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Mass spectrometry-based proteomics technology in pancreatic cancer research

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胰腺病学杂志(英文) 2024年第2期07卷 145-163页

作者： Sun Xue Wang Siyuan Wong catherine C.L. First School of Clinical Medicine Peking University Health Science Center Peking University Beijing China School of Pharmacy University of Wisconsin-Madison Madison Wisconsin United States State Key Laboratory of Complex Severe and Rare Diseases Clinical Research Institute Peking Union Medical College Hospital Chinese Academy of Medical Science &amp Peking Union Medical College Beijing China Tsinghua-Peking University Joint Center for Life Sciences Tsinghua University Beijing China

Pancreatic ductal adenocarcinoma (PDAC) has become a significant health concern with increasing incidence and mortality rates over the past few decades. Researchers have turned their attention to cutting-edge mass spectrometry (MS) technology due to its high-throughput and accurate detection capacity, which plays a vital role in understanding the mechanisms and discovering biomarkers for pancreatic diseases. In this review, we comprehensively investigate various methodologies of quantitative and qualitative proteomics MS technologies, alongside bioinformatical platforms employed in pancreatic cancer research. The integration of these optimized approaches provides novel insights into the molecular mechanisms underlying tumorigenesis and disease progression, ultimately facilitating the discovery of potential diagnostic, prognostic biomarkers, and therapeutic targets. The robust MS-based strategy shows promise in paving the way for early diagnosis and personalized medicine for pancreatic cancer patients.

关键词： Biomarkers Mass spectrometry Pancreatic cancer Pancreatic ductal adenocarcinoma Proteomics

Comparison between seismic analysis of twisting and regular 52-story towers considering soil-structure interaction

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earthquake engineering and engineering Vibration 2024年第3期23卷 663-675页

作者： Mohamed Naguib Abouelsaad Mohammed Shaaban Salah el Bagalaty Mohamed e.el Madawy Structural engineering Department Faculty of EngineeringMansura UniversityMansoura 35511Egypt Faculty of engineering Delta University for Science and TechnologyGamasa 35712Egypt

A dynamic analysis of both twisting and regular towers is carried out to determine the results of considering soil-structure interaction(SSI)on high-rise *** addition,the difference between the seismic performance of using twisting towers over regular ones is *** twisting tower is a simulation of the evolution Tower(Moscow).The towers’skeletons consist of RC elements and rest on a reinforced concrete piled-raft *** soil model is considered as multi-layered with the same soil properties as the zone chosen for the analysis(New Mansoura City,egypt).The only difference between both towers is their shape in *** whole system is modelled and analyzed in a single step as one full 3D model,which is known as the direct approach in *** analyses are carried out using finite-element software(Midas GTS NX).Dynamic output responses due to three records of seismic loads are proposed and presented in some *** on the results,it is concluded that SSI has a considerable effect on the dynamic response of tall buildings mainly because of the foundation flexibility,as it leads to lengthening the vibration period,increasing the story drift and the base shear for both cases.

关键词： soil-structure interaction seismic analysis twisting towers base shear story drift finite element method Midas GTS NX

Challenges for cysteamine stabilization,quantification,and biological effects improvement

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Journal of Pharmaceutical Analysis 2020年第6期10卷 499-516页

作者： Carla Atallah catherine Charcosset Helene Greige-Gerges Bioactive Molecules Research Laboratory Doctoral School of Sciences and TechnologiesFaculty of SciencesLebanese UniversityLebanon Laboratory of Automatic Control Chemical and Pharmaceutical EngineeringClaude Bernard Lyon 1 UniversityFrance

The aminothiol cysteamine,derived from coenzyme A degradation in mammalian cells,presents several biological ***,the bitter taste and sickening odor,chemical instability,hygroscopicity,and poor pharmacokinetic profile of cysteamine limit its *** use of encapsulation systems is a good methodology to overcome these undesirable properties and improve the pharmacokinetic behavior of ***,the conjugation of cysteamine to the surface of nanoparticles is generally proposed to improve the intra-oral delivery of cyclodextrin-drug inclusion complexes,as well as to enhance the colorimetric detection of compounds by a gold nanoparticle aggregation *** the other hand,the detection and quantification of cysteamine is a challenging mission due to the lack of a chromophore in its structure and its susceptibility to oxidation before or during the *** agents are therefore applied for the quantification of this *** our knowledge,the derivatization techniques and the encapsulation systems used for cysteamine delivery were not reviewed ***,this review aims to compile all the data on these methods as well as to provide an overview of the various biological applications of cysteamine focusing on its skin application.

关键词： Cysteamine Detection encapsulation Skin Stability

The role of low-density lipoprotein （LDL） and high-density lipoprotein （HDL） in comparison with whole egg yolk for sperm cryopreservation in rhesus monkeys

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Asian Journal of Andrology 2011年第3期13卷 459-464,513页

作者： Qiao-Xiang Dong Sarah e Rodenburg Dana Hill catherine A VandeVoort School of environmental Science and Public Health Wenzhou Medical College Wenzhou 325035 China California National Primate Research Center University of California Davis CA 95616 USA Department of Obstetrics and Gynecology School of Medicine University of California Davis CA 95616 USA

Low-density lipoprotein （LDL） extracted from hen egg yolk has recently been considered to be superior to whole egg yolk in sperm cryopreservation of various animal species. Meanwhile, there was a notion that high-density lipoprotein （HDL） in egg yolk may have a negative effect on post-thaw survival. The role of LDL and HDL in sperm cryopreservation of rhesus monkeys has not been explored. The present study evaluates their effect in comparison with egg yolk with or without the addition of permeable cryoprotectant （glycerol） on sperm cryopreservation of rhesus macaques. In addition, various additives intended to change the lipid composition of LDL-sperm membrane complex have also been tested for their effectiveness in preserving post-thaw viability. Our findings indicated that LDL is the main component in egg yolk that is responsible for its protective role for sperm cryopreservation in rhesus monkeys. Regardless of the presence or absence of glycerol, the protective role of LDL is similar to that of egg yolk and we did not observe any superiority in post-thaw survival with LDL when compared to egg yolk. Modifying the lipid composition of LDL-sperm membrane complex with the addition of cholesterol, cholesterol loaded cyclodextrin and phosphatidylcholine also did not yield any improvements in pest-thaw survival; while addition of methyl-β-cyclodextrin reduced post-thaw motility. HDL plays a neutral role in sperm cryopreservation of rhesus monkeys. The present study suggests that egg yolk may still hold advantages when compared with LDL as effective components in extenders for sperm cryopreservation in rhesus monkeys.

关键词： non-human primates sperm cryopreservation low-density lipoprotein high-density lipoprotein egg yolk

Applicability of five models to simulate water infiltration into soil with added biochar

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Journal of Arid Land 2017年第5期9卷 701-711页

作者： WANG Tongtong catherine e STeWART MA Jiangbo ZHeNG Jiyong ZHANG Xingchang State Key Laboratory of Soil erosion and Dryland Farming on the Loess Plateau Institute of Soil and Water Conservation Northwest A&F University Yangling 712100 China College of Natural Resources and environment Northwest A&F University Yangling 712100 China Soil-Plant-Nutrient Research Unit United States Department of Agriculture-Agricultural Research Service Fort Collins CO 80526-8119 USA

As a soil amendment, biochar can reduce soil bulk density, increase soil porosity, and alter soil aggregates and thus affect the infiltration. Researchers have proposed and revised several theoretical models to describe the process of soil infiltration. Although these models have been successfully used to evaluate the soil infiltration in different scenarios in agricultural fields, little effort has been devoted to assess their performances in arid and semi-arid soils after the addition of biochar. A laboratory experiment was performed to study the infiltration characteristics of two typical Loess Plateau soils at three particle sizes（2–1, 1–0.25, and 〈0.25 mm） and five biochar application amounts（0, 10, 50, 100, and 150 g/kg）. The performance of five models（i.e., the Philip model, Kostiakov model, Mezencev model, USDA-NRCS model, and Horton model） in simulating the infiltration process was then evaluated based on the adjusted coefficient of determination and a reduced Chi-Square test. Results indicated that the Horton model best simulated the water-infiltration process in an aeolian sandy soil with added biochar. However, the Mezencev model best simulated the infiltration process in a loamy clay soil（eum-Orthic Anthrosol）. The three-parameter model, i.e., Mezencev and Horton models can better describe the relationship between cumulative infiltration and infiltration time. In conclusion, biochar reduced the soil infiltration capacity of the aeolian sandy soil and increased that of the eum-Orthic Anthrosol.

关键词： infiltration models biochar Horton model Mezencev model Loess Plateau

Bounding species distribution models

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Current Zoology 2011年第5期57卷 642-647页

作者： Thomas J. STOHLGReN catherine S. JARNeVICH Wayne e. eSAIAS Jeffrey T. MORISeTTe Fort Collins Science Center U.S. Geological Survey 2150 Centre Avenue Fort Collins CO 80526USA Code 614.5. NASA/Goddard Space Flight Center. Greenbelt MD 20771 USA

Species distribution models are increasing in popularity for mapping suitable habitat for species of management con- cern. Many investigators now recognize that extrapolations of these models with geographic information systems （GIS） might be sensitive to the environmental bounds of the data used in their development, yet there is no recommended best practice for ＂clamping＂ model extrapolations. We relied on two commonly used modeling approaches： classification and regression tree （CART） and maximum entropy （Maxent） models, and we tested a simple alteration of the model extrapolations, bounding ex- trapolations to the maximum and minimum values of primary environmental predictors, to provide a more realistic map of suit-able habitat of hybridized Africanized honey bees in the southwestern United States. Findings suggest that multiple models of bounding, and the most conservative bounding of species distribution models, like those presented here, should probably replace the unbounded or loosely bounded techniques currently used [Current Zoology 57 （5）： 642-647,2011].

关键词： Niche models Geographic information systems extrapolation Clamping

Muscle energy technique for chronic obstructive pulmonary disease:A feasibility study

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Journal of Integrative Medicine 2023年第3期21卷 245-253页

作者： Danielle A.Baxter Meaghan e.Coyle catherine J Hill Christopher Worsnop Johannah L.Shergis School of Health and Biomedical Sciences Royal Melbourne Institute of Technology UniversityBundooraVictoria 383Australia Department of Physiotherapy Austin HealthHeidelbergVictoria 3084Australia Institute for Breathing and Sleep HeidelbergVictoria 3084Australia

Objective:This study aimed to investigate the feasibility of implementing a manual therapy technique(muscle energy technique,MeT)protocol in a hospital pulmonary rehabilitation(PR)program for patients with moderate to severe chronic obstructive pulmonary disease(COPD).Methods:Participants aged 40 years and over,with moderate to severe COPD,were recruited into this 12-week *** primary outcome measures were feasibility(acceptability of the intervention and attendance/adherence to the trial)and safety(adverse events,Aes).All participants received the MeT and PR *** and assessors were ***-standardized MeT was delivered on 6 occasions(a maximum of once per week)at the hospital directly before a PR *** undertook PR sessions as per the hospital program at a frequency of two days per week for 8 *** were contacted 4 weeks after their final MeT treatment via a telephone call to assess acceptability of the ***:Thirty-three participants were enrolled,with a median age of 74 years(range 45-89 years).The median number of MeT sessions that participants attended was 5(range O-6)out of a possible 6 sessions(83%attendance).At follow-up,participants overwhelmingly enjoyed the MeT treatment with some subjectively reporting improved *** were no major Aes related to the intervention,with the majority of Aes classified as expected events related to COPD ***:It is feasible to implement a manual therapy protocol using MeT as an adjunct to PR in a hospital *** rates were satisfactory and there were no Aes related to the MeT component of the intervention.

关键词： Manual therapy Pulmonary rehabilitation Chronic obstructive pulmonary disease

Transcatheter Device Closure of a Perimembranous Ventricular Septal Defect in Congenitally Corrected Transposition of the Great Arteries

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Congenital Heart Disease 2022年第2期17卷 193-199页

作者： catherine e.Tomasulo Lindsay S.Rogers Lauren Andrade Michael LO’Byrne Division of Cardiology The Children’s Hospital of PhiladelphiaPhiladelphiaUSA Division of Cardiology Hospital of the University of PennsylvaniaPhiladelphiaUSA Center for Pediatric Clinical effectiveness The Children’s Hospital of PhiladelphiaPhiladelphiaUSA Leonard Davis Institute and Center for Cardiovascular Outcomes Qualityand Evaluative ResearchUniversity of PennsylvaniaPhiladelphiaUSA

The majority of patients with congenitally corrected transposition of the great arteries,also known as transposition of the great arteries{S,L,L}have ventricular septal defects(VSD),most commonly perimembranous VSD(pmVSD).Transcatheter device closure of pmVSD in these patients has not been widely *** present a case of device closure of pmVSD in L-TGA with an Amplatzer Duct Occluder II(ADOII)device using a deployment starting in the subpulmonary left *** case demonstrates some of the technical advantages of the ADOII device for VSD closure,specifically its low profile,symmetric shape,and soft *** characteristics are advantageous in closing conventional pmVSD but are especially useful in patients with challenging anatomic substrates.

关键词： Percutaneous catheterization congenital heart disease thromboembolism

Neuroimaging of inflammation in alcohol use disorder: a review

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Science China(Information Sciences) 2020年第7期63卷 19-37页

作者： Dana e.FeLDMAN Katherine L.MCPHeRSON catherine L.BIeSeCKeR Corinde e.WIeRS Peter MANZA Nora D.VOLKOW Gene-Jack WANG National Institute on Alcohol Abuse and Alcoholism National Institute on Drug Abuse

Alcohol use disorder(AUD) is a global health concern associated with several *** health problems related to AUD, such as cognitive deficits, have been linked to *** use has been associated with changes in neuroimmune activity, although current literature has yielded mixed results. For example, markers of gliosis, including translocator protein 18-kDa(TSPO), proinflammatory cytokines, glutamate(Glu), and myo-inositol(mI), are disrupted in the alcohol-dependent brain. Further, neuroinflammatory-related phenomena including membrane turnover, blood brain barrier(BBB) permeability, and adenosine release have also shown alterations in AUD. However, current literature remains inconclusive about the directionality of these changes. Both in vivo and in vitro studies have provided insight on the relationship between alcohol use and neuroinflammatory processes, suggesting considerable treatment potential for alcohol use disorder and its inflammatory comorbidities. Here, we review current neuroimaging literature assessing the impacts of alcohol use on neuroimmune activity in the brain.

关键词： acetate adenosine alcohol use disorder blood brain barrier choline gliosis glutamate myoinositol neuroimaging neuroinflammation