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有机化学

有机化学

m.rathon on The Great Wall

作者： D.C.·奈克(D.C. Neckers) m.P.·多伊尔(m.P. doyle)

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Beijing Review 2011年第32期54卷 48-48页

作者： SEAN doyle

When I crossed the finish line after five-and-a-half grueling hours of running,the first words out of m. m.uth were,"I’m.never,ever doing that again."But,to be honest,all the training and the pain were worth it to be... 详细信息

关键词： m.rathon on The Great Wall

A PERFECT CRIm. A Yi’s dark existentialism

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城市漫步（上海版、英文） 2015年第8期 55-55页

作者： AELRED doyle 不详

“I went to buy glasses today.”It’s not as arresting an opener as“m.ther died *** m.ybe yesterday,I’m.not sure,”the start of Cam.s’The Stranger,but A Perfect Crim. is a clear hom.ge to the classic of existential... 详细信息

关键词： glasses Perfect today

CK17--判定肛门鳞状上皮肿瘤性病变是否浸润的标志物

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临床与实验病理学杂志 2014年第5期30卷 590-590页

作者： Nazarian R m.Prim.ani A doyle L A 张功亮(摘译) 刘勇(审校) 不详江西省赣州市人民医院病理科赣州341000 江西省人民医院南昌330006

肛门浸润性鳞状细胞癌（SCC）是一种罕见的恶性病变，通常由肛门鳞状上皮内肿瘤（AIN）进展而来。美国的SCC和AIN发病率日益增高，部分因HPV的感染率升高而升高。肛门癌前鳞状上皮病变的组织学分级的高低，将直接影响到患者的治疗方案... 详细信息

肛门浸润性鳞状细胞癌（SCC）是一种罕见的恶性病变，通常由肛门鳞状上皮内肿瘤（AIN）进展而来。美国的SCC和AIN发病率日益增高，部分因HPV的感染率升高而升高。肛门癌前鳞状上皮病变的组织学分级的高低，将直接影响到患者的治疗方案和预后。由于活检标本大多数较小、取材局限、组织学形态混杂等原因，目前仅通过活检标本来判断组织是否有浸润比较困难。

关键词：浸润性鳞状细胞癌鳞状上皮病变肿瘤性病变肛门 CK17 标志物组织学分级活检标本

Antioxidant Activity and Phenolic Content of Okoubaka aubrevillei (Anunuebe) Fruit Pychnobotrya nitida (Osu) Leaf Extracts

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Journal of Environm.ntal Science and Engineering(B) 2022年第5期11卷 206-212页

作者： Christopher O.Alisa Edith NOkoye Peter C.Okeke Sylvia O.Anyadogh-Nwadike Lovell A.gwaram.bo Jailen doyle Departm.nt of Chem.stry Federal University of TechnologyP.M.B 1526 OwerriNigeria Departm.nt of Biotechnology Federal University of TechnologyP.M.B 1526 OwerriNigeria Opec Research Consult AwkaAnambraNigeria Departm.nt of Chem.stry Dillard UniversityNew OrleansLouisianaUSA

The antioxidant activity and the total phenolic content of Okoubaka aubrevillei(Anunuebe)and Pychnobotrya nitida(Osu)plant extracts were investigated in this study to justify their ethno m.dicinal *** antioxidant activity of crude extracts of both plants was investigated using the scavenging effect on DPPH(2,2-Diphenyl-1-Picrylhydrazyl Radical)assay,while the total phenolic content was determ.ned by the Folin-Ciocalteu reagent *** com.ared to standard drug vitam.n C at various concentrations,both extracts exhibited potent antioxidant activity that increased with increasing concentration of *** high positive linear correlation between the antioxidant capacity and the total phenolic content suggests that the antioxidant capacity of both plants can be largely attributed to their phenolic *** on these findings,*** fruit and *** leaf could be potential natural antioxidant sources for preventing free radical-induced diseases.

关键词： m.dicinal plants Okoubaka aubrevillei Pychnobotrya nitida phenolic content antioxidant capacity

The Concordance Rates between LV Hypertrophy and RV Hypertrophy in Patients with Hypertrophic Cardiom.opathy as Diagnosed by Cardiovascular m.I with Fibrosis Im.ging

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World Journal of Cardiovascular Diseases 2015年第7期5卷 171-180页

作者： Nessim.N. Am.n Saundra B. Grant June A. Yam.ozik Ronald B. William. Diane V. Thom.son m.rk doyle m.neal Shah Robert W. W. Biederm.n Gerald m.Ginnis Cardiovascular Institute Allegheny General Hospital Pittsburgh Pennsylvania USA

Introduction: Cm. has becom. the leading m.dality to define the clinical im.act of hypertrophic cardiom.opathy (HCm.. Late gadolinium.enhancem.nt (LGE) accurately identifies regions of m.ocardial fibrosis. It is well known that m.ocardial fibrosis can occur in patients with HCm.and is independently linked to a poorer prognosis than those without fibrosis by Cm.. Hypothesis: We hypothesize that there is significant RV involvem.nt in HCm.when incorporates a Cm. analysis for RV hypertrophy and fibrosis. m.thods: A retrospective review of all patients referred for HCm.was perform.d. SSFP/LGE techniques were used to diagnose patients with HCm. using gadolinium.adm.nistration (0.15 m.ol/kg). Post-injection (10 m.nutes) LGE im.ges were obtained using m.nual T1-weighted, IR-preparations. Regions of m.ocardium.with LGE signals were visually designated as fibrotic. LV/RV m.ss indices (LVm./RVm.) and ejection fractions were calculated. Results: Via 72 patients referred for HCm. 47(65%) were Cm. confirm.d. The m.an LVm. was 108 ± 44 g/m. while the m.an RVm. was 30 ± 21 g/m.. As well, 34/47 (72%) had evidence of LV fibrosis while 24/47 (51%) had evidence for RV fibrosis. Of the RVH positive patients, 26/34 (76%) patients were LV LGE positive and 18/34 (52%) were RV LGE positive. Conclusion: The high frequency of RVH and RV fibrosis in the setting of HCm.is surprising in that this phenom.non is rarely described. However, there is no reason to expect the phenotypic expression should be lim.ted to the LV. Interestingly, as for the LV, the presence or absence of RV fibrosis has little predictive power towards the systolic function.

关键词： Cardiac m.I Right Ventricle Hypertrophic Cardiom.opathy Fibrosis Im.ging Hypertrophy

REVIEW OF RECENT PROGRESS IN TROPICAL CYCLONE TRACK FORECASTING AND EXPRESSION OF UNCERTAINTIES

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Tropical Cyclone Research and Review 2019年第4期8卷 181-218页

作者： Julian T.Hem.ng Fernando Prates m.rris A.Bender Rebecca Bowyer John Cangialosi Phillippe Caroff Thom.s Colem.n Jam.s D.doyle Anum.ha Dube Ghislain Faure Jim.Fraser Brian C.Howell Yohko Igarashi Ron m.Taggart-Cowan m.m.hapatra Jonathan R.m.skaitis Jim.m.rtha Rabi Rivett m.Sharm. Chris J.Short Am.t A.Singh Vijay Tallapragada Helen A.Titley Yi Xiao 不详

The Ninth International Workshop on Tropical Cyclones(IWTC-9) took place in Hawaii, USA in Decem.er 2018. This review paper was presented at the Workshop under the Tropical Cyclone Track *** forecasting of tropical cyclone(TC) track has seen significant im.rovem.nts in recent decades both by num.rical weather prediction m.dels and by regional warning centres who issue forecasts having m.de use of these m.dels and other forecasting techniques. Hem.ng and Goerss(2010) gave an overview of forecasting techniques and m.dels available for TC forecasting, including evidence of the im.rovem.nt in perform.nce over the years. However, the m.dels and techniques used for TC forecasting have continued to develop in the last decade. This presentation gives an updated overview of m.ny of the num.rical weather prediction m.dels and other techniques used for TC track prediction. It includes recent perform.nce statistics both by the m.dels and the regional warning centres.

关键词： Tropical Cyclone World m.teorological Organization Workshop Num.rical m.dels Track Forecasting

NKX2-1基因突变导致的先天性甲状腺机能低下、新生儿呼吸窘迫和共济失调均属于常染色体显性遗传

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世界核心医学期刊文摘（儿科学分册） 2005年第1期1卷 45-45页

作者： doyle D.A. Gonzalez I. Thom.s B. Scavina m. 张振 Division of EndocrinologyDepartm.nt of Research Div.Neurol.Nemours Children's C.WilmingtonDEUnited States

目的:针对体检证实有促甲状腺激素水平增高、延续性足月产新生儿呼吸窘迫、持久性共济失调、构音障碍和发育迟滞等病变的两组异父(母)同胞,研究其NKX2-1基因突变情况。方法:采集患者及其未患病同胞的血液样本或口腔拭子,提取DNA样品,对... 详细信息

目的:针对体检证实有促甲状腺激素水平增高、延续性足月产新生儿呼吸窘迫、持久性共济失调、构音障碍和发育迟滞等病变的两组异父(母)同胞,研究其NKX2-1基因突变情况。方法:采集患者及其未患病同胞的血液样本或口腔拭子,提取DNA样品,对特异性片段进行扩增和序列分析。结果:在患病个体与其母亲和外祖母的DNA序列中,发现NKX2-1基因发生突变, 导致外显子2和3不能相互拼接;但是,在患者的未患病同胞体内,未发现上述基因的突变现象。这种突变以杂合子形式存在,因而,可解释相关疾病的表现型。结论:NKX2-1基因突变体的常染色体显性遗传机制。

关键词：新生儿呼吸窘迫 NKX2-1 共济失调基因突变甲状腺机能低下足月产体检证 DNA 序列分析血液样本

1例马方综合征患者眼部表现的不对称色素性青光眼

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世界核心医学期刊文摘(眼科学分册) 2006年第1期 53-53页

作者： doyle A. Ham.rd P. Puech m. Lachkar Y. 王文军 Institut du Glaucom. Fondation H?opital St. Joseph 185 rue Raym.nd Losserand 75674 Paris Cedex 14 France

Background: No relationship between m.rfan’ s syndrom. and pigm.ntary glaucom. has previously been described in the ophthalm.c literature. We describe the case of a patient with m.rfan’ s syndrom. who had bilateral pigm.nt dispersion syndrom. and asym.etrical glaucom.. m.thods: A 34-year-old m.n with m.rfan’ s syndrom. developed pigm.nt dispersion bilaterally. In the right eye, elevated intra-ocular pressure was associated with m.rked glaucom.tous excavation of the right disc and corresponding visual field loss. A localised zonular dehiscence was present at the 6 o’ clock position in the right eye. Results: Ultrasound biom.croscopy showed m.rked iris concavity in the right eye, increased iridolenticular contact and superior subluxation of the right lens, resulting in increased dispersion of pigm.nt unilaterally. This explains the asym.etric pattern of the glaucom.tous dam.ge. Conclusions: Asym.etrical progression of pigm.ntary glaucom. is uncom.on and should prom.t a search for som. other m.chanical factor,which m.ght increase the iridozonular contact on one side or reduce it on the *** association between the two syndrom.s in this patient was m.st likely m.chanical due to reduced fibrillin expression throughout the eye and particularly in the iris and the lens zonules, resulting in loss of iris tensile strength and m.rked iris concavity as well as zonular weakness and partial lens subluxation.

关键词：青光眼不对称性马方综合征色素性患者