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Recurrence rates after endoscopic resection of large colorectal polyps:A systematic review and meta-analysis

World Journal of Gastroenterology 2022年第29期28卷 4007-4018页

作者： carola Rotermund Roupen Djinbachian Mahsa Taghiakbari Markus D Enderle Axel Eickhoff Daniel von Renteln Research and Basic Technologies ERBE Elektromedizin GmbHTuebingen 72072Germany Division of Internal Medicine Montreal University Hospital CenterMontreal QC H2X 3E4Canada Montreal University Hospital Research Center Montreal University Hospital CenterMontreal QC H2X 3E4Canada Department of Internal Medicine II Klinikum HanauHanau 63450Germany

BACKGROUND Complete polyp resection is the main goal of endoscopic removal of large colonic *** techniques have evolved in recent years and endoscopic submucosal dissection(ESD),endoscopic mucosal resection(EMR)with margin ablation,cold snare polypectomy(CSP),cold EMR,and underwater EMR have been ***,efficacy of these techniques with regard to local recurrence rates(LRRs)vs traditional hot snare polypectomy and standard EMR remains *** To analyze LRR of large colonic polyps in a systematic review and *** MEDLINE,EMBASE,EBM Reviews,and CINAHL were searched for prospective studies reporting LRR or incomplete resection rate(IRR)after colonic polypectomy of polyps≥10 mm,published between January 2011 and July *** outcome was LRR for polyps≥10 *** Six thousand nine hundred and twenty-eight publications were identified,of which 34 prospective studies were *** for polyps≥10 mm at up to 12 mo’follow-up was 11.0%(95%CI,7.1%-14.8%;15 studies;4904 polyps).ESD(1.7%;95%CI,0%-3.4%;3 studies,221 polyps)and endoscopic mucosal resection with margin ablation(3.3%;95%CI,2.2%-4.5%;2 studies,947 polyps)significantly reduced LRR vs standard EMR without(15.2%;95%CI,12.5%-18.0%;4 studies,650 polyps)or with unsystematic margin ablation(16.5%;95%CI,15.2%-17.8%;6 studies,3031 polyps).CONCLUSION LRR is significantly lower after ESD or EMR with routine margin ablation;thus,these techniques should be considered standard for endoscopic removal of large colorectal *** techniques,such as CSP,cold EMR,and underwater EMR require further evaluation in prospective studies before their routine implementation in clinical practice can be recommended.

关键词： Colonoscopy Adenoma Polyp Endoscopic mucosal resection Colorectal cancer

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Assessing the effectiveness of quarantine measures during the COVID-19 pandemic in Chile using Bayesian structural time series models

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Infectious Disease Modelling 2022年第4期7卷 625-636页

作者： Claudia Barría-Sandoval Guillermo Ferreira Bernardo Lagos carola Montecino Bacigalupo Nursing School Faculty of Health and Social SciencesUniversidad de las AméricasConcepciònChile Faculty of Nursing Universidad de ConcepciònConcepciònChile Department of Statistics Universidad de ConcepciònConcepciònChile Applied Mathematics Group(GMA)Faculty of Sciences Universidad del BiobíoConcepciònChile Nursing School Faculty of Health and Social SciencesUniversidad de las AméricasSantiagoChile

Background:With the emergence of the COVID-19 pandemic,all existing health protocols were tested under the worst health crisis humanity has experienced since the Black Death in the 14th *** in Latin America have been the epicenter of the COVID-19 pandemic,with more than 1.5 million people *** health measures have included quarantines,border closures,social distancing,and mask use,among *** particular,Chile implemented total or partial quarantine measures depending on the number of infections in each region of the ***,it is necessary to study the effectiveness of these quarantines in relation to the public health measures implemented by government entities at the national ***:The main objective of this study is to analyze the effectiveness of national-and region-level quarantines in Chile during the pandemic based on information published by the Chilean Ministry of Health,and answers to the following question are sought:Were quarantine measures in Chile effective during the COVID-19 pandemic?Methods:The causal effect between the rates of COVID-19 infections and the population rates in Phase 1 and Phase 2 quarantines in the period from March 2020 to March 2021 in different regions of Chile were evaluated using intervention analyses obtained through Bayesian structural time series *** addition,the Kendall correlation coefficient obtained through the copula approach was used to evaluate the comovement between these ***:In 75%of the Chilean regions under study(12 regions out of a total of 16),an effective Phase 1 quarantine,which was implemented to control and reduce the number of cases of COVID-19 infection,was *** main regions that experienced a decrease in cases were those located in the north and center of *** Phase 2,the COVID-19 pandemic was effectively managed in 31%(5 out of 16)of the *** the southcentral and extreme southern regions of Chile,the effectiveness o

关键词： Comovement Bayesian time series models Novel coronavirus 2010 MSC 00e01 99-00

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Proton pump inhibitors and dysbiosis: Current knowledge and aspects to be clarified

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World Journal of Gastroenterology 2019年第22期25卷 2706-2719页

作者： Giovanni Bruno Piera Zaccari Giulia Rocco Giulia Scalese Cristina Panetta Barbara Porowska Stefano Pontone carola Severi Department of Internal Medicine and Medical Specialties Gastroenterology UnitSapienza University of RomeRome 00161Italy Department of Surgical Sciences Sapienza University of RomeRome 00161Italy Department of Cardio-Thoracic Vascular Surgery and TransplantsSapienza University of RomeRome 00161Italy

Proton pump inhibitors (PPIs) are common medications within the practice of gastroenterology. These drugs, which act through the irreversible inhibition of the hydrogen/potassium pump (H+/K+-ATPase pump) in the gastric parietal cells, are used in the treatment of several acid-related disorders. PPIs are generally well tolerated but, through the long-term reduction of gastric acid secretion, can increase the risk of an imbalance in gut microbiota composition (i.e., dysbiosis). The gut microbiota is a complex ecosystem in which microbes coexist and interact with the human host. Indeed, the resident gut bacteria are needed for multiple vital functions, such as nutrient and drug metabolism, the production of energy, defense against pathogens, the modulation of the immune system and support of the integrity of the gut mucosal barrier. The bacteria are collected in communities that vary in density and composition within each segment of the gastrointestinal (GI) tract. Therefore, every change in the gut ecosystem has been connected to an increased susceptibility or exacerbation of various GI disorders. The aim of this review is to summarize the recently available data on PPI-related microbiota alterations in each segment of the GI tract and to analyze the possible involvement of PPIs in the pathogenesis of several specific GI diseases.

关键词： Proton pump inhibitors Hypochloridria Gut microbiota Dysbiosis Gastrointestinal tract Cancer Helicobacter pylori Gastrointestinal infections

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Lower marine productivity increases agonistic interactions between sea lions and fur seals in Northern Pacific Patagonia

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Current Zoology 2022年第6期68卷 657-666页

作者： Felipe MONTALVA Hector PAVES Diego PEREZ-VENEGAS Karin G BARRIENTOS E carola VALENCIA Diego MIRANDA-URBINA Mauricio SEGUEL Facultad de Ciencias Biologicas Pontificia Universidad Catolica de ChileSantiagoChile Departamento de Ciencias Basicas Facultad de CienciasUniversidad Santo TomasOsornoChile Centro de Investigacion y Gestion de Recursos Naturales(CIGREN) Instituto de BiologıaFacultad de CienciasUniversidad de ValparaısoValparaısoChile Programa de Doctorado en Ciencias Agrarias Escuela de Graduados de laFacultad de Ciencias Agrarias y AlimentariasUniversidad Austral de ChileValdiviaChile Facultad de Medicina Veterinaria Sede PatagoniaUniversidad San SebastianPuerto MonttChile Instituto de Ciencias Biologicas Universidad de TalcaTalcaChile Department of Pathobiology Ontario Veterinary CollegeUniversity of GuelphGuelphCanada

Interspecific interactions are key drivers of individual and population-level fitness in a wide range of ***,in marine ecosystems,it is relatively unknown which biotic and abiotic factors impact behavioral interactions between competing *** assessed the impact of weather,marine productivity,and population structure on the behavioral agonistic interactions between South American fur seals(SAFSs),Arctocephalus australis,and South American sea lions(SASLs),Otaria byronia,in a breeding colony of *** hypothesized that agonistic interactions between SAFSs and SASLs respond to biotic and abiotic factors such as SAFS population structure,marine productivity,and *** found that SASL and SAFS interactions almost always resulted in negative impacts on the social structure or reproductive success of the SAFS *** adult males initiated stampedes of SAFS and/or abducted and predated SAFS *** SAFS males abundance and severe weather events were negatively correlated with agonistic interactions between ***,proxies for lower marine productivity such as higher sea surface temperature and lower catches of demerso-pelagic fish were the most important predictors of more frequent agonistic interactions between SAFS and *** the current scenario of decline in marine biomass due to global climate change and overfishing,agonistic interactions between competing marine predators could increase and exacerbate the negative impacts of environmental change in these species.

关键词： interspecific interactions climate change Guafo Island sea surface temperature South American fur seal South American sea lion

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Numerical simulation of blood flow and interstitial fluid pressure in solid tumor microcirculation based on tumor-induced angiogenesis

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Acta Mechanica Sinica 2007年第5期23卷 477-483页

作者： Gaiping Zhao Jie Wu Shixiong Xu M. W. Collins Quan Long carola S. Konig Yuping Jiang Jian Wang A. R. Padhani Department of Mechanics and Engineering Science Fudan University Shanghai 200433 China Brunel Institute for Bioengineering School of Engineering and Design Brunel University Uxbridge Middlesex UK Department of Neurology Huashan Hospital Fudan University Shanghai 200040 China Paul Strickland Scanner Centre Mount Vernon Hospital Rickmansworth Road Northwood Middlesex HA6 2RN UK

A coupled intravascular-transvascular-interstitial fluid flow model is developed to study the distributions of blood flow and interstitial fluid pressure in solid tumor microcirculation based on a tumor-induced microvascular network. This is generated from a 2D nine-point discrete mathematical model of tumor angiogenesis and contains two parent vessels. Blood flow through the microvascular network and interstitial fluid flow in tumor tissues are performed by the extended Poiseuille＇s law and Darcy＇s law, respectively, transvascular flow is described by Starling＇s law; effects of the vascular permeability and the interstitial hydraulic conductivity are also considered. The simulation results predict the heterogeneous blood supply, interstitial hypertension and low convection on the inside of the tumor, which are consistent with physiological observed facts. These results may provide beneficial information for anti-angiogenesis treatment of tumor and further clinical research.

关键词： Solid tumor pressure-Angiogenesis Blood flow - Interstitial Numerical simulation

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Caring about symptoms in person-centred care

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Open Journal of Nursing 2013年第8期3卷 563-567页

作者： Eva Brink carola Skott Department of Nursing Health and CultureUniversity WestTrollhattanSweden Institute of Health and Care Sciences University of GothenburgGothenburgSweden Centre for Person-Centred Care(GPCC) University of GothenburgGothenburgSweden

In the present article, we emphasize the symptom experience perspective in person-centred care and discuss barriers to implementation of this approach. There are obstacles to overcome: the diversity of understandings of symptoms in clinical settings, the current biomedical discourse and the incompleteness of symptom research. Since the 19th century, the biomedical perspective has been powerful in conceptualizing symptoms in terms of pathology and diagnosis. Many diagnoses conjure up preconceived notions about the persons receiving them. This perspective may influence person-centred care negatively. Yet symptoms often mean something beyond the diagnosis. Recognizing this discrepancy, it is crucial that we consider a perspective that starts from each person’s symptom experience, thus complementing the biomedical perspective. Using the notion caring about symptoms, we advocate a person-centred approach that includes a symptom experience perspective. This requires health-care professionals to be skilled in listening to patient narratives and acquire knowledge about how symptom experiences can be individually expressed and interpreted. Listening to symptom experiences may give insights into the personal meaning of illness as well as information about bodily and social restrictions caused by symptom distress. In this way, caring about symptoms will improve the prerequisites for establishing person-centred care planning.

关键词： Biomedical Perspective Nursing Practice Patient-Centred Care Symptom Experience

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Whole Chia Flour as Yield Enhancer, Potential Antioxidant and Input of n-3 Fatty Acid in a Meat Product

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Food and Nutrition Sciences 2016年第10期7卷 855-865页

作者： carola Noelia Riernersman Romero Ana Marí a Consejo Nacional de Investigaciones Cientí ficas y Té cnicas (CONICET) Roque S&aacute enz Peñ a Argentina Universidad Nacional del Chaco Austral (UNCAus) Roque S&aacute enz Peñ a Argentina

In this paper, the effect of the addition of whole chia flour and water at cooked fish burgers on yield, water and fat retention, n-3 fatty acids content and oxidative stability were studied. The results showed that 94% of yield, 92% of water retention and 97% of fat retention were achieved with the addition of 5.92 g of whole chia flour and 15 g of water per 100 g of burger. The n-3 fatty content increased from 704.57 ± 21.66 mg to 1551.71 ± 47.71 mg/100g of cooked burger when the chia flour was added, enhancing nutritional quality indices of lipid. A good oxidative stability, with minimum formation of conjugated dienes, hydroperoxides and thiobarbituric acid reactive substances during 30 days frozen storage was obtained too, probably due to the presence of polyphenolic compounds with antiradical activity and reducing power in the fibrous fraction of the flour chia. The results from the present study highlight remarkable technological applications of whole chia flour as food ingredient in the design of healthier fish meat commodities.

关键词： Freshwater Fish Whole Chia Flour Potential Antioxidant Yield Fortified Foods

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美国及欧洲的医疗卫生服务体系现状分析

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中华医院管理杂志 2009年第9期25卷 581-584页

作者： carola Fink-Anthe 全球医药卫生基金会德国黑森州法兰克福60594

介绍了英国、德国和美国近年来的医疗卫生体系、医疗费用筹集制度、医疗保险覆盖程度、卫生服务提供情况和医疗管理体制现状，重点论述了各医疗卫生体系存在的问题和目前的改革措施，提出医疗卫生改革的基本原则，以期为我国的医疗体制... 详细信息

介绍了英国、德国和美国近年来的医疗卫生体系、医疗费用筹集制度、医疗保险覆盖程度、卫生服务提供情况和医疗管理体制现状，重点论述了各医疗卫生体系存在的问题和目前的改革措施，提出医疗卫生改革的基本原则，以期为我国的医疗体制改革提供借鉴。

关键词：美国欧洲医疗卫生,服务体系现状分析

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The Search for Indicators of ICT： Preliminary Study on Industrial Enterprises of Cordoba and Rosario

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Computer Technology and Application 2011年第7期2卷 550-557页

作者： carola Jones Alicia Marchese Paula Nahirnak Departamento de lnformatica y Facultad de Ciencias Economicas Universidad Nacional de Cordoba Cordoba 5000 Argentina Departamento de Administracion Facultad de Ciencias Economicas Universidad Nacional de Rosario Rosario 5000 Argentina Instituto de Estudios sobre la Realidad Argentina y Latinoamericana （IERAL） Buenos Aires C1053ABN Argentina

In this paper, the incorporation and use of ICT （Information and Communication Technologies） in organizations are recognized as a process that occurs in stages involving progressive levels of maturity towards the integration of the extended value chain. In the beginning, ICT are applied to the digitalization of tasks and processes within the organization that facilitates the transition to the stage of integration of information systems and internal communication. Once this level of maturity is reached, it is possible to extend the application oflCT in inter-organizational processes. The main objective of this work is to identify factors that encourage the integration of inter-organizational information systems and the development of the extended value chain. One of the difficulties that this kind of study has to face is on the lack of precise empirical tools that enable comparability of results, both in time and between sectors and countries. It is therefore necessary to perform specific works that shed light on whether the efforts of local organizations to integrate ICT enhance collaborative processes with the environment and the factors influencing these results. It was applied a mixed methodology that combines ad-hoc survey and Tool Assessment Websites, carried out on 23 industrial manufacturing companies located in Rosario and Cordoba Argentina. The search was oriented to the identification of a limited number of indicators, but with the advantage of being amenable to being followed in time, for a number of companies in the region under study. The results indicate that companies with customers and/or suppliers abroad denote a higher level of maturity in the application of ICT.

关键词： Knowledge-based economy information technologiecs and communication value chain integration e-business

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Targeting adenosine receptor 2B in triple negative breast cancer

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 171-177页

作者： carola A.Neumann Kevin Levine Steffi Oesterreich Department of Pharmacology&Chemical Biology University of Pittsburgh Medical Center Hillman Cancer CenterWomens Cancer Research CenterMagee Womens Research InstitutePittsburghPA 15213USA Department of Pathology University of PittsburghPittsburghPA 15261USA

In the review“Role of adenosine in tumor progression:focus on A2B receptor as potential therapeutic target”,Sorrentino and Morello make a compelling case for considering adenosine 2B receptor(A2BR)as a target in cancer therapy(J Cancer Metastasis Treat 2017;3:127-38).A large body of evidence has accumulated suggesting A2BR to play an active role in tumor immune suppression and ***,this commentary will discuss the intriguing possibility of targeting A2BR in specific breast cancers that express high levels of A2BR and attract infiltrating immune cells.

关键词： breast cancer Cancer

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