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The Hippo Tumor Suppressor Pathway(YAP/TAZ/TEAD/MST/LATS)and EGFR-RAS-RAF-MEK in cancer metastasis

Genes & Diseases 2021年第1期8卷 48-60页

作者： Mohammad Reza Zinatizadeh Seyed Rouhollah Miri Peyman Kheirandish Zarandi Ghanbar Mahmoodi Chalbatani catarina Raposo Hamid Reza Mirzaei Mohammad Esmaeil Akbari Habibollah Mahmoodzadeh Cancer Research Center Shahid Beheshti University of Medical SciencesTehranIran Cancer Research Center Cancer Institute of IranTehran University of Medical ScienceTehranIran Department of Immunology School of MedicineTehran University of Medical SciencesTehranIran Department of Immunology Medical SchoolShahid Beheshti University of Medical SciencesTehranIran Faculty of Pharmaceutical Sciences State University of Campinas-UNICAMP Campinas SPBrazil Cancer Research Center Shohadae Tajrish HospitalDepartment of Radiation OncologyShahid Beheshti University of Medical SciencesTehranIran

Hippo Tumor Suppressor Pathway is the main pathway for cell growth that regulates tissue enlargement and organ size by limiting cell *** pathway is activated in response to cell cycle arrest signals(cell polarity,transduction,and DNA damage)and limited by growth factors or mitogens associated with EGF and *** major pathway consists of the central kinase of Ste20 MAPK(Saccharomyces cerevisiae),Hpo(Drosophila melanogaster)or MST kinases(mammalian)that activates the mammalian AGC kinase dmWts or LATS effector(MST and LATS).YAP in the nucleus work as a cofactor for a wide range of transcription factors involved in proliferation(TEA domain family,TEAD1-4),stem cells(Oct4 mononuclear factor and SMAD-related TGFb effector),differentiation(RUNX1),and Cell cycle/apoptosis control(p53,p63,and p73 family members).This is due to the diverse roles of YAP and may limit tumor progression and *** also coordinates various signal transduction pathways such as Hippo,WNT,TGFb and EGFR,and effects on lack of regulation of TEAD cancerous genes,such as KRAS,BRAF,LKB1,NF2 and MYC,which play essential roles in tumor progression,metastasis,cancer metabolism,immunity,and drug ***,RAS signaling is a pivotal factor in the inactivation of Hippo,which controls EGFR-RAS-RAF-MEK-ERKmediated interaction of Hippo ***,the loss of the Hippo pathway may have significant consequences on the targets of RAS-RAF mutations in cancer.

关键词： Cancer Hippo pathway Metastasis Signaling Tumor suppressor

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风土营销:葡萄酒旅游经济

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中南民族大学学报（人文社会科学版） 2017年第1期37卷 77-80页

作者： David Picard catarina Moreira 撒露莎瑞士洛桑大学地理与可持续发展研究院葡萄牙里斯本大学生态进化及环境变迁研究中心中南民族大学预科教育学院湖北武汉430073

探讨在葡萄酒业中旅游如何作为战略营销工具用于品牌推广,并从多角度论证葡萄酒旅游成功的运营模式。基于在全球主要葡萄酒产地的比较研究可知,通过为游客提供戏剧性、仪式性的休闲旅游环境,葡萄酒生产商及分销商可以成功塑造并提升葡... 详细信息

探讨在葡萄酒业中旅游如何作为战略营销工具用于品牌推广,并从多角度论证葡萄酒旅游成功的运营模式。基于在全球主要葡萄酒产地的比较研究可知,通过为游客提供戏剧性、仪式性的休闲旅游环境,葡萄酒生产商及分销商可以成功塑造并提升葡萄酒产品品牌形象。

关键词：品牌营销葡萄酒业旅游运营模式品牌形象

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Recent Advances in Drug Delivery Systems

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journal of Biomaterials and Nanobiotechnology 2011年第5期2卷 510-526页

作者： Nuno Martinho Christiane Damgé catarina Pinto Reis 不详

Drug targeting to specific organs and tissues has become one of the critical endeavors of the century since the use of free drugs in conventional dosage forms generally involves difficulties in achieving the target site at the appropriate dose after or during a proper time period. Consequently, the search for new drug delivery approaches and new modes of action represent one of the frontier research areas. New drug delivery systems include lipidic, proteic and polymeric technologies to provide new sustained drug delivery with better body distribution, drug protection from harsh external environment and avoidance of drug clearance. Many of these technologies have reached the market therefore proving the benefits of these new carriers. This review covers the generalities of those new carriers and their new advances in drug delivery.

关键词： Nanomedicine Nanoparticles Liposomes Cyclodextrins Dendrimers ADEPT

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Plug-In Vehicle Acceptance and Probable Utilization Behaviour

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journal of Transportation Technologies 2012年第1期2卷 67-74页

作者： Patrícia Baptista catarina Rolim Carla Silva 不详

This paper presents a study undertaken to understand the plug-in vehicle acceptance and probable utilization behaviour in terms of charging habits and utility factor (probability of driving in electrical mode). A survey was designed to be answered via World Wide Web, throughout 3 months and only accessible to Portuguese inhabitants. The survey was composed by biographical and car ownership info, mobility patterns, awareness toward plug-in vehicle technologies, price premium and, finally, potential buyer’s attitudes regarding charging vehicles with electricity from the grid. An explanation of how each vehicle technology works in the case of a regular hybrid (HEV), a plug-in hybrid (PHEV) and a pure electric vehicle (EV) was provided. A total sample of 809 volunteers answered the survey, aged above 18 years old, 50% male and 50% female. The results allowed the estimation of the typical daily driving distance, the Utility Factor curve for plug-in hybrid future users, the charging preferences for future users of pure electric or plug-in hybrid vehicles and the necessary feebates to promote the market penetration of such technologies. Other correlations were also analyzed between driving patterns, type of owned car, price premium and the willingness to buy pure electric and plug-in hybrid vehicles. The main policy implications are that an increase of awareness campaigns is necessary if the government intends to support the plug-in electric vehicle technology widespread and a minimum of 5000 € investment per ton of avoided CO2 will be necessary in a year.

关键词： Pure Electric Vehicles Plug-In Hybrid Vehicles Utility Factor Frequency Period of Recharging

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BOLIN： Linguistic and Literary journal

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Sino-US English Teaching 2016年第9期13卷 710-716页

作者： josimar Goncalves Ribeiro Maria catarina Paiva Repoles Instituto Federal do Sudeste de Minas Gerais Campus Rio Pomba Brazil

This article proposes a pedagogical strategy to develop proficiency in writing and comprehension in native and foreign languages. It is a pilot project which intends to explore, develop, build, collect, select, analyze, and prepare an action plan for that purpose. The strategy is being used at a Federal Institute in Brazil--IF Sudeste MG, Rio Pomba campus. The subjects involved in this process of investigation are students of two classes who attend their first year at High School integrated to technical courses. The methodology involves the use of a school journal as a teaching and learning resource to encourage literary reading and the production of different genres. The goal is to establish an interaction between the reading and writing mediated by a young and playful context offering an additional instrument for instruction, aimed at the use and reflection of the language.

关键词： school journal teaching resource genre production

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Facial Expression Recognition of Portuguese using American Data as a Reference

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journal of Psychological Research 2020年第1期2卷 35-39页

作者： catarina Iria Rui Paixao Fernando Barbosa University of Coimbra Portugal University of Porto Portugal

It is unknown if the ability of Portuguese in the identification of NimStim data set,which was created in America to provide facial expressions that could be recognized by untrained people,is(or not)similar to the *** test this hypothesis the performance of Portuguese in the recognition of Happiness,Surprise,Sadness,Fear,Disgust and Anger NimStim facial expressions was compared with the Americans,but no significant differences were *** both populations the easiest emotion to identify was Happiness while Fear was the most difficult ***,with exception for Surprise,Portuguese tend to show a lower accuracy rate for all the emotions *** highlighted some cultural differences.

关键词： NimStim Emotions Facial expression Facial expression recognition Facial affect

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Appropriate search techniques to estimate Weibull function parameters in a Pinus ***

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journal of Forestry Research 2021年第6期32卷 2423-2435页

作者： Lais Almeida araujo Rafael Menali Oliveira Mario Dobner Jr Carolina Souza Jarochinskie Silva Lucas Rezende Gomide Department of Forest Sciences Federal University of LavrasLavrasMinas GeraisBrazil Department of Agriculture Biodiversity and ForestsFederal University of Santa CatarinaCuritibanosSanta CatarinaBrazil

The Weibull function,a continuous probability distribution,is widely used for diameter distribution modelling,in which parameter estimation performance is affected by stand attributes and fitting *** Weibull cumulative distribution function is nonlinear,and classical fitting methods may provide a not optimal *** the use of artificial intelligence by metaheuristics is reasonable for this optimisation ***,aimed and compared(1)the metaheuristics genetic algorithm and simulated annealing performance over the moment and percentile methods;(2)the hybrid strategy merging the metaheuristics tested and the percentile method and,(3)the metaheuristics fitness functions under basal area and density errors.A long-term experiment in a Pinus taeda stand subjected to crown thinning was *** to our findings,all methods have a similar performance,independent of the thinning regimes and *** pattern of the estimated parameters tends to be acceptable,as b increases over time and c increases after ***,our findings suggest that methods based on metaheuristics have a higher precision than classical methods for estimating Weibull *** to the classification test,the methods that involved simulated annealing stood *** hybrid method involving this metaheuristic also stood out,with accurate *** methods showed the poorest performance,and we therefore suggest the use of simulated annealing due to its faster processing time and high-quality solution.

关键词： Forest management Diameters distribution Weibull function Genetic algorithm Simulated annealing

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Imaging evaluation of the liver in oncology patients:A comparison of techniques

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World journal of Hepatology 2021年第12期13卷 1936-1955页

作者： Patrícia S Freitas catarina Janicas joséVeiga António P Matos Vasco Herédia Miguel Ramalho Department of Radiology Centro Hospitalar Universitário de Lisboa CentralLisbon 1150-199Portugal Department of Radiology Centro Hospitalar de Lisboa OcidentalLisbon 1449-005Portugal Department of Radiology Hospital Garcia de OrtaEPEAlmada 2805-267Portugal Department of Radiology Hospital CUF TejoLisbon 1350-352Portugal Department of Radiology Hospital Espírito Santo deÉvora-EPEÉvora 7000-811Portugal Department of Radiology Hospital da LuzLisbon 1500-650Portugal

The liver is commonly affected by metastatic ***,it is essential to detect and characterize liver metastases,assuming that patient management and prognosis rely on *** imaging techniques that allow non-invasive assessment of liver metastases include ultrasonography,computed tomography(CT),magnetic resonance imaging(MRI),positron emission tomography(PET)/CT,and PET/*** this paper,we review the imaging findings of liver metastases,focusing on each imaging modality’s advantages and potential *** also assess the importance of different imaging modalities for the management,follow-up,and therapy response of liver *** date,both CT and MRI are the most appropriate imaging methods for initial lesion detection,follow-up,and assessment of treatment *** MRI is frequently used as a problem-solving technique for liver lesions and has evolved substantially over the past decade,including hardware and software developments and specific intravenous contrast *** studies have shown that MRI performs better in small-sized metastases and moderate to severe liver steatosis *** state-of-the-art MRI shows a greater sensitivity for detecting and characterizing liver metastases,CT remains the chosen *** also present the controversial subject of the"economic implication"to use CT over MRI.

关键词： Liver metastases Magnetic resonance imaging Computed tomography Oncology Ultrasound Follow-up

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Regeneration of critical-sized defects, in a goat model, using a dextrin-based hydrogel associated with granular synthetic bone substitute

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Regenerative Biomaterials 2021年第1期8卷 73-82页

作者： Isabel Pereira jose Eduardo Pereira Luis Maltez Alexandra Rodrigues catarina Rodrigues Manuela Oliveira Dina MSilva Ana Rita Caseiro Justina Prada Ana Colette Mauricio jose Domingos Santos Miguel Gama CEB Centre of Biological EngineeingUniversity of MinhoCampus de GualtarBraga 4710-057Portugal CECAV Animal and Veterinary Research CentreUniversity of Trias-os-Montes e Alto DouroVila Real 5001-801Portugal Department of Veterinary Sciences University of Tras-os-Montes e Alto DouroVila Real 5001-801Portugal Bios ckin Molecular and Cell Therapies S.A.Laboratorio CriovidaTecMaiaRua Engenheiro Frederico Ulrich 2650Moreira da Maia 4470-605Portugal Departamento de Clinicas Veterinarias Instituto de Ciencias Biomedicas de Abel Salazar(ICBAS)Universidade do Porto(UP)Rua de Jorge Viterbo Ferreiran°228Porto 4050-313Portugal Centro de Estudos de Ciencia Animal(CECA) Instituto de CienciasTecnologias e Agroambiente da Universidade do Porto(ICETA)Rua D.Manuel IApartado 55142Porto 4051-401 Portugal Centro de Investigaqao Vasco da Gama(CIVG)/Escola Universitaria Vasco da Gama(EUVG) Avenida Jose R.Sousa Femandesn°197 LordemaoCoimbra 3020-210Portugal REQUIMTE/LAQV Departamento de Engenharia Metalurgica e MateriaisFaculdade de EngenhariaUniversidade do PortoRua Dr Roberto FriasPorto 4200-495Portugal

The development of injectable bone substitutes(IBS)have obtained great importance in the bone re-generation field,as a strategy to reach hardly accessible defects using minimally invasive techniques and able to fit to irregular *** this scenario,the association of injectable hydrogels and bone graft granules is emerging as a well-established ***,in situ forming hydrogels have arisen as a new IBS *** in situ forming and injectable dextrin-based hydrogel(HG)was developed,aiming to act as a carrier of granular bone substitutes and bioactive *** this work,the HG was associated to a granular bone substitute(Bonelike)and implanted in goat critical-sized calvarial defects(14mm)for 3,6 and *** results showed that HG improved the han-dling properties of the Bonelike granules and did not affect its osteoconductive features,neither impairing the bone regener ation *** multipotent mesenchymal stromal cells from the umbilical cord,extracellular matrix hydrolysates and the pro-angiogenic peptide LLKKK18 were also combined with the *** bioactive agents did not enhance the new bone formation significantly under the conditions tested,according to micro-computed tomography and histological analysis.

关键词： polysaccharide injec table hydrogel granular ceramics Bonelike' bone regen eration calvarial defect

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Impact of Drug-Drug Interaction between CDK4/6 Inhibitors and Proton Pump Inhibitors on Survival Outcomes in the Treatment of Metastatic Breast Cancer—Real World Data from a Portuguese Center

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journal of Cancer Therapy 2022年第5期13卷 266-274页

作者： joana Reis Inês Costa Mariana Costa Ana Valente catarina Almeida Marta Freitas Cláudia Caeiro catarina Fernandes Nuno Tavares Miguel Barbosa Centro Hospitalar SÃ O joÃ O E.P.E. Porto Portugal

Introduction: Proton pump inhibitors (PPi) are widely prescribed, including in patients undergoing treatment for advanced breast cancer (ABC). Due to the pharmacokinetic characteristics of the CDK4/6 inhibitor (Ci) palbociclib a drug interaction with PPi was hypothesized. It was shown in a retrospective study that this association was an independent predictive factor for worse progression-free survival (PFS). Objective: To verify the impact of concomitant administration of PPi with Ci on overall survival (OS) and PFS. Material and Methods: This is a retrospective cohort study of patients treated with Ci for HR+HER2-ABC in the period from Feb/2017 to Aug/2020. SPSS software was used for data processing. Univariate analysis was done by the Kaplan-Meier method and log-rank test, and multivariate analysis by COX regression. P-value < 0.05 was considered significant. Results: 80 patients were included. The median age at diagnosis of ABC was 56 years (25 - 75). Treatment with Ci was 1st line for ABC in 68.8%. Choice of Ci was palbociclib in 73.8% (n = 59) and ribociclib in 26.3% (n = 21). The hormone partner was a nonsteroidal aromatase inhibitor in 45.0%, and fulvestrant in 55.0% of cases. 37.5% of patients were on PPi, and 70.0% of them were during the entire treatment (23.3% omeprazole, 73.4% pantoprazole, 3.3% others). Patients taking concomitant PPi and Ci had lower OS (OS-3 years 42.6% vs. 63.4%, p = 0.254) and PFS (PFS med 15 m. vs. 21 m., p = 0.733), although with no statistically significant difference. Discussion: In the sample, there was a numerical difference, without the statistical significance in the use of PPi in the survival of patients under Ci. This difference could be more evident with a longer follow-up and a larger sample size. This study intends to alert to the growing importance of checking for drug interactions. Polymedication, advanced age and the presence of several comorbidities are real problems in patients with ABC. Conclusion: Real-world dat

关键词： Drug Interaction Survival Impact Advanced Breast Cancer CDK4/6 Inhibitors Proton Pump Inhibitors

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