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Assessment of programmed death-ligand 1 expression in primary tumors and paired lymph node metastases of gastric adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 883-893页

作者： Brendha Cação Coimbra Marina Alessandra Pereira leonardo Cardili Venancio Avancini Ferreira Alves Evandro Sobroza de Mello Ulysses Ribeiro Jr marcus Fernando Kodama Pertille Ramos Department of Gastroenterology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Department of Pathology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 01246000Brazil

BACKGROUND Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-l1)immuno-therapy has demonstrated promising results on gastric cancer(GC).However,PD-l1 can express differently between metastatic sites and primary tumors(PT).AIM To compare PD-l1 status in PT and matched lymph node metastases(lNM)of GC patients and to determine the correlation between the PD-l1 status and clinicopathological *** We retrospectively reviewed 284 GC patients who underwent ***-l1 was evaluated by immunohistochemistry(clone SP142)using the com-bined positive *** PD-l1+PT staged as pN+were also tested for PD-l1 expression in their ***-l1(-)GC with pN+served as the comparison *** Among 284 GC patients included,45 had PD-l1+PT and 24 of them had pN+.For comparison,44 PD-l1(-)cases with pN+were included(sample loss of 4 cases).Of the PD-l1+PT,54.2%(13/24 cases)were also PD-l1+in the *** PD-l1(-)PT,9.1%(4/44)had PD-l1+in the *** agreement between PT and lNM had a kappa value of *** tumor size and moderate/severe peritumoral inflammatory response were associated with PD-l1 positivity in both *** was no statistical difference in overall survival for PT and lNM according to the PD-l1 status(P=0.166 and P=0.837,respectively).CONClUSION Intra-patient heterogeneity in PD-l1 expression was observed between the PT and matched *** disagreement in PD-l1 status may emphasize the importance of considering different tumor sites for analyses to select patients for immunotherapy.

关键词： Gastric cancer lymph node Programmed death ligand 1 Stomach neoplasms Immunohistochemistry Metastasis

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Exenatide efficacy in unselected patients: Comparison with clinical trials

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Journal of Diabetes Mellitus 2012年第1期2卷 118-121页

作者： carole Collet-Gaudillat Gwenaelle Petit-Aubert Virginie Desforges-Bullet Jean Paul Beressi Service de Diabetologie Endocrinologie Hopital Andre MignotLe ChesnayFrance

Exenatide is a Glucagon-like Peptide-1 (GlP-1) analog improving fasting and post-prandial glycaemia, approved in patients treated with a combination of sulfonylureas and metformin and not achieving good metabolic control. This retrospective cohort study compared the efficacy and safety of exenatide in unselected patients with outcomes of FDA trials and other uncontrolled published studies. Exenatide was prescribed in 108 patients between April 2008 and December 2009, 80% of the patients were treated with 10 ug of exenatide twice daily. Mean follow up was 4.5 months for the 1st follow up. Changes in HbA1c (-1.1%), BMI (-1.1) and fasting glucose (-0.61 g/l) from baseline were significant, and coherent with controlled trials. 32% of patients had at least one side effect, often gastro intestinal. 23% stopped the treatment, a quarter (1/4) of which for inefficacity. Patients with a higher BMI (>40) (n = 29) at baseline did not show a better response in HbA1c or weight. Results at the second follow-up show a slight tendency of rising on HbA1c, BMI and fasting blood glucose. Finally, a third follow-up at a mean of 17 months is available for 11 patients, which shows stability in HA1c, BMI and fasting glucose. In our experience, Exenatide was safe and effective in reducing HbA1c and weight in patients who were able to tolerate it. Our results are close to results published elsewhere. There are still gaps in the literature on exenatide, especially on the long term effect, which need to be assessed by more publications.

关键词： Diabetes Mellitus Exenatide long Term Effect

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三种生物黄酮类化合物及其与棉酚相互作用抑制豚鼠肾脏11β-羟甾脱氢酶(英文)

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Acta Pharmacologica Sinica 2002年第1期23卷 94-98页

作者：王茂山,史红,王恪申,marcus M REIDENBERG 浙江省医学科学院计划生育研究所生化药理研究室浙江省医学科学院计划生育研究所生化药理研究室浙江省医学科学院计划生育研究所生化药理研究室 Now in Department of Pharmacology and Medicine.Comell University Medical College.1300 York Ave New York NY 10021 USA 杭州中国 310013 杭州中国 310013 杭州中国 310013

目的:探讨三种生物黄酮类化合物在棉酚诱发低血钾中的作用.方法:从豚鼠肾脏制备11β-羟甾脱氢酶,NAD为辅酶,加入待测化合物,37℃反应一小时后提取甾体,反相高压液相测定酶活性,热辐射图像法分析药物相互作用.结果:所试生物黄酮类化合物... 详细信息

目的:探讨三种生物黄酮类化合物在棉酚诱发低血钾中的作用.方法:从豚鼠肾脏制备11β-羟甾脱氢酶,NAD为辅酶,加入待测化合物,37℃反应一小时后提取甾体,反相高压液相测定酶活性,热辐射图像法分析药物相互作用.结果:所试生物黄酮类化合物均能抑制11β-羟甾脱氢酶,其IC50（95％可信限）分别为:槲皮素164（7-341）μmol/l,桑色素 913（385-2173）μmol/l,柑桔素2193 （1114-4315）μmol/l.当11β-羟甾脱氢酶分别用槲皮素,红桔素,桑色素,柑桔素加上棉酚处理时,其C1值分别为:0.92、0.85、0.98和1.01,结论:三种生物黄酮类化合物与棉酚在抑制11β-羟甾脱氢酶中具有协同或相加作用.

关键词：药物相互作用黄酮类棉酚羟甾类脱氢酶类低钾血症

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Dougherty博士与光敏剂Photofrin

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中国激光医学杂志 2019年第5期28卷 288-291页

作者：黄正 Stuart l.marcus Ron R Allison 福建师范大学医学光电科学与技术教育部重点实验室和福建省光子技术重点实验室福州市350007 SlM Clinical Development Consulting LLC.New YorkUSA Carolina Radiation Medicine North CarolinaUSA

被称为现代光动力医学之父的美国Roswell Park癌症研究所(Roswell Park Cancer Institute,RPCI)光动力中心终身主任Thomas ***博士于2018年10月不幸病逝。Dougherty在上世纪七十年代研发的Photofrin是全球第一个获得批证的用于肿瘤光动... 详细信息

被称为现代光动力医学之父的美国Roswell Park癌症研究所(Roswell Park Cancer Institute,RPCI)光动力中心终身主任Thomas ***博士于2018年10月不幸病逝。Dougherty在上世纪七十年代研发的Photofrin是全球第一个获得批证的用于肿瘤光动力疗法的光敏剂,目前仍在欧美和亚洲部分国家和地区使用。他的工作也是现代光动力医学的一个重要里程碑。根据Dougherty本人以及和他共事过的美国同事提供的资料,本文对Dougherty博士和Photofrin研发过程中的一些重要历史人物和事件做一回顾性介绍。

关键词：癌症研究所光动力 Photofrin 光敏剂肿瘤光动力疗法

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The effect of laves phases and nano-precipitates on the electrochemical corrosion resistance of Mg-Al-Ca alloys under alkaline conditions

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Journal of Magnesium and Alloys 2024年第6期12卷 2447-2461页

作者： Markus Felten Veronika Chaineux Siyuan Zhang Ali Tehranchi Tilmann Hickel Christina Scheu Joshua Spille Marta lipińska-Chwałek Joachim Mayer Benjamin Berkels marcus Hans Imke Greving Silja Flenner Sandra Sefa Daniela Zander Chair of Corrosion and Corrosion Protection RWTH Aachen UniversityAachen 52072 Germany Max-Planck-Institut für Eisenforschung GmbH Düsseldorf 40237 Germany Central Facility for Electron Microscopy RWTH Aachen UniversityAachen 52074 Germany Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons Forschungszentrum Jülich GmbHJülich 52428Germany Mathematical Image and Signal Processing Aachen Institute for Advanced Study in Computational Engineering ScienceRWTH Aachen UniversityAachen 52062 Germany Materials Chemistry RWTH Aachen UniversityAachen 52074 Germany Institute of Materials Physics Helmholtz-Zentrum HereonGeesthacht 21502 Germany

The electrochemical corrosion mechanisms of Mg alloys were extensively studied in previous investigations of different chemical com-positions,modified surface states and various electrolyte ***,recent research focused on the active state of Mg dissolution,leading to unresolved effects of secondary phases adjacent to a stableα-solid solution passive *** present study investigates the fundamental electrochemical corrosion mechanisms of three different laves phases with varying phase morphologies and phase fractions in the passive state of Mg-Al-Ca *** microstructure was characterized by(transmission-)electron microscopy and synchrotron-based transmission X-ray *** electrochemical corrosion resistance was determined with a standard three-electrode setup and advanced in-situ flow cell measurements.A new electrochemical activity sequence(C15>C36>α-Mg>C14)was obtained,as a result of a stable passive layer formation on theα-solid ***,nm-scale Mg-rich precipitates were identified within the laves phases,which tend to inhibit the corrosion kinetics.

关键词： laves phase STEM Magnesium Corrosion Passive layer

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Expression of c-kit receptor in human cholangiocarcinoma and in vivo treatment with imatinib mesilate in chimeric mice

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World Journal of Gastroenterology 2006年第10期12卷 1583-1590页

作者： Thomas Kamenz Karel Caca Thilo Blüthner Andrea Tannapfel Joachim Mssner marcus Wiedmann Department of Internal Medicine Ⅱ University of leipzig Philipp-Rosenthal-Str.2704103 LeipzigGermany Institute of Pathology University of leipzig Liebigstr.2604103 LeipzigGermany

AIM： To investigate the c-kit expression in biliary tract cancer cell lines and histological sections from patients with extrahepatic cholangiocarcinoma （CC） and to evaluate the efficacy of in vitro and in vitro treatment with imatinib mesilate. METHODS： The protein expression of c-kit in the human biliary tract cancer cell lines Mz-ChA-2 and EGI-1 and histological sections from 19 patients with extrahepatic CC was assessed by immunoblotting, immunocytochemistry, and immunohistochemistry. The anti-proliferative effect of imatinib mesilate on biliary tract cancer cell lines Mz-ChA-2 and EGI-1 was studied in vitro by automated cell counting. In addition, immunodeficient NMRI mice （Taconic^TM） were subcutaneously injected with 5 × 10^6 cells of cell lines MzChA-2 and EGI-1. After having reached a tumour volume of 200 mm^3, daily treatment was started intraperitoneally with imatinib mesilate at a dose of 50 mgikg or normal saline （NS）. Tumor volume was calculated with a Vernier caliper. After 14 d, mice were sacrificed with tumors excised and tumor mass determined.RESUlTS： Immunoblotting revealed presence of c-kit in Mz-ChA-2 and absence in EGI-1 cells. Immunocytochemistry with c-kit antibodies displayed a cytoplasmatic and membraneous localization of receptor protein in Mz-ChA-2 cells and absence of c-kit in EGI-1 cells, c-kit was expressed in 7 of 19 （37%） extrahepatic humanCC tissue samples, 2 showed a moderate and 5 a rather weak immunostaining. Imatinib mesilate at a low concentration of 5 μmolil caused a significant growth inhibition in the c-kit positive cell line Mz-ChA-2 （31%）, but not in the c-kit negative cell line EGI-1 （0%）（P〈0.05）. Imatinib mesilate at an intermediate concentration of 10 μmolil inhibited cellular growth of both cell lines （51% vs 57%）. Imatinib mesilate at a higher concentration of 20 μmolil seemed to have a general toxic effect on both cell lines. The IC50 values were 9.7 μmolil and 11 μmolil, respectively. After 14 d of in vitro treat

关键词： Cholangiocarcinoma Imatinib Tyrosine kinase inhibitor c-kit Chimeric mice

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Modular micro-PCR system for the onsite rapid diagnosis of COVID-19

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Microsystems & Nanoengineering 2022年第4期8卷 125-136页

作者： Phuong Quoc Mai Nguyen Ming Wang Nelisha Ann Maria Adelicia Yongling li Hsih Yin Tan Gordon Minru Xiong Meng-Kwang marcus Tan Ali Asgar S.Bhagat Catherine W.M.Ong Chwee Teck lim Institute for Health Innovation and Technology(iHealthtech) National University of SingaporeMD614 Medical Drive#14-01Singapore 117599Singapore Department of Biomedical Engineering National University of Singapore4 Engineering Drive 3Block 4#04-08Singapore 117583Singapore Advanced MedTech 2 Venture Drive#23-18 Vision ExchangeSingapore 608526Singapore Infectious Diseases Translational Research Programme Department of MedicineYong Loo Lin School of MedicineNational University of SingaporeNUHS Tower Block1E Kent Ridge Road Level 11Singapore 119228Singapore

Effective containment of the COVID-19 pandemic requires rapid and accurate detection of the *** chain reaction(PCR)remains the gold standard for COVID-19 *** this article,we report the performance of a cost-effective modular microfluidic reverse transcription(RT)-PCR and RT-loop mediated isothermal amplification(RTlAMP)platform,Epidax®,for the point-of-care testing and confirmation of *** platform is versatile and can be reconfigured either for screening using endpoint RT-PCR or RT-lAMP tests or for confirmatory tests using realtime ***®is highly sensitive and detects as little as 1 RNA copy perµl for real-time and endpoint RT-PCR,while using only half of the *** achieved comparable results with those of a commercial platform when detecting SARS-CoV-2 viruses from 81 clinical RNA ***®can also detect SARS-CoV-2 from 44 nasopharyngeal samples without RNA extraction by using a direct RT-PCR assay,which shortens the sample-to-answer time to an hour with minimal user ***,we validated the technology using an RT-lAMP assay on 54 clinical RNA ***,our platform provides a sensitive,cost-effective,and accurate diagnostic solution for lowresource settings.

关键词： fir confirmation diagnosis

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年龄相关椎体骨赘发生率及其分布的参考值(英文)

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中国临床康复 2004年第11期8卷 2144-2145页

作者：邵增务 marcus Schiltenwolf Gerhard Rompe 华中科技大学同济医学院协和医院骨科湖北省武汉市430022 德国海德堡大学骨科医院德国69118

背景:在工伤等所引起的腰椎间盘病变的鉴定中,由于缺乏年龄相关的椎体骨赘发生率及其分布的参考值而很难对其做出正确的评判。目的:建立年龄相关的椎体骨赘发生率及其分布的参考值数据库。设计:相互对照的回顾性研究。地点和对象:由华... 详细信息

背景:在工伤等所引起的腰椎间盘病变的鉴定中,由于缺乏年龄相关的椎体骨赘发生率及其分布的参考值而很难对其做出正确的评判。目的:建立年龄相关的椎体骨赘发生率及其分布的参考值数据库。设计:相互对照的回顾性研究。地点和对象:由华中科技大学同济医学院协和医院骨科和德国海德堡大学骨科医院完成,研究对象:选用德国海德堡大学骨科医院资料库中1980/1999腰椎侧位X线片1240张,男性X线片633张,平均年龄20～87岁;女性607张,平均年龄20～92岁。干预:测量腰椎侧位X片1240张,将T12～l5椎体骨赘分为椎体上缘刺状骨赘及椎体下缘刺状骨赘,均以“有”或“无”记录,男、女两组分别按每10岁一个年龄段分为Ⅰ,Ⅱ,Ⅲ,Ⅳ,Ⅴ,Ⅵ组计算骨赘发生率,进行统计学分析。主要观察指标:年龄、性别对骨赘发生率的影响及骨赘分布。结果:椎体骨赘发生率随年龄的增长而增加,Ⅴ组分别为48.5%和33.7%,男性发生率明显高于女性发生率(χ2=4.38,P<0.05);男性骨赘最好发于第4腰椎,女性骨赘最好发于第3腰椎。结论:应用年龄相关的椎体骨赘发生率及其分布的参考值数据库,通过对比分析,可对椎体骨赘的发生情况做出客观评价。

关键词：椎体骨赘发生率腰椎间盘病变年龄性别

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Impact of COVID-19 on Biological Diagnosis of Malaria: Case of the Thierno Mouhamadoul Mansour Barro Hospital in Mbour, Senegal

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Advances in Infectious Diseases 2023年第1期13卷 31-40页

作者： Isaac Akhénaton Manga Coura Seye Ameth Dramé Cheikh Binetou Fall Souleye lélo carole Pab Minlekib Marie Pierre Diouf Jean louis Abdourahim Ndiaye Khadime Sylla Babacar Faye Service Parasitologie-Mycologie FMPO UCAD Dakar Senegal Ministry of Health and Social Action Dakar Senegal Hôpital Thierno Mouhamadoul Mansour Barro de Mbour Medical Region of Thiès Mbour Senegal Parasitology-Mycology Department UFR Santé Université Iba Der Thiam de Thiès Thiès Senegal

Background: In Africa, malaria-endemic regions have not been spared from COVID-19 outbreak which emerged in the first quarter of 2020. This pandemic has shown clinical and therapeutic similarities with malaria. This following study sought to determine the impact of COVID-19 on the malaria diagnosis. Method: A review of laboratory registers and an exploitation of the District Health Information Software 2 (DHIS2) to collect information on the diagnosis of malaria by microscopy and by rapid diagnostic test (RDT), but also that of COVID-19 was done from 2017 to 2021 at the Thierno Mouhamadoul Mansour Hospital in Mbour, Senegal. Results: In 2017, 199 Thick drops (TDs) and 1852 RDTs were performed for malaria diagnosis. In 2018, it was 2352 malaria tests with 2138 RDTs and 214 TDs, before reaching a peak of 3943 tests in 2019 including 3742 RDTs and 201 TDs. By 2020, 2263 tests were performed with 2097 malaria RDTs, 158 TDs and 8 COVID RDTs. The latter increased significantly in 2021, reaching 444 COVID RDTs, while TDs and malaria RDT kept decreasing to 147 and 1036 respectively. Positive TDs were higher in 2020 (11.4%) compared to 2017 (3.5%), 2018 (1.4%), 2019 (6.5%) and 2021 (6.8%). For malaria RDTs, a decrease in the number of positive tests was noted between 2017 (4.5%) and 2021 (1.3%). The COVID RDTs were all negative in 2020, 29.5% were positive and 4.1% were undetermined in 2021. Conclusion: COVID-19 has led to changes in efforts to diagnose malaria as well as an increase in malaria prevalence directed towards children under 5 years of age.

关键词： Impact COVID-19 Biological Diagnosis Malaria Senegal

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Can Really Regularized Amplitudes Be Obtained as Consistent with Their Expected Symmetry Properties?

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Journal of Modern Physics 2018年第6期9卷 1153-1178页

作者： Orimar Antonio Battistel Gilson Dallabona marcus Vinicios Fonseca luciana Ebani Departamento de Física Universidade Federal de Santa MariaSanta MariaBrazil Departamento de Física Universidade Federal de LavrasLavrasBrazil Instituto Federal Farroupilha Sao Vicente do SulBrazil Centro Brasileiro de Pesquisas Física Rio de JaneiroBrazil

Through a very detailed investigation involving a set of simple perturbative amplitudes we show that the answer for the question put in the title of the present work is: undoubtedly NO! We are not restricting the sentence to the amplitudes which are considered as anomalous. The referred investigation is performed by using a procedure alternative to the traditional regularization methods. In the context of such a strategy the amplitudes are not modified in intermediary steps of the calculation, like traditional regularization procedures do, and only the validity of the linearity in the integration operation is assumed in the operations made in Feynman integrals typical of the perturbative calculations. The central point of the investigation is the question related to the consistent interpretation of the amplitudes. For these purposes, in all amplitudes having power counting indicating the possibility of divergences, the relations among Green functions, Ward identities and low energy limits are analyzed, in a model having different species of massive 1/2 spin fermions coupled to spin 0 and 1 (even and odd parity) boson fields, formulated in a space-time dimension D=1+1. We show that the maintenance of the linearity in operations involving Feynman integrals excludes the possibility of an anomalous term in the Ward identity relating the axial-vector and the pseudo-scalar-vector two point functions amplitudes. In addition, we show that it is not possible the maintenance of Ward identities and low energy limits in a consistent way if the amplitudes of the perturbative calculations are quantities to be regularized, just because there is no regularization method which is capable to give acceptable results for the divergent objects present in the calculations. This conclusion includes the Dimensional Regularization method which cannot give unique results if the linearity and the symmetric integration are simultaneously required in Feynman integrals. The qualitative conclusio

关键词： Perturbative Calculations Anomalies Ward Identities Consistency

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