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Bridging the gap:Unveiling the crisis of physical inactivity in inflammatory bowel diseases

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World Journal of Gastroenterology 2024年第10期30卷 1261-1265页

作者： Remus Stafie Ana-Maria Singeap Adrian Rotaru carol Stanciu Anca Trifan Department of Gastroenterology Faculty of Medicine“Grigore T.Popa”University of Medicine and PharmacyIasi 700115Romania Institute of Gastroenterology and Hepatology “St.Spiridon”University HospitalIasi 700111Romania

In this editorial we comment on the article titled“Inflammatory bowel diseases patients suffer from significant low levels and barriers to physical activity:The BE-FIT-IBD study”published in a recent issue of the World Journal of Gastroen-terology 2023;29(41):*** bowel diseases(IBD)are emerging as a significant global health concern as their incidence continues to rise on a global scale,with detrimental impacts on quality of *** many advances have been made regarding the management of the disease,physical inactivity in these patients represents an underexplored issue that may hold the key for further and better understanding the ramifications of *** pain,fatigue,and fear of exacerbating symptoms promotes physical inactivity among IBD patients,while the lack of clear guidelines on safe exercise regimens contributes to a norm of physical *** activity(PA)is accepted to have a positive effect on disease outcomes and quality of life,while inactivity exacerbates comorbidities like cardiovascular disease and mental health ***“BE-FIT-IBD”study,focusing on PA levels and barriers in IBD patients of Southern Italy,revealed that a significant proportion(42.9%)were physically *** lack of PA is attributed to barriers such as fear of flare-ups and misconceptions about exercise exacerbating the *** study also highlighted the need for better communication between healthcare providers and patients regarding the benefits of PA and safe incorporation into ***,physical inactivity may also contribute to disability in IBD patients,having a great impact on employment *** note is the fact that IBD also comes with an important psychological burden with relevant evidence suggesting that regular PA can improve mood,reduce anxiety,and enhance mental ***“BE-FIT-IBD”study advocated for the integration of PA into IBD management,emphasizing the bidirectional link between PA and *** exe

关键词： Inflammatory bowel disease Physical activity Disability Psychological burden Body composition Quality of life

氧化铝基质低水泥浇注料粒度级配探讨与减水剂的应用

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氧化铝基质低水泥浇注料粒度级配探讨与减水剂的应用

Repeatability,interocular correlation and agreement of optic nerve head vessel density in healthy eyes:a sweptsource optical coherence tomographic angiography study

2019年全国耐火原料学术交流会

作者： Jér?me Kiennemann carol ulrich 魏昊李正钦 ALTEO 阿泰欧法铝业(上海)有限公司

微粉不仅在浇注料的流动特性中起主要作用,而且影响浇注料的最终性能。为了优化浇注料的颗粒堆积,可以使用不同种类的氧化铝微粉来形成基质:煅烧的、半活性的、单峰或多峰氧化铝微粉。在前人的研究中,使用了不同种类的氧化铝微粉,进行... 详细信息

微粉不仅在浇注料的流动特性中起主要作用,而且影响浇注料的最终性能。为了优化浇注料的颗粒堆积,可以使用不同种类的氧化铝微粉来形成基质:煅烧的、半活性的、单峰或多峰氧化铝微粉。在前人的研究中,使用了不同种类的氧化铝微粉,进行了系统的方法来研究在低水泥浇注配方中优化粒度的堆积。这些氧化铝微粉的典型平均粒度范围为0.3～6μm。新氧化铝微粉产品的潜力,作为活性氧化铝微粉的竞争性替代品,它具有约3μm的中值粒径(d50),并且具有单峰粒度,其具有约0.5μm的一些细粒,来自其特定的研磨技术。Dinger和Funk的粒度堆积模型被用于优化该氧化铝的浇注料的粒度堆积设计。在许多情况下,在配方中单独使用这种氧化铝微粉可以完全满足应用。在其他情况下,与活性氧化铝微粉(d=0.5μm)的组合可用于进一步改善流变性质。通常发现双峰氧化铝微粉在实际配方应用上,有效地获得良好的流变性。研究粒度堆积曲线的影响,以理解对浇注性能的影响。针对浇注料在混合期间的流动性行为和扭矩流变行为,可通过使用特定添加剂,补偿各种氧化铝微粉之间的差异。

关键词：低水泥浇注料基质氧化铝微粉颗粒级配减水剂

来源： cnki会议评论

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 896-903页

作者： Dan-Qi Fang Da-Wei Yang Xiao-Ting Mai carol Y Cheung Hao-Yu Chen Joint Shantou International Eye Center Shantou University&the Chinese University of Hong KongShantou 515041Guangdong ProvinceChina Department of Ophthalmology and Visual Sciences Chinese University of Hong KongHong Kong 999077China

AIM:To assess the repeatability,interocular correlation,and agreement of quantitative swept-source optical coherence tomography angiography(OCTA)optic nerve head(ONH)parameters in healthy ***:Thir ty-three healthy subjects were *** ONH of both eyes were imaged four times by a swept-source-OCTA using a 3 mm×3 mm scanning *** of the radial peripapillary capillary were analyzed by a customized Matlab program,and the vessel density,fractal dimension,and vessel diameter index were *** repeatability of the four scans was determined by the intraclass correlation coefficient(ICC).The most well-centered optic disc from the four repeated scans was then selected for the interocular correlation and agreement analysis using the Pearson correlation coefficient,ICC and Bland-Altman ***:All swept-source-OCTA ONH parameters exhibited certain repeatability,with ICC>0.760 and coefficient of variation(CoV)≤7.301%.The obvious interocular correlation was observed for papillary vessel density(ICC=0.857),vessel diameter index(ICC=0.857)and fractal dimension(ICC=0.906),while circumpapillary vessel density exhibited moderate interocular correlation(ICC=0.687).Bland-Altman plots revealed an agreement range of-5.26%to 6.21%for circumpapillary vessel ***:OCTA ONH parameters demonstrate good repeatability in healthy *** interocular correlations of papillary vessel density,fractal dimension and vessel diameter index are high,but the correlation for circumpapillary vessel density is moderate.

关键词： interocular correlation repeatability optic nerve head optical coherence tomography angiography vessel density

Purple acid phosphatase promoted hydrolysis of organophosphate pesticides in microalgae

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Environmental Science and Ecotechnology 2024年第2期18卷 137-149页

作者： Xiang Wang Guo-Hui He Zhen-Yao Wang Hui-Ying Xu Jin-Hua Mou Zi-Hao Qin carol Sze Ki Lin Wei-Dong Yang Yalei Zhang Hong-Ye Li Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes College of Life Science and TechnologyJinan UniversityGuangzhou510632China School of Energy and Environment City University of Hong KongTat Chee AvenueKowloonHong Kong Centre for Technology in Water and Wastewater School of Civil and Environmental EngineeringUniversity of Technology SydneyUltimoNSW2007Australia Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou510000China State Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and EngineeringTongji UniversityShanghai200092China

When organophosphate pesticides(OPs)are not used and handled in accordance with the current rules and standards,it results in serious threats to the aquatic environment and human *** tricornutum is a prospective microalgae-based system for pollutant removal and carbon *** engineered ***,designated as the OE line(endogenously expressing purple acid phosphatase 1[PAP1]),can utilize organic phosphorus for cellular ***,the competencies and mechanisms of the microalgae-based system(namely the OE line of ***)for metabolizing OPs remain to be *** this study,the OE line exhibited the effective biodegradation competencies of 72.12%and 68.2%for 30 mg L^(-1)of dichlorvos and 50 mg L^(-1)of glyphosate,accompanied by synergistic accumulations of biomass(0.91 and 0.95 g L^(-1))and lipids(32.71%and 32.08%),***,the biodiesel properties of the lipids from the OE line manifested a high potential as an alternative feedstock for microalgae-based biofuel production.A plausible mechanism of OPs biodegraded by overexpressed PAP1 is that sufficient inorganic P for adenosine triphosphate and concurrent carbon flux for the reduced form of nicotinamide adenine dinucleotide phosphate biosynthesis,which improved the OP tolerance and biodegradation competencies by regulating the antioxidant system,delaying programmed cell death and accumulating lipids via the upregulation of related *** sum up,this study demonstrates a potential strategy using a genetically engineered strain of *** to remove high concentrations of OPs with the simultaneous production of biomass and biofuels,which might provide novel insights for microalgae-based pollutant biodegradation.

关键词： Biodegradation Lipid accumulation Organophosphate pesticide Phaeodactylum tricornutum Purple acid phosphatase

AI-Based Advanced Approaches and Dry Eye Disease Detection Based on Multi-Source Evidence:Cases,Applications,Issues,and Future Directions

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Big Data Mining and Analytics 2024年第2期7卷 445-484页

作者： Mini Han Wang Lumin Xing Yi Pan Feng Gu Junbin Fang Xiangrong Yu Chi Pui Pang Kelvin Kam-Lung Chong carol Yim-Lui Cheung Xulin Liao Xiaoxiao Fang Jie Yang Ruoyu Zhou Xiaoshu Zhou Fengling Wang Wenjian Liu Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University/The First Affiliated Hospital of Faculty of Medicine Macao University of Science and Technology) Zhuhai 519000China Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong 999077China Faculty of Data Science City University of MacaoMacao 999078China Zhuhai Institute of Advanced Technology Chinese Academy of Sciences Zhuhai 519000China Perspective Technology Group Zhuhai 519000China First Affiliated Hospital of Shandong First Medical University Shandong Provincial Qianfoshan Hospital Jinan 250000China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518000China College of Staten Island The City University of New YorkNY 10314USA Department of Optoelectronic Engineering Jinan UniversityGuangzhou 510000China Zhuhai Aier Eye Hospital Zhuhai 519000China College of Artificial Intelligence Chongqing Industry and Trade PolytechnicChongqing 400000China Centre for Science and Technology Exchange and Cooperation between China and Portuguese-Speaking Countries Zhuhai 519000China School of Artificial Intelligence Hezhou UniversityHezhou 542899China

This study explores the potential of Artificial Intelligence(AI)in early screening and prognosis of Dry Eye Disease(DED),aiming to enhance the accuracy of therapeutic approaches for eye-care *** the promising opportunities,challenges such as diverse diagnostic evidence,complex etiology,and interdisciplinary knowledge integration impede the interpretability,reliability,and applicability of AI-based DED detection *** research conducts a comprehensive review of datasets,diagnostic evidence,and standards,as well as advanced algorithms in AI-based DED detection over the past five *** DED diagnostic methods are categorized into three groups based on their relationship with AI techniques:(1)those with ground truth and/or comparable standards,(2)potential AI-based methods with significant advantages,and(3)supplementary methods for AI-based DED *** study proposes suggested DED detection standards,the combination of multiple diagnostic evidence,and future research directions to guide further ***,the research contributes to the advancement of ophthalmic disease detection by providing insights into knowledge foundations,advanced methods,challenges,and potential future perspectives,emphasizing the significant role of AI in both academic and practical aspects of ophthalmology.

关键词： Artificial Intelligence(AI) ophthalmology Dry Eye Disease(DED)detection multi-source evidence

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女性商学院院长增多缩小性别差距

商业周刊（中文版） 2024年第5期 14-15页

作者： carol Hymowitz 汪泽(译) 不详

在美国商学院中,担任领导职务的女性和男性之间的差距一直在缩小,特别是越来越多的女性被提拔到有望担任院长的后备职位上。据美国精英商学院协会(Association to Advance Collegiate Schools of Business,简筒称AACSB)的一项研究,2023-... 详细信息

在美国商学院中,担任领导职务的女性和男性之间的差距一直在缩小,特别是越来越多的女性被提拔到有望担任院长的后备职位上。据美国精英商学院协会(Association to Advance Collegiate Schools of Business,简筒称AACSB)的一项研究,2023-2024年,美国368所商学院的女院长占总数的30%。这比2007-08年的17%有所提高。

关键词：领导职务 AACSB 商学院性别差距

描绘今天世界的“野草”——浅议第八届横滨三年展的策展方法

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美术观察 2024年第9期 26-31页

作者：卢迎华刘鼎中间美术馆不详

本文以第八届横滨三年展为例,通过分析展览的问题意识、展览主旨的内涵、展览章节的构思、展览叙事的建构和展览语言的设计等几个方面,来呈现笔者对于展览创作的思考与实践。

关键词：第八届横滨三年展双/三年展策展展览创作展览语言

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Lonely Moon

语数外学习(初中版) 2024年第6期 1-1页

作者： carol Coven Grannick

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Understanding protein palmitoylation:Biological significance and enzymology

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Science China Chemistry 2011年第12期54卷 1888-1897页

作者： FIERKE carol A. Departments of Chemistry and Biological Chemistry University of Michigan930 N University

Protein palmitoylation is a widespread lipid modification in which one or more cysteine thiols on a substrate protein are modified to form a thioester with a palmitoyl *** lipid modification is readily reversible;a feature of protein palmitoylation that allows for rapid regulation of the function of many cellular *** in palmitoyltransferases(PATs),the enzymes that catalyze the formation of this modification,are associated with a number of neurological diseases and cancer *** review summarizes the crucial role of palmitoylation in biological systems,the discovery of the DHHC protein family that catalyzes protein palmitoylation,and the development of methods for investigating the catalytic mechanism of PATs.

关键词： protein palmitoylation palmitoyltransferase (PAT) DHHC protein family catalytic mechanism palmitoylation assay

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