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Acta Pharmaceutica Sinica B 2020年第10期10卷 1814-1834页

作者： Gianluca Sferrazza Marco Corti Gloria Brusotti Pasquale Pierimarchi caterina Temporini Annalucia Serafino Enrica Calleri Department of Drug Sciences University of PaviaPavia 27100Italy Institute of Translational Pharmacology National Research Council of ItalyRome 03018Italy

The Wnt/β-catenin signaling is a conserved pathway that has a crucial role in embryonic and adult *** of the Wnt/β-catenin pathway has been associated with diseases including cancer,and components of the sisnaling have been proposed as innovative therapeutic targets,mainly for cancer *** attention of the worldwide researchers paid to this issue is increasing,also in view of the therapeutic potential of these agents in diseases,such as Parkinson’s disease(PD),for which no cure is existing *** evidence indicates that abnormal Wnt/β-catenin signaling is involved in tumor immunology and the targeting of Wnt/β-catenin pathway has been also proposed as an attractive strategy to potentiate cancer *** the last decade,several products,including naturally occurring dietary agents as well as a wide variety of products from plant sources,including curcumin,quercetin,berberin,and ginsenosides,have been identified as potent modulators of the Wnt/β-catenin signaling and have gained interest as promising candidates for the development of chemopreventive or therapeutic drugs for *** this review we make an overview of the nature-derived compounds reported to have antitumor activity by modulating the Wnt/β-catenin signaling,also focusing on extraction methods,chemical features,and bio-activity assays used for the screening of these compounds.

关键词： Wnt/β-catenin pathway Nature-derived compounds Anticancer therapy Cancer prevention

Mediterranean diet and nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2018年第19期24卷 2083-2094页

作者： caterina Anania Francesco Massimo Perla Francesca Olivero Lucia Pacifico Claudio Chiesa Policlinico Umberto I Hospital Sapienza University of Rome Institute of Translational Pharmacology National Research Council

Nonalcoholic fatty liver disease(NAFLD) is emerging as the most common chronic liver disease, and is characterized by a wide spectrum of fat-liver disorders that can result in severe liver disease and cirrhosis. Inflammation and oxidative stress are the major risk factors involved in the pathogenesis of NAFLD. Currently, there is no consensus concerning the pharmacological treatment of NAFLD. However, lifestyle interventions based on exercise and a balanced diet for quality and quantity, are considered the cornerstone of NAFLD management. Mediterranean diet(MD), rich in polyunsaturated fats, polyphenols, vitamins and carotenoids, with their anti-inflammatory and antioxidant effects, has been suggested to be effective in preventing cardiovascular risk factors. In adults, MD has also been demonstrated to be efficacious in reducing the risk of metabolic syndrome. However, few studies are available on the effects of the MD in both adult and pediatric subjects with NAFLD. Thus, the aims of the present narrative review are to analyze the current clinical evidence on the impact of MD in patients with NAFLD, and to summarize the main mechanisms of action of MD components on this condition.

关键词： Mediterranean diet children Nonalcoholic fatty liver disease adults

Relaxin influences ileal muscular activity through a dual signaling pathway in mice

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World Journal of Gastroenterology 2018年第8期24卷 882-893页

作者： Eglantina Idrizaj Rachele Garella Fabio Francini Roberta Squecco Maria caterina Baccari Department of Experimental and Clinical Medicine Section of Physiological Sciences University of Florence

AIM To investigate the signaling pathways involved in the relaxin(RLX) effects on ileal preparations from mice through mechanical and electrophysiological *** For mechanical experiments, ileal preparations from female mice were mounted in organ baths containing Krebs-Henseleit solution. The mechanical activity was recorded via force-displacement transducers, which were coupled to a polygraph for continuous recording of isometric tension. Electrophysiological measurements were performed in current-and voltage-clamp conditions by a microelectrode inserted in a single smooth muscle cell(SMC) of the ileal longitudinal layer. Both the membrane passive properties and inward voltage-dependent L-type Ca2+ currents were recorded using suitable solutions and voltage stimulation *** Mechanical experiments showed that RLX induced a decay of the basal tension and a reduction in amplitude of the spontaneous contractions. The effects of RLX were partially reduced by 1 H-[1,2,4]oxadiazolo[4,3-a ]-quinoxalin-1-one(ODQ) or 9-cyclopentyladenine mesylate(9 CPA), inhibitors of guanylate cyclase(GC) and adenylate cyclase(AC), respectively, and were abolished in the concomitant presence of both drugs. Electrophysiological experiments demonstrated that RLX directly influenced the biophysical properties of ileal SMCs, decreasing the membrane conductance, hyperpolarizing the resting membrane potential, reducing the L-type calcium current amplitude and affecting its kinetics. The voltage dependence of the current activation and inactivation time constant was significantly speeded by RLX. Each electrophysiological effect of RLX was reduced by ODQ or 9 CPA, and abolished in the concomitant presence of both drugs as observed in mechanical experiments. CONCLUSION Our new findings demonstrate that RLX influences ileal muscle through a dual mechanism involving both GC and AC.

关键词： Relaxin Gastrointestinal motility Smooth muscle AC/cAMP GC/cGMP

Do green roofs really provide significant energy saving in a Mediterranean climate? Critical evaluation based on different case studies

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Frontiers of Architectural Research 2021年第2期10卷 447-465页

作者： Fabio Fantozzi Carlo Bibbiani caterina Gargari Roberto Rugani Giacomo Salvadori Department of Energy SystemsTerritory and Constructions EnsineerinsUniversity of Pisa56122PisaItaly Department of Veterinary Science University of Pisa56124PisaItaly

Green roofs represent a growing technology that is spreading increasingly and rapidly throughout the building *** latest national and international regulations are promoting their application for refurbishments and new buildings to increase the energy efficiency of the building *** recent years,vegetative coverings have been studied to demonstrate their multiple benefits,such as the reduction of the urban heat island phenomenon and the increase in the albedo of *** the contrary,this study aims to verify the actual benefit of applying a green roof on a sloped cover compared with installing a highly insulated tiled *** EnergyPlus tool has been used to perform dynamic analyses,which has allowed to understand the behavior of two different stratigraphies in accordance with weather conditions,rain,and irrigation *** have shown that the installation of a green roof cannot always be considered the best solution for reducing building energy consumption,especially if compared with a classic highly insulated clay tile *** terms of summer air conditioning,the maximum saving is 0.72 kWh/*** presence of water in the soil has also been proven a crucial factor.

关键词： Green roof Mediterranean climate Building energy performance Dynamic energy simulation Energy policy

Boceprevir is highly effective in treatment-experienced hepatitis C virus-positive genotype-1 menopausal women

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World Journal of Gastroenterology 2014年第44期20卷 16726-16733页

作者： Veronica Bernabucci Alessia Ciancio Salvatore Petta Aimilia Karampatou Laura Turco Silvia Strona Rosina Critelli Paola Todesca caterina Cerami caterina Sagnelli Mario Rizzetto Calogero Cammà Erica Villa Division of Gastroenterology Azienda Ospedaliero-Universitaria Policlinico di Modena Italy Università degli Studi di Modena e Reggio Emilia Division of Gastroenterology University of Turin Division of Gastroenterology Di Bi MIS University of Palermo Dipartimento Medico-Chirurgico di Internistica Clinica e Sperimentale "F. Magrassi-A. Lanzara" Second University of Naples

AIM: To investigate the safety/efficacy of Boceprevirbased triple therapy in hepatitis C virus(HCV)-G1 menopausal women who were historic relapsers, partial-responders and null-responders. METHODS: In this single-assignment, unblinded study, we treated fifty-six menopausal women with HCV-G1, 46% F3-F4, and previous PEG-α/RBV failure(7% null, 41% non-responder, and 52% relapser) with 4 wk lead-in with PEG-IFNα2b/RBV followed by PEGIFNα2b/RBV+Boceprevir for 32 wk, with an additional 12 wk of PEG-IFN-α-2b/RBV if patients were HCV-RNApositive by week 8. In previous null-responders, 44 wk of triple therapy was used. The primary objective of retreatment was to verify whether a sustained virological response(SVR)(HCV RNA undetectable at 24 wk of follow-up) rate of at least 20% could be obtained. The secondary objective was the evaluation of the percent of patients with negative HCV RNA at week 4(RVR), 8(RVR BOC), 12(EVR), or at the end-of-treatment(ETR) that reached SVR. To assess the relationship between SVR and clinical and biochemical parameters, multiple logistic regression analysis was ***: After lead-in, only two patients had RVR; HCV-RNA was unchanged in all but 62% who had ≤1 log10 decrease. After Boceprevir, HCV RNA became undetectable at week 8 in 32/56(57.1%) and at week 12 in 41/56(73.2%). Of these, 53.8% and 52.0%, respectively, achieved SVR. Overall, SVR was obtained in 25/56(44.6%). SVR was achieved in 55% previous relapsers vs. 41% non-responders(P = 0.250), in 44% F0-F2 vs 54% F3-F4(P = 0.488), and in 11/19(57.9%) of patients with cirrhosis. At univariate analysis for baseline predictors of SVR, only previous response to antiviral therapy(OR = 2.662, 95%CI: 0.957-6.881, P = 0.043), was related with SVR. When considering "on treatment" factors, 1 log10 HCV RNA decline at week 4(3.733, 95%CI: 1.676-12.658, P = 0.034) and achievement of RVR BOC(7.347, 95%CI: 2.156-25.035, P = 0.001) were significantly related with the SVR, although RVR BOC only(6.794

关键词： Hepatitis C virus treatment Pegylated In-terferon Viral Hepatitis Menopause Genotype 1

Epidemiological and clinical aspects of hepatitis B virus infection in Italy over the last 50 years

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World Journal of Gastroenterology 2022年第26期28卷 3081-3091页

作者： caterina Sagnelli Antonello Sica Massimiliano Creta Armando Calogero Massimo Ciccozzi Evangelista Sagnelli Department of Mental Health and Public Medicine Section of Infectious DiseasesUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy Department of Precision Medicine University of Campania“Luigi Vanvitelli”Naples 80131Italy Department of Neurosciences Reproductive Sciences and OdontostomatologyUniversity of Naples Federico IINaples 80138Italy Department of Advanced Biomedical Sciences-UO General Surgery University Federico II of NaplesNaples 80127Italy Medical Statistics and Molecular Epidemiology Unit Campus Bio-Medico UniversityRome 80138Italy

A relevant gradual reduction of both the incidence rate of acute hepatitis B(AHB)and prevalence of chronic hepatitis B has occurred in Italy in the last 50 years,due to substantial epidemiological changes:Improvement in socioeconomic and hygienic conditions,reduction of the family unit,accurate screening of blood donations,abolition of re-usable glass syringes,hepatitis B virus(HBV)-universal vaccination started in 1991,use of effective well tolerated nucleo(t)side analogues able to suppress HBV replication available from 1998,and educational mediatic campaigns against human immunodeficiency virus infection focusing on the prevention of sexual and parenteral transmission of *** an example,AHB incidence has gradually decreased from 10/100000 inhabitants in 1985 to 0.21 in ***,the coronavirus disease 2019(COVID-19)pandemic has interrupted the trend towards HBV *** fact,several HBV chronic carriers living in the countryside have become unable to access healthcare facilities for screening,diagnosis,clinical management,and nucleo(t)side analogue therapy in the COVID-19 pandemic,mainly for anxiety of becoming infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),movement restrictions,and reduced gains from job *** addition,one-third of healthcare facilities and personnel for HBV patients have been devolved to the COVID-19 assistance.

关键词： Hepatitis B virus Hepatitis B virus epidemiology Acute hepatitis B COVID-19

Nanoscale electron tomography and atomic scale high-resolution electron microscopy of nanoparticles and nanoclusters:A short survey

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Progress in Natural Science:Materials International 2013年第3期23卷 222-234页

作者： John Meurig Thomas Paul A.Midgley caterina Ducati Rowan K.Leary Department of Materials Science and Metallurgy University of CambridgePembroke StreetCambridgeCB2 3QZUK

The outstanding merits of scanning transmission electron tomography as a technique for the investigation of the internal structure and morphology of nanoparticle and nanocluster materials are summarized with the aid of numerous typical *** is made also to the significant advances that have arisen in probing ultrastructural characteristics of nanoscale solids using aberrationcorrected(AC) electron microscopy(EM).Information of a unique kind may be retrieved by combining the imaging and analytical power of ACEM.

关键词： Nanoclusters Nanoparticles Atomic structure Electron tomography Aberration-corrected electron microscopy

Reactivation of hepatitis B virus infection in patients with hemolymphoproliferative diseases, and its prevention

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World Journal of Gastroenterology 2019年第26期25卷 3299-3312页

作者： caterina Sagnelli Mariantonietta Pisaturo Federica Calò Salvatore Martini Evangelista Sagnelli Nicola Coppola Department of Mental Health and Public Medicine Section of Infectious Diseases University of Campania Luigi Vanvitelli

Reactivation of hepatitis B virus(HBV)replication is characterized by increased HBV-DNA serum values of about 1 log or by HBV DNA turning positive if previously undetectable in serum,possibly associated with liver damage and seldom *** to HBV reactivation,hepatitis B surface antigen(HBsAg)-negative/anti-HBc-positive subjects may revert to *** patients with hemo-lymphoproliferative disease,the frequency of HBV reactivation depends on the type of lymphoproliferative disorder,the individual's HBV serological status and the potency and duration of *** particular,it occurs in 10%-50%of the HBsAg-positive and in 2%-25%of the HBsAg-negative/anti-HBc-positive,the highest incidences being registered in patients receiving rituximab-based *** reactivation can be prevented by accurate screening of patients at risk and by a pharmacological prophylaxis with anti-HBV nucleo(t)sides starting 2-3 wk before the beginning of immunosuppressive treatment and covering the entire period of administration of immunosuppressive drugs and a long subsequent period,the duration of which depends substantially on the degree of immunodepression *** with significant HBV replication before immunosuppressive therapy should receive anti-HBV nucleo(t)sides as a long-term(may be life-long)*** review article is mainly directed to doctors engaged every day in the treatment of patients with onco-lymphoproliferative diseases,so that they can broaden their knowledge on HBV infection and on its reactivation induced by the drugs with high immunosuppressive potential that they use in the care of their patients.

关键词： Hepatitis B virus reactivation Hepatitis B virus infection Hemolymphoproliferative diseases Immunosuppressive therapy Hepatitis B virus therapy Hepatitis B virus prophylasis

Hepatitis c virus markers in infection by hepatitis c virus: In the era of directly acting antivirals

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World Journal of Gastroenterology 2015年第38期21卷 10749-10759页

作者： Nicola Coppola Mariantonietta Pisaturo Rosa Zampino Margherita Macera caterina Sagnelli Evangelista Sagnelli Department of Mental Health and Public Medicine Section of Infectious DiseasesSecond University of Naples Division of Infectious Diseases AORN Sant’Anna e San Sebastiano di Caserta Internal Medicine and Hepatology Second University of Naples Department of Clinical and Experimental Medicine and Surgery "F. Magrassi e A. Lanzara" Second University of Naples

About 130-170 million people are infected with the hepatitis C virus(HCV) worldwide and more than 350000 people die each year of HCV-related liver diseases. The combination of pegylated interferon(Peg-IFN) and ribavirin(RBV) was recommended as the treatment of choice for chronic hepatitis C for nearly a decade. In 2011 the directly acting antivirals(DAA) HCV NS3/4A protease inhibitors,telaprevir and boceprevir,were approved to treat HCV-genotype-1 infection,each in triple combination with Peg-IFN and RBV. These treatments allowed higher rates of SVR than the double Peg-IFN + RBV,but the low tolerability and high pill burden of these triple regimes were responsible for reduced adherence and early treatment discontinuation. The second and third wave DAAs introduced in 2013-2014 enhanced the efficacy and tolerability of anti-HCV treatment. Consequently,the traditional indicators for disease management and predictors of treatment response should be revised in light of these new therapeutic options. This review article will focus on the use of the markers of HCV infection and replication,of laboratory and instrumental data to define the stage of the disease and of predictors,if any,of response to therapy in the DAA era. The article is addressed particularly to physicians who have patients with hepatitis C in care in their everyday clinical practice.

关键词： Chronic hepatitis C Hepatitis C virus replication

Role of genetic polymorphisms in hepatitis C virus chronic infection

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World Journal of Clinical Cases 2015年第9期3卷 807-822页

作者： Nicola Coppola Mariantonietta Pisaturo caterina Sagnelli Lorenzo Onorato Evangelista Sagnelli Department of Mental Health and Public Medicine Section of Infectious DiseasesSecond University of Naples Department of Clinical and Experimental Medicine and Surgery "F.Magrassi e A.Lanzara" Second University of Naples

AIM: To analyze the host genetics factors influencing the clinical course and the response to antiviral treatment in patients with chronic hepatitis C(CHC).METHODS: We conducted an electronic search on the Pub Med and MEDLINE(2000-2014) databases and Cochrane library(2000-2014). A total of 73 articles were retrieved and their data were extensively evaluated and discussed by the authors and then analyzed in this review ***: Several studies associated polymorphisms in the interleukin 28 B gene on chromosome 19(19q13.13) with a spontaneous viral clearance in acute hepatitis C and with the response to pegylated interferon(PegIFN)-based treatment in chronic hepatitis C patients. Other investigations demonstrated that inosine triphosphate pyrophosphatase genetic variants protect hepatitis C virus-genotype-1 CHC patients from ribavirin-induced anemia, and other studies that a polymorphism in the patatin-like phospholipase domain-containing protein 3 was associated with hepatic steatosis in CHC patients. Although not conclusive, some investigations suggested that the vitamin D-associated polymorphisms play an important role in the achievement of sustained virologic response in CHC patients treated with Peg-IFN-based antiviral therapy. Several other polymorphisms have been investigated to ascertain their possible impact on the natural history and on the response to treatment in patients with CHC, but the data are preliminary and warrant confirmation. CONCLUSION: Several genetic polymorphisms seem to influence the clinical course and the response to antiviral treatment in patients with CHC, suggesting individualized follow up and treatment strategies.

关键词： Single nucleotide polymorphism Hepatitis C virus infection Interleukin 28B Inosine triphosphate pyrophosphatase Patatin-like phospholipase domaincontaining protein 3