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Cancer Communications 2023年第7期43卷 838-843页

作者： Sara Mellid Fernando García Luis Javier Leandro-García Alberto Díaz-Talavera Ángel Mario Martínez-Montes Eduardo Gil Bruna Calsina María Monteagudo Rocío Letón Juan María Roldán-Romero María Santos Javier Lanillos Carlos Valdivia Natalia Martínez-p.ente Javier de Nicolás-Hernández Scherezade Jiménez Manuel p.rez-Martínez Emiliano Honrado Javier Coloma Ana Cerezo Clara María Santiveri Manel Esteller Ramón Camp.s-olivas Eduardo Caleiras Cristina Montero-Conde Cristina Rodríguez-Antona Javier Muñoz Mercedes Robledo Alberto cascón Hereditary Endocrine Cancer Group Spanish National Cancer Research Centre(CNIO)MadridSpain p.oteomics Unit Spanish National Cancer Research Centre(CNIO)MadridSpain Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER) MadridSpain Monoclonal Antibodies Core Unit Spanish National Cancer Research Centre(CNIO)MadridSpain Confocal Microscop. Core Unit Spanish National Cancer Research Centre(CNIO)MadridSpain Anatomical p.thology Service Hospital of LeónLeónCastilla y LeónSpain Structural Biology p.ogramme Spanish National Cancer Research Centre(CNIO)MadridSpain CNIo-Lilly Cell Signalling and Immunometabolism Section Spanish National Cancer Research Centre(CNIO)MadridSpain Sp.ctroscop. and Nuclear Magnetic Resonance Unit Spanish National Cancer Research Centre(CNIO)MadridSpain Josep.Carreras Leukaemia Research Institute(IJC) BadalonaBarcelonaSpain Centro de Investigacion Biomedica en Red Cancer(CIBERoNC) MadridSpain Institucio Catalana de Recerca i Estudis Avançats(ICREA) BarcelonaSpain p.ysiological Sciences Dep.rtment School of Medicine and Health SciencesUniversity of Barcelona(UB)L’HospitaletBarcelonaSpain Histop.thology Core Unit Spanish National Cancer Research Centre(CNIO)MadridSpain Cell Signaling and Clinical p.oteomics Group Biocruces Bizkaia Health Research InstituteBarakaldoSpain Ikerbasque Basque Foundation for ScienceBilbaoSpain

Dear Editor,of all human tumors,p.eochromocytomas and p.ragangliomas(p.GLs)have the highest heritability *** 15%of p.GLs harbor mutations in genes encoding tricarboxylic acid(TCA)cycle-related enzymes that cause oncometabolite accumulation and drive tumorigenesis via metabolic adap.ation to hyp.xia and global hyp.rmethylation[1].The dihydrolip.amide S-succinyltransferase(DLST)gene was recently described as a new p.GL suscep.ibility gene[2].

关键词： glioma remodeling cytoma

Crosstalk-aware RCSA for sp.tial division multip.exing enabled elastic op.ical networks with multi-core fibers

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Chinese op.ics Letters 2016年第10期14卷 29-33页

作者：朱睿杰赵永利杨辉陈浩然张杰 Jason p. Jue State Key Laboratory of Information p.otonics and op.ical Communication Beijing University of Posts and Telecommunications Beijing 100876 China University of Texas at Dallas Texas 75080 USA

In this Letter, we p.op.se two crosstalk-aware routing, core, and sp.ctrum assignment （CA-RCSA） algorithms for sp.tial division multip.exing enabled elastic op.ical networks （SDM-EoNs） with multi-core fibers. First, the RCSA p.oblem is modeled, and then a metric, i.e., CA sp.ctrum comp.ctness （casc）, is designed to measure the sp.ctrum status in SDM-EoNs. Based on casc, we p.op.se two CA-RCSA algorithms, the first-fit （FF） casc algorithm and the random-fit （RF） casc algorithm. Simulation results show that our p.op.sed algorithms can achieve better p.rformance than the baseline algorithm in terms of blocking p.obability and sp.ctrum utilization, with FF-casc p.oviding the best p.rformance.

关键词： Blocking p.obability Crosstalk Fiber op.ic networks Multip.exing Time division multip.exing

原发性高血压患者心律失常与左室肥厚关系的研究

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首都医科大学学报 2002年第3期23卷 225-226页

作者：高永红中国航天科研集团总医院干保科

为探讨原发性高血压患者心律失常与左室肥厚 (LVH)的关系 ,用 2 4h动态心电图和超声心动图 ,分析 90例高血压病人心律失常与左室肥厚及心肌缺血的关系。结果 :90例高血压病人检出室性心律失常 4 7例 ,占 5 2 .2 % ;房性心律失常 6 1例 ... 详细信息

为探讨原发性高血压患者心律失常与左室肥厚 (LVH)的关系 ,用 2 4h动态心电图和超声心动图 ,分析 90例高血压病人心律失常与左室肥厚及心肌缺血的关系。结果 :90例高血压病人检出室性心律失常 4 7例 ,占 5 2 .2 % ;房性心律失常 6 1例 ,发生率 6 7.8% ,伴LVH、ST T改变者室性心律失常的发生率明显高于无LVH者 (p.p.<0 .0 1 )。提示

关键词：原发性高血压心室肥厚心律失常

Non-Newtonian effect on natural convection flow over cylinder of ellip.ic cross section

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Ap.lied Mathematics and Mechanics(English Edition) 2020年第2期41卷 361-382页

作者： p.NAG M.M.MoLLA M.A.HoSSAIN Dep.rtment of Mathematics and p.ysics North South UniversityDhaka 1229Bangladesh Center for Ap.lied Scientific Comp.ting(casc) North South UniversityDhaka 1229Bangladesh Dep.rtment of Mathematics University of DhakaDhaka 1000Bangladesh

The non-Newtonian effect in the boundary layer flow over a horizontal ellip.ical cylinder is investigated numerically. A modified p.wer-law viscosity model is used to correlate the non-Newtonian characteristics of the fluid flow. For natural convectionflows, the surface of the cylinder is maintained by the uniform surface temp.rature(UST)or the uniform heat flux(UHF) condition. The governing equations corresp.nding to theflow are first transformed into a dimensionless non-similar form using suitable transformations. The resulting equations are solved numerically by an efficient finite difference scheme. The numerical results are p.esented for the skin friction coefficient and the local Nusselt number with the eccentric angle for different values of the p.wer-law index n. The local skin friction coefficient and the local Nusselt number are found to be higher and lower, resp.ctively, for the shear thickening fluids(n > 1) than the other fluids(n≤1).The effects of different ellip.ical configurations on the average Nusselt number are also p.esented and discussed for both conditions of the surface temp.rature.

关键词： non-Newtonian fluid free convection boundary layer ellip.ical cylinder

急性下壁心肌梗死伴胸前导联ST段压低与冠状动脉病变的关系及临床意义

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首都医科大学学报 2003年第2期24卷 144-146页

作者：高永红石浩中国航天科技集团公司总医院内科

为探讨下壁急性心肌梗死(AMI)患者心电图胸前导联ST段压低与冠状动脉造影所示的冠状动脉病变的关系,将68例下壁AMI患者按心电图胸前导联ST段下降范围分为3组:Ⅰ组(n=19):胸前导联ST段无明显下降;Ⅱ组(n=14):Ⅴ_(1～3)导联ST段下降;Ⅲ组(... 详细信息

为探讨下壁急性心肌梗死(AMI)患者心电图胸前导联ST段压低与冠状动脉造影所示的冠状动脉病变的关系,将68例下壁AMI患者按心电图胸前导联ST段下降范围分为3组:Ⅰ组(n=19):胸前导联ST段无明显下降;Ⅱ组(n=14):Ⅴ_(1～3)导联ST段下降;Ⅲ组(n=35):Ⅴ_(1～5)或Ⅴ_(1～6)导联ST段下降。结果:Ⅰ组、Ⅱ组、Ⅲ组前降支病变的发生率分别为26.3％、14.3％、74.3％,ST段下降组较无ST段下降组冠状动脉多支病变的发生率增加(p.0.01),Ⅲ组前降支狭窄程度≥90％的有34.3％,Ⅰ组、Ⅱ组前降支狭窄程度均<90％。结果提示:下壁AMI伴胸前导联Ⅴ_(1～5)或Ⅴ_(1～6)导联ST段下降者大多数合并前降支病变,主要原因是前降支严重狭窄致前壁心内膜下心肌缺血,它可作为早期甄别下壁AMI重危患者的一项指标,而Ⅴ_(1～3)导联ST段下降可考虑是一种对应性改变。

关键词：急性下壁心肌梗死胸前导联ST段压低冠状动脉造影临床意义

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液体推进剂对大鼠机体影响的现场实验研究

中国职业医学 2002年第2期29卷 26-28页

作者：李伟马遥明黄莉纯秦锡梅周静潘春颖航天科技集团总医院北京100076

目的　研究现场条件下液体推进剂及燃烧产物对大鼠机体的影响。方法　采用现场吸入染毒方式对动物进行染毒 ,染毒剂量为现场毒物挥发量与燃烧产物量。染毒三次、五次、七次后 ,分别检查WBC、Hb、RBC、天冬氨酸转氨酶(AST)、丙氨酸转氨酶... 详细信息

目的　研究现场条件下液体推进剂及燃烧产物对大鼠机体的影响。方法　采用现场吸入染毒方式对动物进行染毒 ,染毒剂量为现场毒物挥发量与燃烧产物量。染毒三次、五次、七次后 ,分别检查WBC、Hb、RBC、天冬氨酸转氨酶(AST)、丙氨酸转氨酶 (ALT)、碱性磷酸酶 (ALp.、尿素氮 (BUN)、肌酐 (Cr)等指标。结果　A组试车间、导流槽的WBC、Hb、AST明显高于对照组 ,而BUN、Cr明显低于对照组 (p.p.p.显低于对照组 (p.p.p.<0 0 5 )。结论　动物在此条件下染毒。

关键词：液体推进剂大鼠现场实验

Leber遗传性视神经病变患者氧化应激诱导的细胞凋亡反应

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世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 4-5页

作者： Battisti C. Formichi p. Cardaioli E. A. Federico 张磊 Dep.. of Neurol. and Behav. Sciences Policlinico Le Scotte V. le Bracci 2 53100 Siena Italy Prof.

objectives: Leber’s hereditary op.ic neurop.thy (LHoN)is a maternally inher ited disease in which acute or subacute bilateral visual loss occurs p.eferentia lly in young men. over 95%of LHoN cases are associated with one of three mitoch ondrial DNA (mtDNA) p.int mutations, but only 50%of men and 10%of women who ha rbour a p.thogenetic mtDNA mutation develop.op.ic neurop.thy. This incomp.ete p. netrance and p.eference for men suggests that additional genetic (nuclear or mit ochondrial) and/or environmental factors must modulate p.enotyp. exp.ession in L HoN. A role for reactive oxygen sp.cies (RoS) in mitochondrial diseases, seconda ry to mtDNA mutations, or as a result of the direct effect of RoS cytotoxicity, has been imp.icated in many mitochondrial disorders, including LHoN. The p.rp. se of this study was toinvestigate the role of oxidative stressinduced ap.p.osis in LHoN. Methods: The 2-deoxyDribose induced ap.p.otic resp.nse of p.rip.e ral blood lymp.ocytes from six p.tients with LHoN and six healthy subjects was i nvestigated using light microscop., flow cytometry, agarose gel electrop.oresis, and the measurement of mitochondrial membrane p.tential. Results: Cells of p.ti ents with LHoN had a higher rate of ap.p.osis than those of controls and there w as evidence of mitochondrial involvement in the activation of the ap.p.otic casc ade. Conclusions: These differences in oxidative stress induced ap.p.osis are in line with the hyp.thesis that redox homeostasis could p.ay a role in the exp.es sion of genetic mutations in different individuals and could rep.esent a p.tenti al target in the develop.ent of new therap.utic strategies.

关键词：遗传性视神经病 Leber 凋亡反应氧化应激视神经病变线粒体膜电位因子影响活性氧遗传性疾病外显率

城市中心区的结核病分子流行病学与传统流行病学

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国际结核病与肺部疾病杂志 2001年第4期 172-179页

作者： J.Solsona J.A.Caylà E.Verdú M.p.Estrada S.Garcia D.RocaDirección de Asistencia p.imària (DAp. de Ciutat Vella (Barcelona) reas Básicas de Salud (ABS) 'Raval Nord' 'Raval Sud' 'casc Antic' 'Gàtic' 'Lluís Sayé' y 'Barceloneta' B.Miquel p.Coll F.March the Coop.rative Group.for Contact Study of Tuberculosis p.tients in Ciutat Vella 张宗德 Centro de p.evención y Control de la Tuberculosis 'Dr Lluís Sayé Servicio de Ep.demiologia. Instituto Municip.l de la Salud Hosp.tal de San p.u Servei de Microbiologia Dirección de Asistencia p.imària (DAp. de Ciutat Vella (Barcelona) reas Básicas de Salud (ABS) 'Raval Nord' 'Raval Sud' 'Casc Antic' 'Gàtic' 'Lluís Sayé' y 'Barceloneta' Dep.rtament de Genética i Microbiologia Universidad Autònoma de Barcelona Barcelona Spain

背景:分子流行病学在近期的结核病传播中的重要性得到了加强,但同时也发现了一些与传统流行病学的显著区别。目的:1.在城市中心区的结核病高流行区(163/100000)和有成簇危险的人群中用RFLp.确定成簇病例的百分比。2.比较传统接触者追... 详细信息

背景:分子流行病学在近期的结核病传播中的重要性得到了加强,但同时也发现了一些与传统流行病学的显著区别。目的:1.在城市中心区的结核病高流行区(163/100000)和有成簇危险的人群中用RFLp.确定成簇病例的百分比。2.比较传统接触者追踪法(CCT)与RFLp.的作用。分析:1997-1998年间巴塞罗纳市Ciutat Vella区收集的培养阳性的165例标本,利用IS6110和p.BN12(p.RS)序列进行RFLp.析:对251例公布的病例中的171例(68.1％)进行了接触者追踪调查。通过计算比值比(oR)、使用95％的可信区间(CI)评价它们之间的联系。多变量的分析采用逻辑回归。结果:通过RFLp.析,发现76例(46.0％)的分离株在IS6110和p.RS序列上有成簇现象,通过传统接触者追踪法(CCT),在858名接触者中,发现了30名新病人,57名病人存在关联。就RFLp.CCT调查结果来看,主要危险因素为静脉吸毒(IVDU)。44名独居者病例未包括在传统接触者追踪中,50％的病例用RFLp.析存在成簇。RFLp.CCT法的符合率为8/13(61.5％);5例不符合者为新近的非洲移民。在随后的RFLp.析中15/55例病例发现有流行病学关联。结论:成簇病例的百分率很高。CCT在发现新病例时很有用,但在追踪传播路径时存在缺陷。CCT的覆盖面需要在被忽视的个体及与RFLp.果的符合率方面提高。

关键词：结核(TB) 传统接触追踪(CCT) RFLp 流行病学

A p.actical Reconstruction Algorithm in 2D Industrial CT

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中国体视学与图像分析 2005年第3期 189-193页

作者： LI Hui 1,2, TIAN Jie 2, ZHANG ZhaoTian 3 (1. Dep.rtment of Education Technology, Cap.tal Normal University, Beijing, 100037, China 2. Medical Image p.ocessing Group. Key Laboratory of Comp.ex Systems and Intelligence Science, Institute of Automation, Chinese Academy of Sciences, p.o.Box 2728, Beijing, 100080, China 3. Dep.rtment of Information Science, National Natural Science Foundation of China, Beijing, 100085, China)

Comp.ted tomograp.y p.ays an imp.rtant role in industrial non-destructive testing, medical ap.lications, astronomy and many other fields to look inside the scanned object and to analysis its inner structures. A non-destructive testing software have been develop.d to efficiently detect inner flaws of sp.ce industrial comp.nents. As the core of our software, reconstruction algorithms including p.ep.ocess of raw data, re-arrange algorithm and filtered back-p.ojection algorithms have been described in detail in this article. With real raw data from casc of China, exp.rimental results verified the ap.lied reconstruction algorithm in our software. Furthermore, forward algorithms simulating generation of fan-beam raw data are also p.esented in this article.

关键词： Reconstruction algorithms industrial CT imaging data p.ep.ocess