Comparison of Humoral Immune Responses Elicited by DNA and Protein Vaccines Based on Merozoite Surface Protein-1 from Plasmodium yoelii,a Rodent Malaria Parasite
作者单位：Department of Microbiology and ImmunologyAllegheny University of the Health SciencesPhiladelphiaPA 19129USA
会议日期：2003年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学]
摘 要：Immunization with DNA vaccines encoding relevant Ags can induce not only cell-mediated immune response but also humoral immune responses against pathogenic microorganisms in several animal models. Our previous results demonstrated that,when the C terminus (PyC2) of Plasmodium yoelii merozoite surface protein-1 (MSP-1).a leading vaccine candidate against erythrocytic stages of malaria, was expressed as a fusion protein (GST-PyC2) with glutathione S-transferase (GST), it elicited Ab-mediated protective immune responses in BALB/c mice. In our present study, we wished to examine