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Comparison of Humoral Immune Responses Elicited by DNA and Protein Vaccines Based on Merozoite Surface Protein-1 from Plasmodium yoelii,a Rodent Malaria Parasite

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Comparison of Humoral Immune Responses Elicited by DNA and P...

狂犬病疫苗免疫策略的卫生经济学评价：系统综述和Meta分析

作者： Paul A．Calvo Thomas M．Daly carole A．Long Department of Microbiology and Immunology Allegheny University of the Health SciencesPhiladelphiaPA 19129USA

Immunization with DNA vaccines encoding relevant Ags can induce not only cell-mediated immune response but also humoral immune responses against pathogenic microorganisms in several animal models. Our previous results demonstrated that,when the C terminus (PyC2) of Plasmodium yoelii merozoite surface protein-1 (MSP-1).a leading vaccine candidate against erythrocytic stages of malaria, was expressed as a fusion protein (GST-PyC2) with glutathione S-transferase (GST), it elicited Ab-mediated protective immune responses in BALB/c mice. In our present study, we wished to examine

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来源： cnki会议评论

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狂犬病疫苗免疫策略的卫生经济学评价：系统综述和Meta分析

作者：如朵（Rukundo Floriane carole）东南大学

学位级别：硕士

背景狂犬病是最令人可怕的传染病之一,总是致命的。尽管许多研究报告了人类和(或)狗的接触后预防(PEP)或接触前预防(PREP)的成本效益,但这些研究的结果是相互矛盾的,也是不确定的。本研究的目的是在系统回顾和meta分析的基础上,评估人群... 详细信息

背景狂犬病是最令人可怕的传染病之一,总是致命的。尽管许多研究报告了人类和(或)狗的接触后预防(PEP)或接触前预防(PREP)的成本效益,但这些研究的结果是相互矛盾的,也是不确定的。本研究的目的是在系统回顾和meta分析的基础上,评估人群和(或)狗的各种免疫策略的卫生经济学。方法通过对CNKI,Wanfang,VIP,Pub Med,Web of Science,Health STAR,LILACS and National Health Service Economic Evaluation等数据库的检索,进行狂犬病疫苗接种的经济学分析,检索时间从建库开始到2017年12月。纳入研究的经济学评价结果使用总增量净收益和95%CI。根据CHEERS进行纳入文献质量评价。所有研究成本转化成2016年美元。结果共有16篇文章纳入,其中2篇为中文14篇为英文。11篇文章采用了社会视角。文献质量评价为1篇优秀,10篇优良,5篇中等。与不接种疫苗相比,实施狂犬病疫苗接种是一种成本效益高的保健干预措施(TINB=404,95%CI 220-587)。研究表明,狂犬病疫苗的接种是符合成本效益的。预防狂犬病的主要策略仍然是预防狂犬病死亡。但是,如果在70%的覆盖率下进行动员和犬类疫苗接种,则成本效益比略高,但这一战略将能够防止所有人因狂犬病而死亡结论从长期来看,联合狗群疫苗接种和人群的暴露后接种是更好地干预策略。

关键词：狂犬病疫苗接种成本效果成本效用成本效益

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支线航空公司的维修模式发生变化

航空维修与工程 2013年第4期 28-29页

作者： carole Shifrin 孙立

支线航空业的变革推动了其维修模式的调整,注重效率的支线航空公司开始审视维修需求与成本的关系。在决定新飞机是外包维修还是自行维修时,可靠性、成本、效率是这些航空公司最看重的因素。

关键词：维修模式航空公司支线自行维修外包维修航空业可靠性成本

Embraer 170／190的维修市场前景

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航空维修与工程 2009年第2期 33-34页

作者： carole Shifrin 孙立(编译)

随着Embraer 170／190喷气机机队规模的扩大，其维修市场也变得很有吸引力。

关键词：维修市场市场前景喷气机吸引力

医生与患者之间关于心肺复苏沟通的前瞻性研究

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世界医学杂志 2002年第14期6卷 46-52页

作者： carole.Golin 赵迎等

Transfatty Acids （TFAs） in Cord Blood and Cord Tissue, in France

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Journal of Food Science and Engineering 2017年第9期7卷 413-422页

作者： Claude Billeaud Nicole Combe Leslie Couedelo Wafae Belcadi Dominique Dallay Jean-Joel Leng carole Vaysse CIC Pddiatrique CHU Pellegrin Universite de Bordeaux Bordeaux 33000 France ITERG Laboratoire de Nutrition Metabolisme et Sante Universite de Bordeaux Bordeaux 33000 France Services de Gynecologie-obstetrique Maternite Pellegrin Universite de Bordeaux Bordeaux 33000 France

Background： Recent studies suggest that dietary transfatty acids （TFAs） at relative high levels （i） increase the risk of coronary heart disease, （ii） inhibit the metabolism of linoleic acid and consequently increase requirement for essential fatty acids （EFAs）. The aim of this prospective study was to estimate TFAs the placental transfer of TFAs to the foetus cord blood and cord tissues in France. Material： TFAs consumption was measured in 59 mother-foetus couples. TFAs transferring across the placenta were estimated by comparative measurement （Capillary Gaz Chromatography） of TFAs in mother＇s blood lipids （n = 59）, cord blood lipids and cord tissue plasma lipids （n = 25） cord red blood tissue （n = 25） and umbilical vessels （n = 15）. Results-Discussion： TFA deposition in cord blood is 0.58% slightly lower than mother level. TFAs incorporation in total lips of cord show selectivity of transfer with lower 18：1 t in cord blood and preferential transfer of diene 18：2 tc in cord blood. There is competition between the 18：2 tc in cholesterol esters （CE） with the linolenic acid and a negative correlation in PLT of arterial tissues with the 18：2 tc and C20：4 n-6 or arachidonic acid （AA）, then there is the same competition in PE of venous tissue. But there is no effect on growth in our population of term newborn. Conclusions： Our results confirm the placental TFAs transfer, a better incorporation in the fetus CE; we demonstrated a selective transfer for the 18：2 9 trans 12 cis （18：2 tc） and a negative correlation （r = -0.76） with the linoleic acid and AA （r = 0.98）. This competition, and the presence of these TFAs in cord tissues, even at a low TFAs consumption, remind us to be a potential risk for the fetus concerning EFA metabolism and growth.

关键词： TFAs pregnancy cord blood and tissues neonate diet.

Prevalence of Malnutrition and Frailty in Elderly Cancer Patients and Resulting Impact on Primary Treatment Recommendations in Colorectal and Breast Cancer

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Journal of Nutritional Oncology 2020年第4期5卷 162-169页

作者： Vittoria Balzano Véronique Dardaine Giraud Carine Sauger carole Lefebvre Patrick Heitzmann Thierry Lecomtef Étienne Dorvalg OncoCentre-Regional Cancerology Network 37000 ToursFrance Geriatric Oncology Coordination Unit Regional Cancerology NetworkToursFranceDepartment of Geriatrics37000 Tours University HospitalFrance Department of Gastroenterology and Digestive Oncology 37000 Tour University HospitalFrance

Objectives To estimate the prevalence of malnutrition in elderly cancer patients and its association with frailty and primary cancer treatment recommendations in patients with the two most prevalent cancers(colorectal cancer,CRC and breast cancer,BC)in the Centre-Val de Loire region of *** The entire cohort of 704 patients aged 75 years or older presenting with cancer who underwent comprehensive geriatric assessment(CGA)between 2014 and 2017 was *** status,frailty(defined by the Balducci classification system based on CGA parameters and comorbidity),and pathological criteria were analyzed in terms of the cancer treatment recommendations suggested by geriatricians both in the whole cohort and in those with CRC and *** In the whole group of 704 patients(84.3+/-4.8 years),the prevalence of malnutrition was 62.9%,and was higher in CRC than in BC patients(71.1%vs 55.4%,P<0.01).In a multivariate analysis,malnutrition and frailty(as determined by the Balducci classification system)were independently related in CRC patients(OR:7.28,95%CI,1.58~34.03;P=0.012)and were unrelated to metastasis[odds ratio(OR):1.34,95%CI,0.56~3.18;P=0.5].By contrast,malnutrition in BC patients was related exclusively to the extent of metastasis(OR:3.52,95%CI,1.50~8.24;P=0.002).It was also demonstrated that geriatricians had a greater tendency to suggest only palliative care to CRC patients presenting with malnutrition(15.4%vs 2.7%,P=0.006)than to BC patients(9.8%vs 5.4%,NS).Conclusion Malnutrition in elderly cancer patients is prevalent,especially in those with colorectal cancer,where malnutrition is frailty-related and may strongly impact on cancer treatment strategies.

关键词： Elderly adult Geriatric oncology Malnutrition Geriatric assessment Treatment decision

英国航空公司赢得研制和生产先进短程导弹的合同

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红外 1994年第2期15卷 41-43页

作者： carole A.Shifrin 李玲

BSA Technology 公司可提供在0.6 至14μm光谱区范围内工作的红外探测器,尤其是高性能室温和热电致冷探测器,也有液氮致冷器件。接近室温探测器的探测率高达1.5×10^(11)cm·Hz^(1/2)/W。利用HgCdZnTe这一相对稳定的低噪声材料可实现... 详细信息

BSA Technology 公司可提供在0.6 至14μm光谱区范围内工作的红外探测器,尤其是高性能室温和热电致冷探测器,也有液氮致冷器件。接近室温探测器的探测率高达1.5×10^(11)cm·Hz^(1/2)/W。利用HgCdZnTe这一相对稳定的低噪声材料可实现环境温度下的高性能。高的工作温度所允许的速度低于1 ns。

关键词：导弹短程导弹合同英国

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减少塑料污染的四种方式

减少塑料污染的四种方式