M.Atkinson ESRC Social Technological and Environmental Pathways to Sustainability(STEPS)CentreInstitute of Development StudiesLibrary RoadFalmerBrightonUK Geography and Environment University of SouthamptonHighfieldSouthampton SO171BJUK Lancaster University LancasterUK University of Utrecht UtrechtUK Queen’s University Belfast BelfastUK department of Veterinary Medicine Disease Dynamics UnitUniversity of CambridgeCambridgeUK Centre for Applied Social Sciences Trust 5 Aberdeen RoadP O Box A1333AvondaleHarareZimbabwe International Livestock Research Institute Naivasha RoadKabeteNairobiKenya Institute of Geography and development Studies School of Environmental SciencesNjala University17Henry StreetFreetownSierra Leone

This review outlines the benefits of using multiple approaches to improve model design and facilitate multidisciplinary research into infectious diseases,as well as showing and proposing practical examples of effective *** looks particularly at the benefits of using participatory research in conjunction with traditional modelling methods to potentially improve disease research,control and *** approaches can lead to more realistic mathematical models which in turn can assist with making policy decisions that reduce disease and benefit local *** emergence,risk,spread and control of diseases are affected by many complex bio-physical,environmental and socio-economic *** include climate and environmental change,land-use variation,changes in population and people’s *** evidence base for this scoping review comes from the work of a consortium,with the aim of integrating modelling approaches traditionally used in epidemiological,ecological and development research.A total of five examples of the impacts of participatory research on the choice of model structure are *** 1 focused on using participatory research as a tool to structure a *** 2 looks at identifying the most relevant parameters of the *** 3 concentrates on identifying the most relevant regime of the system(e.g.,temporal stability or otherwise),Example 4 examines the feedbacks from mathematical models to guide participatory research and Example 5 goes beyond the so-far described two-way interplay between participatory and mathematical approaches to look at the integration of multiple methods and *** scoping review describes examples of best practice in the use of participatory methods,illustrating their potential to overcome disciplinary hurdles and promote multidisciplinary collaboration,with the aim of making models and their predictions more useful for decision-making and policy formulation.

关键词： Africa Zoonoses Modelling Interdisciplinary One health Participatory Disease

102例HIV-1感染者病毒株反转录酶基因多态性及耐药性变异研究

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诊断学理论与实践 2007年第3期6卷 197-202页

作者：刘莉张云智卢洪洲 Mireille henry catherine Tamalet 上海市公共卫生中心(复旦大学附属公共卫生临床中心)感染科 Laboratory of Virology Timone Hospital and CNRS UMR6020264 Rue St Pierre13385 Marseille Cedex 05 France

目的:目前中国未接受或已接受反转录酶抑制剂(RTI)治疗的HIV感染者的HIV反转录酶基因类型的数据较少。本研究探讨了HIV-1反转录酶的基因多态性,及在RTI选择性压力下出现的已知和未知变异位点。方法:分析研究21例未接受治疗及81例接受RT... 详细信息

目的:目前中国未接受或已接受反转录酶抑制剂(RTI)治疗的HIV感染者的HIV反转录酶基因类型的数据较少。本研究探讨了HIV-1反转录酶的基因多态性,及在RTI选择性压力下出现的已知和未知变异位点。方法:分析研究21例未接受治疗及81例接受RTI治疗的HIV感染者的RT基因。大部分感染者(>80%)应用司他夫定(d4T)+地达诺新(ddI)+奈韦拉平(NVP)或d4T+拉米夫定(3TC)+依菲韦仑(EFV)三联HAART治疗方案。结果:在未接受治疗的患者中,发现了4个高度多态性位点(122、200、207和211)。在接受RTI治疗的患者中,发现了2种耐药相关变异(RAMs):①接受ddI+d4T+NVP治疗方案的患者中发现,K65R(9.8%)、L74V(7.4%)、M184V(7.4%)、Q151M(5%)和胸腺嘧啶类似物变异(TAMs)(9.3%),包括T215Y(5.5%);②接受d4T+3TC+EFV治疗方案的患者中发现,T215Y(23%)、M184V(20%)和TAMs(15.4%)。在所有病例中,非核苷反转录酶抑制剂(NNRTI)RAM的出现率很高(41.9%),而在142、221、224和228位点发现了4种可疑的新RAMs。结论:目前中国非核苷类反转录酶抑制剂(NNRTI)耐药相关变异十分普遍,本研究描述了RTI选择性变异的基因模式,提出了新的一些变异与RTI治疗的相关性。

关键词： HIV-1 反转录酶抑制剂药物相关变异自然多态性反转录酶

未接受蛋白酶抑制剂治疗者的HIV-1基因的多态性及蛋白酶抑制剂耐药相关性变异

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诊断学理论与实践 2011年第2期10卷 133-137页

作者：刘莉卢洪洲 Mireille henry Christian Tourres catherine Tamalet 复旦大学附属(上海市)公共卫生临床中心感染科复旦大学附属华山医院感染科复旦大学上海医学院内科学系 catherine Tamalet 13385 Marseille Cedex 05 France

目的:研究未接受蛋白酶抑制剂(PIs)治疗的人类获得性免疫缺陷病毒1(HIV-1)感染者HIV-1多态性以及PIs耐药相关性变异的分布情况。方法:取自中国4个省市(上海、安徽、河南和云南)81例未接受PIs治疗的HIV-1感染者中分离的病毒株,经反转录... 详细信息

目的:研究未接受蛋白酶抑制剂(PIs)治疗的人类获得性免疫缺陷病毒1(HIV-1)感染者HIV-1多态性以及PIs耐药相关性变异的分布情况。方法:取自中国4个省市(上海、安徽、河南和云南)81例未接受PIs治疗的HIV-1感染者中分离的病毒株,经反转录聚合酶链反应(RT-PCR)扩增HIV-1病毒的pol基因,并进行测序及进化分析。结果:HIV-1病毒株基因最多的为B′亚型(82.7%),其他分别为CRF01_AE亚型(11%)、CRF07_BC或CRF08_BC亚型(3.7%)、CRF02_AG亚型(1.2%)以及B亚型(1.2%)。B′亚型主要存在于有偿助血员以及经输血感染的患者中。R41K、K70Q/R/E和L89M变异在非B亚型中比在B′和B亚型中更为常见。次要PIs耐药相关性变异I15M/V、K20M/R/I、M36I和H69K在非B亚型中比在B和B′亚型中更为常见。相对于非B亚型,次要PIs耐药相关性变异I62V、L63P、A71V/T、V77I和I93L则在B和B′亚型中更为常见。在3例(3.7%)感染B亚型的患者中发现了主要PIs耐药相关性变异M46I。结论:在未接受PIs治疗的患者中,HIV-1病毒基因多态性及次要PIs耐药相关性变异的出现率较高,而主要PIs耐药相关性变异的流行率则较低。

关键词：人类获得性免疫缺陷病毒蛋白酶抑制剂多态性

Colposcopy Is Not Necessary To Assess The Risk To The Cervix In HIV-positive Women:An International Cohort Study Of Cervical Pathology In HIV-positive Women

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Colposcopy Is Not Necessary To Assess The Risk To The Cervix...