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Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

Bone Research 2024年第1期12卷 180-198页

作者： morten S.Hansen Kaja madsen maria Price Kent Søe Yasunori Omata mario m.Zaiss caroline m.gorvin morten Frost Alexander Rauch molecular Endocrinology Laboratory(KmEB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Department of Clinical Research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of metabolism and Systems Research(ImSR)and Centre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for membrane Proteins and Receptors(COmPARE) Universities of Birmingham and NottinghamBirmingham B152TTUK Department of molecular medicine University of Southern DenmarkDK-5000 Odense CDenmark Department of Orthopedic Surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Department of Internal medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsches Zentrum Immuntherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Steno Diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment *** study aimed to provide an overview of transcriptional reprogramming during human osteoclast *** were differentiated from CD14+monocytes from eight female *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across *** patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on RNA from iliac crest biopsies and bone mineral density *** analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at the monocyte stage,such as filamin B(FLNB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the resorptive activity of mature *** expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density SNPs,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(C5AR1),somatostatin receptor 2(SSTR2),and free fatty acid receptor 4(FFAR4/GPR120).Activating C5AR1 enhanced osteoclast formation,while activating SSTR2 decreased the resorptive activity of mature osteoclasts,and activating FFAR4 decreased both the number and resorptive activity of mature *** conclus

关键词： osteoclast programming identif

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ANALYZING TAX CREDITS FOR RESIDENTIAL ENERGY EFFICIENCY USING ENERGY mODELING

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Journal of Green Building 2018年第1期13卷 83-94页

作者： caroline m.Clevenger moatassem Abdallah Jayapradha madhavan Construction Engineering and management College of Engineering&Applied ScienceUniversity of Colorado Denver1200 Larimer StreetDenverCO USA

From roughly 2013 to 2016,ten building product categories related to residential energy efficiency were eligible for United States ENERGY STAR Federal Tax *** general,the objective of residential energy-efficiency tax credits is to encourage individuals to increase residential energy-efficiency investments and invest in properties that generate renewable *** research analyses eight of the available tax credit categories for four climatic zones and recommends packages based on low Life Cycle Cost and low First Cost for the eligible ENERGY STAR *** experiment was conducted using energy modeling software for different tax credits and costs combinations,to explore potential variability in economic impact of the federal *** used Building America B10 Benchmark as a reference,and the energy computations were completed using Building Energy Optimization(BEopt)*** suggest that ENERGY STAR product packages that include PV systems generally have the lowest(best)Life Cycle Costs and packages that include Geothermal Heat Pumps generally have the highest(worst)Life Cycle ***,there are tradeoffs between cost savings and energy source savings,and the particular economics of tax incentives for ENERGY STAR products depend on project specifics as well as owner priorities.

关键词： ENERGY STAR products energy performance lifecycle costs

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On the Stability of Racing Sailing Boats with Foils

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Chinese Annals of mathematics,Series B 2018年第3期39卷 427-450页

作者： Philippe DESTUYNDER caroline FABRE Département d'ingénierie mathématique Laboratoire M2N Conservatoire National des Arts et Métiers 292rue saint Martin75003 ParisFrance Laboratoire de mathématiques d'Orsay Univ.Paris-SudCNRSUniversitéParis-Saclay 91405 OrsayFrance

The development of foils for racing boats has changed the strategy of sailing. Recently, the America＇s cup held in San Francisco, has been the theatre of a tragicomic history due to the foils. During the last round, the New-Zealand boat was winning by 8 to 1 against the defender USA. The winner is the first with 9 victories. USA team understood suddenly （may be） how to use the control of the pitching of the inain foils by adjusting the rake in order to stabilize the ship. And USA won by 9 victories against 8 to the challenger NZ. The goal in this paper is to point out few aspects which could be taken into account in order to improve this mysterious control law which is known as the key of the victory of the USA team. There are certainly many reasons and in particular the cleverness of the sailors and of all the engineering team behind this project. But it appears interesting to have a mathematical discussion, even if it is a partial one, on the mechanical behaviour of these extraordinary sailing boats. The nunlerical exanlples given here are not the true ones. They have just been invented in order to explain the theoretical developments concerning three points： The possibility of tacking on the foils for sailing upwind, the nature of foiling instabilities, if there are, when the boat is flying and the control laws.

关键词： Hydrodynamics of foils mathematical analysis Stability

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How well does XAD resin extraction recover halogenated disinfection byproducts for comprehensive identification and toxicity testing?

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Journal of Environmental Sciences 2022年第7期34卷 264-275页

作者： Xiaobin Liao Joshua m.Allen caroline O.Granger Susan D.Richardson Department of Chemistry and Biochemistry University of South CarolinaColumbiaSouth Carolina 29208USA Institute of municipal and Environmental Engineering College of Civil EngineeringHuaqiao UniversityFujian 361021China Currently at LanzaTech 535 Commerce DriveSopertonGeorgia 30457USA

Halogenated disinfection byproducts(DBPs) are an unintended consequence of drinking water disinfection, and can have significant toxicity. XAD resins are commonly used to extract and enrich trace levels of DBPs for comprehensive, nontarget identification of DBPs and also for in vitro toxicity studies. However, XAD resin recoveries for complete classes of halogenated DBPs have not been evaluated, particularly for low, environmentally relevant levels(ng/L to low μg/L). Thus, it is not known whether levels of DBPs or the toxicity of drinking water might be underestimated. In this study, DAX-8/XAD-2 layered resins were evaluated, considering both adsorption and elution from the resins, for extracting 66 DBPs from water. Results demonstrate that among the 7 classes of DBPs investigated, trihalomethanes(THms), including iodo-THms, were the most efficiently adsorbed, with recovery of most THms ranging from 50%-96%, followed by halonitromethanes(40%-90%). The adsorption ability of XAD resins for haloacetonitriles, haloacetamides, and haloacetaldehydes was highly dependent on the individual species. The adsorption capacity of XAD resins for haloacetic acids was lower(5%-48%), even after adjusting to p H 1 before extraction. Recovery efficiency for most DBPs was comparable with their adsorption, as most were eluted effectively from XAD resins by ethyl acetate. DBP polarity and molecular weight were the two most important factors that determine their recovery. Recovery of trichloromethane, iodoacetic acid, chloro-and iodo-acetonitrile, and chloroacetamide were among the lowest, which could lead to underestimation of toxicity, particularly for iodoacetic acid and iodo-acetonitrile, which are highly toxic.

关键词： XAD resins Disinfection byproducts DBPs Recovery Toxicity

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Old dog,new trick:The PHR-SPX system regulates arbuscular mycorrhizal symbiosis

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molecular Plant 2022年第2期15卷 225-227页

作者： Debatosh Das caroline Gutjahr CUHK Shenzhen Research Institute No.10 Yuexing 2nd RoadNanshanShenzhenChina Plant Genetics TUM School of Life SciencesTechnical University of Munich(TUM)Emil Ramann Strasse 485354 FreisingGermany

Plant growth depends on the continuous availability of the macro-nutrient phosphate(Pi).However,in most soils,Pi is only poorly accessible to plants,resulting in Pi deficiency and triggering a number of Pi starvation *** strategy of plants to over-come Pi limitation is to form a symbiosis with arbuscular mycor-rhizal(Am)fungi(Smith et al.,2011),which occurs with approximately 80%of land *** fungi improve the uptake of Pi and other mineral nutrients and thereby increase plant performance and stress *** collect these minerals with an extraradical hyphal network from the soil and release them from highly branched structures,called arbuscules,into root cortex ***,Pi sufficiency causes inhibition of internal root colonization(Balzergue et al.,2011;Breuillin et al.,2010).The mechanistic basis for this has long remained *** studies have now solved this long-standing mystery and demonstrated that a canonical Pi-response regulatory module regulates Am symbiosis in accordance with the plant Pi status(Shi et al.,2021;Das et al.,2022).

关键词： thereby symbiosis release

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Oxidative stress physiology in relation to life history traits of a free-living vertebrate:the spotted snow skink,Niveoscincus ocellatus

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Integrative Zoology 2011年第2期6卷 140-149页

作者： caroline ISAKSSON Geoffrey m.WHILE mats OLSSON Jan KOmDEUR Erik WAPSTRA University of Groningen Animal Ecology GroupHarenThe Netherlands University of Wollongong School of Biological SciencesWollongongNew South Wales University of Tasmania School of ZoologyHobartTasmaniaAustralia

Recent research suggests that oxidative stress,via its links to metabolism and senescence,is a key mechanism linking life history traits such as fecundity and growth with survival;however,this has rarely been put under empirical scrutiny within free-living *** a wild population of live-bearing skinks,we explored how plasma antioxidant activity(OXY),reactive oxidative metabolites(ROm),and the estimated oxidative stress index are associated with female and male life *** found that male skinks have a significantly higher ROm and estimated oxidative stress index than female skinks,but this was not accompanied by a sex difference in *** sexes showed a non-linear association between OXY and age,indicating that the oldest and youngest individuals had the lowest ***,female skinks with high OXY showed a decreased probability of survival to the following ***,we found no significant associations between female reproductive investment(litter size or litter mass)or parturition date(***)and oxidative ***,our results offer mixed support for a role of oxidative stress in mediating life history traits and suggest that future studies need to explore oxidative stress during vitellogenesis in addition to using an intra-individual approach to understand the cost of reproduction and patterns of aging.

关键词： antioxidants life history Niveoscincus ocellatus oxidative stress reptile

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The Belt and Road Initiative and Technical and Vocational Education and Training(TVET)in Kenya:The Kenya-China TVET Project

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Frontiers of Education in China 2018年第3期13卷 346-374页

作者： caroline m.mUSYImI Joseph mALECHWANZI LUO Heng Department of Engineering Coast Institute of TechnologyVoi 80300Kenya School of Educational Information Technology Central China Normal UniversityWuhan 430079China

This study explores the impact of China’s Belt and Road Initiative on improving vocational education quality and employment rates in Kenya through a collaborative educational program known as the Kenya-China Technical and Vocational Education and Training(TVET)*** opinions and narratives of teachers and students with vibrant knowledge of the project were analyzed through the theoretical lenses of globalization and *** results show that the Kenya-China TVET Project has improved Kenyan TVET classrooms with modern equipment to meet industrial standards and allowed essential skills to be developed through various collaborative opportunities with Chinese *** minor challenges and obstacles,early evidence suggests benefits brought by the project including increased self-employment,a growth in Kenya’s manufacturing,and more mutual understanding between the two countries.

关键词： Technical and Vocational Education and Training(TVET) the Belt and Road Initiative(BRI) educational collaboration employment Kenya

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Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro

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Asian Journal of Andrology 2016年第4期18卷 620-626页

作者： mark J mcCabe caroline FH Foo marcel E Dinger Peter m Smooker Peter G Stanton male Fertility Regulation Laboratory Hudson Institute of Medical Research Monash Medical Centre Clayton Victoria 3168 Australia School of Applied Sciences Royal Melbourne Institute of Technology University Bundoora Victoria 3088 Australia Kinghorn Centre for Clinical Genomics Garvan Institute of Medical Research Darlinghurst New South Wales 2010 Australia St Vincent's Clinical School UNSW Sydney New South Wales 2052 Australia.

The Sertoli cell tight junction （T J） is the key component of the blood-testis barrier, where it sequesters developing germ cells undergoing spermatogenesis within the seminiferous tubules. Hormonally regulated claudin-11 is a critical transmembrane protein involved in barrier function and its murine knockout results in infertility. We aimed to assess quantitatively the significance of the contribution of claudin-11 to TJ function, in vitro, using siRNA-mediated gene silencing. We also conducted an analysis of the contribution of occludin, another intrinsic transmembrane protein of the TJ. Silencing of claudin-11 and/or occludin was conducted using siRNA in an immature rat Sertoli cell culture model. Transepithelial electrical resistance was used to assess quantitatively TJ function throughout the culture. Two days after siRNA treatment, cells were fixed for immunocytochemical localization of junction proteins or lyzed for RT-PCR assessment of mRNA expression. Silencing of claudin-11, occludin, or both resulted in significant decreases in TJ function of 55% （P 〈 0.01）, 51% （P 〈 0.01）, and 62% （P 〈 0.01）, respectively. Data were concomitant with significant decreases in mRNA expression and marked reductions in the localization of targeted proteins to the Sertoli cell TJ. We provide quantitative evidence that claudin-11 contributes significantly （P 〈 0.01） to Sertoli cell TJ function in vitro. Interestingly, occludin, which is hormonally regulated but not implicated in infertility until late adulthood, is also a significant （P 〈 0.01） contributor to barrier function. Our data are consistent with in vivo studies that clearly demonstrate a role for these proteins in maintaining normal TJ barrier structure and function.

关键词： blood-testis barrier claudin-11 occludin Sertoli cell tight junction siRNA

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The influence of resistance exercise training prescription variables on skeletal muscle mass,strength,and physical function in healthy adults:An umbrella review

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Journal of Sport and Health Science 2024年第1期13卷 47-60页

作者： Jonathan C.mcleod Brad S.Currier caroline V.Lowisz Stuart m.Phillips Department of Kinesiology Faculty of ScienceMcMaster UniversityHamilton L8S4L8Canada

Purpose:The aim of this umbrella review was to determine the impact of resistance training(RT)and individual RT prescription variables on muscle mass,strength,and physical function in healthy ***:Following Preferred Reporting Items for Systematic Reviews and meta-Analyses(PRISmA)guidelines,we systematically searched and screened eligible systematic reviews reporting the effects of differing RT prescription variables on muscle mass(or its proxies),strength,and/or physical function in healthy adults aged>18 ***:We identified 44 systematic reviews that met our inclusion *** methodological quality of these reviews was assessed using A measurement Tool to Assess Systematic Reviews;standardized effectiveness statements were *** found that RT was consistently a potent stimulus for increasing skeletal muscle mass(4/4 reviews provide some or sufficient evidence),strength(4/6 reviews provided some or sufficient evidence),and physical function(1/1 review provided some evidence).RT load(6/8 reviews provided some or sufficient evidence),weekly frequency(2/4 reviews provided some or sufficient evidence),volume(3/7 reviews provided some or sufficient evidence),and exercise order(1/1 review provided some evidence)impacted RT-induced increases in muscular *** discovered that 2/3 reviews provided some or sufficient evidence that RT volume and contraction velocity influenced skeletal muscle mass,while 4/7 reviews provided insufficient evidence in favor of RT load impacting skeletal muscle *** was insufficient evidence to conclude that time of day,periodization,inter-set rest,set configuration,set end point,contraction velocity/time under tension,or exercise order(only pertaining to hypertrophy)influenced skeletal muscle adaptations.A paucity of data limited insights into the impact of RT prescription variables on physical ***:Overall,RT increased muscle mass,strength,and physical function compared to no ***

关键词： Hypertrophy Resistance training Resistance training prescription variables Strength Umbrella review

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Differences in functional traits among distinct populations of the plant invader Bunias orientalis

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Journal of Plant Ecology 2022年第3期15卷 524-537页

作者： Blaise Binama caroline müller Department of Chemical Ecology Bielefeld UniversityUniversitätsstr.2533615 BielefeldGermany

Plants that expand their range and become invasive in other areas may shift several functional traits in response to specific ***,local conditions at the place of origin may have shaped the functional traits,which may to some extent remain visible in plants growing in new *** present study aimed to explore the trait variation in different plant populations of native,invasive and naturalized status of Bunias orientalis grown in common conditions in relation to the climatic conditions at their place of *** of *** were collected from 12 populations(4 per status)in 8 countries and grown under standardized conditions in a common field *** variation in several functional traits related to phenology,growth and reproduction was compared among status and among *** did not differ according to ***,several plants of the native populations,originating from areas with low annual temperatures,did not start *** of the invasive populations produced more leaves than natives,potentially indicating their vigor in building up vegetative *** and mass of silicles and other growth traits did not differ among status groups but varied among *** of the variation in functional traits may be explained by long-term adaptations to local conditions at the areas of origin and genetic diversity,while other environmental factors differing in the novel environment may contribute to a high trait variation.

关键词： Bunias orientalis invasive species phenology ecological status trait variation

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