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Surface Modification of Intraocular Lenses

Chinese Medical Journal 2016年第2期129卷 206-214页

作者： Qi Huang George Pak-Man Cheng kin chiu Gui-Qin Wang Department of Ophthalmology Navy General Hospital of PLA Beijing 100048 China Department of Ophthalmilogy Third Clinical Medical College of Southern Medical University Guangzhou Guangdong 510515 China Department of Ophthalmology Hong Kong Laser Eye Center Hong Kong 999077 China Department of Ophthalmology Laboratory of Retina Brain Research l:he Univeisity of Hong Kong Hong Kong 999077 China State Key Laboratory of Brain and Cognitive Sciences The University of Hong Kong Hong Kong 999077 China Research Centre of Heart Brain Hormone and Healthy Aging The University of Hong Kong Hong Kong 999077 China

Objective： This paper aimed to review the current literature on the surface modification ofintraocular lenses （IOLs）. Data Sources： All articles about surface modification of IOLs published up to 2015 were identified through a literature search on both PubMed and ScienceDirect. Study Selection： The articles on the surface modification of 1OLs were included, but those on design modification and surface coating were excluded. Results： Technology of surface modification included plasma, ion beam, layer-by-layer self-assembly, ultraviolet radiation, and ozone. The main molecules introduced into IOLs surface were poly （ethylene glycol）, polyhedral oligomeric silsesquioxane, 2-methacryloyloxyethyl phosphorylcholine, TiO2, heparin, F-heparin, titanium, titanium nitride, vinyl pyrrolidone, and inhibitors of cytokines. The surface modification either resulted in a more hydrophobic lens, a more hydrophilic lens, or a lens with a hydrophilic anterior and hydrophobic posterior surface. Advances in research regarding surface modification of ｜OLs had led to a better biocompatibility in both in vitro and animal experiments. Conclusion： The surface modification is an efficient, convenient, economic and promising method to improve the biocompatibility of IOLs.

关键词： Biocompatibility Capsule Biocompatibility Cataract Intraocular Lenses Surface Modification Uveal Biocompatibility

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Retinal safety and toxicity study of artesunate in vitro and in vivo

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Advances in Ophthalmology Practice and Research 2023年第2期3卷 47-54页

作者： Bing-Wen Lu Yu-Xiang Liang Jin-Feng Liu Zhong-Qing Sun Kwok-Fai So kin chiu Department of Ophthalmology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong KongChina Department of Psychology Faculty of Social SciencesThe University of Hong KongHong KongChina Guangdong-Hongkong-Macao(GHM)Institute of CNS Regeneration Ministry of EducationCNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouChina

Background:Artesunate(ART),a member of the artemisinin family,possesses multi-properties,including antiinflammation,anti-oxidation,and *** was recently reported to show anti-neovascularization effect on the cornea,iris,and *** to the expensive anti-VEGF treatment,this versatile,economical treatment option is attractive in the ophthalmic *** safety and toxicity profile of ART intravitreal application are in utmost ***:In this study,immortalized microglial(IMG)cells were treated with ART to determine the safe concentrations without inducing overt inflammatory *** transcription-polymerase chain reaction analysis was used to detect the cytokine expressions in IMG cells in response to ART *** doses of ART were intravitreally injected into the right eyes of C57BL/6 *** function was tested by electroretinogram,and retinal ganglion cell(RGC)survival was evaluated by counting Brn3a stained cells in flat-mounted retinas at 7 days after ART ***:ART below 5μM was safe for IMG cells in *** 2.5 and 5μM ART treatment increased IL-10 gene expression in IMG cells while not changing IL-1β,IL-6,TNF-α,and *** the in vivo study,intravitreal injection of ART below 100μM did not cause deterioration in the retinal function and RGC survival of the mouse eyes,while 1 mM ART treatment significantly attenuated both the scotopic and photopic b-wave amplitudes and impaired RGC *** addition,treatment with ART of 25,50,and 100μM significantly decreased TNF-αgene expression while ART of 100μM significantly increased IL-10 in the mouse ***:Intravitreal injection of 100μM ART could downregulate TNF-αwhile upregulate IL-10 in the mouse retina without causing retinal functional deterioration and RGC *** might be used as anti-inflammatory agent for retinal disorders.

关键词： Artesunate Safety Retina Microglia

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Clinical factors affecting rejection rates in liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2015年第4期14卷 367-373页

作者： kin Pan Au See-Ching Chan Kenneth Siu-Ho Chok William Wei Sharr Wing-chiu Dai Sui-Ling Sin Tiffany Cho-Lam Wong Chung-Mau Lo Department of Surgery the University of Hong Kong Medical Center Queen Mary Hospital

With improvements in survival, liver trans- plant recipients now suffer more morbidity from long-term immunosuppression. Considerations were given to develop individualized immunosuppression based on their risk of re- jection. METHOD： We retrospectively analyzed the data of 788 liver transplants performed during the period from October 1991 to December 2011 to study the relationship between acute cel- lular rejection （ACR） and various clinical factors. RESULTS： Multivariate analysis showed that older age （P=0.04, OR=0.982）, chronic hepatitis B virus infection （P=0.005, OR= 0.574）, living donor liver transplantation （P=0.02, OR=0.648） and use of interleukin-2 receptor antagonist on induction （P〈0.001, OR=0.401） were associated with fewer ACRs. Patients with fulminant liver failure （P=.004, OR=4.05） were more likely to develop moderate to severe grade ACR. CONCLUSIONS： Liver transplant recipients with older age, chronic hepatitis B virus infection, living donor liver trans- plantation and use of interleukin-2 receptor antagonist on in- duction have fewer ACR. Patients transplanted for fulminant liver failure are at higher risk of moderate to severe grade ACR. These results provide theoretical framework for developing individualized immunosuppression.

关键词： liver transplantation acute rejection immunosuppression

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Activation of endogenous neurogenesis and angiogenesis by basic fibroblast growth factor-chitosan gel in an adult rat model of ischemic stroke

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Neural Regeneration Research 2024年第2期19卷 409-415页

作者： Hongmei Duan Shulun Li Peng Hao Fei Hao Wen Zhao Yudan Gao Hui Qiao Yiming Gu Yang Lv Xinjie Bao kin chiu Kwok-Fai So Zhaoyang Yang Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Department of Epidemiology and Statistics School of Public Health and ManagementNingxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina Department of Physical Education Capital University of Economics and BusinessmBeijingChina Department of Neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Psychology State Key Lab of Brain and Cognitive SciencesThe University of Hong KongHong Kong Special Administration RegionChina Guangdong-Hongkong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

Attempts have been made to use cell transplantation and biomaterials to promote cell proliferation,differentiation,migration,and survival,as well as angiogenesis,in the context of brain ***,whether bioactive materials can repair the damage caused by ischemic stroke by activating endogenous neurogenesis and angiogenesis is still *** this study,we applied chitosan gel loaded with basic fibroblast growth factor to the stroke cavity 7 days after ischemic stroke in *** gel slowly released basic fibroblast growth factor,which improved the local microenvironment,activated endogenous neural stem/progenitor cells,and recruited these cells to migrate toward the penumbra and stroke cavity and subsequently differentiate into neurons,while enhancing angiogenesis in the penumbra and stroke cavity and ultimately leading to partial functional *** study revealed the mechanism by which bioactive materials repair ischemic strokes,thus providing a new strategy for the clinical application of bioactive materials in the treatment of ischemic stroke.

关键词： adult endogenous neurogenesis angiogenesis basic fibroblast growth factor-chitosan gel chitosan functional recovery ischemic stroke neural stem cell newborn neuron

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The Saturation Characteristics of Glucose Transport in Bovine Retinal Pigment Epithelium

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眼科学报 1998年第3期14卷 126-129页

作者： Chi Ho To kin Kwok Cheung Shing Hon chiu Hon Ming Lai Ka Shun Lung Laboratory of Ocular Physiology and Biochemistry Department of Optometry and Radiography The Hong Kong Polytechnic UniversityHung HomKawloonHong Kong

Purpose:To study the saturation characteristics of the glucose transport across the bovine retinal pigment epithelium(RPE).Methods:The bovine RPE preparations were munted with a modified Ussing *** L-[^(3)H]-glucose and 3-0-methyl-D-[^(14)C]-glucose fluxes across the RPE from the choroid to retina were studied at different glucose ***:The glucose transport was found to be stereospecific,with 3-0-methyl-D-glucose(MDG)being transported about three times faster than *** glucose transport showed typical saturation characteristics in Michaelis-Menten *** V_(max)and the K_(m)of corrected MDG were 2452 nmol cm^(-2)h^(-1)and 30.8 mM *** was shown that the glucose transport system was saturated at 61.6 ***:The saturation characteristics of the corrected MDG flux suggested that the capacity of glucose transport through the bovine RPE is immense.

关键词： ussing chamber retinal pigment epithelium glucose transport saturation kinetics

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Young adults’perceptions of breastfeeding in public:a focus group study

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Frontiers of Nursing 2020年第3期7卷 217-226页

作者： Ka-Huen Yip Yuk-chiu Yip catherine Man-Yin Lee Mei-Yi Siu Shu-Ying Ngai Mei-Kuen Chow School of Health Sciences Caritas Institute of Higher EducationHong KongChina School of Nursing The University of Hong KongHong KongChina

Objective:To elucidate the perceptions of young Chinese adults aged 18–25 toward adopting breastfeeding in public in Hong Kong Special Administrative Region(Hong Kong),***:A descriptive and exploratory study design was *** were recruited by convenience *** group data were collected from three semi-structured *** from 18 participants were audiotaped,transcribed verbatim,coded,and analyzed using content ***:Four themes emerged that described the young adults’perceptions and barriers toward breastfeeding practices:(1)adaptability of self and others,(2)cultural deem and practice,(3)convenience and connection,and(4)education and ***,all respondents(male and female)are aware of the benefits of *** negative perceptions toward breastfeeding initiation and continuation originate from factors that are essentially extraneous to the mother-infant dyads(such as the breadth and intensity of sociopolitical support,the dominant social beliefs and norms,and the inadequacy of breastfeeding education in adolescent years).Conclusions:In general,the young adult’s perception of breastfeeding is dominated by sociopolitical and cultural-related *** particular,sexualization of breasts as a deep-rooted belief in the Chinese context negatively affects young adults’perceptions and limits their breastfeeding practices.

关键词： breastfeeding young adult perceptions Chinese Hong Kong

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电刺激治疗骨骼肌肉疾病的应用研究进展

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中华解剖与临床杂志 2024年第6期29卷 421-426页

作者：吴泽霖陈紫航艾斯玛尔古丽·艾斯克尔郑小飞 kin chiu 王华军暨南大学附属第一医院运动医学科/广州市精准骨科与再生医学重点实验室/广东省速度能力研究重点实验室广州510630 香港大学李嘉诚医学院心理系/脑与认知科学国家重点实验室(香港大学) 中国香港999077

目的总结电刺激(EStim)技术治疗骨骼肌肉系统疾病的临床效果及其作用机制方面的研究进展。方法在中国知网、万方数据、Springer Link、PubMed等中、英文数据库中,检索自2000年1月以后公开发表的有关EStim与骨骼肌肉系统的文章共2778篇,... 详细信息

目的总结电刺激(EStim)技术治疗骨骼肌肉系统疾病的临床效果及其作用机制方面的研究进展。方法在中国知网、万方数据、Springer Link、PubMed等中、英文数据库中,检索自2000年1月以后公开发表的有关EStim与骨骼肌肉系统的文章共2778篇,最终纳入57篇文献进行系统复习及归纳总结。结果EStim技术对骨骼、肌肉、肌腱、韧带、关节软骨等骨骼肌肉系统各组成部分的疾病,如骨折、骨质疏松、肌肉萎缩,以及肌腱、韧带、关节软骨和周围神经损伤等,均有积极的治疗效果,且具备经济性、安全性、便捷性与有效性等优势。EStim对骨骼肌肉系统疾病的作用机制是通过物理、分子生物学等途径,对骨骼肌肉系统的血液循环、细胞分化、机械运动、蛋白质代谢等产生影响,甚至有可能促进软骨细胞增殖、加速神经轴突再生。结论采用EStim技术治疗骨骼肌肉系统疾病,其方法可行、疗效肯定;其作用机制是通过物理和生化两个方面的途径来实现的。

关键词：骨骼肌肉系统电刺激骨骼肌肉肌腱韧带软骨

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Revisiting oral fluoropyrimidine with cetuximab in metastatic colorectal cancer: Real-world data in Chinese population

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World Journal of Gastrointestinal Oncology 2019年第11期11卷 1031-1042页

作者： Ka-On Lam Man-Chi Fu kin-Sang Lau Kam-Mo Lam Cheuk-Wai Choi Wan-Hang chiu Cheng-Man Yuen Lai-Han Kwok Fong-Kit Tam Wing-Lok Chan Sum-Yin Chan Pui-Ying Ho To-Wai Leung Ho-Fun Lee Department of Clinical Oncology LKS Faculty of MedicineThe University of Hong KongHong KongChina Department of Clinical Oncology Queen Mary HospitalHong KongChina Clinical Oncology Centre The University of Hong Kong-Shenzhen HospitalShenzhen 518053Guangdong ProvinceChina Department of Pharmacy Queen Mary HospitalHong KongChina Department of Diagnostic Radiology LKS Faculty of MedicineThe University of Hong KongHong KongChina

BACKGROUND Cetuximab in combination with oral fluoropyrimidine(FP)remains controversial in metastatic colorectal cancer(mCRC).In view of the regional variation in the tolerability of FP,we conducted a retrospective analysis to compare oral FP with infusional FP in combination with cetuximab in Chinese *** To compare the efficacy and safety profile of cetuximab in combination with oral FP and infusional FP in Chinese population in the real-world *** A retrospective cohort study was done to analyse consecutive patients with Kras wild-type mCRC who received first-line treatment with cetuximab and FP-based chemotherapy in our unit from January 2010 to December ***-five eligible patients were *** median follow-up of our cohort was 65.0 *** The median progression-free survival(mPFS)and median overall survival(mOS)of the entire cohort were 9.66 mo(95%CI:7.72–12.5)and 25.8 mo(95%CI:18.7–35.6),*** oral FP and infusional FP,there was no statistical significant difference in the mPFS[9.79 mo(95%CI:7.49–12.7)vs 9.63 mo(95%CI:6.34–13.4);P=0.72]and mOS[25.8 mo(95%CI:15.2–35.6)vs 26.3 mo(95%CI:18.7–41.2);P=0.63].Grade 3 or above adverse events were reported in 28.4%of patients,being similar with oral and infusional FP,and included 10.5%of neutropenia and 2.1%of diarrhoea *** The current analysis demonstrates comparable efficacy and safety profiles of cetuximab in combination with oral and infusional FP in Chinese *** results expand treatment options for Chinese patients and invite revision of existing treatment guidelines to incorporate oral FP-based chemotherapy plus cetuximab.

关键词： Capecitabine 5-Fluorouracil Cetuximab Metastatic colorectal cancer Chinese

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Neuroprotective Effects of Lyicium Barbarum（Wolfberry） on Retinas after Partial Optic Nerve Transection

Neuroprotective Effects of Lyicium Barbarum（Wolfberry） on ...

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第十四届全国中药和天然药物学术研讨会

作者： Hongying Li Patrick HW Chu Henry HL Chan Yuxiang Liang kin chiu Raymond Chuen-Chung Chang Kwok-Fai So The University of Hong Kong

＜正＞Our group has shown that the polysaccharides extracted from Lycium barbarum（LBP）are neuroprotective for retinal ganglion cells（RGCs）in different animal *** RGCs from secondary degeneration is a promising direction for therapy in glaucoma *** partial optic nerve transection（PONT）model can be used to study secondary degeneration of RGCs because primary and secondary degeneration of RGCs can be

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Determinants for asthma control, quality of life and use of complementary and alternative medicine in asthmatic pediatric patients in four cities

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World Journal of Pediatrics 2018年第5期14卷 482-491页

作者： Kam Lun Hon Yan Min Bao Kate C.Chan kin Wai Chau Rong-Shan Chen Kun Tat Gary Cheok Wa Keung chiu Li Deng Chun-Hui He kin Mui Ieong Jeng Sum C.Kung Ping Lam Shu Yan David Lam Qun Ui Lee So Lun Lee Ting Fan Leung Theresa N.H.Leung Lei Shi Ka Ka Siu Wei-Ping Tan Maggie Haitian Wang Tak Wai Wong Bao-Jing Wu Ada Y.F.Yip Yue-Jie Zheng Daniel K.Ng Department of Pediatrics The Chinese University of Hong Kong 6/F Prince of Wales HospitalRoom 84042ShatinN.THong Kong SARChina Department ofR espiratory Diseases Shenzhen Children’s HospitalShenzhen 518026China Hong Kong Society of P ediatric Respirology and Aller gy Hong K ong S ARChina Pediatric Respiratory andSleep Disorders Center Room 1315DArgyle Centre Phase 1688 Nathan RoadMongkokKowloonHong K ong S ARChina Department of R espiration Guangzhou Women and Children’s Medical CenterGuangzhou 510623China Department of P ediatrics Kiang Wu HospitalMacaoChina Department of P ediatrics and A dolescent Medicine United Christian Hospital130Hip Wo StreetKwun TongHong K ong S ARChina Department of P ediatrics Central Hospital Conde S.JanuarioMacaoChina Department of P ediatrics and A dolescent Medicine Caritas Medical Center111Wing Hong StreetSham Shui PoHong K ong S ARChina Department of P ediatrics and A dolescent Medicine Tuen Mun Hospital23 Tsing Chung Koon RoadTuen MunNewT erritoriesHongK ongS ARChina Department of P ediatrics and A dolescent Medicine Princess Margaret Hospital2-10 Princess Margaret Hospital RoadLai Chi KokKowloonHong K ong S ARChina Department of P ediatrics and A dolescent Medicine Queen Mary Hospital102Pokfulam RoadHong K ong S ARChina Department of P ediatrics and A dolescent Medicine The University of Hong KongHong K ong S ARChina Department of P ediatrics and A dolescent Medicine Pamela Youde Nethersole Eastern Hospital3Lok Man RoadChaiwanHong K ong S ARChina Department of P ediatrics The University of Hong Kong-Shenzhen Hospital1Haiyuan 1st RoadFutianShenzhenChina Department of P ediatrics and A dolescent Medicine Kwong Wah Hospital25 Waterloo RoadKLN Hong K ong S ARChina Department of P ediatrics Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China JC School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong K ong S ARChina Department of P ediatrics and A dolescen

Background Asthma is a significant chronic health problem worldwide. Management aims at disease control by reducing functional impairment and exacerbations and improving quality of life (QoL). We report a multi-center study to survey asthma control and QoL in four cities in the Pearl River Delta. Methods The conjoint survey involved ten Hong Kong pediatric hospitals/units, two Shenzhen hospitals, two Macao hos-pitals, and two Guangzhou hospitals on asthma control (using Asthma Control Test) and QoL (Pediatric Allergic Disease Quality of Life Questionnaire, PADQLQ). Acceptability of a treatment is graded as very good/good/fair/poor. Results Good asthma control was only reported in 80% subjects in Hong Kong, but higher in sister cities (85–94%, P<0.001). Allergic rhinitis, 'incense burning', and 'smoker in family' were prevalent among the four cities. Logistic regres-sion showed better control of asthma was associated with better PADQLQ (B=?0.029, P < 0.001), better acceptability of bronchodilator (B=?1.488, P = 0.025), negatively with 'smoker in family' (B=?0.83, P = 0.015) and various PADQLQ domains. Conversely, worse PADQLQ was associated with allergic rhinitis severity (B=4.77, P <0.001), poor control of asthma (B=7.56, P <0.001), increased frequency of traditional Chinese medicine use (B=1.7, P < 0.05), increased fre-quency of bronchodilator usage (B=1.05, P < 0.05), 'smoker in family' (B=4.05, P < 0.05), and incense burning at home (B=3.9, P < 0.05). Conclusions There are some clinical and cultural differences among the four southern Chinese cities within the Guangdong province. This study identifies potentially modifiable environmental and treatment factors associated with poor asthma control and QoL for health-care interventions. Having a smoker in the family is independently associated with poor asthma control and QoL.

关键词： Asthma Complementary and alternative medicine Control Inhaled bronchodilator Inhaled corticosteroid Pediatric Allergic Disease Quality of Life Questionnaire Smoking Traditional Chinese medicine

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