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Local bone metabolism balance regulation via double-adhesive hydrogel for fixing orthopedic implants

Bioactive Materials 2022年第6期7卷 169-184页

作者： Wei Jiang Fushan Hou Yong Gu Qimanguli Saiding Pingping Bao Jincheng Tang Liang Wu Chunmao Chen Cailiang Shen catarina leite pereira Marco Sarmento Bruno Sarmento Wenguo Cui Liang Chen Department of Orthopaedic Surgery Orthopedic InstituteThe First Affiliated Hospital of Soochow University708 Renmin RdSuzhouJiangsu215006PR China Department of Orthopedics The Second Hospital of Shanxi Medical UniversityNo.382 Wuyi RoadTaiyuanShanxi030001PR China Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of Medicine197 Ruijin 2nd RoadShanghai200025PR China Department of Electrocardiography The First Affiliated Hospital of Anhui Medical University218 Jixi RoadShushan DistrictHefeiAnhui230022PR China Department of Orthopedics The First Affiliated Hospital of Anhui Medical University218 Jixi RoadShushan DistrictHefeiAnhui230022PR China i3S-Instituto de Investigacao e Inovacao em Saude and INEB-dica Universidade do PortoRua Alfredo Allen 2084200-393PortoPortugal CESPU-Institute for Research and Advanced Training in Health Sciences and Technologies Rua Central de Gandra 13174585-116GandraPortugal Faculty of Medicine Universidade de LisboaAvenida Professor Egas Moniz1649-028LisboaPortugal

The effective osteointegration of orthopedic implants is a key factor for the success of orthopedic ***,local metabolic imbalance around implants under osteoporosis condition could jeopardize the fixation *** by the bone structure and the composition around implants under osteoporosis condition,alendronate(A)was grafted onto methacryloyl hyaluronic acid(H)by activating the carboxyl group of methacryloyl hyaluronic acid to be bonded to inorganic calcium phosphate on trabecular bone,which is then integrated with aminated bioactive glass(AB)modified by oxidized dextran(O)for further adhesion to organic collagen on the trabecular *** hybrid hydrogel could be solidified on cancellous bone in situ under UV irradiation and exhibits dual adhesion to organic collagen and inorganic apatite,promoting osteointegration of orthopedic implants,resulting in firm stabilization of the implants in cancellous bone *** vitro,the hydrogel was evidenced to promote osteogenic differentiation of embryonic mouse osteoblast precursor cells(MC3T3-E1)as well as inhibit the receptor activator of nuclear factor-κB ligand(RANKL)-induced osteoclast differentiation of macrophages,leading to the upregulation of osteogenic-related gene and protein *** a rat osteoporosis model,the bone-implant contact(BIC)of the hybrid hydrogel group increased by 2.77,which is directly linked to improved mechanical stability of the orthopedic ***,this organic-inorganic,dual-adhesive hydrogel could be a promising candidate for enhancing the stability of orthopedic implants under osteoporotic conditions.

关键词： Hydrogels Osteoporosis Osseointegration Dual-functional Peri-implant

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Catalytically active membranes for esterification:A review

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Chinese Journal of Chemical Engineering 2023年第1期53卷 142-154页

作者： Monique Juna L.leite Ingrid Ramalho Marques Mariane Carolina Proner Pedro H.H.Araújo Alan Ambrosi Marco Di Luccio Laboratory of Membrane Processes LABSEMDepartment of Chemical and Food EngineeringFederal University of Santa Catarina88040-970 FlorianópolisSCBrazil Laboratory of Control and Polymerization Processes LCPDepartment of Chemical and Food EngineeringFederal University of Santa Catarina88040-970 FlorianópolisSCBrazil

Esterification is an important process in the food industry and can be carried out via homogeneous or heterogeneous *** homogeneous catalyst,despite providing high conversion,can cause corrosion in reactors,which is not observed with the use of heterogeneous ***,some of these catalysts require a high process temperature and may lose their catalytic activity with ***,catalytic membranes have been proposed as a promising *** combination of catalysis and separation in a single module provides greater conversion,reduction of excess reagents,compact industrial plant,making the process more *** this context,this work aims to present a literature review on the catalytic membrane for the synthesis of esters,improving the understanding of the production and *** review examines the materials,catalysts used,and synthetic pathways.A comparison between the methods,as well as limitations and gaps in the literature,are highlighted.

关键词： Catalytic membrane Esterification Optimization Pervaporation Separation Selectivity

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Role of lysophosphatidic acid and its receptors in health and disease:novel therapeutic strategies

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Signal Transduction and Targeted Therapy 2021年第3期6卷 630-647页

作者： Luiz Henrique Medeiros Geraldo Tania Cristina leite de Sampaio Spohr Rackele Ferreira do Amaral Anna Carolina Carvalho da Fonseca Celina Garcia Fabio de Almeida Mendes catarina Freitas Marcos Fabio dosSantos Flavia Regina Souza Lima Institute de Ciencias BiomedicasUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Universite de Paris PARCCINSERMF-75015 ParisFrance Institute Estadual do Cerebro Paulo Niemeyer-Secretaria de Estado de Saude Rio de JaneiroBrazil Instituto de Saiide de Nova Friburgo Universidade Federal Fluminense28625-650 Nova FriburgoBrazil

Lysophosphatidic acid(LPA)is an abundant,bioactive phospholipid,with multiple functions both in development and in pathological ***,we review the literature about the differential signaling of LPA through its specific receptors,which makes this lipid a versatile signaling *** differential signaling is important for understanding how this molecule can have such diverse effects during central nervous system development and angiogenesis;and also,how it can act as a powerful mediator of pathological conditions,such as neuropathic pain,neurodegenerative diseases,and cancer ***,we review the preclinical and clinical uses of Autotaxin,LPA,and its receptors as therapeutic targets,approaching the most recent data of promising molecules modulating both LPA production and *** review aims to summarize the most update knowledge about the mechanisms of LPA production and signaling in order to understand its biological functions in the central nervous system both in health and disease.

关键词： therapeutic clinical diseases

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Culture Circle as a Teaching Approach in the Education of Teenager Health Multipliers on Leprosy Awareness

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Health 2015年第14期7卷 1813-1823页

作者： Estela Maria leite Meirelles Monteiro Amanda Araújo das Merces Amanda Carla Borba de Souza Cavalcanti Ana Márcia Tenorio de Souza Cavalcanti Ana catarina Torres de Lacerda Rosália Daniela Medeiros da Silva Andrea Rosane Sousa Silva Waldemar Brandao Neto Graduate Program in Nursing Federal University of Pernambuco (UFPE) Recife Brazil Graduate Program in Child and Adolescent Health Centre of Health Sciences Federal University of Pernambuco Recife Brazil Nursing Department at the Federal University of Pernambuco Recife Brazil

Objective: The study aims to evaluate the use of a teaching method proposed by Paulo Freire, Culture Circles, in the education of teenagers multipliers on leprosy awareness. Methods: It is an action-research study with a qualitative approach developed in a public school in Pernambuco, Brazil. Five Culture Circles were conducted involving the participation of 26 teenagers. The followings were used as data collection tools: observation, field notes, photography and filming. Results: The educational intervention on health addressed the following topics: 1) Definition and transmission of leprosy;2) Characteristics and diagnosis of leprosy;3) Treatment of leprosy;4) Aesthetics, prejudice and mental health related to leprosy;and 5) Planning of educational activities for teenagers as health multipliers on leprosy awareness. The educational action on health provided this age group to perceive themselves, act as political subjects in the development of Culture Circles, and act as protagonists in the dissemination of knowledge on leprosy. Conclusions: This study highlights that the application of active methodologies, such as Culture Circles, is able to encourage the engagement of young people in community empowerment and bring together health professionals and the school community in an intersectoral work in order to develop action strategies involving the promotion of health in the context of neglected diseases such as leprosy.

关键词： Adolescents School Health Leprosy Awareness Culture Circles Health Promotion

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Characterization of Clinical and Environmental Isolates of <i>Cryptococcus neoformans</i>/<i>Cryptococcus gattii</i>Complex Maintained in Yeast Culture Collection in São Paulo, Brazil

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Open Journal of Epidemiology 2018年第2期8卷 76-92页

作者： Pedro Henrique Magalhã es Cardoso Bosco Christiano Maciel da Silva Jairo Ivo dos Santos Rennan Luiz Oliveira dos Santos Diniz pereira leite Jú nior Marcos Ereno Auler Luciana da Silva Ruiz Eriques Gonç alves da Silva Dé bora Moreira Carina Domaneschi Francisco de Assis Baroni Marcia de Souza Carvalho Melhem Marilena dos Anjos Martins Claudete Rodrigues Paula Faculty of Veterinary Medicine and Zootechny-FMVZ-USP University of S&#227 o Paulo (USP) S&#227 o Paulo Brazil Faculty of Medicine/FMUSP University of S&#227 o Paulo (USP) S&#227 o Paulo Brazil Federal University of Santa catarina (UFSC) Florian&oacute polis Brazil Faculty of Dentistry University of S&#227 o Paulo (FOUSP) S&#227 o Paulo Brazil Faculty of Medicine Federal University of Mato Grosso (UFMT) Cuiab&aacute Brazil Faculty of Pharmacy University of the Western Center of Paran&aacute (UNICENTRO) Guarapuava Brazil Institute Adolfo Lutz (IAL) Bauru Brazil Federal Rural University of Rio de Janeiro (UFRRJ) Serop&eacute dica Brazil Institute Adolfo Lutz (IAL) S&#227 o Paulo Brazil

Objective: As isolates of Cryptococcus are frequently kept collection stocks in institutions, sometimes without proper characterization, we sought to determine the genotype profiles, protease and phospholipase activities “in vitro” and the susceptibility testing for azoles and amphotericin B. Methodology: 84 isolates from several regions of Brazil (40 samples from clinical origin and 44 isolates from environmental origin) were maintained at the microorganism’s bank of the Biomedical Science Institute (ICB-USP) of the São Paulo University, in São Paulo, Brazil. This isolates was submitted fungal strains determination, DNA extraction and purification, determination of genotype by URA5 gene RFLP of CGB-positive isolates, protease and phospholipase activity and susceptibility to antifungals. Results: Of six CGB positive isolates tested by RFLP-PCR, only four presented a genomic profile consistent C. gattii species (VGII), while two other were C. neoformans (VNI and VNIII), indicating the existence of canavanine-resistante C. neoformans isolates in the culture collections. The clinical isolates secreted higher levels of phospholipase and environmental isolates but no differences were observed for the protease levels. Almost all isolates were sensible to azoles and amphotericin B. Conclusion: We point out in this research the existence of C. neoformans strains resistant to canavanine and intrinsic characteristic of C. gatti. These results demonstrate the importance to perform a detailed characterization of isolates kept in culture collections.

关键词： Cryptococcus Complex Genotyping Protease Phospholipase Etest Culture Collection

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Instantly Investigating the Adsorption of Polymeric Corrosion Inhibitors on Magnesium Alloys by Surface Analysis under Ambient Conditions

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Journal of Surface Engineered Materials and Advanced Technology 2014年第5期4卷 282-294页

作者： Livia M.Garcia Goncalves Larissa C.Sanchez Stephani Stamboroski Yendry R.Corrales Urena Welchy leite Cavalcanti Jorg Ihde Michael Noeske Marko Soltau Kai Brune Fraunhofer Institute for Manufacturing Technology and Advanced Materials IFAM BremenGermany CAPES Foundation Ministry of Education of BrazilBrasiliaBrazil Department of Materials Engineering UFSCarFederal University of Sao CarlosSao CarlosBrazil Department of Chemistry UFSCFederal University of Santa CatarinaFlorianopolisBrazil UNESP Sao Paulo State University Sao PauloBrazil Straetmans High TAC GmbH HamburgGermany

Surface engineering of magnesium alloys requires adequate strategies, processes and materials permitting corrosion protection. Liquid formulations containing corrosion inhibitors often are to be optimized according to the demands of the respective substrate and following the service conditions during its application. As an interdisciplinary approach, a combination of several techniques for instantly monitoring or elaborately analyzing the surface state of magnesium was accomplished in order to characterize the performance of new adsorbing sustainable amphiphilic polymers which recently were developed to facilitate a multi-metal corrosion protection approach. The application of established techniques like Contact Angle measurements and X-ray Photoelectron Spectroscopy investigations was supplemented by introducing related and yet faster online-capable and larger-scale techniques like Aerosol Wetting Test and Optically Stimulated Electron Emission. Moreover, an inexpensive setup was configured for scaling the inset and the extent of degradation processes which occur at local electrochemical circuits and lead to hydrogen bubble formation. Using these analytical tools, changes of the surface state of emeried AM50 samples were investigated. Even in contact with water, being a moderate corrosive medium, the online techniques facilitated detecting surface degradation of the unprotected magnesium alloy within some seconds. In contrast, following contact with a 1 weight% formulation of a polymeric corrosion inhibitor, surface monitoring indicated a delay of the onset of degradation processes by approximately two orders of magnitude in time. Mainly based on the spectroscopic investigations, the corrosion inhibiting effects of the investigated polymer are attributed to the adsorption of a primary polymer layer with a thickness of a few nanometers which occurs within some seconds. Immersion of magnesium for several hours brings up a protective film with around ten nanometers th

关键词： Online Surface Monitoring Magnesium Alloys Polymeric Corrosion Inhibitors Fast Screening of Effective Formulations Optimization of Application Process

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On the Impact of Brazil's Largest Recent Oil Spill on Regional Oceans

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Sustainable Marine Structures 2021年第2期3卷 1-14页

作者： Liana de Figueiredo Mendes Patricia Pinheiro Beck Eichler Tatiana leite Ana Beatriz Alves Bennemann Clara de Souza Melo Andressa Lima Ferreira Khalil Bow Ltaif Garcia Luzia Liniane do Nascimento Silva Christofer Paul Barker Helenice Vital Moab Praxedes Gomes Priscila F.M.Lopes Department of Ecology Federal University of Rio Grande do Norte(UFRN)University CampusLagoa Nova59072-970 NatalRNBrazil Graduate Program in Geodynamics and Geophysics(PPGG) Laboratory of Marine Geology and Geophysics and Environmental MonitoringFederal University of Rio Grande do Norte 0JFRN)University CamposLagoa Nova59072-970 NatalRNBrazil ***(California USA) Department of Ecology and Zoology Federal University of Santa CatarinaTrindade88040-900FlorianopolisSCBrazil

In 2019,an oil spill in Brazil,of unknown origin,severely impacted coastal environs with the worst environmental disaster ever recorded in any tropical coastal region globally severely damaging South Pirangi Reef area in the state of Rio Grande do Norte(RN).Here we discuss acute and chronic impacts including chemical contamination and economic consequences all over the world and show some evidence of the oil spill in this biodiverse ***,the lapse between the moment of the disastei;and the action to manage it,was hampered by a political agenda coinciding with local and global tragedies that redirected public *** almost 2 years have passed still without the offending party identification or culpability;and poor communities may continue to absorb its deleterious impacts for decades without consideration or *** disaster occurred during the Brazilian government's current issues involving extensive environmental mismanagement,resulting in a slow response from an inept *** is with urgent necessity to spotlight this tragedy in this unique and sensitive reef habitat experiencing the ongoing damaging effects that include socio-economic losses not yet addressed.

关键词： Environmental impacts Socioeconomic losses Government Brazilian coast Oil spill Disaster

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Interleukin 28B-related polymorphisms: A pathway for understanding hepatitis C virus infection?

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World Journal of Gastroenterology 2013年第42期19卷 7399-7404页

作者： Raquel Francine Liermann Garcia Simone Moreira Ana Lucia de Araújo Ramos Leslie Ecker Ferreira Angelo Alves de Mattos Cristiane Valle Tovo Lysandro Alsina Nader Juliene Antonio Ramos Edson Rondinelli Arnaldo de Jesus Dominici Christian Evangelista Garcia Mauro de Souza leite Pinho Carlos Eduardo Brando-Mello Cristiane Alves Villela-Nogueira Paulo Henrique Condeixa de Frana Departamento de Medicina Universidade da Regio de Joinville/UnivilleJoinville89219-719 Santa CatarinaBrazil Departamento de Clinica Médica e Cirurgia Geral Hospital Municipal So José Joinville89202-000 Santa CatarinaBrazil Departamento de Clínica Médica Servio de HepatologiaFaculdade de Medicina/Hospital Universitário Clementino Fraga Filho/Universidade Federal do Rio de Janeiro21941-913 Rio de JaneiroBrazil Servio de Gastroenterologia e Hepatologia Irmandade da Santa Casa de Misericórdia/ISCMPAPorto Alegre90020-090 Rio Grande do SulBrazil Servio de Endoscopia Universidade Federal de Pelotas/UFPelPelotas96010-610 Rio Grande do SulBrazil Instituto de Biofísica Carlos Chagas Filho/UFRJ 21941-902 Rio de JaneiroBrazil Departamento de Gastroenterologia Hospital Universitário da Universidade Federal do Maranh o/UFMASo Luis65020-560 MaranhoBrazil Servio de Gastroenterologia Hospital Universitário Gaffrée Guinle/HUGG/UNIRIO20270-004 Rio de JaneiroBrazil

AIM:To analyze the role of rs12979860 and rs8099917polymorphisms in hepatitis C virus(HCV)genotype 1infection of ***:A total of 145 adult patients diagnosed with genotype 1 chronic hepatitis C(CHC)who had completed a 48-wk regimen of pegylated-interferonα-2a or-2b plus ribavirin combination therapy were recruited from six large urban healthcare centers and199 healthy blood donors(controls)from a single site between January 2010 and January *** on the patients’response to treatment was *** chain reaction-restriction fragment length polymorphism genotyping of the interleukin(IL)28B gene fragment encompassing the single nucleotide polymorphisms(SNPs)rs12979860(C/T)and rs8099917(T/G)was carried out for 79 of the CHC patients and 199 of the ***-directional amplicon sequencing of the two SNPs was carried out for the remaining 66 CHC ***:SNP rs12979860 genotyping was successful in 99.5%of the controls and 97.2%of the CHC patients,whereas the SNP rs8099917 genotyping was successful in 95.5%of the controls and 100%of the CHC *** genotype and allele distributions for both rs12979860 and rs8099917 were significantly different between the control and CHC patient groups,with significantly higher genotype frequencies of CC and TT in the controls(P=0.037 and 0.046,respectively)and of TT and GG in the CHC patients(P=0.0009and 0.0001,respectively).Analysis of the CHC patients who achieved sustained virological response(SVR)to treatment(n=55)indicated that the rs12979860 C allele and CC genotype were predictors of SVR(P=0.02).No significant correlation was found between rs8099917 genotypes and treatment response,but carriers of the T allele showed significantly higher rates of SVR(P=0.02).Linkage disequilibrium analysis of the group that achieved SVR showed a significant association between rs12979860 and rs8099917(P=0.07).CONCLUSION:The higher allele frequency of rs12979860 C and rs8099917 T observed in non-HCVinfec

关键词： Hepatitis C Interleukin 28B Single nucleotide polymorphisms Sustained virological response Brazil

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Determination of Zn and Mg in Milk Powder Samples Using Conventional and Alternative Sample Preparations and FAAS

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Journal of Food Science and Engineering 2019年第5期9卷 171-173页

作者： Deborah Cristina Crominski da Silva Clecius Henrique Chemim Leticia Yuriko Togawa Fabiano Piechotcoski Erica Roberta Lovo da Rocha Watanabe Priscilla dos Santo Gaschi leite Eduardo Sidinei Chaves Simone Delezuk Inglez Department of Chemical Engineering Federal University of Technology-Paraná Ponta Grossa Paraná 84016-210 Brazil Department of Chemistry Federal University of Santa Catarina Florianópolis Santa Catarina 88040-900 Brazil

Conventional procedures for sample preparation, such as calcination and acid digestion, were compared with an alternative procedure: alkaline solubilization and ultrasound-assisted extraction. The procedures were evaluated by the application of the mentioned sample preparation and subsequent determination of Mg and Zn in milk powder samples by flame atomic absorption spectrometry (FAAS). The results indicated that ultrasound-assisted extraction was not suitable for Zn and Mg extraction, whereas alkaline solubilization using TMAH was efficient only for determination of Mg.

关键词： Milk powder trace elements ultrasound-assisted extraction alkaline solubilization FAAS.

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