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Journal of Sport and Health Science 2024年第4期13卷 537-547页

作者： Jacqueline Josee van Ierssel Olivia Galea Kirsten Holte Caroline Luszawski Elizabeth Jenkins Jennifer O’Neil carolyn A Emery Rebekah Mannix Kathryn Schneider Keith Owen Yeates Roger Zemek Children’s Hospital of Eastern Ontario Research Institute OttawaON K1H 8L1Canada The Centre for Health Activity and Rehabilitation ResearchUniversity of OtagoDunedin 9016New Zealand Sport Injury Prevention Research Centre Faculty of KinesiologyUniversity of CalgaryCalgaryAB T2N 1N4Canada Alberta Children’s Hospital Research Institute University of Calgary CalgaryAB T2N 1N4Canada Hotchkiss Brain Institute University of CalgaryCalgaryAB T2N 4N1Canada Department of Psychology University of CalgaryCalgaryAB T2N 1N4Canada g Faculty of MedicineUniversity of OttawaOttawaON K1H 8M5Canada School of Rehabilitation Sciences University of OttawaOttawaON K1H 8M5Canada Bruyere Research Institute OttawaON K1N 5C8Canada Departments of Pediatrics and Emergency Medicine Harvard Medical SchoolBostonMA 02115USA Departments of Pediatrics and Emergency Medicine University of OttawaOttawaON K1H 8M5Canada

Purpose:The study aimed to examine the reporting completeness of randomized controlled trials(RCTs)of non-pharmacological interventions following ***:We searched MEDLINE,Embase,PsycInfo,CINAHL,and Web of Science up to May *** reviewers independently screened studies and assessed reporting completeness using the Template for Intervention Description and Replication(TIDieR),Consensus on Exercise Reporting Template(CERT),and international Consensus on Therapeutic Exercise aNd Training(i-CONTENT)*** information was sought my study authors where reporting was *** of bias(ROB)was assessed with the Cochrane ROB-2 *** examining non-pharmacological interventions following ***:We included 89 RCTs(n=53 high ROB)examining 11 different interventions for concussion:sub-symptom threshold aerobic exercise,cervicovestibular therapy,physical/cognitive rest,vision therapy,education,psychotherapy,hyperbaric oxygen therapy,transcranial magnetic stimulation,blue light therapy,osteopathic manipulation,and head/neck *** scores were:TIDieR 9/12(75%;interquartile range(IQR)=5;range:5-12),CERT 17/19(89%;IQR=2;range:10-19),and i-CONTENT 6/7(86%;IQR=1;range:5-7).Percentage of studies completely reporting all items was TIDieR 35%(31/89),CERT 24%(5/21),and i-CONTENT 10%(2/21).Studies were more completely reported after publication of TIDieR(t_(87)=2.08;p=0.04)and CERT(t_(19)=2.72;p=0.01).Reporting completeness was not strongly associated with journal impact factor(TIDieR:rs=0.27;p=0.01;CERT:r_(s)=-0.44;p=0.06;i-CONTENT:r_(s)=-0.17;p=0.48)or ROB(TIDieR:rs=0.11;p=0.31;CERT:rs=0.04;p=0.86;i-CONTENT:rs=0.12;p=0.60).Conclusion:RCTs of non-pharmacological interventions following concussion demonstrate moderate to good reporting completeness,but are often missing key components,particularly modifications,motivational strategies,and qualified *** completeness improved after TIDieR and CERT publication,but p

关键词： Concussion Intervention Randomized controlled trial Systematic review

Complement factor H in molecular regulation of angiogenesis

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Medical Review 2024年第5期4卷 452-466页

作者： Jiang Li Kaili Wang Maria N.Starodubtseva Eldar Nadyrov carolyn M.Kapron Josephine Hoh Ju Liu Laboratory of Translational Medicine in Microvascular Regulation Institute of Microvascular MedicineMedical Research CenterThe First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalJinanShandong Province250014China Shandong Provincial Key Medical and Health Laboratory of Translational Medicine in Microvascular Aging JinanShandong ProvinceChina Medical Research Center Shandong Provincial Qianfoshan HospitalShandong UniversityJinanShandong Province 250014China Gomel State Medical University GomelBelarus Institute of Radiobiology of NAS of Belarus GomelBelarus Department of Biology Trent UniversityPeterboroughONCanada Department of Ophthalmology Yale School of MedicineNew HavenCTUSA

Angiogenesis,the process of formation of new capillaries from existing blood vessels,is required for multiple physiological and pathological *** factorH(CFH)is a plasma protein that inhibits the alternative pathway of the complement *** of CFH enhances the alternative pathway and increases complement activation fragments with pro-angiogenic capacity,including complement 3a,complement 5a,and membrane attack *** protein contains binding sites for C-reactive protein,malondialdehyde,and endothelial heparan *** of CFH prevents its interaction with these molecules and initiates pro-angiogenic *** in the CFH gene have been found in patients with age-related macular degeneration characterized by choroidal *** Cfh-deficient mice show an increase in angiogenesis,which is decreased by administration of recombinant CFH pro*** this review,we summarize the molecular mechanisms of the anti-angiogenic effects of CFH and the regulatory mechanisms of CFH *** therapeutic potential of recombinant CFH protein in angiogenesisrelated diseases has also been discussed.

关键词： complement factor H angiogenesis mechanical properties therapeutic target

LonP1 Links Mitochondria–ER Interaction to Regulate Heart Function

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Research 2024年第1期2023卷 595-609页

作者： Yujie Li Dawei Huang Lianqun Jia Fugen Shangguan Shiwei Gong Linhua Lan Zhiyin Song Juan Xu Chaojun Yan Tongke Chen Yin Tan Yongzhang Liu Xingxu Huang carolyn K.Suzuki Zhongzhou Yang Guanlin Yang Bin Lu The Affiliated Nanhua Hospital and School of Basic Medical Sciences Hengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityWenzhouZhejiang 325035China National Health Commission Key Laboratory of Birth Defect Research and Prevention Hunan Provincial Maternal and Child Health Care HospitalChangshaHunan 410008China Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications Ministry of Education of ChinaLiaoning University of Traditional Chinese MedicineShenyangLiaoning 110847China Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Hubei Key Laboratory of Cell Homeostasis College of Life SciencesWuhan UniversityWuhanHubei 430072China Nanjing Maternity and Child Health Care Hospital Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical UniversityNanjing 210004China Animal Center Wenzhou Medical UniversityWenzhouZhejiang 325035China Department of Cardiology The First Affiliated Hospital of University of South ChinaHengyangHunanChina School of Life Science and Technology Shanghai Tech UniversityShanghai 201210China Department of Microbiology Biochemistry and Molecular GeneticsNew Jersey Medical School-RutgersThe State University of New JerseyNewarkNJUSA State Key Laboratory of Pharmaceutical Biotechnology Department of CardiologyNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical School and MOE Key Laboratory of Model Animal for Disease StudyModel Animal Research CenterNanjing UniversityNanjing 210061China

Interorganelle contacts and communications are increasingly recognized to play a vital role in cellular function and *** particular,the mitochondria–endoplasmic reticulum(ER)membrane contact site(MAM)is known to regulate ion and lipid transfer,as well as signaling and organelle ***,the regulatory mechanisms of MAM formation and their function are still ***,we identify mitochondrial Lon protease(LonP1),a highly conserved mitochondrial matrix protease,as a new MAM tethering *** removal of LonP1 substantially reduces MAM formation and causes mitochondrial ***,deletion of LonP1 in the cardiomyocytes of mouse heart impairs MAM integrity and mitochondrial fusion and activates the unfolded protein response within the ER(UPR^(ER)).Consequently,cardiac-specific LonP1 deficiency causes aberrant metabolic reprogramming and pathological heart *** findings demonstrate that LonP1 is a novel MAM-localized protein orchestrating MAM integrity,mitochondrial dynamics,and UPR^(ER),offering exciting new insights into the potential therapeutic strategy for heart failure.

关键词： offering programming insight

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外刊选粹

中国文化遗产 2024年第4期 126-127页

作者： carolyn H 赵毓(编译) 不详西北大学文化遗产学院

文化失调:围绕遗产的争议及其对殖民城市遗产认定的影响在批判性遗产研究领域,遗产认定的内在矛盾完全凸显出来,但在殖民城市的遗产实践中,这一现实却仍然处于被掩盖的状态。而授权遗产话语继续将目前国家主导的遗产认定体系界定为当代... 详细信息

文化失调:围绕遗产的争议及其对殖民城市遗产认定的影响在批判性遗产研究领域,遗产认定的内在矛盾完全凸显出来,但在殖民城市的遗产实践中,这一现实却仍然处于被掩盖的状态。而授权遗产话语继续将目前国家主导的遗产认定体系界定为当代和未来一代的“公共利益”。在殖民城市中,政府当局不断尝试将原住民的观点和价值观纳入遗产框架。然而,目前遗产认定的法律程序却被证明是很难变化的。在私有财产权中,文物实体仍被置于优先考虑的范畴,此举削弱了遗产领域认可其他可能性和真正参与去殖民化转型的能力。文章研究了三个在授权遗产话语之外爆发抗议和保护行动的案例,并分析其中导致抗议行动的价值观争议,以及每个遗产对象“授权”的尝试及其结果。

关键词：私有财产权政府当局认定体系文化失调公共利益原住民去殖民化价值观

Association between baseline levels of muscular strength and risk of stroke in later life:The Cooper Center Longitudinal Study

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Journal of Sport and Health Science 2024年第5期13卷 642-649页

作者： Stephen W.Farrell David Leonard Qing Li carolyn E.Barlow Kerem Shuval Jarett D.Berry Andjelka Pavlovic Laura F.DeFina Research Division The Cooper InstituteDallasTX 75230USA Department of Internal Medicine University of Texas at Tyler School of MedicineTylerTX 75799USA

Background:Muscular strength is an important component of physical *** evaluated the relationship between baseline muscular strength and risk of stroke among adults who were aged≥65 years during ***:We included 7627 healthy adults(mean age=43.9 years,86.0%male)underwent a baseline physical examination between 1980 and *** strength was determined by 1-repetition maximum measures for bench press and leg press and categorized into age-and sex-specific tertiles for each *** fitness(CRF)was assessed via a maximal treadmill exercise *** enrolled in fee-for-service Medicare from 1999 to 2019 were included in the *** between baseline strength and stroke outcomes were estimated using a modified Cox proportional hazards *** a secondary analysis,we examined stroke risk by categories of CRF where Quintile 1=low,Quintiles 2-3=moderate,and Quintiles 4-5=high CRF based on age and ***:After 70,072 person-years of Medicare follow-up,there were 1211 earliest indications of incident *** multivariable analyses,the hazard ratio(95%confidence interval(95%CI))for stroke across bench press categories were 1.0(referent),0.96(0.83-1.11),and 0.89(0.77-1.04),respectively(p trend=0.14).The trend across categories of leg press was also non-significant(p trend=0.79).Adjusted hazard ratio(95%CI)for stroke across ordered CRF categories were 1.0(referent),0.90(0.71-1.13),and 0.72(0.57-0.92)(p trend<0.01).Conclusion:While meeting public health guidelines for muscular strengthening activities is likely to improve muscular strength as well as many health outcomes in older adults,performing such activities may not be helpful in preventing ***,meeting guidelines for aerobic activity is likely to improve CRF and lower stroke risk.

关键词： Cardiorespiratory fitness Medicare Muscular strength Stroke

Tensorial tomographic Fourier ptychography with applications to muscle tissue imaging

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Advanced Photonics 2024年第2期6卷 50-60页

作者： Shiqi Xu Xi Yang Paul Ritter Xiang Dai Kyung Chul Lee Lucas Kreiss Kevin C.Zhou Kanghyun Kim Amey Chaware Jadee Neff carolyn Glass Seung Ah Lee Oliver Friedrich Roarke Horstmeyer Duke University DurhamNorth CarolinaUnited States Friedrich-Alexander University ErlangenGermany UC San Diego La JollaCaliforniaUnited States Yonsei University SeoulRepublic of Korea UC Berkeley BerkeleyCaliforniaUnited States Duke University Medical Center DurhamNorth CarolinaUnited States

We report tensorial tomographic Fourier ptychography(T^(2)oFu),a nonscanning label-free tomographic microscopy method for simultaneous imaging of quantitative phase and anisotropic specimen information in *** upon Fourier ptychography,a quantitative phase imaging technique,T^(2)oFu additionally highlights the vectorial nature of *** imaging setup consists of a standard microscope equipped with an LED matrix,a polarization generator,and a polarization-sensitive *** tensors of anisotropic samples are computationally recovered from polarized intensity measurements across three *** demonstrate T^(2)oFu’s efficiency through volumetric reconstructions of refractive index,birefringence,and orientation for various validation samples,as well as tissue samples from muscle fibers and diseased heart *** reconstructions of healthy muscle fibers reveal their 3D fine-filament structures with consistent ***,we demonstrate reconstructions of a heart tissue sample that carries important polarization information for detecting cardiac amyloidosis.

关键词： computational imaging three-dimensional imaging phase retrieval microscopy polarization-sensitive imaging labelfree imaging

Sex steroids and glucose metabolism

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Asian Journal of Andrology 2014年第2期16卷 232-238,I0008页

作者： carolyn A Allan Prince Henry's Institute Clayton Australia Monash Health Clayton Australia Department of Obstetrics and Gynaecology Monash University Clayton Australia Andrology Australia c/o School of Public Health and Preventive Medicine Monash University Prahran Australia

Testosterone levels are lower in men with metabolic syndrome and type 2 diabetes mellitus （T2DM） and also predict the onset of these adverse metabolic states. Body composition （body mass index, waist circumference） is an important mediator of this relationship. Sex hormone binding globulin is also inversely associated with insulin resistance and T2DM but the data regarding estrogen are inconsistent. Clinical models of androgen deficiency including Klinefelter＇s syndrome and androgen deprivation therapy in the treatment of advanced prostate cancer confirm the association between androgens and glucose status. Experimental manipulation of the insulin/ glucose milieu and suppression of endogenous testicular function suggests the relationship between androgens and insulin sensitivity is bidirectional. Androgen therapy in men without diabetes is not able to differentiate the effect on insulin resistance from that on fat mass, in particular visceral adiposity. Similarly, several small clinical studies have examined the efficacy of exogenous testosterone in men with T2DM, however, the role of androgens, independent of body composition, in modifying insulin resistance is uncertain.

关键词： androgen glucose metabolism sex steroids testosterone

经静脉置入起搏/除颤导线引起的心脏血管慢性病理改变

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中华心血管病杂志 2015年第5期43卷 423-427页

作者：李延辉 Richard dykoski 李剑明清华大学第一附属医院心脏中心北京100016 美国明尼苏达大学退役军人中心医院心内科美国明尼苏达大学退役军人中心医院病理科

目的观察长期置入起搏/除颤导线相关的慢性病理学改变.方法本研究共包括3部分,第一对2008年3月至2011年3月38例应用准分子激光消融拔除的患者的83根起搏/除颤导线的病理学观察,第二对1例应用准分子激光消融拔除起搏/除颤导线死亡患者... 详细信息

目的观察长期置入起搏/除颤导线相关的慢性病理学改变.方法本研究共包括3部分,第一对2008年3月至2011年3月38例应用准分子激光消融拔除的患者的83根起搏/除颤导线的病理学观察,第二对1例应用准分子激光消融拔除起搏/除颤导线死亡患者的尸体进行解剖研究,第三对10例既往置入起搏/除颤导线后因各种原因死亡患者的尸体进行解剖研究.结果导线在血管内和心腔内可以形成广泛的纤维结缔组织包裹和粘连.上腔静脉近右心房处常粘连较为严重,且此处较薄弱,外侧为胸膜腔,易穿孔且穿孔后局部不能产生压迫止血作用,是本研究中1例拔出导线致死的原因.导线与三尖瓣和腱索的粘连往往较严重.位于心尖部右心室游离壁的导线尖端离心外膜较近.导线及血管、心腔内壁的血栓较常见,甚至有较大的血栓（尤其心耳内）.结论经静脉置入的起搏/除颤导线在血管内和心腔内可形成广泛的纤维结缔组织包裹和粘连,导线和三尖瓣及腱索形成复杂的解剖关系和严重的粘连,有些心室导线的顶端已经进入肌层、接近心外膜,导线及血管、心腔内壁的血栓较常见.上腔静脉近心房处组织薄弱且粘连严重,导线拔出操作可导致透壁性损伤而致患者死亡.

关键词：心脏起搏器,人工除颤器,植入型病理学,临床

Beta secretase activity in peripheral nerve regeneration

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Neural Regeneration Research 2017年第10期12卷 1565-1574页

作者： carolyn Tallon Mohamed H.Farah Department of Neurology at Johns Hopkins School of Medicine BaltimoreMDUSA

While the peripheral nervous system has the capacity to regenerate following a nerve injury,it is often at a slow rate and results in unsatisfactory recovery,leaving patients with reduced *** regeneration associated genes have been identified over the years,which may shed some insight into how we can manipulate this intrinsic regenerative ability to enhance repair following peripheral nerve *** lab has identified the membrane bound protease beta-site amyloid precursor protein-cleaving enzyme 1（BACE1）,or beta secretase,as a potential negative regulator of peripheral nerve *** beta secretase activity levels are abolished via a null mutation in mice,peripheral regeneration is enhanced following a sciatic nerve crush ***,when activity levels are greatly increased by overexpressing beta secretase in mice,nerve regeneration and functional recovery are impaired after a sciatic nerve crush *** addition to our work,many substrates of beta secretase have been found to be involved in regulating neurite outgrowth and some have even been identified as regeneration associated *** this review,we set out to discuss BACE1 and its substrates with respect to axonal regeneration and speculate on the possibility of utilizing BACE1 inhibitors to enhance regeneration following acute nerve injury and potential uses in peripheral neuropathies.

关键词： peripheral nerve axonal regeneration beta-site amyloid precursor protein-cleaving enzyme 1