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Journal of Biosciences and Medicines 2019年第8期7卷 42-67页

作者： María Fernanda Izaguirre carolina daniela galetto Lautaro Baró Víctor Hugo Casco Laboratorio de Microscopía Aplicada a Estudios Moleculares y Celulares Facultad de Ingeniería Universidad Nacional de Entre Ríos Oro Verde Entre Ríos República Argentina Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática (IBB) Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET) CABA República Argentina

E-cadherin molecules are cell-cell molecular connectors, but also act attaching cell surface to the cytoskeleton through catenin’s and additional partner proteins. Its main function is to regulate cellular adhesion and motility, and therefore acts as an invasion suppressor system. Its role is crucial in the induction and maintenance of cell polarity and differentiation, and in the organization and maintenance of tissue architecture. Downregulation or loss of its function is associated with an invasive and aggressive phenotype in many types of human cancers. In alterations of animal development, E-cadherin dysfunction influence in premature lethality or epidermal barrier and immunity defects. However, new hypothesis over its promoter role in tissue invasion is on focus. In addition to its tumor suppressor role, E-cadherin is a guiding molecule in collective cell migration increasing the metastasis risk during in vivo tumorigenesis. This E-cadherin function explains the retention of the functional E-cadherin expression, and that the epithelial-mesenchymal transition (EMT) is not required for the metastasis occurrence. However, like a switch, in some tumoral environments E-cadherin post-translational modifications may cause cell cluster migration. Like in development, in certain in vivo tumoral contexts, E-cadherin apparently involves signaling rather than cell contact formation. In this report, we explore the possibility of a novel role of thyroid hormones (THs) in the signal via E-cadherin-catenins, this not only should be involved in development and homeostasis, but also in cancer susceptibility of gastrointestinal tract.

关键词： Cell Adhesion Molecules Complexes E-Cadherin Cancer Thyroid Hormones

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Tropical dendrochronology applied to invasive tree species in the Brazilian Atlantic Forest

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Journal of Forestry Research 2021年第1期32卷 91-101页

作者： carolina Nogueira Xavier daniela Granato-Souza Ana carolina M.C.Barbosa JoséReinaldo Moreira da Silva Forest Sciences Department Federal University of Lavras(UFLA)C.P.3037Lavras 37200-000Brazil Department of Geosciences University of ArkansasFayettevilleAR 72701USA

The Atlantic Forest is one of the largest and most biodiverse rainforests of South America but anthropogenic activities are drastically changing these *** invasion of alien or exotic species is one of the greatest threats to *** are few studies of invasive species in tropical Brazilian *** research examines growth and ecological aspects of Syzygium cumini and Clitoria fairchildiana,two invasive tree species in the Pedra Branca State Park,an Atlantic Forest remnant in southeastern *** species were successfully dated,indicating an average age of 58 and 31 years,respectively.A positive relationship between growth and precipitation of the previous growing season suggests an ecological adaptive strategy,which could be facilitating their invasion into the *** growth diameter curves indicate slow and fast growth rates for *** and ***,*** release episodes detected in the tree rings indicate increased anthropogenic disturbances over the last 50 years.

关键词： Atlantic Forest biome Invasive species Protected areas Tree rings

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COVID-19 pandemic in the intensive care unit:Psychological implications and interventions,a systematic review

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World Journal of Psychiatry 2023年第4期13卷 191-217页

作者： Laura Monti Elisa Marconi Maria Grazia Bocci Georgios Demetrios Kotzalidis Marianna Mazza carolina Galliani Sara Tranquilli Giovanni Vento Giorgio Conti Gabriele Sani Massimo Antonelli daniela Pia Rosaria Chieffo UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy UOC Anestesia RianimazioneTerapia Intensiva e Tossicologia ClinicaDipartimento di Scienze Dell’EmergenzaAnestesiologiche e Della RianimazioneFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy NESMOS Department Facoltàdi Medicina e PsicologiaSant’Andrea University HospitalRome 00189Italy Department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Psychology UniversitàCattolica del Sacro CuoreRome 00168Italy UOC Neonatologia Dipartimento di Scienze Della Salute Della DonnaDel Bambino e di SanitàPubblicaFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy UOC Neonatologia UniversitàCattolica del Sacro CuoreRome 00168Italy UOC Terapia Intensiva Pediatrica e Trauma Center Pediatrico Dipartimento di Scienze Dell’EmergenzaAnestesiologiche e Della RianimazioneFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy UOC Terapia Intensiva Pediatrica e Trauma Center Pediatrico UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Anesthesiology and Intensive Care Medicine UniversitàCattolica del Sacro CuoreRome 00168Italy

BACKGROUND The coronavirus disease 2019(COVID-19) pandemic produced changes in intensive care units(ICUs) in patient care and health organizations. The pandemic event increased patients’ risk of developing psychological symptoms during and after hospitalisation. These consequences also affected those family members who could not access the hospital. In addition, the initial lack of knowledge about the virus and its management, the climate of fear and uncertainty, the increased workload and the risk of becoming infected and being contagious, had a strong impact on healthcare staff and organizations. This highlighted the importance of interventions aimed at providing psychological support to ICUs, involving patients, their relatives, and the staff;this might involve the reorganisation of the daily routine and rearrangement of ICU staff *** To conduct a systematic review of psychological issues in ICUs during the COVID-19 pandemic involving patients, their relatives, and ICU *** We investigated the PubMed and the *** databases and found 65 eligible articles,upon which we *** Our results point to increased perceived stress and psychological distress in staff, patients and their relatives and increased worry for being infected with severe acute respiratory syndrome coronavirus-2 in patients and relatives. Furthermore, promising results were obtained for some psychological programmes aiming at improving psychological measures in all ICU *** As the pandemic limited direct inter-individual interactions, the role of interventions using digital tools and virtual reality is becoming increasingly important. All considered, our results indicate an essential role for psychologists in ICUs.

关键词： COVID-19 Intensive care unit Psychological interventions Pandemic Mental health Health care professionals

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Chronic Diseases of Childhood and the International Classification of Functioning, Disability, and Health: A Systematic Review

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Health 2022年第7期14卷 751-765页

作者： daniela Koeller Rodrigues Vieira Carla Trevisan M. Ribeiro Roseane de Lima Ribeiro Lara carolina Januário Cabral Center for Assistive Technology and Health Products National Institute for Women Children and Adolescents Fernandes Figueira Oswaldo Cruz Foundation (IFF-Fiocruz) Rio de Janeiro Brazil

The increase in chronic diseases in childhood highlights the need for a biopsychosocial approach to deal with the complexity of these health conditions. The International Classification of Functioning, Disability, and Health (ICF) results from the need to implement new explanatory evaluative and therapeutic models. Thus, the present systematic review aims to identify published studies on the use of the ICF in chronic childhood diseases. As a secondary objective, to map the themes that have already been studied in the area to support the discussion on the expansion of the use of this classification in health services. The systematic review followed the PRISMA protocol, and the model was the PICO acronym, where Population was children and adolescents with chronic diseases, Intervention/Exposure was evaluation based on ICF concepts, Comparator was any tool, instrument, or intervention, and outcome was direct or indirect use of the ICF. We selected eight articles, five of which used the ICF as a conceptual tool and three as a classification system, divided into the following themes: quality of life, evaluation of patients (without using coding) and mapping the inclusion of the activity’s results and participation in clinical trials. Thus, use of the ICF in clinical practice is still incipient, although it has been recommended in guidelines. Further studies are necessary to expand the number of contributions by the ICF and to develop the necessary approaches for understanding the classification’s use.

关键词： Chronic Diseases International Classification of Functioning Disability and Health Child Adolescent Disabled Children

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The transfer and resulting negative effects of nano-and micro-plastics through the aquatic trophic web—A discreet threat to human health

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Water Biology and Security 2022年第4期1卷 1-8页

作者： Charles V.Neves Christine C.Gaylarde Jose Antonio Baptista Neto Khaue S.Vieira Bruno Pierri carolina C.C.Waite daniela C.Scott Estefan M.da Fonseca Department of Geology and Geophysics/LAGEMAR–Laboratorio de Geologia Marinha Instituto de GeocienciasUniversidade Federal FluminenseAvenida Litoranea S/n24210-340NiteroiRJBrazil Department of Microbiology and Plant Biology Oklahoma University770 Van Vleet OvalNormanOK73019USA

The ubiquitous occurrence of plastic nano-and micro-particle contamination has raised concerns about its potential risks and impacts on the global environment,especially in aquatic *** of aquatic species,from different trophic levels,have been affected by this“new”contaminant,which has been reported mainly in their digestive ***,current knowledge about plastic nano-and micro-particle spread and the potential impact on aquatic biota is growing ***,there is a significant lack of understanding of the trophic spread of microplastic contamination and integration of knowledge derived from laboratory assays with that from field research is *** experiments are unable to deal with differentiating between directly and indirectly ingested plastic *** the other hand,laboratory assays evaluating the influence of plastic microparticles and of their adhered or constitutive toxins on representative species cannot satisfactorily simulate the real *** a result,little is known about the effective transfer of plastic particles through the trophic net and the resulting human health *** present review seeks to gather information that can give a more accurate idea of the current situation and future challenges to be faced in mitigating the environmental and human effects of plastic particle pollution in aquatic,particularly estuarine,ecosystems.

关键词： Trophic transfer Plastic matrix additives Anthropogenic pollution Human health Microplastics

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Inflammatory bowel disease: A descriptive study of 716 local Chilean patients

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World Journal of Gastroenterology 2016年第22期22卷 5267-5275页

作者： daniela Simian daniela Fluxá Lilian Flores Jaime Lubascher Patricio Ibánez carolina Figueroa Udo Kronberg Raúl Acuna Mauricio Moreno Rodrigo Quera Academic Research Unit Clinica Las Condes Santiago 7591046 Chile Gastroenterology Departament Clinica Las Condes Santiago 7591046 Chile Inflammatory Bowel Disease Program Gastroenterology Department Clinica Las Condes Santiago 7591046 Chile Inflammatory Bowel Disease Program Colorectal Surgery Department Clinica Las Condes Santiago 7591046 Chile Laboratory of Oncology and Molecular Genetics Colorectal Surgery Clinica Las Condes Santiago 7591046 Chile

AIM: To demographically and clinically characterize inflammatory bowel disease(IBD) from the local registry and update data previously published by our ***: A descriptive study of a cohort based on a registry of patients aged 15 years or older who were diagnosed with IBD and attended the IBD program at Clínica Las Condes in Santiago, Chile. The registry was created in April 2012 and includes patients registered up to October 2015. The information was anonymously downloaded in a monthly report, and the information on patients with more than one visit was updated. The registry includes demographic, clinical and disease characteristics, including the Montreal Classification, medical treatment, surgeries and hospitalizations for crisis. Data regarding infection with Clostridium difficile(C. difficile) were incorporated in the registry in 2014. Data for patients who received consultations as second opinions and continued treatment at this institution were also analyzed. RESULTS: The study included 716 patients with IBD: 508 patients(71%) were diagnosed with ulcerative colitis(UC), 196 patients(27%) were diagnosed with Crohn's disease(CD) and 12 patients(2%) were diagnosed with unclassifiable IBD. The UC/CD ratio was 2.6/1. The median age was 36 years(range 16-88), and 58% of the patients were female, with a median age at diagnosis of 29 years(range 5-76). In the past 15 years, a sustained increase in the number of patients diagnosed with IBD was observed, where 87% of the patients were diagnosed between the years 2001 and 2015. In the cohort examined in the present study, extensive colitis(50%) and colonic involvement(44%) predominated in the patients with UC and CD, respectively. In CD patients, nonstricturing/non-penetrating behavior was more frequent(80%), and perianal disease was observed in 28% of the patients. There were significant differences in treatment between UC and CD, with a higher use of corticosteroids, and immunosuppressive and biological thera

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis South America Latin America Chile Epid

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Prevention of bile spillage during cholecystectomy: current evidences and considerations

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Hepatobiliary Surgery and Nutrition 2020年第1期9卷 109-111页

作者： Maurizio Zizzo Lorenzo Manzini Magda Zanelli Loredana De Marco carolina Castro Ruiz Antonio Manenti Valerio Annessi Surgical Oncology Unit Azienda UnitàSanitaria Locale-IRCCS di Reggio EmiliaArcispedale Santa Maria Nuova di Reggio EmiliaReggio EmiliaItaly Clinical and Experimental Medicine PhD Program University of Modena and Reggio EmiliaModenaItaly Pathology Unit Azienda UnitàSanitaria Locale-IRCCS di Reggio EmiliaArcispedale Santa Maria Nuova di Reggio EmiliaReggio EmiliaItaly General Surgery Unit Azienda UnitàSanitaria Locale-IRCCS di Reggio EmiliaOspedale Civile di GuastallaReggio EmiliaItaly Department of General Surgery Azienda Ospedaliero-Universitaria-PoliclinicoModenaItaly

We really appreciated Geramizadeh, " Bile spillage and incidental gall bladder adenocarcinoma ", and Sandstrom et al. ,"Bile spillage should be avoided in elective cholecystectomy " (1,2). Both papers have been recently published in HepatoBiliary Surgery and Nutrition, 2019 (1,2). Starting from an analysis of the recent paper by Horkoff et al. "Adverse outcomes after bile spillage in incidental gall bladder cancer " in Annals of Surgery April 2019, they introduced a comprehensive discussion about epidemiology, diagnosis, therapy, prognostic factors and outcomes of incidental gallbladder cancer (1-3). They analyzed the possible risks related to bile spillage after cholecystectomy, in particular (1,2).

关键词： Surgery cholecystectomy epidemiology diagnosis

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Laparoscopic liver resection for malignancies confined to Couinaud's segment VII in the robotic surgery era

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Hepatobiliary Surgery and Nutrition 2019年第4期8卷 439-441页

作者： Maurizio Zizzo Lara Ugoletti carolina Castro Ruiz Magda Zanelli Loredana De Marco Claudio Pedrazzoli Valerio Annessi Surgical Oncology Unit Azienda UnitàSanitaria Locale-IRCCS di Reggio EmiliaArcispedale Santa Maria Nuova di Reggio EmiliaReggio EmiliaItaly Clinical and Experimental Medicine PhD Program University of Modena and Reggio EmiliaModenaItaly General Surgery Unit Azienda UnitàSanitaria Locale-IRCCS di Reggio EmiliaOspedale Civile di GuastallaReggio EmiliaItaly Pathology Unit Azienda UnitàSanitaria Locale-IRCCS di Reggio EmiliaArcispedale Santa Maria Nuova di Reggio EmiliaReggio EmiliaItaly

We read with pleasure papers by Cai et al. and Jia et al. published in HepatoBiliary Surgery and Nutrition, 2018, Volume 7, Issue 2 and 4, respectively (1,2). Both papers introduced comprehensive up-to-date literature reviews on indications and patient selection, surgical instruments, techniques, and outcomes of laparoscopic liver resections (LLRs) (1,2). Papers mentioned final statements by 2008 Louisville Statement and 2014 Morioka Consensus Conference (1,2). They stressed LLR non-inferiority to open procedures, in both minor and major liver resections as far as oncological and intraoperative/perioperative outcomes are concerned: reduced blood loss, lower postoperative morbidity and shorter length of hospitalization (1,2). Such results were corroborated by recent meta-analyses (3,4). Furthermore, some previous limitations for LLR look like they have been recently overcome (1-5). For example, tumor size, patient's old age and high BMI are no longer limitations for LLR, as Southampton Consensus guidelines suggested (5). Likewise, cirrhosis has been suggested as a further indication of LLR in highly selected patients with hepatocellular carcinoma and where it was performed by experienced surgeons (1-5).

关键词： Surgery overcome mentioned

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Can we really opt in terms of ergonomic methodologies and/or approaches?

Can we really opt in terms of ergonomic methodologies and/or...

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第十七届国际工效学大会暨中国人类工效学会成立20周年庆祝大会

作者： Marcello Silva e Santos José Mario Carvo daniela Alessandra Cassano Raphael Pacheco da Rocha carolina Moura Mattos José Roberto Mafra Renato José Bonfatti Mario Cesar Vidal Ergonomic Research Unit GENTELuis Alberto Coimbra Research InstituteCOPPEFederal University of Rio de JaneiroUFRJ

The aim of this paper is to contribute to the discussion of the supposed epistemological conflict among ergonomic *** supposed unifying lemma of ergonomics-fit the task to the humans-in reality set us in front of serious dilemmas concerning the adequate choice of pertinent *** the singularity of the majority of micro-ergonomics approaches,Ergonomics work analysis and Macroergonomics,we shows an alternative approach-the ergonomic screening-enlightened by two case studies in building and in a process *** conclusion,some major advise should be outlined,under a practitioner point of view:a) obtaining a few positives results is much better than have no results at all;b) The present is the door for the past as well as it leads to the Future,c) Beginning is just a start,but we must do it before proceeding.

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Neuromuscular Electrical Stimulation in Intensive Care Unit Patients:Integrative Review

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Modern Research in Inflammation 2019年第2期8卷 11-27页

作者： Miriam Viviane Baron Marcus Vinicius de Mello Pinto Janine Koepp Cristine Brandenburg Paulo Ricardo Martins Amanda Correa dos Santos daniela Moraes carolina Goncalves Pinheiro Nathália Ken Pereira Iketani Bartira Ercilia Pinheiro da Costa Nephrology Laboratory Department of Postgraduate of Medicine and Health SciencesSchool of MedicinePontifical Catholic University of Rio Grande do SulPorto AlegreBrazil Celulare Institute Rio de JaneiroBrazil Nursing Course Department of Nursing and DentistryUniversity of Santa Cruz do SulSanta Cruz do SulBrazil Postgraduate Program in Brazilian Education Department of Fundamentals of EducationFederal University of CearáFortalezaBrazil School of Medicine Pontifical Catholic University of Rio Grande do SulPorto AlegreBrazil Physiotherapy Course Department of PhysiotherapyVale do Salgado FacultyIcóBrazil Department of Physiotherapy Dom Luiz I Hospital-Portuguese Beneficent of BelemParaBrazil

Intensive care units’ acquired muscle weakness is present in approximately 50% of the patients. Although active muscle training can attenuate weakness, a large proportion of critical patients cannot participate in any active mobilization. Neuromuscular electrical stimulation may be an alternative strategy to reverse muscle weakness. The objective of the study was to review the scientific publications on the use of neuromuscular electrical stimulation and its parameters and the main results in patients hospitalized in intensive care units. This is an integrative review surveying studies in online databases. The studies were selected from the following descriptors: neuromuscular electrical stimulation AND parameters AND intensive care units AND muscle weakness. The inclusion criteria included articles that addressed the topic of neuromuscular electrical stimulation and the parameters used in patients admitted to intensive care units, aged 18 years or older. Exclusion criteria were studies involving animals, case reports, letters to the editor and book chapters. The search comprised articles in the Portuguese, English and Spanish languages from January 2013 to March 2019. Of the 185 articles identified, nine met the eligibility criteria. The studies were evaluated assessing the level of evidence, and the relevant information was presented in the table and discussed. The parameters of the neuromuscular electrical stimulation employed in the studies showed positive results for the maintenance of strength and muscle mass. There was evidence of benefits in the local and systemic microcirculation, potentially mobilizing endothelial stem cells, to prevent atrophy, to reduce mechanical ventilation time and stay in intensive care unit;and when incorporated into the usual physiotherapy care, proved to be more effective than usual care. Its use is safe and viable in critically ill patients.

关键词： Muscle Weakness Critical Illness Polyneuropathy Sepsis Electric Stimulation Therapy Physical Therapy Modalities

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