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In vitro toxicity of particulate matter emissions from residential pellet combustion

Journal of Environmental Sciences 2022年第5期34卷 215-226页

作者： Estela D.Vicente Daniela Figueiredo Catia Goncalves Isabel lopes Helena Oliveira Nora Kovats Teresa Pinheiro Celia A.Alves Department of Environment and Planning and CESAM-Centre for Environmental and Marine Studies University of Aveiro3810-193 AveiroPortugal Department of Biology and CESAM-Centre for Environmental and Marine Studies University of Aveiro3810-193 AveiroPortugal Centre of Natural Environmental Sciences University of PannoniaEgyetem str.108200 VeszpremHungary Instituto de Bioengenharia e Biociencias Departamento de Engenharia e Ciencias NuclearesInstituto Superior TecnicoUniversidade de LisboaAv.Rovisco Pais 11049-001 LisboaPortugal

Particulate matter emissions(PM10)from the combustion,in a residential stove,of two com-mercial brands of certified(ENplus A1)pellets,a non-certified brand and laboratory made pellets of acacia were tested for their ability to induce ecotoxic,cytotoxic,and mutagenic re-sponses in unicellular organisms and a human cell *** was evaluated through the Vibrio fischeri bioluminescence inhibition ***,cytotoxicity was assessed at two time points(24-and 48-hr)through two complementary techniques in order to evaluate the cellular metabolic activity and membrane integrity of human lung epithelial cells *** Ames test using two Salmonella typhimurium strains(TA100 and TA98)was employed to assess the mutagenic potential of the polycyclic aromatic hydrocarbon fraction extracted from the PM10 *** obtained with the bioluminescent bacteria indicated that only particles from the combustion of acacia pellets were *** samples induced im-pairment on the A549 cells metabolic activity,while no significant release of lactate dehy-drogenase was ***10 emissions from acacia pellets were the most cytotoxic,while samples from both certified pellets evoked significant cytotoxicity at lower ***-icity time-dependency was only observed for PM10 from the combustion of acacia pellets and one of the brands of certified *** activity was not detected in both *** murium *** study emphasises the role of the raw material for pellet manu-facturing on the toxicological profile of PM *** raw materials should be deeply investigated before their use in pelletisation and combustion in residential appli-ances.

关键词： Ecotoxicity Cytotoxicity Mutagenicity Fuel quality Pellet combustion PM10 emissions

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Distinct T helper cell-mediated antitumor immunity:T helper 2 cells in focus

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Cancer Pathogenesis and Therapy 2023年第1期1卷 76-86页

作者： Rafael Cardoso Maciel Costa Silva Marcela Freitas lopes Leonardo Holanda Travassos Laboratory of Immunoreceptors and Signaling Carlos Chagas Filho Biophysics InstituteFederal University of Rio de JaneiroRio de Janeiro 21941-902Brazil Laboratory of Immunity Biology George DosReis Carlos Chagas Filho Biophysics InstituteFederal University of Rio de JaneiroRio de Janeiro 21941-902Brazil

The adaptive arm of the immune system is crucial for appropriate antitumor immune *** is generally accepted that clusters of differentiation 4^(+)(CD4^(+))T cells,which mediate T helper(Th)1 immunity(type 1 immunity),are the primary Th cell subtype associated with tumor *** this review,we discuss evidence showing that antitumor immunity and better prognosis can be associated with distinct Th cell subtypes in experimental mouse models and humans,with a focus on Th2 *** aim of this review is to provide an overview and understanding of the mechanisms associated with different tumor outcomes in the face of immune responses by focusing on the(1)site of tumor development,(2)tumor properties(i.e.,tumor metabolism and cytokine receptor expression),and(3)type of immune response that the tumor initially ***,we discuss how low-tolerance organs,such as lungs and brains,might benefit from a less tissue-destructive immune response mediated by Th2 *** addition,Th2 cells antitumor effects can be independent of CD8^(+)T cells,which would circumvent some of the immune escape mechanisms that tumor cells possess,like low expression of major histocompatibility-I(MHC-I).Finally,this review aims to stimulate further studies on the role of Th2 cells in antitumor immunity and briefly discusses emerging treatment options.

关键词： Cancer Immunology Adaptive immunity Immunotherapy Immunogenetics Antitumor immune response

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Evaluation of the regional distribution of the pediatric surgery workforce and surgical load in Brazil

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World Journal of Pediatric Surgery 2023年第2期6卷 85-91页

作者： Joaquim Bustorff-Silva Marcio lopes Miranda Amanda Rosendo Ayla Gerk Antonio Goncalves Oliveira-filho Pediatric Surgery State University of Campinas Medical SchoolCampinasBrazilPediatric SurgeryState University of Campinas Medical SchoolCampinasBrazil Medicine Pontificia Universidad Católica ArgentinaBuenos AiresArgentina

Objective The purpose of this study is to examine the regional distribution of the pediatric surgery workforce and the expected local demand for pediatric surgical procedures in *** We collected data on the pediatric surgical workforce,surgical volume,Gross Domestic Product per capita,and mortality for gastrointestinal tract malformations(MGITM)across the different regions of Brazil for *** Data from the Federal Medical Council reported 1515 pediatric surgery registries in Brazil,corresponding to 1414 pediatric surgeons(some pediatric surgeons are registered in more than one state),or 2.4 pediatric surgeons per 100000 children 14 years of age and *** were 828 men and 586 *** mean age was 51.5±12.8 years,and the mean time from graduation was 3.4±5.7 *** is a higher concentration of pediatric surgeons in the wealthier Central-West,South,and Southeast *** surgical volume ranged from 88 to 245 operations/year(average 146 operations/year)depending on the *** these,only nine(6.1%)were high-complexity(including neonatal)*** tended to be higher in the poorer North and Northeast regions than in other regions of *** Our findings suggest significant disparities in the surgical workforce and workload across Brazil related to socioeconomic *** with an increased surgical workforce were associated with lower *** average number of complex operations performed annually by each pediatric surgeon was considerably *** investment and well-defined health policies are imperative to enhance the quality of surgical care in the different regions of Brazil.

关键词： pediatric operations distribution

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Autoimmune hepatitis and eosinophilia:A rare case report

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World Journal of Hepatology 2023年第2期15卷 311-317页

作者： Isabel Garrido Susana lopes Elsa Fonseca Fátima Carneiro Guilherme Macedo Department of Gastroenterology and Hepatology Centro Hospitalar Universitário de São JoãoWorld Gastroenterology Organization Porto Training CenterFaculty of Medicine of the University of PortoPortoPortugal Department of Pathology Centro Hospitalar Universitário de São JoãoInstituto de Investigação e Inovação em Saúde(i3S)and Institute of Molecular Pathology and ImmunologyUniversity of Porto(Ipatimup)Faculty of Medicine of the University of PortoPortoPortugal

BACKGROUND Autoimmune hepatitis consists of a chronic liver disease whose etiology is *** is comprised of relevant immunological aspects and of immunemediated liver *** may be a considerable feature,particularly happening in male *** SUMMARY We report here a Crohn´s disease patient presenting with de novo hypergammaglobulinemia,circulating autoantibodies and elevated transaminase *** also had significant peripheral eosinophilia and elevated immunoglobulin E levels at *** pathology findings from liver biopsy were compatible with autoimmune hepatitis with eosinophilic *** This is the first report of autoimmune hepatitis with exuberant eosinophilic infiltration in the liver and bone marrow,described in a patient with Crohn’s disease.

关键词： Autoimmune hepatitis Eosinophilia Bone marrow Crohn’s disease Case report

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Multi-target prediction of wheat flour quality parameters with near infrared spectroscopy

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Information Processing in Agriculture 2020年第2期7卷 342-354页

作者： Sylvio Barbon Junior Saulo Martielo Mastelini Ana Paula ACBarbon douglas Fernandes Barbin Rosalba Calvini Jessica Fernandes lopes Alessandro Ulrici Computer Science Department Londrina State University(UEL)Londrina 86057-970Brazil Animal Science Department Londrina State University(UEL)Londrina 86057-970Brazil Department of Food Engineering Campinas State University(UNICAMP)Campinas 13083-862Brazil Department of Life Science University of Modena and Reggio Emilia(UNIMORE)42122 Reggio EmiliaItaly

Near Infrared(NIR)spectroscopy is an analytical technology widely used for the nondestructive characterisation of organic samples,considering both qualitative and quantitative *** the present study,the combination of Multi-target(MT)prediction approaches and Machine Learning algorithms has been evaluated as an effective strategy to improve prediction performances of NIR data from wheat flour *** different Multi-target approaches have been tested:Multi-target Regressor Stacking(MTRS),Ensemble of Regressor Chains(ERC)and Deep Structure for Tracking Asynchronous Regressor Stack(DSTARS).Each one of these techniques has been tested with different regression methods:Support Vector Machine(SVM),Random Forest(RF)and Linear Regression(LR),on a dataset composed of NIR spectra of bread wheat flours for the prediction of qualityrelated *** combining all MT techniques and predictors,we obtained an improvement up to 7%in predictive performance,compared with the corresponding Single-target(ST)*** results support the potential advantage of MT techniques over ST techniques for analysing NIR spectra.

关键词： Random forest Support Vector Machine Near-infrared spectroscopy Machine learning MTRS DSTARS Partial Least Squares ERC

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A Differential Evolution Approach for Protein Folding Using a Lattice Model

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Journal of Computer Science & Technology 2007年第6期22卷 904-908页

作者： Heitor Silverio lopes Reginaldo Bitello Bioinformatics Laboratory Federal University of Technology-ParanáAv.7 de setembro3165 80230-901 CuritibaBrazil

Protein folding is a relevant computational problem in Bioinformatics, for which many heuristic algorithms have been proposed. This work presents a methodology for the application of differential evolution （DE） to the problem of protein folding, using the bi-dimensional hydrophobic-polar model. DE is a relatively recent evolutionary algorithm, and has been used successfully in several engineering optimization problems, usually with continuous variables. We introduce the concept of genotype-phenotype mapping in DE in order to provide a mapping between the real-valued vector and an actual folding. The methodology is detailed and several experiments with benchmarks are done. We compared the results with other similar implementations. The proposed DE has shown to be competitive, statistically consistent and very promising.

关键词： bioinformatics differential evolution evolutionary computation protein folding

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Entropy model to assess sediment resuspension probability and trap efficiency of small dams

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International Journal of Sediment Research 2022年第5期37卷 675-686页

作者： Francisco Jairo Soares Pereira Antonio Viana da Silva Filho José Wellington Batista lopes José Carlos de Araújo Department of Agricultural Engineering Federal University of Ceará Campus Do Pici Rural Federal University of Pernambuco Federal University of Piauí

In the Brazilian drylands, there are tens of thousands of small dams. Despite their paramount importance to the rural population, they are rarely monitored. Water demand increases with time while, simultaneously, siltation reduces reservoir water capacity and availability. Reservoir siltation models are, therefore, mandatory to manage the numerous ungauged small dams in these *** objective of the current study is to improve sediment trap efficiency(TE) modeling by including resuspension as a key probabilistic process. The Shannon entropy was used to estimate the sediment resuspension probability, which was merged with the Camp model and generated the RETSED entropy model. To validate the RETSED model, an experimental check dam(ECD, 300 m3), located in the Gilbu es desertification site, Brazil, was monitored hourly during one hydrological year(July 2018-July 2019). Measurements show that the annual volumetric decline of the check dam was 12%; and that the average trap efficiency equaled 86%. Only 9.5% of the hourly sediment concentration outflow exceeded the average plus one standard deviation, showing that the reservoir is well mixed; a fact which highlights the relevance of the resuspension process. Three empirical models failed to mimic the experimental results: Churchill(TE = 99%), Brune(TE = 75%), and Maryland(TE = 94%). According to the RETSED entropy model, the resuspension probability during the experiment was 10%and TE = 81%, a value only 6% below the measured one. The Camp model simulated TE = 89%, only 3%higher than the measured value, but confirmed the Camp model’s tendency to overestimate TE due to a disregard of resuspension. The deterministic model showed low sensitivity concerning the hydrodynamic effects, whereas the entropy formulation proved to be more consistent with physical behavior: the resuspension probability clearly increased and trap efficiency decreased with rising reservoir discharge.

关键词： Erosion Check dam Sedimentation Ungauged basins Camp model

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Movement behaviors and their association with depressive symptoms in Brazilian adolescents:A cross-sectional study

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Journal of Sport and Health Science 2022年第2期11卷 252-259页

作者： Bruno Goncalves Galdino da Costa Jean-Philippe Chaput Marcus Vinicius Veber lopes Luis Eduardo Argenta Malheiros Kelly Samara Silva Research Centre in Physical Activity and Health Federal University of Santa CatarinaFlorianopolis88040-900Brazil Healthy Active Living and Obesity Research Group Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada

Background:Physical activity,sleep,and sedentary behaviors compose 24-h movement behaviors and have been independently associated with depressive ***,it is not clear whether it is the movement behavior itself or other contextual factors that are related to depressive *** objective of the present study was to examine the associations between self-reported and accelerometer-measured movement behaviors and depressive symptoms in ***:Cross-sectional data from 610 adolescents(14-18 years old)were *** answered questions from the Center for Epidemiological Studies Depression scale and reported time spent watching videos,playing videogames,using social media,time spent in various physical activities,and daytime ***-worn accelerometers were used to measure sleep duration,sleep efficiency,sedentary time,and physical ***-effects logistic regressions were ***:Almost half of the adolescents(48%)were classified as being at high risk for depression(score≥20).No significant associations were found between depressive symptoms and accelerometer-measured movement behaviors,self-reported non-sport physical activity,watching videos,and playing ***,higher levels of self-reported total physical activity(odd ratio(OR)=0.92,95%confidence interval(95%CI):0.86-0.98)and volume of sports(OR=0.88,95%CI:0.79-0.97),in minutes,were associated with a lower risk of depression,while using social media for either 2.0-3.9 h/day(OR=1.77,95%CI:1.58-2.70)or>3.9 h/day(OR=1.67,95%CI:1.10-2.54),as well as higher levels of daytime sleepiness(OR=1.17,95%CI:1.12-1.22),were associated with a higher risk of ***:What adolescents do when they are active or sedentary may be more important than the time spent in the movement behaviors because it relates to depressive *** daytime sleepiness,promoting sports,and limiting social media use may benefit adolescents.

关键词： Accelerometry Depression Physical activity Sedentary behavior Sleep

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Cyst fluid glucose: An alternative to carcinoembryonic antigen for pancreatic mucinous cysts

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World Journal of Gastroenterology 2019年第19期25卷 2271-2278页

作者： César Vivian lopes Department of Gastroenterology and Digestive Endoscopy Santa Casa Hospital

Pancreatic cystic lesions(PCLs) have been increasingly recognized in clinical practice. Although inflammatory cysts(pseudocysts) are the most common PCLs detected by cross-sectional imaging modalities in symptomatic patients in a setting of acute or chronic pancreatitis, incidental pancreatic cysts with no symptoms or history of pancreatitis are usually neoplastic cysts. For these lesions,it is imperative to identify mucinous cysts(intraductal papillary mucinous neoplasms and mucinous cystic neoplasms) due to the risk of their progression to malignancy. However, no single imaging modality alone is sufficient for a definitive diagnosis of all PCLs. The cyst fluid obtained by endoscopic ultrasound-guided fine needle aspiration provides additional information for the differential diagnosis of PCLs. Current recommendations suggest sending cyst fluid for cytology evaluation and measurement of carcinoembryonic antigen(CEA) levels. Unfortunately, the sensitivity of cytology is greatly limited, and cyst fluid CEA has demonstrated insufficient accuracy as a predictor of mucinous cysts. More recently, cyst fluid glucose has emerged as an alternative to CEA for distinguishing between mucinous and nonmucinous lesions. Herein, the clinical utility of cyst fluid glucose and CEA for the differential diagnosis of PCLs was evaluated.

关键词： Carcinoembryonic antigen Differential diagnosis Fine-needle biopsy Glucose Pancreatic cyst Tumor marker

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Time-dependent impact of a high-fat diet on the intestinal barrier of male mice

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World Journal of Methodology 2024年第1期14卷 114-123页

作者： Carolline Santos Miranda Daiana Araujo Santana-Oliveira Isabela lopes Vasques-Monteiro Nathan Soares Dantas-Miranda Jade Sancha de Oliveira Glauser Flavia Maria Silva-Veiga Vanessa Souza-Mello Department of Anatomy Rio de Janeiro State UniversityRio de Janeiro 20551030Brazil

BACKGROUND Excessive saturated fat intake compromises the integrity of the intestinal mucosa,leading to low-grade inflammation,impaired mucosal integrity,and increased intestinal permeability,resulting in the migration of lipopolysaccharide(LPS)to other *** To evaluate the chronic effects(at 10 and 16 wk)of a high-fat diet(HFD)(with 50%energy as fat)on the phylogenetic gut microbiota distribution and intestinal barrier structure and protection in C57BL/6 *** Forty adult male mice were divided into four nutritional groups,where the letters refer to the type of diet(control and HFD or HF)and the numbers refer to the period(in weeks)of diet administration:Control diet for 10 wk,HFD for 10 wk,control diet for 16 wk,and HFD for 16 *** sacrifice,biochemical,molecular,and stereological analyses were *** The HF groups were overweight,had gut dysbiosis,had a progressive decrease in occludin immunostaining,and had increased LPS *** progression reduced the number of goblet cells per large intestine area and Mucin2 expression in the HF16 group,consistent with a completely disarranged intestinal ultrastructure after 16 wk of HFD *** Chronic HFD intake causes overweight,gut dysbiosis,and morphological and functional alterations of the intestinal barrier after 10 or 16 ***-dependent reductions in goblet cell numerical density and mucus production have emerged as targets for countering obesity-driven intestinal damage.

关键词： High-fat diet Intestine Ultrastructure Goblet cells Gut microbiota

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