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Performance of Dexcom G5 and FreeStyle libre sensors tested simultaneously in people with type 1 or 2 diabetes and advanced chronic kidney disease

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World Journal of Clinical Cases 2022年第22期10卷 7794-7807页

作者： Arndís FinnaÓlafsdóttir Mervi Andelin Aso Saeed Sheyda Sofizadeh Hussein Hamoodi Per-Anders Jansson marcus lind Department of Medicine NU-Hospital GroupUddevallaSweden Department of Molecular and Clinical Medicine Institute of MedicineSahlgrenska AcademyUniversity of GothenburgGöteborgSweden Department of Nephrology Gothenburg UniversitySahlgrenska AcademyInstitute Internal MedicineGöteborgSweden Statistiska Konsultgruppen GöteborgSweden Wallenberg laboratory Department of Molecular and Clinical MedicineInstitute of MedicineSahlgrenska AcademyUniversity of GothenburgGöteborgSweden

BACKGROUND Advanced chronic kidney disease(CKD) is a common complication for people with type 1 and 2 diabetes and can often lead to glucose instability. Continuous glucose monitoring(CGM) helps users monitor and stabilize their glucose levels. To date, CGM and intermittent scanning CGM are only approved for people with diabetes but not for those with advanced *** To compare the performance of Dexcom G5 and FreeStyle libre sensors in adults with type 1 or 2 diabetes and advanced *** This was a non-randomized clinical trial that took place in two outpatient clinics in western Sweden. All patients with type 1 or 2 diabetes and an estimated glomerular filtration rate(eGFR) of l/min per 1.73 m^(2) were invited to participate. Forty patients(full analysis set = 33) carried the Dexcom G5 sensor for 7 d and FreeStyle libre sensor for 14 d simultaneously. For referencing capillary blood glucose(SMBG) was measured with a high accuracy glucose meter(HemoCue®) during the study period. At the end of the study, all patients were asked to answer a questionnaire on their experience using the *** The mean age was 64.1(range 41-77) years, hemoglobin A1 c was 7.0% [standard deviation(SD) 3.2], and diabetes duration was 28.5(SD 14.7) years. A total of 27.5% of the study population was on hemodialysis and 22.5% on peritoneal dialysis. The mean absolute relative difference for Dexcom G5 vs SMBG was significantly lower than that for FreeStyle libre vs SMBG [15.2%(SD 12.2) vs 20.9%(SD 8.6)], with a mean difference of 5.72 [95% confidence interval(CI): 2.11-9.32;P = 0.0036]. The mean absolute difference was also significantly lower for Dexcom G5 than for FreeStyle libre, 1.21 mmol/l(SD 0.78) and 1.76 mmol/l(SD 0.78), with a mean diffrenec of 0.55(95%CI: 0.27-0.83;P = 0.0004).The mean difference(MD) was-0.107 mmol/l and-1.10 mmol/l(P = 0.0002), respectively. In all, 66% of FreeStyle libre values were in the no risk zone on the surveillance error grid compared t

关键词： Type 1 diabetes Type 2 diabetes Chronic kidney disease Continuous glucose monitoring Accuracy Mean absolute relative difference

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An early evaluation of translocation actions for endangered plant species on Mediterranean islands

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Plant Diversity 2019年第2期41卷 94-104页

作者： Giuseppe Fenu Gianluigi Bacchetta S.Christodoulou Charalambos Christini Fournaraki Gian Pietro Giusso del Galdo Panagiota Gotsiou Angelos Kyratzis carole Piazza Magdalena Vicens Maria Silvia Pinna Bertrand de Montmollin Centro Conservazione Biodiversità (CCB) Dipartimento di Scienze della Vita e dell'Ambiente (DISVA) Università degli Studi di Cagliari Hortus Botanicus Karalitanus (HBK) Università degli Studi di Cagliari Department of Forests Ministry of Agriculture Rural Development and Environment CIHEAM Mediterranean Agronomic Institute of Chania (MAICh) Department of Biological Geological and Environmental Sciences University of Catania Agricultural Research Institute Ministry of Agriculture Rural Development and Environment Office de l’Environnement de la Corse (OEC) Jardí Botànic de Sóller Foundation (JBS) Mediterranean Plant Specialist Group (IUCN/SSC)

In situ conservation is widely considered a primary conservation strategy. Plant translocation, specifically, represents an important tool for reducing the extinction risk of threatened species. However, thus far, few documented translocations have been carried out in the Mediterranean islands. The CareMediflora project, carried out on six Mediterranean islands, tackles both short-and long-term needs for the insular endangered plants through in situ and ex situ conservation actions. The project approach is based on using ex situ activities as a tool to improve in situ conservation of threatened plant *** island plants(representing 45 taxa) were selected for translocations using common *** the translocations, several approaches were used, which differed in site selection method, origin of genetic material, type of propagative material, planting method, and more. Although only preliminary data are available, some general lessons can be learned from the experience of the CareMediflora project. Among the factors restricting the implementation of translocations, limited financial resources appear to be the most important. Specific preliminary management actions, sometimes to be reiterated after translocation, increase the overall cost, but often are necessary for translocation success. Translocation using juvenile/reproductive plants produces better results over the short term,although seeds may provide good results over the long run(to be assessed in the future). Regardless,plant translocation success can only be detected over long periods; therefore, proper evaluation of plant translocations requires a long-term monitoring protocol. Care-Mediflora project represents the first attempt to combine the existing approaches in a common plant conservation strategy specifically focusing on the Mediterranean islands.

关键词： Care-Mediflora project ex situ conservation in situ conservation Insular flora Threatened plant populations

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中国英语学习者对前缀和后缀派生词的识别加工差异

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现代外语 2019年第5期42卷 623-635页

作者：李俊敏 marcus Taft 朱正才张北镇上海交通大学外国语学院上海市200240 浙江大学城市学院新南威尔士大学上海交通大学江苏大学

本研究考查以汉语为母语的高水平英语学习者对前缀与后缀派生词的识别加工是否存在差异。研究含两个实验,实验一采用前掩蔽启动词汇判断任务,考查前缀派生词对其词根(如disagree-AGREE)的判断是否存在促进作用以及后缀派生词对其词根的... 详细信息

本研究考查以汉语为母语的高水平英语学习者对前缀与后缀派生词的识别加工是否存在差异。研究含两个实验,实验一采用前掩蔽启动词汇判断任务,考查前缀派生词对其词根(如disagree-AGREE)的判断是否存在促进作用以及后缀派生词对其词根的启动效应(如sailor-SAIl)是否存在差异,并对比与前后缀相对应的词形相关词对其内镶嵌词(如nuclearClEAR、pillow-PIll)的启动情况。实验二要求被试对带有前缀或后缀的有词素结构假词(如resuit、printful)和相应的无词素结构假词(如lesuit、printfil)进行词汇判断,比较二者的加工差异。结果表明,高水平英语学习者对于前缀与后缀派生词的识别都存在词素分解过程,前缀比后缀更难识别。前缀加工与英语水平有关,而后缀加工与英语水平无关。

关键词：前缀后缀派生词识别加工

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Robotic-assisted laparoscopic partial nephrectomy: A comparison of approaches to the posterior renal mass

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World Journal of Clinical Urology 2016年第1期5卷 60-65页

作者： Jessica J Wetterlin Robert H Blackwell Sarah Capodice Stephanie Kliethermes marcus l Quek Gopal N Gupta Department of Urology Loyola University Medical Center Stritch School of Medicine Loyola University Medical Center Department of Public Health Loyola University Medical Center

AIM: To evaluate outcomes of robotic-assisted laparoscopic partial nephrectomy performed for posterior renal tumors via a transperitoneal or retroperitoneal ***: Retrospective review was performed for patients who underwent robotic-assisted laparoscopic partial nephrectomy(RAlPN) for a posterior renal tumor between 2009-2015. Patient demographic characteristics, operative factors, pathology, oncologic outcomes, renal function, and tumor complexity were obtained. Radius of the tumor, exophytic/endophytic properties of the tumor, nearness of tumor to the collecting system, anterior/posterior position, location relative to the polar line(RENAl) nephrometry scores were calculated. nephrometry scores were calculated. The operative approach was determined by the primary surgeon. RESUlTS: A total of 91 patients were identified who underwent RAlPN for a posterior renal tumor. Fifty-four procedures were performed via the retroperitoneal(RP) approach, and 37 via the transperitoneal(TP) approach. There were no significant differences in patient factors(race, sex, age and body mass index), RENAl nephrometry scores, tumor size, conversion rates, or margin status. Among procedures performed on-clamp, therewas no significant difference in warm ischemia times. Total operative time(180.7 min for RP vs 227.8 min for TP, P le time(126.9 min for RP vs 164.3 min for TP, P lood loss(32.5 m l for RP vs 150 ml for TP, P ly lower via the RP approach. Off-clamp RAlPN was performed for 31(57.4%) of RP procedures vs 9(24.3%) of TP procedures. Oncologic and renal functional outcomes were ***: The RP approach to RAlPN for posterior renal tumors is superior with regard to operative time and blood loss and the ability to be performed off-clamp.

关键词： Retroperitoneal Transperitoneal Roboticassisted laparoscopic partial nephrectomy Posterior renal masses

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Inhibition of 11 β-hydroxysteroid dehydrogenase in gulinea pig kidney by three bioflavonoids and their interactions with gossypol

Inhibition of 11 β-hydroxysteroid dehydrogenase in gulinea ...

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作者： marcus M Reidenberg Department of pharmacology and medicineCornell University Medical College

Objective To study the effects of some bioflavonoids on the gossypol-induced *** The 11β-hydroxysteroid dehydrogenase (11β-OHSD)protein was prepared from guinea pig kidney .The activity of 11β-OHSD with NAD as the coenzyme was measured by *** drug interaction was analysed by isobolographic *** The 11β-OHSD can be inhibited by some *** IC50(95% confidence limits) values were:quercetin 164(79341)μmol/l,morin 913(385173)μmol/l,and naringenin 2193(1114315)μmol/*** the 11β-OHSD was treated with quercetin,tangeretin,morin,naringenin plus gossypol,the combination index (CI)values were 0.92,0.85,0.98,and 1.01 *** The interaction of some bioflavonoids with gossypol might be one of the factors for gossypol induced hypokalemia.

关键词： Drug interactions Flavones Gossypol Hydroxysteroid dehydrogenases Hypokalemia

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Angle-tunable intersubband photoabsorption and enhanced photobleaching in twisted bilayer graphene

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Nano Research 2021年第8期14卷 2797-2804页

作者： Eva A.A.Pogna Xianchong Miao Driele von Dreifus Thonimar V.Alencar marcus V.O.Moutinho Pedro Venezuela Cristian Manzoni Minbiao Ji Giulio Cerullo Ana Maria de Paula Istituto di Nanoscienze CNR-NANO Laboratory NESTPiazza San Silvestro 12Pisa 56127Italy State Key laboratory of Surface Physics and Department of Physics Fudan UniversityShanghai 200433China Departamento de Fisica Institute de Ciencias ExatasUniversidade Federal de Minas GeraisBelo Horizonte-MG 31270-901Brazil Departamento de Fisica Institute de Ciencias Exatas e BiologicasUniversidade Federal de Ouro PretoOuro Preto-MG 35400-000Brazil Ndcleo Multidisciplinar de Pesquisas em Computagao-NUMPEX-COMP Campus Duque de CaxiasUniversidade Federal do Rio de JaneiroDuque de Caxias-RJ25265-970Brazil Institute de Fisica Universidade Federal FluminenseUFFNiteroi-RJ24210-346Brazil IFN-CNR Dipartimento di FisicaPolitecnico di MilanoPiazza L.da Vinci 32Milano 20133Italy

Van der Waals heterostructures obtained by artificially stacking two-dimensional crystals represent the frontier of material engineering,demonstrating properties superior to those of the starting *** control of the interlayer twist angle has opened new possibilities for tailoring the optoelectronic properties of these *** bilayer graphene with a strong interlayer coupling is a prototype of twisted heterostructure inheriting the intriguing electronic properties of *** the effects of the twist angle on its out-of-equilibrium optical properties is crucial for devising optoelectronic *** this aim,we here combine excitation-resolved hot photoluminescence with femtosecond transient absorption *** hot charge carrier distribution induced by photo-excitation results in peaked absorption bleaching and photo-induced absorption bands,both with pronounced twist angle *** simulations of the electronic band structure and of the joint density of states enable to assign these bands to the blocking of interband transitions at the van Hove singularities and to photo-activated intersubband *** tens of picoseconds relaxation dynamics of the observed bands is attributed to the angle-dependence of electron and phonon heat capacities of twisted bilayer graphene.

关键词： twisted bilayer graphene transient absorption microscopy hot-photoluminescence van der Waals heterostructures optoelectronic properties van Hove singularities

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Perioperative outcomes and survival of radical cystectomy as a function of body mass index

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World Journal of Clinical Urology 2016年第1期5卷 53-59页

作者： Bethany K Burge Robert H Blackwell Andrew Wilson Robert C Flanigan Gopal N Gupta marcus l Quek Department of Urology Loyola University Medical Center Stritch School of Medicine Loyola University

AIM: To evaluate the perioperative and long term outcomes of cystectomy in obese ***: This is a retrospective review of 580 patients for whom radical cystectomy(RC) was performed for primary urothelial bladder cancer between November 1996-April 2013 at a single institution. Body mass index(BMI) was available for 424 patients who were categorized as underweight(l(18.5-24.9), overweight(25.0-29.9), and obese(≥ 30). Baseline demographics, perioperative outcomes, and survival were assessed. Overall survival(OS) and disease specific survival(DSS) was estimated by Kaplan-Meier method. Medians were compared using the Mann-Whitney U Test. Categorical variables were compared using the χ2 test. A P-value of lly significant. Statistical analyses were performed using the Software Package for the Social Sciences(SPSS), Version 20(International Business Machines SPSS, Chicago, Il, United States). RESUlTS: The median age of all patients was 69 years(inter-quartile range 60-75) and median followup was 23.4 mo(8.7-55.1). Patients were characterized as underweight [9,(2.1%)], normal [113,(26.7%)],overweight [160,(37.8%)], or obese [142,(33.5%)]. Estimated blood loss during RC was higher in the obese group(800 m l) as compared to the normal weight group(500 m l). However, need for transfusion(47.7% vs 52.1%), number of lymph nodes resected(32 vs 30), length of stay(9 d vs 8 d), and 30-d readmission(29.7% vs 25.2%) between obese and normal BMI patients were similar. Obese patients underwent ileal neobladder diversion in 42% of cases, compared to 24% of normal BMI patients(0.003). Normal BMI and obese patients had comparable urinary incontinence(21.4% vs 25.6%, P = 0.343), and need for intermittent catheterization(14.3% vs 5.2%, P = 0.685) at 2 years follow-up. Overall survival was better in obese compared to normal BMI patients on univariate analysis, with median survival of 67 mo vs 37 mo, respectively(P = 0.031). Disease spec

关键词： Urinary bladder neoplasms Body mass index Obesity Cystectomy Underweight

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Impact of steroid maintenance on the outcomes in firsttime deceased donor kidney transplant recipients: Analysis by induction type

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World Journal of Transplantation 2014年第3期4卷 188-195页

作者： Kalathil K Sureshkumar Sabiha M Hussain Ngoc l Thai Tina Y Ko Khaled Nashar Richard J marcus Divisions of Nephrology and Hypertension Department of Medicine Allegheny General Hospital Pittsburgh PA 15212 United States Abdominal Transplantation Allegheny General Hospital Pittsburgh PA 15212 United States

AIM: To analyze the impact of steroid maintenance on the outcomes in kidney transplant recipients stratified by induction agent ***: Patients who underwent first-time deceased donor kidney transplantation between 2000 and 2008 after receiving induction therapy with rabbitantithymocyte globulin(r-ATG), alemtuzumab or an interleukin-2 receptor blocker(Il-2B) and discharged on a calcineurin inhibitor(CNI)/mycophenolate mofetil(MMF)-regimen along with or without steroids were identified from the Organ Procurement and Transplant Network/United Network of Organ Sharing *** each induction type, adjusted overall and deathcensored graft as well as patient survivals were compared between patients discharged on steroid vs no steroid. Among r-ATG induced patients, analysis was repeated after splitting the group into low and high immune risk ***: Among the 37217 patients included in the analysis, 17863 received r-ATG(steroid = 13001, nosteroid = 4862), 3028 alemtuzumab(steroid = 852, no-steroid = 2176) and 16326 Il-2B(steroid = 15008, no-steroid = 1318). Adjusted overall graft survival was inferior(HR = 1.16, 95%CI: 1.06-1.27, P = 0.002) with similar death-censored graft survival(HR = 0.99, 95%CI: 0.86-1.14, P = 0.86) for steroid vs no-steroid groups in r-ATG induced patients. Both adjusted overall and death-censored graft survivals for steroid vs nosteroid groups were similar in alemtuzumab(HR = 0.92, 95%CI: 0.73-1.15, P = 0.47 and HR = 0.87, 95%CI: 0.62-1.22, P = 0.43 respectively) and Il-2B(HR = 1.05, 95%CI: 0.91-1.21, P = 0.48 and HR = 0.94, 95%CI: 0.75-1.18, P = 0.60 respectively) induced groups. Adjusted patient survivals were inferior for steroid vs nosteroid groups in r-ATG induced(HR = 1.31, 95%CI: 1.15-1.49, P lar in alemtuzumab(HR = 1.02, 95%CI: 0.75-1.38, P = 0.92) and Il-2B(HR = 1.17, 95%CI: 0.97-1.40, P = 0.10) induced patients. Among the r-ATG induced group there were 4346 patients in the low immune risk and 13517

关键词： Induction agent Steroid maintenance Graft failure risk Patient death risk High immune risk

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Heparan-mimetics:Potential agents of tissue regeneration for bone and periodontal therapies

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Medicine in Novel Technology and Devices 2021年第3期11卷 1-10页

作者： Maroun Bou Karam Joe El Khoury carole Chakar Sylvie Changotade Didier lutomski Nada Naaman Gaston Godeau Abdellatif Elm’selmi Ronald Younes Karim Senni Craniofacial Research laboratory Faculty of Dental MedicineSaint Joseph University of BeirutLebanon Department of Periodontology Faculty of Dental MedicineSaint Joseph University of BeirutLebanon Universite Sorbonne Paris Nord Unite de Recherche Biomateriaux Innovants et InterfacesURB2IUR 4462F-93000BobignyFrance Universite de Paris F-92049MontrougeFrance EBInnov School of Industrial Biology-EBICergyFrance Department of Oral Surgery Faculty of Dental MedicineSaint Joseph University of BeirutLebanon

Heparan sulfate glycosaminoglycans are key players of tissue repair and can be regarded as useful compounds for regenerative ***,their therapeutic uses face many technical,industrial,and regulatory hurdles due to their animal ***,some non-animal sulfated polysaccharides mimic heparan sulfate properties and offer interesting solutions to replace *** them,dextran derivatives,seaweed polysaccharides,or marine bacterial polysaccharides are the best known and have demonstrated their pro-regenerative capabilities by promoting both extracellular matrix structuring and angiogenesis and limiting degenerative processes such as inflammatory cell migration or tissue *** polysaccharides have also shown their ability to specifically promote osteoblastic differentiation and bone wound ***,recent works shows that heparan-mimetics can be used as an additive to improve the cytocompatibility of bone substitutes commonly used in periodontal *** use of these polysaccharides can be regarded as a clever approach to improve the biointegration of bone substitutes.

关键词： Bone biomaterials Periodontal surgery Heparan-mimetics Marine biotechnology Dextran derivatives Bacterial exopolysaccharides Fucoidans

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Comprehensive evaluation of the metabolic effects of insect meal from Tenebrio molitor *** growing pigs by transcriptomics, metabolomics and lipidomics

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Journal of Animal Science and Biotechnology 2020年第2期11卷 527-544页

作者： Sandra Meyer Denise K.Gessner Maria S.Braune Theresa Friedhoff Erika Most marcus Höring Gerhard liebisch Holger Zorn Klaus Eder Robert Ringseis Institute of Animal Nutrition and Nutrition Physiology Justus Liebig University GiessenHeinrich-Buff-Ring 26-3235392 GiessenGiessenGermany Institute of Clinical Chemistry and laboratory Medicine University Hospital of RegensburgFranz-Josef-Strauss-Allee 1193053 RegensburgGermany Institute of Food Chemistry and Food Biotechnology Justus Liebig University GiessenHeinrich-Buff-Ring 1735392 GiessenGiessenGermany Fraunhofer Institute for Molecular Biology and Applied Ecology Winchester Str.235394 GiessenGiessenGermany

Background:The hypothesis was tested that insect meal(IM)as protein source influences intermediary metabolism of growing *** test this,30 male,5-week-old crossbred pigs were randomly assigned to 3 groups of 10 pigs each with similar body weights(BW)and fed isonitrogenous diets either without(CON)or with 5%IM(IM5)or 10%IM(IM10)from Tenebrio molitor *** 4 weeks and key metabolic tissues(liver,muscle,plasma)were analyzed using ***:Most performance parameters did not differ across the groups,whereas ileal digestibilities of most amino acids were 6.7 to 15.6%-units lower in IM10 than in CON(Pliver and skeletal muscle revealed a total of 166 and 198,respectively,transcripts differentially expressed between IM10 and CON(Plasma metabolomics revealed higher concentrations of alanine,citrulline,glutamate,proline,serine,tyrosine and valine and a lower concentration of asparagine in IM10 than in CON(Ply one out of fourteen quantifiable amino acid metabolites,namely methionine sulfoxide(MetS),in plasma was elevated by 45%and 71%in IM5 and IM10,respectively,compared to CON(Plasma concentrations of both,major carnitine/acylcarnitine species and bile acids were not different across *** of liver and plasma demonstrated no differences in the concentrations of triacylglycerols,cholesterol and the main phospholipids,lysophospholipids and sphingolipids between *** percentages of all individual phosphatidylcholine(PC)and phosphatidylethanolamine(PE)species in the liver showed no differences between groups,except those with 6 double bonds(PC 38:6,PC 40:6,PE 38:6,PE 40:6),which were markedly lower in IM10 than in CON(Pline with this,the percentage of C22:6n-3 in hepatic total lipids was lower in IM10 than in the other groups(Plusions:Comprehensive analyzes of the transcriptome,lipidome and metabolome of key metabolic tissues indicate that partial or complete replacement o

关键词： Animal nutrition Insect meal lipidome liver Metabolism Metabolome Pigs Plasma Skeletal muscle Transcriptome

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